MOUSE:FOXJ1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Foxj1 (synonyms: Fkhl13, Hfh4)
Protein Name(s)	Forkhead box protein J1 Forkhead-related protein FKHL13 Hepatocyte nuclear factor 3 forkhead homolog 4 HFH-4
External Links
UniProt	Q61660
EMBL	L13204 AK140847 AL645861 CH466558
CCDS	CCDS25665.1
PIR	I49734
RefSeq	NP_032266.3 XP_006532332.1
UniGene	Mm.378938
ProteinModelPortal	Q61660
SMR	Q61660
BioGrid	200289
Ensembl	ENSMUST00000036215
GeneID	15223
KEGG	mmu:15223
UCSC	uc007mkv.2
CTD	2302
MGI	MGI:1347474
eggNOG	COG5025
GeneTree	ENSGT00760000118794
HOGENOM	HOG000112631
HOVERGEN	HBG056832
InParanoid	Q61660
KO	K09402
OMA	HGHHIDC
OrthoDB	EOG7T4MKM
TreeFam	TF333250
ChiTaRS	Foxj1
NextBio	287811
PRO	PR:Q61660
Proteomes	UP000000589
Bgee	Q61660
CleanEx	MM_FOXJ1
Genevestigator	Q61660
GO	GO:0005634 GO:0003700 GO:0000976 GO:0030036 GO:0032862 GO:0007420 GO:0002508 GO:0042384 GO:0060271 GO:0060429 GO:0035089 GO:0072016 GO:0006959 GO:0060972 GO:0050900 GO:0035502 GO:0050869 GO:0002635 GO:0002924 GO:0045409 GO:0032088 GO:0033085 GO:0042130 GO:0000122 GO:0002897 GO:1901248 GO:0045944 GO:0030856 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:28666954^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:27914912^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9096351^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:27965440^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:27965440^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044458	motile cilium assembly	PMID:10873152^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:9096351^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9096351^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:9096351^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:9739041^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060429	epithelium development	PMID:9096351^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000706)	Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	PMID:16339515^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050869	negative regulation of B cell activation	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045409	negative regulation of interleukin-6 biosynthetic process	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	PMID:17488776^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042130	negative regulation of T cell proliferation	PMID:14963332^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033085	negative regulation of T cell differentiation in thymus	PMID:16339515^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	PMID:17488776^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:17488776^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:9096351^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000706)	Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:16339515^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002897	positive regulation of central B cell tolerance induction	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002635	negative regulation of germinal center formation	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002508	central tolerance induction	PMID:16339515^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16002694^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901248	positive regulation of lung ciliated cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060972	left/right pattern formation	PMID:10873152^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158221	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16574095^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044458	motile cilium assembly	PMID:22357932^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3053002	P	occurs_in:(EMAPA:16075)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035089	establishment of apical/basal cell polarity	PMID:14996907^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181746	P	occurs_in:(EMAPA:16855)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030856	regulation of epithelial cell differentiation	PMID:16574095^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0002368)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:25807483^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:25807483^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17383628^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16737) part_of:(CL:0000067)\|part_of:(EMAPA:16737) part_of:(CL:0000067)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16574095^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000322)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14625387^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11724907^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17655)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92949	C		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92949	F		Seeded From UniProt	complete
involved_in	GO:1901248	positive regulation of lung ciliated cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	P		Seeded From UniProt	complete
involved_in	GO:0072016	glomerular parietal epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	P		Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	P		Seeded From UniProt	complete
involved_in	GO:0035502	metanephric part of ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	C		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92949 ensembl:ENSP00000323880	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Stauber, M et al. (2017) 1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis. Dev. Biol. 429 186-199 PubMed GONUTS page
↑ Stauber, M et al. (2017) Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev. Biol. 423 170-188 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lim, L et al. (1997) The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 94 3094-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Weidemann, M et al. (2016) CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development 143 4736-4748 PubMed GONUTS page
↑ ^5.0 ^5.1 Brody, SL et al. (2000) Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am. J. Respir. Cell Mol. Biol. 23 45-51 PubMed GONUTS page
↑ Chen, J et al. (1998) Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Invest. 102 1077-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Srivatsan, S & Peng, SL (2005) Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress. J. Immunol. 175 7805-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Lin, L et al. (2005) Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. J. Immunol. 175 951-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Pan, J et al. (2007) RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J. Cell. Sci. 120 1868-76 PubMed GONUTS page
↑ Lin, L et al. (2004) Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Science 303 1017-20 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Park, KS et al. (2006) Sox17 influences the differentiation of respiratory epithelial cells. Dev. Biol. 294 192-202 PubMed GONUTS page
↑ Alten, L et al. (2012) Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development 139 1276-84 PubMed GONUTS page
↑ Gomperts, BN et al. (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J. Cell. Sci. 117 1329-37 PubMed GONUTS page
↑ ^14.0 ^14.1 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
↑ Danielian, PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev. Biol. 305 564-76 PubMed GONUTS page
↑ Huang, T et al. (2003) Foxj1 is required for apical localization of ezrin in airway epithelial cells. J. Cell. Sci. 116 4935-45 PubMed GONUTS page
↑ Miller, LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J. Histochem. Cytochem. 49 1593-604 PubMed GONUTS page

