PMID:16002694

Citation	Lin, L, Brody, SL and Peng, SL (2005) Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. J. Immunol. 175:951-8
Abstract	The forkhead transcription factor Foxj1 inhibits spontaneous autoimmunity, in part by antagonizing NF-kappaB activation in T cells. We demonstrate here that Foxj1 also inhibits humoral immune responses intrinsically in B cells; Foxj1 deficiency in B cells results in spontaneous and accentuated germinal center formation, associated with the development of pathogenic autoantibodies and accentuated responses to immunizations-all reflecting excessive activity of NF-kappaB and its target gene IL-6, and correlating with a requirement for Foxj1 to regulate the inhibitory NF-kappaB component IkappaBbeta. Thus, Foxj1 restrains B cell activation and the maturation of humoral responses, demonstrating a critical role for at least this forkhead transcription factor in the regulation of B lymphocyte homeostasis.
Links	PubMed
Keywords	Animals; Antibody Formation/genetics; Autoantibodies/biosynthesis; Autoantibodies/metabolism; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; Base Sequence; Binding Sites, Antibody/genetics; Cells, Cultured; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Forkhead Transcription Factors; Interleukin-6/antagonists & inhibitors; Interleukin-6/metabolism; Lymphocyte Activation/genetics; Lymphocyte Activation/immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Inbred NZB; Mice, Knockout; Mice, Nude; Molecular Sequence Data; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Transcription Factors/deficiency; Transcription Factors/genetics; Transcription Factors/physiology
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