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MOUSE:DRD2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Drd2
Protein Name(s) D(2) dopamine receptor

Dopamine D2 receptor

External Links
UniProt P61168
EMBL X55674
CH466522
BC105663
BC105664
BC105665
BC105666
CCDS CCDS40615.1
PIR S13921
RefSeq NP_034207.2
XP_006510059.1
UniGene Mm.41970
ProteinModelPortal P61168
SMR P61168
BioGrid 199306
IntAct P61168
MINT MINT-5313868
STRING 10090.ENSMUSP00000075170
BindingDB P61168
ChEMBL CHEMBL2109245
GuidetoPHARMACOLOGY 215
PhosphoSite P61168
PRIDE P61168
Ensembl ENSMUST00000075764
GeneID 13489
KEGG mmu:13489
UCSC uc009pja.1
CTD 1813
MGI MGI:94924
eggNOG NOG309657
GeneTree ENSGT00770000120457
HOGENOM HOG000239242
HOVERGEN HBG106962
InParanoid P61168
KO K04145
OMA RNWSRPF
OrthoDB EOG769ZMG
TreeFam TF334382
Reactome REACT_250376
REACT_253535
NextBio 284001
PRO PR:P61168
Proteomes UP000000589
Bgee P61168
CleanEx MM_DRD2
Genevestigator P61168
GO GO:0001669
GO:0030424
GO:0043679
GO:0030425
GO:0043197
GO:0030139
GO:0005887
GO:0016328
GO:0016020
GO:0043204
GO:0014069
GO:0036126
GO:0030672
GO:0035240
GO:0004952
GO:0001591
GO:0008144
GO:0004930
GO:0032147
GO:0021984
GO:0007195
GO:0030534
GO:0007628
GO:0050482
GO:0008306
GO:0031223
GO:0007409
GO:0048148
GO:0048149
GO:0048755
GO:0021853
GO:0032922
GO:0042417
GO:0007212
GO:0007631
GO:0002031
GO:0007186
GO:0007625
GO:0035556
GO:0007626
GO:0007616
GO:0007194
GO:0045776
GO:0030336
GO:0008285
GO:0042321
GO:0051481
GO:0060160
GO:0033602
GO:0046676
GO:0051898
GO:0050709
GO:0051967
GO:1901386
GO:0001976
GO:0007270
GO:0021769
GO:0030432
GO:0046488
GO:0060158
GO:0043473
GO:0032467
GO:0051482
GO:0051586
GO:0070374
GO:0045745
GO:0060124
GO:1900273
GO:0040018
GO:0002052
GO:0002092
GO:0035815
GO:0045944
GO:0035810
GO:0060134
GO:0008104
GO:0014059
GO:0051584
GO:0002027
GO:0090325
GO:0048169
GO:0043666
GO:0043266
GO:0002028
GO:0051823
GO:0050804
GO:0032228
GO:0051209
GO:0001975
GO:0048678
GO:0042220
GO:0042493
GO:0034776
GO:0001666
GO:0014854
GO:0010039
GO:0009416
GO:0043278
GO:0035094
GO:0009636
GO:0007608
GO:0001964
GO:0021756
GO:0007416
GO:0001963
GO:0001659
GO:0008542
GO:0016055
InterPro IPR001922
IPR000929
IPR000276
IPR017452
Pfam PF00001
PRINTS PR00567
PR00242
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045824

negative regulation of innate immune response

PMID:23242137[1]

ECO:0000315

P

Figure 2 in this publication displays data that the authors found to indicate that Drd2 knockout mice were hyper-responsive with higher neuroinflammation

complete
CACAO 6437

involved_in

GO:0045824

negative regulation of innate immune response

PMID:23242137[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:12223553[2]

ECO:0007016

voltammetry evidence used in manual assertion

P

  • occurs_in:(GO:0098691)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:22586226[3]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:12223553[2]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

  • occurs_in:(GO:0098691)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:22586226[3]

ECO:0006039

genetically encoded fluorescent electrophysiology assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:22586226[3]