[PMID:28666954-1] Stauber, M et al. (2017) 1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis. Dev. Biol. 429 186-199 PubMed GONUTS page

[PMID:27914912-2] Stauber, M et al. (2017) Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev. Biol. 423 170-188 PubMed GONUTS page

[PMID:9096351-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Lim, L et al. (1997) The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 94 3094-9 PubMed GONUTS page

[PMID:27965440-4] 4.0 ^4.1 Weidemann, M et al. (2016) CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development 143 4736-4748 PubMed GONUTS page

[PMID:10873152-5] 5.0 ^5.1 Brody, SL et al. (2000) Ciliogenesis and left-right axis defects in forkhead factor HFH-4-null mice. Am. J. Respir. Cell Mol. Biol. 23 45-51 PubMed GONUTS page

[PMID:9739041-6] Chen, J et al. (1998) Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J. Clin. Invest. 102 1077-82 PubMed GONUTS page

[PMID:16339515-7] 7.0 ^7.1 ^7.2 ^7.3 Srivatsan, S & Peng, SL (2005) Cutting edge: Foxj1 protects against autoimmunity and inhibits thymocyte egress. J. Immunol. 175 7805-9 PubMed GONUTS page

[PMID:16002694-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Lin, L et al. (2005) Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. J. Immunol. 175 951-8 PubMed GONUTS page

[PMID:17488776-9] 9.0 ^9.1 ^9.2 Pan, J et al. (2007) RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1. J. Cell. Sci. 120 1868-76 PubMed GONUTS page

[PMID:14963332-10] Lin, L et al. (2004) Modulation of Th1 activation and inflammation by the NF-kappaB repressor Foxj1. Science 303 1017-20 PubMed GONUTS page

[PMID:16574095-11] 11.0 ^11.1 ^11.2 Park, KS et al. (2006) Sox17 influences the differentiation of respiratory epithelial cells. Dev. Biol. 294 192-202 PubMed GONUTS page

[PMID:22357932-12] Alten, L et al. (2012) Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development 139 1276-84 PubMed GONUTS page

[PMID:14996907-13] Gomperts, BN et al. (2004) Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. J. Cell. Sci. 117 1329-37 PubMed GONUTS page

[PMID:25807483-14] 14.0 ^14.1 Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page

[PMID:17383628-15] Danielian, PS et al. (2007) E2f4 is required for normal development of the airway epithelium. Dev. Biol. 305 564-76 PubMed GONUTS page

[PMID:14625387-16] Huang, T et al. (2003) Foxj1 is required for apical localization of ezrin in airway epithelial cells. J. Cell. Sci. 116 4935-45 PubMed GONUTS page

[PMID:11724907-17] Miller, LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J. Histochem. Cytochem. 49 1593-604 PubMed GONUTS page

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MOUSE:FOXJ1

Contents

Annotations

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References

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