MOUSE:FYN

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fyn
Protein Name(s)	Tyrosine-protein kinase Fyn Proto-oncogene c-Fyn p59-Fyn
External Links
UniProt	P39688
EMBL	M27266 U70324 AK156584 AK171646 BC032149 BC092217
CCDS	CCDS23788.1 CCDS48538.1
PIR	A44991
RefSeq	NP_001116364.1 NP_001116365.1 NP_032080.2 XP_006512602.1 XP_006512603.1
UniGene	Mm.4848
PDB	3UF4
PDBsum	3UF4
ProteinModelPortal	P39688
SMR	P39688
BioGrid	199773
DIP	DIP-198N
IntAct	P39688
MINT	MINT-85422
ChEMBL	CHEMBL4517
PhosphoSite	P39688
PaxDb	P39688
PRIDE	P39688
Ensembl	ENSMUST00000063091 ENSMUST00000099967 ENSMUST00000126486 ENSMUST00000135242 ENSMUST00000146287
GeneID	14360
KEGG	mmu:14360
UCSC	uc007evx.2 uc007evy.2
CTD	2534
MGI	MGI:95602
eggNOG	COG0515
GeneTree	ENSGT00760000118938
HOGENOM	HOG000233858
HOVERGEN	HBG008761
InParanoid	P39688
KO	K05703
OMA	SHNSGYR
TreeFam	TF351634
Reactome	REACT_188185 REACT_188194 REACT_188578 REACT_196487 REACT_196588 REACT_198634 REACT_204081 REACT_220092 REACT_225107 REACT_225233 REACT_226151 REACT_226341 REACT_227425 REACT_237796 REACT_241951 REACT_243590 REACT_243939 REACT_244852 REACT_246154 REACT_248291 REACT_254306 REACT_257032 REACT_257088 REACT_257656 REACT_258158 REACT_261451 REACT_261568
ChiTaRS	Fyn
NextBio	285821
PRO	PR:P39688
Proteomes	UP000000589
Bgee	P39688
CleanEx	MM_FYN
ExpressionAtlas	P39688
Genevestigator	P39688
GO	GO:0005884 GO:0071944 GO:0005829 GO:0005768 GO:0045121 GO:0005739 GO:0005634 GO:0005886 GO:0014069 GO:0005524 GO:0001664 GO:0044325 GO:0046872 GO:0004715 GO:0004672 GO:0004713 GO:0015631 GO:0050798 GO:0007166 GO:0071375 GO:0036120 GO:0071560 GO:0048813 GO:0050966 GO:0030900 GO:0042552 GO:2001240 GO:0010629 GO:0043524 GO:0042177 GO:0001764 GO:0018108 GO:0043123 GO:0010976 GO:0014068 GO:1900182 GO:0046777 GO:0006468 GO:0008360 GO:0042493 GO:0045471 GO:0050852
Gene3D	3.30.505.10
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:20978343^[1]	ECO:0000314			P		Treatment of WT VSMCs with 1-(Palmitoyl)- 2-(5-keto-6-octene-dioyl)phosphatidylcholine (KodiA-PC) (24), a specific CD36 ligand, dramatically increased Fyn phosphorylation (Figure 6B)	complete
	GO:0004713	protein tyrosine kinase activity	PMID:20978343^[1]	ECO:0000314			F		Treatment of WT VSMCs with 1-(Palmitoyl)- 2-(5-keto-6-octene-dioyl)phosphatidylcholine (KodiA-PC) (24), a specific CD36 ligand, dramatically increased Fyn phosphorylation (Figure 6B)	complete
	GO:0010629	negative regulation of gene expression	PMID:20978343^[1]	ECO:0000315			P		Figure 6C. Fyn deletion increases Prdx2 and Nrf2 expression in VSMCs.	complete
	GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	PMID:23438599^[2]	ECO:0000315			P		Fig 3	complete CACAO 7498
	GO:1900182	positive regulation of protein localization to nucleus	PMID:20142099^[3]	ECO:0000315			P		Supplementary figure 3. Figure 4.	complete CACAO 9085
involved_in	GO:0003015	heart process	PMID:27525436^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9JHI8	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:27525436^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q9JHI8) occurs_in:(UBERON:0000948) negatively_regulates:(GO:1903409)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:11826099^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10637	F	occurs_in:(CL:0000128) occurs_at:(GO:0045121) positively_regulates:(GO:0106091)	Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000128) occurs_at:(GO:0045121)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0097386	glial cell projection	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
part_of	GO:0044297	cell body	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925,UniProtKB:Q01097	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925,UniProtKB:Q01097	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1905664	regulation of calcium ion import across plasma membrane	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) causally_upstream_of:(GO:1901216) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q01097) regulates:(GO:0098703)	Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:20655099^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:20655099^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(GO:0030425) part_of:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	PMID:22820466^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q01097)	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:23438599^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:20142099^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001664	G protein-coupled receptor binding	PMID:23169819^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q923Z0	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:12538589^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EPK8	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:1361685^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:1361685^[10]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:1361685^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:1361685^[10]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521487 UniProtKB:P06241	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:Q9H3Y6 WB:WBGene00005077	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P08631	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 RGD:621423	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P07948	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262733 PANTHER:PTN002521528 RGD:2641 RGD:620795 RGD:621017 UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95527 PANTHER:PTN002521528 UniProtKB:P09769 UniProtKB:P51451 UniProtKB:Q13882 WB:WBGene00005077	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905430	cellular response to glycine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905232	cellular response to L-glutamate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903202	negative regulation of oxidative stress-induced cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900182	positive regulation of protein localization to nucleus	PMID:20142099^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:17623777^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:21829547^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98397 MGI:MGI:99147	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	PMID:16190898^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930480	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050852	T cell receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050798	activated T cell proliferation	PMID:1516132^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179145	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:12372285^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930480	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:8175795^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	PMID:9381182^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	C		Seeded From UniProt	complete
colocalizes_with	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:23169819^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1927596	P	regulates_o_occurs_in:(CL:0000136)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
enables	GO:0042610	CD8 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
enables	GO:0042609	CD4 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