ECO:0006013

patch-clamp recording evidence used in manual assertion

P

  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:2000300

regulation of synaptic vesicle exocytosis

PMID:12223553[2]

ECO:0001225

knockout evidence used in manual assertion

P

  • occurs_in:(GO:0098691)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

PMID:27035941[4]

ECO:0006003

electron microscopy evidence used in manual assertion

C

  • part_of:(GO:0098982)
  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

PMID:27035941[4]

ECO:0006003

electron microscopy evidence used in manual assertion

C

  • part_of:(GO:0098978)
  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

PMID:27035941[4]

ECO:0006003

electron microscopy evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:27035941[4]

ECO:0006003

electron microscopy evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0098691

dopaminergic synapse

PMID:12223553[2]

ECO:0007016

voltammetry evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0098691

dopaminergic synapse

PMID:12223553[2]

ECO:0006054

pharmacological assay evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

part_of

GO:0098691

dopaminergic synapse

PMID:12223553[2]

ECO:0001225

knockout evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:0051580

regulation of neurotransmitter uptake

PMID:12223553[2]

ECO:0007016

voltammetry evidence used in manual assertion

P

  • occurs_in:(GO:0098691)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:0051580

regulation of neurotransmitter uptake

PMID:12223553[2]

ECO:0006054

pharmacological assay evidence used in manual assertion

P

  • occurs_in:(GO:0098691)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:0051580

regulation of neurotransmitter uptake

PMID:12223553[2]

ECO:0001225

knockout evidence used in manual assertion

P

  • occurs_in:(GO:0098691)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002435)

Seeded From UniProt

complete

involved_in

GO:0071880

adenylate cyclase-activating adrenergic receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001205212
UniProtKB:P08588
UniProtKB:P18871

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000664502
RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004514
FB:FBgn0035538
FB:FBgn0038541
FB:FBgn0038542
PANTHER:PTN000664502
UniProtKB:P07550
UniProtKB:P08913
UniProtKB:P14416
UniProtKB:P18825
UniProtKB:P18871
UniProtKB:P35462
WB:WBGene00004777

C

Seeded From UniProt

complete

enables

GO:0004935

adrenergic receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87934
MGI:MGI:87935
PANTHER:PTN000664502

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901386

negative regulation of voltage-gated calcium channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901386

negative regulation of voltage-gated calcium channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900273

positive regulation of long-term synaptic potentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0099170

postsynaptic modulation of chemical synaptic transmission

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090325

regulation of locomotion involved in locomotory behavior

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060548

negative regulation of cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0060170

ciliary membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060160

negative regulation of dopamine receptor signaling pathway

PMID:12097513[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94925
MGI:MGI:99578

P

regulates_o_occurs_in:(EMAPA:16895)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060158

phospholipase C-activating dopamine receptor signaling pathway

PMID:17194762[7]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95766
MGI:MGI:95776
MGI:MGI:99578

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060158

phospholipase C-activating dopamine receptor signaling pathway

PMID:15016423[8]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(EMAPA:16895)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060158

phospholipase C-activating dopamine receptor signaling pathway

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060134

prepulse inhibition

PMID:17712281[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060134

prepulse inhibition

PMID:12417685[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060134

prepulse inhibition

PMID:10341260[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

NOT|acts_upstream_of_or_within

GO:0060134

prepulse inhibition

PMID:17324452[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060124

positive regulation of growth hormone secretion

PMID:11897683[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051967

negative regulation of synaptic transmission, glutamatergic

PMID:11160501[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051898

negative regulation of protein kinase B signaling

PMID:17251429[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895
MGI:MGI:2675755

