GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:11303741
| Citation |
Vukhac, KL, Sankoorikal, EB and Wang, Y (2001) Dopamine D2L receptor- and age-related reduction in offensive aggression. Neuroreport 12:1035-8 |
|---|---|
| Abstract |
The dopamine D2 receptor (D2) has been implicated in attention-deficit hyperactive disorder (ADHD) and aging. Two isoforms of D2 have been identified, termed D2L (long form) and D2S (short form). In this study, we investigated the role of D2L in offensive aggression, using mice lacking the dopamine D2L receptor (D2L-/-) as a model system and the resident-intruder test. We found that D2L-/- mice showed much lower levels of aggression than wild-type mice. Interestingly, offensive aggression also decreased as the age of the mice increased. These results suggest that both the D2L receptor and aging play roles in the modulation of offensive aggression. This finding may contribute to our understanding of the neurobiological basis of aggression. |
| Links | |
| Keywords |
Aggression/physiology; Aggression/psychology; Aging/physiology; Aging/psychology; Animals; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity/physiology; Receptors, Dopamine D2/deficiency; Receptors, Dopamine D2/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