enables	GO:0042608	T cell receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	PMID:16841086^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036120	cellular response to platelet-derived growth factor stimulus	PMID:17623777^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	PMID:24627473^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_input:(MGI:MGI:1913391)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:16162939^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98397	P	results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15073522^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:98397	P	results_in_development_of:(EMAPA:35256)\|results_in_development_of:(EMAPA:35257)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:9381182^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930480	P	has_input:(MGI:MGI:95819)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:17923684^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857172	P	occurs_in:(EMAPA:28239)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:8196616^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:8175795^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:17923684^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(MGI:MGI:1891396)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10872802^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	PMID:18354028^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98247	P	regulates_o_occurs_in:(EMAPA:17787) regulates_o_occurs_in:(CL:0001031)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008360	regulation of cell shape	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007166	cell surface receptor signaling pathway	PMID:9177270^[27]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000576)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:9892651^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930480	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:16190898^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930480	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	C		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:17623777^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:17623777^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8196616^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8175795^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:24627473^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1913391)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:20142099^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:17923684^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:16841086^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:3580016)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10872802^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11826099^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003015	heart process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06241	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:16162939^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98397	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)\|occurs_in(EMAPA:17074) results_in_movement_of:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:15073522^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930480	P	occurs_in:(EMAPA:35256) results_in_movement_of:(CL:0000117)\|occurs_in(EMAPA:35257) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000304	response to singlet oxygen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2641	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	F		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	F		Seeded From UniProt	complete
involved_in	GO:0003015	heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06241 ensembl:ENSP00000346671	P		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:1905430	cellular response to glycine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:1905232	cellular response to L-glutamate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:1903202	negative regulation of oxidative stress-induced cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
enables	GO:0042610	CD8 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0042609	CD4 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0042608	T cell receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
involved_in	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	F		Seeded From UniProt	complete
involved_in	GO:0000304	response to singlet oxygen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62844 ensembl:ENSRNOP00000000733	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-9032771	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-421138 Reactome:R-NUL-421136 Reactome:R-NUL-420398 Reactome:R-NUL-420388 Reactome:R-NUL-420386 Reactome:R-MMU-983702 Reactome:R-MMU-420394 Reactome:R-MMU-420382 Reactome:R-MMU-3928635 Reactome:R-MMU-3928613 Reactome:R-MMU-2395436 Reactome:R-MMU-1433273	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-NUL-420398 Reactome:R-MMU-983702 Reactome:R-MMU-3928613	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042552	myelination	PMID:11826099^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page
↑ ^2.0 ^2.1 Tse, MC et al. (2013) Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction. Mol. Cell. Biol. 33 1797-808 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Yamada, E et al. (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab. 11 113-24 PubMed GONUTS page
↑ ^4.0 ^4.1 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Klein, C et al. (2002) Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J. Neurosci. 22 698-707 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page
↑ ^7.0 ^7.1 Ittner, LM et al. (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142 387-97 PubMed GONUTS page
↑ ^8.0 ^8.1 Kim, YJ et al. (2012) GPRC5B activates obesity-associated inflammatory signaling in adipocytes. Sci Signal 5 ra85 PubMed GONUTS page
↑ Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Grant, SG et al. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258 1903-10 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Sandilands, E et al. (2007) The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J. Cell. Sci. 120 2555-64 PubMed GONUTS page
↑ Samarakoon, R et al. (2011) Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6 e22896 PubMed GONUTS page
↑ ^14.0 ^14.1 Abe, T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur. J. Neurosci. 22 1445-54 PubMed GONUTS page
↑ Appleby, MW et al. (1992) Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70 751-63 PubMed GONUTS page
↑ Sasaki, Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35 907-20 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Burns, CM et al. (1994) CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J. Biol. Chem. 269 13594-600 PubMed GONUTS page
↑ ^18.0 ^18.1 Miyakawa, T et al. (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278 698-701 PubMed GONUTS page
↑ ^19.0 ^19.1 Tang, X et al. (2007) Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell Death Differ. 14 368-77 PubMed GONUTS page
↑ ^20.0 ^20.1 Chesarino, NM et al. (2014) Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination. J. Biol. Chem. 289 11986-92 PubMed GONUTS page
↑ ^21.0 ^21.1 Kuo, G et al. (2005) Absence of Fyn and Src causes a reeler-like phenotype. J. Neurosci. 25 8578-86 PubMed GONUTS page
↑ ^22.0 ^22.1 Yuasa, S et al. (2004) Defective neocortical development in Fyn-tyrosine-kinase-deficient mice. Neuroreport 15 819-22 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Garg, P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol. Cell. Biol. 27 8698-712 PubMed GONUTS page
↑ ^24.0 ^24.1 Gauen, LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol. Cell. Biol. 14 3729-41 PubMed GONUTS page
↑ ^25.0 ^25.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page
↑ Brackenbury, WJ et al. (2008) Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J. Neurosci. 28 3246-56 PubMed GONUTS page
↑ Sammar, M et al. (1997) Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem. Biophys. Res. Commun. 234 330-4 PubMed GONUTS page
↑ Tezuka, T et al. (1999) PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc. Natl. Acad. Sci. U.S.A. 96 435-40 PubMed GONUTS page