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051823

regulation of synapse structural plasticity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051586

positive regulation of dopamine uptake involved in synaptic transmission

PMID:9886065[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051584

regulation of dopamine uptake involved in synaptic transmission

PMID:12223553[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051482

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051481

negative regulation of cytosolic calcium ion concentration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050804

modulation of chemical synaptic transmission

PMID:10974427[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

  • regulates_o_occurs_in:(EMAPA:17549)
  • regulates_o_has_participant:(CL:0000117)|regulates_o_occurs_in(EMAPA:35380)
  • regulates_o_has_participant:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050769

positive regulation of neurogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050709

negative regulation of protein secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050482

arachidonic acid secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048755

branching morphogenesis of a nerve

PMID:11438590[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048169

regulation of long-term neuronal synaptic plasticity

PMID:9169514[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048149

behavioral response to ethanol

PMID:12837020[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048149

behavioral response to ethanol

PMID:11166059[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048149

behavioral response to ethanol

PMID:11105945[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048148

behavioral response to cocaine

PMID:17426149[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046717

acid secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046676

negative regulation of insulin secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045776

negative regulation of blood pressure

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045745

positive regulation of G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0043679

axon terminus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043473

pigmentation

PMID:9140068[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576789

P

occurs_in:(EMAPA:18769)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043408

regulation of MAPK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043278

response to morphine

PMID:9252189[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043278

response to morphine

PMID:12182883[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2656648

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043278

response to morphine

PMID:11567069[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043278

response to morphine

PMID:11264672[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043266

regulation of potassium ion transport

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

regulates_o_occurs_in:(EMAPA:17952)|regulates_o_occurs_in:(EMAPA:19279)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043266

regulation of potassium ion transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0043197

dendritic spine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042756

drinking behavior

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:16136297[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:7549459[31]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042417

dopamine metabolic process

PMID:7925842[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042321

negative regulation of circadian sleep/wake cycle, sleep

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042220

response to cocaine

PMID:12185400[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042220

response to cocaine

PMID:11923462[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042220

response to cocaine

PMID:18671743[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040018

positive regulation of multicellular organism growth

PMID:11897683[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

part_of

GO:0036126

sperm flagellum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035815

positive regulation of renal sodium excretion

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

regulates_o_has_participant:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035810

positive regulation of urine volume

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

regulates_o_has_participant:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035556

intracellular signal transduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

enables

GO:0035255

ionotropic glutamate receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

enables

GO:0035240

dopamine binding

PMID:15716360[36]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

enables

GO:0035240

dopamine binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034776

response to histamine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033602

negative regulation of dopamine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032922

circadian regulation of gene expression

PMID:16606840[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

  • regulates_o_occurs_in:(EMAPA:17168)
  • has_regulation_target:(MGI:MGI:1098283)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032467

positive regulation of cytokinesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032228

regulation of synaptic transmission, GABAergic

PMID:10934242[38]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99402

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032228

regulation of synaptic transmission, GABAergic

PMID:15080900[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

regulates_o_occurs_in:(EMAPA:32673)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032147

activation of protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031223

auditory behavior

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030900

forebrain development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0030672

synaptic vesicle membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030534

adult behavior

PMID:11303741[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2656648

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030432

peristalsis

PMID:15272078[41]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99578

P

occurs_in:(EMAPA:35443)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030432

peristalsis

PMID:16525059[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

occurs_in:(EMAPA:18939)

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:10051229[43]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35835)
  • part_of:(CL:0000700)

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:10051229[43]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35835)
  • part_of:(CL:0000700)

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030336

negative regulation of cell migration

PMID:17409246[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

  • regulates_o_occurs_in:(EMAPA:16910)
  • regulates_o_results_in_movement_of:(CL:0000617)

Seeded From UniProt

complete

part_of

GO:0030139

endocytic vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021984

adenohypophysis development

PMID:9140068[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576789

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021853

cerebral cortex GABAergic interneuron migration

PMID:17409246[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

  • occurs_in:(EMAPA:16910)
  • results_in_movement_of:(CL:0000617)

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016055

Wnt signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009416

response to light stimulus

PMID:16715079[45]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008542

visual learning

PMID:12097513[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008306

associative learning

PMID:15061865[46]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008306

associative learning

PMID:12182883[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2656648

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008306

associative learning

PMID:12084937[47]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:9247268[48]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97762

