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MOUSE:FOXJ1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Foxj1 (synonyms: Fkhl13, Hfh4)
Protein Name(s) Forkhead box protein J1

Forkhead-related protein FKHL13 Hepatocyte nuclear factor 3 forkhead homolog 4 HFH-4

External Links
UniProt Q61660
EMBL L13204
AK140847
AL645861
CH466558
CCDS CCDS25665.1
PIR I49734
RefSeq NP_032266.3
XP_006532332.1
UniGene Mm.378938
ProteinModelPortal Q61660
SMR Q61660
BioGrid 200289
Ensembl ENSMUST00000036215
GeneID 15223
KEGG mmu:15223
UCSC uc007mkv.2
CTD 2302
MGI MGI:1347474
eggNOG COG5025
GeneTree ENSGT00760000118794
HOGENOM HOG000112631
HOVERGEN HBG056832
InParanoid Q61660
KO K09402
OMA HGHHIDC
OrthoDB EOG7T4MKM
TreeFam TF333250
ChiTaRS Foxj1
NextBio 287811
PRO PR:Q61660
Proteomes UP000000589
Bgee Q61660
CleanEx MM_FOXJ1
Genevestigator Q61660
GO GO:0005634
GO:0003700
GO:0000976
GO:0030036
GO:0032862
GO:0007420
GO:0002508
GO:0042384
GO:0060271
GO:0060429
GO:0035089
GO:0072016
GO:0006959
GO:0060972
GO:0050900
GO:0035502
GO:0050869
GO:0002635
GO:0002924
GO:0045409
GO:0032088
GO:0033085
GO:0042130
GO:0000122
GO:0002897
GO:1901248
GO:0045944
GO:0030856
GO:0006351
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00657
PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:28666954[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:27914912[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9096351[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:27965440[4]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:27965440[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044458

motile cilium assembly

PMID:10873152[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:9096351[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9096351[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:9096351[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:9739041[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060429

epithelium development

PMID:9096351[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

occurs_in:(CL:0000706)

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

PMID:16339515[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050869

negative regulation of B cell activation

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045409

negative regulation of interleukin-6 biosynthetic process

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

PMID:17488776[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

PMID:14963332[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033085

negative regulation of T cell differentiation in thymus

PMID:16339515[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

PMID:17488776[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

PMID:17488776[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:9096351[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

occurs_in:(CL:0000706)

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

PMID:16339515[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002924

negative regulation of humoral immune response mediated by circulating immunoglobulin

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002897

positive regulation of central B cell tolerance induction

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002635

negative regulation of germinal center formation

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002508

central tolerance induction

PMID:16339515[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:16002694[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901248

positive regulation of lung ciliated cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92949

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060972

left/right pattern formation

PMID:10873152[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158221

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16574095[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92949

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0044458

motile cilium assembly

PMID:22357932[12]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:3053002

P

occurs_in:(EMAPA:16075)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035089

establishment of apical/basal cell polarity

PMID:14996907[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2181746

P

occurs_in:(EMAPA:16855)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030856

regulation of epithelial cell differentiation

PMID:16574095[11]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_results_in_acquisition_of_features_of:(CL:0002368)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:25807483[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007368

determination of left/right symmetry

PMID:25807483[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17383628[15]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16737)
  • part_of:(CL:0000067)|part_of:(EMAPA:16737)
  • part_of:(CL:0000067)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16574095[11]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000322)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:14625387[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11724907[17]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17655)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92949

C

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q92949

F

Seeded From UniProt

complete

involved_in

GO:1901248

positive regulation of lung ciliated cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

P

Seeded From UniProt

complete

involved_in

GO:0072016

glomerular parietal epithelial cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

P

Seeded From UniProt

complete

involved_in

GO:0060428

lung epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

P

Seeded From UniProt

complete

involved_in

GO:0035502

metanephric part of ureteric bud development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

C

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q92949
ensembl:ENSP00000323880

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Stauber, M et al. (2017) 1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis. Dev. Biol. 429 186-199 PubMed GONUTS page
  2. Stauber, M et al. (2017) Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev. Biol. 423 170-188 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Lim, L et al. (1997) The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 94 3094-9 PubMed GONUTS page
  4. 4.0 4.1 Weidemann, M et al. (2016) CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development 143 4736-4748 PubMed GONUTS page
  5. 5.0 5.1 Brody, SL et al. (2000) Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am. J. Respir. Cell Mol. Biol. 23 45-51 PubMed GONUTS page
  6. Chen, J et al. (1998) Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Invest. 102 1077-82 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Srivatsan, S & Peng, SL (2005) Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress. J. Immunol. 175 7805-9 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Lin, L et al. (2005) Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. J. Immunol. 175 951-8 PubMed GONUTS page
  9. 9.0 9.1 9.2 Pan, J et al. (2007) RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J. Cell. Sci. 120 1868-76 PubMed GONUTS page
  10. Lin, L et al. (2004) Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Science 303 1017-20 PubMed GONUTS page
  11. 11.0 11.1 11.2 Park, KS et al. (2006) Sox17 influences the differentiation of respiratory epithelial cells. Dev. Biol. 294 192-202 PubMed GONUTS page
  12. Alten, L et al. (2012) Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development 139 1276-84 PubMed GONUTS page
  13. Gomperts, BN et al. (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J. Cell. Sci. 117 1329-37 PubMed GONUTS page
  14. 14.0 14.1 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
  15. Danielian, PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev. Biol. 305 564-76 PubMed GONUTS page
  16. Huang, T et al. (2003) Foxj1 is required for apical localization of ezrin in airway epithelial cells. J. Cell. Sci. 116 4935-45 PubMed GONUTS page
  17. Miller, LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J. Histochem. Cytochem. 49 1593-604 PubMed GONUTS page