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PMID:9381182
| Citation |
Miyakawa, T, Yagi, T, Kitazawa, H, Yasuda, M, Kawai, N, Tsuboi, K and Niki, H (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278:698-701 |
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| Abstract |
Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol. |
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| Keywords |
Animals; Central Nervous System Depressants/pharmacology; Ethanol/pharmacology; Excitatory Postsynaptic Potentials/drug effects; Flurazepam/pharmacology; Hippocampus/metabolism; Hypnotics and Sedatives/pharmacology; Male; Mice; Mice, Knockout; Motor Activity/drug effects; N-Methylaspartate/pharmacology; Phosphorylation; Phosphotyrosine/metabolism; Protein-Tyrosine Kinases/deficiency; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-fyn; Receptors, N-Methyl-D-Aspartate/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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