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:9717839[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:9247268[48]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:9247267[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:9140068[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576789

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:10537166[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

F

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008104

protein localization

PMID:10828532[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007631

feeding behavior

PMID:15272078[41]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99578

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007628

adult walking behavior

PMID:7566118[53]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:9354330[54]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94925
MGI:MGI:99578

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:16280580[55]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1351342
MGI:MGI:99402

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:15272078[41]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99578

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11864730[56]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94925

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11172060[57]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99402

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11150348[58]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94862

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:10908627[59]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99402

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:9547254[60]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:15080900[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:12837020[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:12185400[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:12175868[61]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:12084937[47]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11557166[62]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11166059[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:10698004[63]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:10471093[64]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007625

grooming behavior

PMID:10698004[63]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007616

long-term memory

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007608

sensory perception of smell

PMID:16765459[65]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

has_participant:(EMAPA:32809)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007409

axonogenesis

PMID:11438590[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

  • occurs_in:(EMAPA:19095)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007270

neuron-neuron synaptic transmission

PMID:12084937[47]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388386

P

has_participant:(EMAPA:32789)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

PMID:12223546[66]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99578
MGI:MGI:99673

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

PMID:12665504[67]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007194

negative regulation of adenylate cyclase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007186

G protein-coupled receptor signaling pathway

PMID:14712229[68]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006914

autophagy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:28154160[69]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

enables

GO:0004952

dopamine neurotransmitter receptor activity

PMID:18671743[35]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004952

dopamine neurotransmitter receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:14712229[68]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002092

positive regulation of receptor internalization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002052

positive regulation of neuroblast proliferation

PMID:17426594[70]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002031

G protein-coupled receptor internalization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002028

regulation of sodium ion transport

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

regulates_o_occurs_in:(EMAPA:17952)|regulates_o_occurs_in:(EMAPA:19279)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002027

regulation of heart rate

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001976

neurological system process involved in regulation of systemic arterial blood pressure

PMID:11566895[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

occurs_in:(EMAPA:16985)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001975

response to amphetamine

PMID:12097513[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94925
MGI:MGI:99578

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001975

response to amphetamine

PMID:18486343[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001964

startle response

PMID:17712281[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|acts_upstream_of_or_within

GO:0001964

startle response

PMID:17324452[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001963

synaptic transmission, dopaminergic

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

part_of

GO:0001669

acrosomal vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001666

response to hypoxia

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001659

temperature homeostasis

PMID:18486343[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001659

temperature homeostasis

PMID:10471093[64]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:9247268[48]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

F

occurs_in:(EMAPA:35998)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:9140068[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3576789

F

occurs_in:(EMAPA:19095)|occurs_in:(EMAPA:32789)|occurs_in:(EMAPA:35616)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:15721235[72]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:11172060[57]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857875

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:11069974[73]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

F

occurs_in:(EMAPA:32768)|occurs_in:(EMAPA:32770)|occurs_in:(EMAPA:19037)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:8836575[74]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:8294904[75]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:8001143[76]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:7566118[53]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)|occurs_in:(EMAPA:35616)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:1980140[77]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:12930822[78]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:11015197[79]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14416

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2520

F

Seeded From UniProt

complete

involved_in

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

part_of

GO:0097730

non-motile cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

C

Seeded From UniProt

complete

part_of

GO:0060170

ciliary membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

C

Seeded From UniProt

complete

involved_in

GO:0060158

phospholipase C-activating dopamine receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

involved_in

GO:0050709

negative regulation of protein secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

involved_in

GO:0050482

arachidonic acid secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

F

Seeded From UniProt

complete

involved_in

GO:0034776

response to histamine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

involved_in

GO:0032467

positive regulation of cytokinesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

F

Seeded From UniProt

complete

involved_in

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

C

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14416
ensembl:ENSP00000354859

