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PMID:9140068
| Citation |
Yamaguchi, H, Aiba, A, Nakamura, K, Nakao, K, Sakagami, H, Goto, K, Kondo, H and Katsuki, M (1996) Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells 1:253-68 |
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| Abstract |
It has been suggested that the dopaminergic system is involved in the inhibitory control of secretion of pituitary hormones and in the regulation of motor function in the striatum. To elucidate the specific role of the dopamine D2 receptor (D2R) in the pituitary and brain, we generated D2R deficient (D2R mutant) mice using the gene targeting method. |
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| Keywords |
Animals; Behavior, Animal; Corpus Striatum/physiology; Dopamine/pharmacology; Electrophysiology; Enkephalins/biosynthesis; Hair Color; Higher Nervous Activity; Immunohistochemistry; In Situ Hybridization; Limbic System/physiology; Mice; Mice, Mutant Strains; Neural Pathways; Pituitary Gland/metabolism; Pro-Opiomelanocortin/biosynthesis; Pro-Opiomelanocortin/genetics; Radioimmunoassay; Receptors, Dopamine D2/deficiency; Receptors, Dopamine D2/genetics; Substantia Nigra/physiology; alpha-MSH/blood |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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