MOUSE:FOXO3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxo3 (ECO:0000312 with MGI:MGI:1890081)
Protein Name(s)	Forkhead box protein O3 (ECO:0000305)
External Links
UniProt	Q9WVH4
EMBL	AF114259 AK047413 AC116179 AC140402 CH466540 BC019532
CCDS	CCDS23810.1
RefSeq	NP_062714.1 XP_006512869.1
UniGene	Mm.338613 Mm.391700 Mm.417859 Mm.466459
ProteinModelPortal	Q9WVH4
SMR	Q9WVH4
BioGrid	208010
IntAct	Q9WVH4
STRING	10090.ENSMUSP00000050683
iPTMnet	Q9WVH4
PhosphoSitePlus	Q9WVH4
EPD	Q9WVH4
MaxQB	Q9WVH4
PaxDb	Q9WVH4
PeptideAtlas	Q9WVH4
PRIDE	Q9WVH4
DNASU	56484
Ensembl	ENSMUST00000056974 ENSMUST00000105502 ENSMUST00000175881
GeneID	56484
KEGG	mmu:56484
UCSC	uc007eyl.1
CTD	2309
MGI	MGI:1890081
eggNOG	KOG2294 COG5025
GeneTree	ENSGT00790000123003
HOGENOM	HOG000169927
HOVERGEN	HBG078744
InParanoid	Q9WVH4
KO	K09408
OMA	WMINPDG
OrthoDB	EOG091G06K3
PhylomeDB	Q9WVH4
TreeFam	TF315583
Reactome	[www.reactome.org/content/detail/R-MMU-1181150 R-MMU-1181150] [www.reactome.org/content/detail/R-MMU-198693 R-MMU-198693] [www.reactome.org/content/detail/R-MMU-5687128 R-MMU-5687128]
ChiTaRS	Foxo3
PRO	PR:Q9WVH4
Proteomes	UP000000589
Bgee	ENSMUSG00000048756
ExpressionAtlas	Q9WVH4
Genevisible	Q9WVH4
GO	GO:0005737 GO:0005829 GO:0016020 GO:0005739 GO:0005654 GO:0005634 GO:0008013 GO:0031490 GO:0001047 GO:0003677 GO:0019901 GO:0043565 GO:0003700 GO:0001228 GO:0001227 GO:0007568 GO:0001547 GO:0048854 GO:1904646 GO:0071386 GO:0071333 GO:0071456 GO:1990090 GO:0034599 GO:0030330 GO:0097192 GO:0042593 GO:0001544 GO:0090090 GO:0045665 GO:0000122 GO:0097150 GO:0001556 GO:0001542 GO:0043065 GO:2000353 GO:0045648 GO:1901300 GO:0043525 GO:1903428 GO:0045944 GO:0045893 GO:2000177 GO:2000377 GO:0006357 GO:0006355 GO:0006417 GO:0071548 GO:0042493 GO:0031667 GO:1990785 GO:0033209
Gene3D	1.10.10.10
InterPro	IPR001766 IPR032067 IPR032068 IPR030456 IPR011991
Pfam	PF00250 PF16676 PF16675
PRINTS	PR00053
SMART	SM00339
SUPFAM	SSF46785
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005741	mitochondrial outer membrane	PMID:29445193^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005759	mitochondrial matrix	PMID:29445193^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014737	positive regulation of muscle atrophy	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18054315^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18054316^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18054316^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:18054316^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:18054316^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014737	positive regulation of muscle atrophy	PMID:18054316^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:19933931^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(RNAcentral:URS000075D8E6_10090) occurs_in:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19933931^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000070144) occurs_in:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23283301^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	PMID:23283301^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0042149)	Seeded From UniProt	complete
enables	GO:0034246	mitochondrial sequence-specific DNA-binding transcription factor activity	PMID:23283301^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	happens_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23283301^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23283301^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	PMID:23283301^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:17521387^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:17521387^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:17521387^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:17521387^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:1891915 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN000215135 UniProtKB:A4L7N3 UniProtKB:P98177 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN002908599 UniProtKB:P98177	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1NNE8 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 WB:WBGene00000912	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2676586 PANTHER:PTN002908599	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002908599 UniProtKB:O43524 WB:WBGene00000912 ZFIN:ZDB-GENE-990708-6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:19896444^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890077	P	occurs_in:(CL:0000337) regulates_o_occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000353	positive regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000177	regulation of neural precursor cell proliferation	PMID:19896444^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890077	P	regulates_o_occurs_in:(EMAPA:32804) occurs_in:(EMAPA:32804) occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12431371^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097150	neuronal stem cell population maintenance	PMID:24483844^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2448480,MGI:MGI:95480	P	occurs_in:(EMAPA:32679)\|occurs_in:(EMAPA:32804)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097150	neuronal stem cell population maintenance	PMID:19896444^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890077	P	occurs_in:(EMAPA:32804)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19896444^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:98956	P	regulates_o_occurs_in:(CL:0000337) occurs_in:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048854	brain morphogenesis	PMID:24483844^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2448480,MGI:MGI:95480	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12048180^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11353388^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:12855809^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	PMID:24483844^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2448480,MGI:MGI:95480	P	occurs_in:(CL:0000047) occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0034246	mitochondrial sequence-specific DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:15383658^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15383658^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007568	aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006417	regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006390	mitochondrial transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12930811^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	C		Seeded From UniProt	complete
colocalizes_with	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15383658^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14966295^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12857750^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14966295^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12857750^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25327288^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15322035^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14966295^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15383658^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14966295^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001556	oocyte maturation	PMID:12855809^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001547	antral ovarian follicle growth	PMID:14978268^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3038979	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001544	initiation of primordial ovarian follicle growth	PMID:12855809^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001542	ovulation from ovarian follicle	PMID:12855809^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668328	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:19896444^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890077	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	F		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309196	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43524	P		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1990785	response to water-immersion restraint stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071548	response to dexamethasone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071386	cellular response to corticosterone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	C		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZBQ1 ensembl:ENSRNOP00000000327	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
enables	GO:0034246	mitochondrial sequence-specific DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
involved_in	GO:0006390	mitochondrial transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43524 ensembl:ENSP00000339527	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9625402 Reactome:R-MMU-9622792	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Celestini, V et al. (2018) Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis 9 231 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Mammucari, C et al. (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6 458-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Zhao, J et al. (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6 472-83 PubMed GONUTS page
↑ ^4.0 ^4.1 Elia, L et al. (2009) Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation 120 2377-85 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Wang, F et al. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6 505-14 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page
↑ Datta, SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3 631-43 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Li, X et al. (2014) Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid. Redox Signal. 21 1675-92 PubMed GONUTS page
↑ Furukawa-Hibi, Y et al. (2002) FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J. Biol. Chem. 277 26729-32 PubMed GONUTS page
↑ Biggs, WH 3rd et al. (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12 416-25 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Castrillon, DH et al. (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301 215-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 You, H et al. (2004) p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc. Natl. Acad. Sci. U.S.A. 101 14057-62 PubMed GONUTS page
↑ Mason, JL et al. (2003) Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination. J. Neurosci. 23 7710-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Martínez-Gac, L et al. (2004) Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol. Cell. Biol. 24 2181-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Jacobs, FM et al. (2003) FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J. Biol. Chem. 278 35959-67 PubMed GONUTS page
↑ Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page
↑ Yauch, LE et al. (2004) Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo. Infect. Immun. 72 5373-82 PubMed GONUTS page
↑ Hosaka, T et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U.S.A. 101 2975-80 PubMed GONUTS page