F

Seeded From UniProt

complete

involved_in

GO:1901386

negative regulation of voltage-gated calcium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:1900273

positive regulation of long-term synaptic potentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0099170

postsynaptic modulation of chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0099055

integral component of postsynaptic membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0090325

regulation of locomotion involved in locomotory behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0051823

regulation of synapse structural plasticity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0051481

negative regulation of cytosolic calcium ion concentration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0050769

positive regulation of neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

involved_in

GO:0046717

acid secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0046676

negative regulation of insulin secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0045745

positive regulation of G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0045471

response to ethanol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0043679

axon terminus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0043408

regulation of MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0043266

regulation of potassium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0043204

perikaryon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0043197

dendritic spine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

involved_in

GO:0042756

drinking behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0042321

negative regulation of circadian sleep/wake cycle, sleep

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0036126

sperm flagellum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

enables

GO:0035255

ionotropic glutamate receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

enables

GO:0035240

dopamine binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

involved_in

GO:0035094

response to nicotine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0033602

negative regulation of dopamine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0031223

auditory behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0030900

forebrain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0030672

synaptic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

part_of

GO:0030139

endocytic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0021769

orbitofrontal cortex development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0021756

striatum development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0014854

response to inactivity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0014069

postsynaptic density

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0010039

response to iron ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

enables

GO:0008144

drug binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

involved_in

GO:0007626

locomotory behavior

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0007616

long-term memory

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0007416

synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0006914

autophagy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

enables

GO:0004952

dopamine neurotransmitter receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

involved_in

GO:0002092

positive regulation of receptor internalization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0002031

G protein-coupled receptor internalization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0001975

response to amphetamine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0001963

synaptic transmission, dopaminergic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

part_of

GO:0001669

acrosomal vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

C

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

P

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P61169
ensembl:ENSRNOP00000043759

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004952

dopamine neurotransmitter receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001922

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

P

Seeded From UniProt

complete

involved_in

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001922

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001922
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:11069937[80]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060134

prepulse inhibition

PMID:12476322[81]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2656648

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032228

regulation of synaptic transmission, GABAergic

PMID:15489038[82]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895
MGI:MGI:2675755

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:7706278[83]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:11069937[80]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2656648

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007212

dopamine receptor signaling pathway

PMID:11089973[84]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99578

P

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

PMID:7706278[83]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95772

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

PMID:7706278[83]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:7706278[83]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:1991517[85]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:12476322[81]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060160

negative regulation of dopamine receptor signaling pathway

PMID:11089973[84]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2675755

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051967

negative regulation of synaptic transmission, glutamatergic

PMID:15489038[82]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895
MGI:MGI:2675755

P

regulates_o_has_participant:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043278

response to morphine

PMID:11943831[86]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042220

response to cocaine

PMID:11943831[86]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032228

regulation of synaptic transmission, GABAergic

PMID:15489038[82]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895
MGI:MGI:2675755

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014059

regulation of dopamine secretion

PMID:11943831[86]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387895
MGI:MGI:2675755

P

regulates_o_occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001975

response to amphetamine

PMID:12476322[81]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2656648

P

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:1991517[85]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001591

dopamine neurotransmitter receptor activity, coupled via Gi/Go

PMID:12476322[81]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:17549)