[PMID:20978343-1] 1.0 ^1.1 ^1.2 ^1.3 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page

[PMID:23438599-2] 2.0 ^2.1 Tse, MC et al. (2013) Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction. Mol. Cell. Biol. 33 1797-808 PubMed GONUTS page

[PMID:20142099-3] 3.0 ^3.1 ^3.2 ^3.3 Yamada, E et al. (2010) Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab. 11 113-24 PubMed GONUTS page

[PMID:27525436-4] 4.0 ^4.1 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page

[PMID:11826099-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Klein, C et al. (2002) Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J. Neurosci. 22 698-707 PubMed GONUTS page

[PMID:22820466-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page

[PMID:20655099-7] 7.0 ^7.1 Ittner, LM et al. (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142 387-97 PubMed GONUTS page

[PMID:23169819-8] 8.0 ^8.1 Kim, YJ et al. (2012) GPRC5B activates obesity-associated inflammatory signaling in adipocytes. Sci Signal 5 ra85 PubMed GONUTS page

[PMID:12538589-9] Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page

[PMID:1361685-10] 10.0 ^10.1 ^10.2 ^10.3 Grant, SG et al. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258 1903-10 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17623777-12] 12.0 ^12.1 ^12.2 ^12.3 Sandilands, E et al. (2007) The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J. Cell. Sci. 120 2555-64 PubMed GONUTS page

[PMID:21829547-13] Samarakoon, R et al. (2011) Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE 6 e22896 PubMed GONUTS page

[PMID:16190898-14] 14.0 ^14.1 Abe, T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur. J. Neurosci. 22 1445-54 PubMed GONUTS page

[PMID:1516132-15] Appleby, MW et al. (1992) Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell 70 751-63 PubMed GONUTS page

[PMID:12372285-16] Sasaki, Y et al. (2002) Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35 907-20 PubMed GONUTS page

[PMID:8175795-17] 17.0 ^17.1 ^17.2 Burns, CM et al. (1994) CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J. Biol. Chem. 269 13594-600 PubMed GONUTS page

[PMID:9381182-18] 18.0 ^18.1 Miyakawa, T et al. (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278 698-701 PubMed GONUTS page

[PMID:16841086-19] 19.0 ^19.1 Tang, X et al. (2007) Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Cell Death Differ. 14 368-77 PubMed GONUTS page

[PMID:24627473-20] 20.0 ^20.1 Chesarino, NM et al. (2014) Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination. J. Biol. Chem. 289 11986-92 PubMed GONUTS page

[PMID:16162939-21] 21.0 ^21.1 Kuo, G et al. (2005) Absence of Fyn and Src causes a reeler-like phenotype. J. Neurosci. 25 8578-86 PubMed GONUTS page

[PMID:15073522-22] 22.0 ^22.1 Yuasa, S et al. (2004) Defective neocortical development in Fyn-tyrosine-kinase-deficient mice. Neuroreport 15 819-22 PubMed GONUTS page

[PMID:17923684-23] 23.0 ^23.1 ^23.2 Garg, P et al. (2007) Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol. Cell. Biol. 27 8698-712 PubMed GONUTS page

[PMID:8196616-24] 24.0 ^24.1 Gauen, LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol. Cell. Biol. 14 3729-41 PubMed GONUTS page

[PMID:10872802-25] 25.0 ^25.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page

[PMID:18354028-26] Brackenbury, WJ et al. (2008) Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J. Neurosci. 28 3246-56 PubMed GONUTS page

[PMID:9177270-27] Sammar, M et al. (1997) Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem. Biophys. Res. Commun. 234 330-4 PubMed GONUTS page

[PMID:9892651-28] Tezuka, T et al. (1999) PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc. Natl. Acad. Sci. U.S.A. 96 435-40 PubMed GONUTS page

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