[PMID:29445193-1] 1.0 ^1.1 Celestini, V et al. (2018) Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy. Cell Death Dis 9 231 PubMed GONUTS page

[PMID:18054315-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Mammucari, C et al. (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 6 458-71 PubMed GONUTS page

[PMID:18054316-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Zhao, J et al. (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 6 472-83 PubMed GONUTS page

[PMID:19933931-4] 4.0 ^4.1 Elia, L et al. (2009) Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation 120 2377-85 PubMed GONUTS page

[PMID:23283301-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page

[PMID:17521387-6] 6.0 ^6.1 ^6.2 ^6.3 Wang, F et al. (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6 505-14 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19896444-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page

[PMID:12431371-9] Datta, SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3 631-43 PubMed GONUTS page

[PMID:24483844-10] 10.0 ^10.1 ^10.2 Li, X et al. (2014) Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid. Redox Signal. 21 1675-92 PubMed GONUTS page

[PMID:12048180-11] Furukawa-Hibi, Y et al. (2002) FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J. Biol. Chem. 277 26729-32 PubMed GONUTS page

[PMID:11353388-12] Biggs, WH 3rd et al. (2001) Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm. Genome 12 416-25 PubMed GONUTS page

[PMID:12855809-13] 13.0 ^13.1 ^13.2 ^13.3 Castrillon, DH et al. (2003) Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301 215-8 PubMed GONUTS page

[PMID:15383658-14] 14.0 ^14.1 ^14.2 ^14.3 You, H et al. (2004) p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc. Natl. Acad. Sci. U.S.A. 101 14057-62 PubMed GONUTS page

[PMID:12930811-15] Mason, JL et al. (2003) Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination. J. Neurosci. 23 7710-8 PubMed GONUTS page

[PMID:14966295-16] 16.0 ^16.1 ^16.2 ^16.3 Martínez-Gac, L et al. (2004) Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol. Cell. Biol. 24 2181-9 PubMed GONUTS page

[PMID:12857750-17] 17.0 ^17.1 Jacobs, FM et al. (2003) FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J. Biol. Chem. 278 35959-67 PubMed GONUTS page

[PMID:25327288-18] Dowdle, WE et al. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol. 16 1069-79 PubMed GONUTS page

[PMID:15322035-19] Yauch, LE et al. (2004) Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo. Infect. Immun. 72 5373-82 PubMed GONUTS page

[PMID:14978268-20] Hosaka, T et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. U.S.A. 101 2975-80 PubMed GONUTS page

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