Seeded From UniProt

complete

involved_in

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001591

P

Seeded From UniProt

complete

involved_in

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001591

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Shao, W et al. (2013) Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature 494 90-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Schmitz, Y et al. (2002) Altered dopamine release and uptake kinetics in mice lacking D2 receptors. J. Neurosci. 22 8002-9 PubMed GONUTS page
  3. 3.0 3.1 3.2 Wang, W et al. (2012) Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. J. Physiol. (Lond.) 590 3743-69 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Uchigashima, M et al. (2016) Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. Proc. Natl. Acad. Sci. U.S.A. 113 4206-11 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 Glickstein, SB et al. (2002) Mice lacking dopamine D2 and D3 receptors have spatial working memory deficits. J. Neurosci. 22 5619-29 PubMed GONUTS page
  7. Rashid, AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 104 654-9 PubMed GONUTS page
  8. Mizuo, K et al. (2004) Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor. Neurosci. Lett. 358 13-6 PubMed GONUTS page
  9. 9.0 9.1 Mohr, D et al. (2007) Accumbal dopamine D2 receptors are important for sensorimotor gating in C3H mice. Neuroreport 18 1493-7 PubMed GONUTS page
  10. Ralph-Williams, RJ et al. (2002) Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice. J. Neurosci. 22 9604-11 PubMed GONUTS page
  11. Ralph, RJ et al. (1999) The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. J. Neurosci. 19 4627-33 PubMed GONUTS page
  12. 12.0 12.1 Vinkers, CH et al. (2007) Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating. Pharmacol. Biochem. Behav. 86 550-8 PubMed GONUTS page
  13. 13.0 13.1 Díaz-Torga, G et al. (2002) Disruption of the D2 dopamine receptor alters GH and IGF-I secretion and causes dwarfism in male mice. Endocrinology 143 1270-9 PubMed GONUTS page
  14. Cepeda, C et al. (2001) Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice. J. Neurophysiol. 85 659-70 PubMed GONUTS page
  15. Beaulieu, JM et al. (2007) Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J. Neurosci. 27 881-5 PubMed GONUTS page
  16. Dickinson, SD et al. (1999) Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. J. Neurochem. 72 148-56 PubMed GONUTS page
  17. Murer, MG et al. (2000) The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice. Neuroscience 99 643-50 PubMed GONUTS page
  18. 18.0 18.1 Parish, CL et al. (2001) The role of dopamine receptors in regulating the size of axonal arbors. J. Neurosci. 21 5147-57 PubMed GONUTS page
  19. Calabresi, P et al. (1997) Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors. J. Neurosci. 17 4536-44 PubMed GONUTS page
  20. 20.0 20.1 Palmer, AA et al. (2003) Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behav. Genet. 33 311-24 PubMed GONUTS page
  21. 21.0 21.1 Cunningham, CL et al. (2000) Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacol. Biochem. Behav. 67 693-9 PubMed GONUTS page
  22. Risinger, FO et al. (2000) Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice. Psychopharmacology (Berl.) 152 343-50 PubMed GONUTS page
  23. Welter, M et al. (2007) Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine. Proc. Natl. Acad. Sci. U.S.A. 104 6840-5 PubMed GONUTS page
  24. 24.0 24.1 24.2 24.3 24.4 24.5 24.6 Li, XX et al. (2001) Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice. Hypertension 38 303-8 PubMed GONUTS page
  25. 25.0 25.1 25.2 25.3 Yamaguchi, H et al. (1996) Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells 1 253-68 PubMed GONUTS page
  26. Maldonado, R et al. (1997) Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Nature 388 586-9 PubMed GONUTS page
  27. 27.0 27.1 Smith, JW et al. (2002) Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning. Neuroscience 113 755-65 PubMed GONUTS page
  28. King, MA et al. (2001) Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system. J. Neurosci. 21 7788-92 PubMed GONUTS page
  29. Dockstader, CL et al. (2001) The D2 receptor is critical in mediating opiate motivation only in opiate-dependent and withdrawn mice. Eur. J. Neurosci. 13 995-1001 PubMed GONUTS page
