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PMID:15016423
| Citation |
Mizuo, K, Narita, M, Miyatake, M and Suzuki, T (2004) Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor. Neurosci. Lett. 358:13-6 |
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| Abstract |
It is well known that the dopamine D(3) receptor plays a critical role in several psychological disorders, such as drug dependence. The present study was designed to investigate the influence of lacking dopamine D(3) receptors in dopamine-induced G-protein activation and Ca(2+) influx in the mouse forebrain. The deletion of dopamine D(3) receptor gene caused the enhancement of dopamine-induced G-protein activation in the limbic forebrain of dopamine D(3) receptor knockout (D(3)KO) mice. Furthermore, the dopamine-induced Ca(2+) influx was enhanced in the coculture of neuron/glia cells obtained from the forebrain of D(3)KO mice. The present data provide direct evidence that a deletion of central dopamine D(3) receptor enhances the dopamine D(1)/D(2) receptor-mediated intracellular signaling. |
| Links |
PubMed Online version:10.1016/j.neulet.2003.12.119 |
| Keywords |
Animals; Dopamine/metabolism; Dopamine/pharmacology; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Knockout; Prosencephalon/drug effects; Prosencephalon/metabolism; Protein Binding/drug effects; Protein Binding/physiology; Receptors, Dopamine D2/deficiency; Receptors, Dopamine D2/genetics; Receptors, Dopamine D3; Signal Transduction/drug effects; Signal Transduction/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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