  30. Elmer, GI et al. (2005) Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice. Psychopharmacology (Berl.) 182 33-44 PubMed GONUTS page
  31. Verma, A & Kulkarni, SK (1995) Role of D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptors in morphine tolerance and dependence in mice. Eur Neuropsychopharmacol 5 81-7 PubMed GONUTS page
  32. Richard, MG & Bennett, JP Jr (1994) Regulation by D2 dopamine receptors of in vivo dopamine synthesis in striata of rats and mice with experimental parkinsonism. Exp. Neurol. 129 57-63 PubMed GONUTS page
  33. 33.0 33.1 Chausmer, AL et al. (2002) Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Psychopharmacology (Berl.) 163 54-61 PubMed GONUTS page
  34. Caine, SB et al. (2002) Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J. Neurosci. 22 2977-88 PubMed GONUTS page
  35. 35.0 35.1 Bailey, A et al. (2008) Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm. Eur. J. Neurosci. 28 759-70 PubMed GONUTS page
  36. Seeman, P et al. (2005) Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proc. Natl. Acad. Sci. U.S.A. 102 3513-8 PubMed GONUTS page
  37. Yujnovsky, I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Natl. Acad. Sci. U.S.A. 103 6386-91 PubMed GONUTS page
  38. Zahniser, NR et al. (2000) Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors. J. Neurosci. 20 5949-57 PubMed GONUTS page
  39. 39.0 39.1 An, JJ et al. (2004) Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors. Mol. Cell. Neurosci. 25 732-41 PubMed GONUTS page
  40. Vukhac, KL et al. (2001) Dopamine D2L receptor- and age-related reduction in offensive aggression. Neuroreport 12 1035-8 PubMed GONUTS page
  41. 41.0 41.1 41.2 Kobayashi, M et al. (2004) Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice. Proc. Natl. Acad. Sci. U.S.A. 101 11465-70 PubMed GONUTS page
  42. Li, ZS et al. (2006) Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. J. Neurosci. 26 2798-807 PubMed GONUTS page
  43. 43.0 43.1 Xu, SG et al. (1999) Neurons exhibiting dopamine D2 receptor immunoreactivity in the substantia nigra of the mutant weaver mouse. Neuroscience 89 191-207 PubMed GONUTS page
  44. 44.0 44.1 Crandall, JE et al. (2007) Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex. J. Neurosci. 27 3813-22 PubMed GONUTS page
  45. Doi, M et al. (2006) Impaired light masking in dopamine D2 receptor-null mice. Nat. Neurosci. 9 732-4 PubMed GONUTS page
  46. Kruzich, PJ & Grandy, DK (2004) Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice. BMC Neurosci 5 12 PubMed GONUTS page
  47. 47.0 47.1 47.2 Tran, AH et al. (2002) Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 99 8986-91 PubMed GONUTS page
  48. 48.0 48.1 48.2 Saiardi, A et al. (1997) Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. Neuron 19 115-26 PubMed GONUTS page
  49. Saiardi, A & Borrelli, E (1998) Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice. Mol. Endocrinol. 12 1133-9 PubMed GONUTS page
  50. Kelly, MA et al. (1997) Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 19 103-13 PubMed GONUTS page
  51. Asa, SL et al. (1999) Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice. Endocrinology 140 5348-55 PubMed GONUTS page
  52. Jung, MY et al. (2000) Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k). Neuroscience 97 495-504 PubMed GONUTS page
  53. 53.0 53.1 Baik, JH et al. (1995) Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377 424-8 PubMed GONUTS page
  54. Xu, M et al. (1997) Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron 19 837-48 PubMed GONUTS page
  55. Kachroo, A et al. (2005) Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J. Neurosci. 25 10414-9 PubMed GONUTS page
  56. Vallone, D et al. (2002) Activity, non-selective attention and emotionality in dopamine D2/D3 receptor knock-out mice. Behav. Brain Res. 130 141-8 PubMed GONUTS page
  57. 57.0 57.1 Chen, JF et al. (2001) The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 98 1970-5 PubMed GONUTS page
  58. Ralph, RJ et al. (2001) Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J. Neurosci. 21 305-13 PubMed GONUTS page
  59. Aoyama, S et al. (2000) Rescue of locomotor impairment in dopamine D2 receptor-deficient mice by an adenosine A2A receptor antagonist. J. Neurosci. 20 5848-52 PubMed GONUTS page
  60. Kelly, MA et al. (1998) Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. J. Neurosci. 18 3470-9 PubMed GONUTS page
  61. Fowler, SC et al. () Motor and associative deficits in D2 dopamine receptor knockout mice. Int. J. Dev. Neurosci. 20 309-21 PubMed GONUTS page
  62. Clifford, JJ et al. (2001) Comparative, topographically-based evaluation of behavioural phenotype and specification of D(1)-like:D(2) interactions in a line of incipient congenic mice with D(2) dopamine receptor 'knockout'. Neuropsychopharmacology 25 527-36 PubMed GONUTS page
  63. 63.0 63.1 Clifford, JJ et al. (2000) Topographical evaluation of behavioural phenotype in a line of mice with targeted gene deletion of the D2 dopamine receptor. Neuropharmacology 39 382-90 PubMed GONUTS page
  64. 64.0 64.1 Boulay, D et al. (1999) Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists. Neuropharmacology 38 1389-96 PubMed GONUTS page
  65. Tillerson, JL et al. (2006) Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor. Behav. Brain Res. 172 97-105 PubMed GONUTS page
  66. Lee, KW et al. (2002) Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase. J. Neurosci. 22 7931-40 PubMed GONUTS page
  67. Iwamoto, T et al. (2003) Motor dysfunction in type 5 adenylyl cyclase-null mice. J. Biol. Chem. 278 16936-40 PubMed GONUTS page
  68. 68.0 68.1 Weissman, JT et al. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway. Oncogene 23 241-9 PubMed GONUTS page
  69. Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
  70. Hiramoto, T et al. (2007) Dopamine D2 receptor stimulation promotes the proliferation of neural progenitor cells in adult mouse hippocampus. Neuroreport 18 659-64 PubMed GONUTS page
  71. 71.0 71.1 Ito, M et al. (2008) Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors. Neurosci. Lett. 438 327-9 PubMed GONUTS page
  72. Goldberg, MS et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45 489-96 PubMed GONUTS page
  73. Bozzi, Y et al. (2000) Neuroprotective role of dopamine against hippocampal cell death. J. Neurosci. 20 8643-9 PubMed GONUTS page
  74. Demotes-Mainard, J et al. (1996) Postnatal ontogeny of dopamine D3 receptors in the mouse brain: autoradiographic evidence for a transient cortical expression. Brain Res. Dev. Brain Res. 94 166-74 PubMed GONUTS page
  75. Qin, ZH et al. (1994) Lesions of mouse striatum induced by 6-hydroxydopamine differentially alter the density, rate of synthesis, and level of gene expression of D1 and D2 dopamine receptors. J. Neurochem. 62 411-20 PubMed GONUTS page
  76. Xu, M et al. (1994) Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell 79 945-55 PubMed GONUTS page
  77. Ratty, AK et al. (1990) Circling behavior exhibited by a transgenic insertional mutant. Brain Res. Mol. Brain Res. 8 355-8 PubMed GONUTS page
  78. Goldberg, MS et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 278 43628-35 PubMed GONUTS page
  79. Javitch, JA et al. (2000) The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle. Biochemistry 39 12190-9 PubMed GONUTS page
  80. 80.0 80.1 Wang, Y et al. (2000) Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions. J. Neurosci. 20 8305-14 PubMed GONUTS page
  81. 81.0 81.1 81.2 81.3 Xu, R et al. (2002) Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice. Mol. Psychiatry 7 1075-82 PubMed GONUTS page
  82. 82.0 82.1 82.2 Centonze, D et al. (2004) Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum. Neuroscience 129 157-66 PubMed GONUTS page
  83. 83.0 83.1 83.2 83.3 Guiramand, J et al. (1995) Alternative splicing of the dopamine D2 receptor directs specificity of coupling to G-proteins. J. Biol. Chem. 270 7354-8 PubMed GONUTS page
  84. 84.0 84.1 Usiello, A et al. (2000) Distinct functions of the two isoforms of dopamine D2 receptors. Nature 408 199-203 PubMed GONUTS page
  85. 85.0 85.1 Montmayeur, JP et al. (1991) Differential expression of the mouse D2 dopamine receptor isoforms. FEBS Lett. 278 239-43 PubMed GONUTS page
  86. 86.0 86.1 86.2 Rouge-Pont, F et al. (2002) Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors. J. Neurosci. 22 3293-301 PubMed GONUTS page