MOUSE:CDN1B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cdkn1b
Protein Name(s)	Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor p27 p27Kip1
External Links
UniProt	P46414
EMBL	U10440 U09968 AK046676 AK047669 AK050240 AC122193 BC014296
CCDS	CCDS20642.1
PIR	I49064
RefSeq	NP_034005.2
UniGene	Mm.2958
ProteinModelPortal	P46414
SMR	P46414
BioGrid	198652
DIP	DIP-445N
IntAct	P46414
MINT	MINT-1780106
STRING	10090.ENSMUSP00000003115
iPTMnet	P46414
PhosphoSite	P46414
PaxDb	P46414
PRIDE	P46414
Ensembl	ENSMUST00000003115 ENSMUST00000067327 ENSMUST00000204807
GeneID	12576
KEGG	mmu:12576
UCSC	uc009ela.2
CTD	1027
MGI	MGI:104565
eggNOG	KOG4743 ENOG410XXN5
GeneTree	ENSGT00530000063588
HOGENOM	HOG000294081
HOVERGEN	HBG073988
InParanoid	P46414
KO	K06624
OMA	YPKPSAC
OrthoDB	EOG7GJ6HD
TreeFam	TF101038
Reactome	R-MMU-176408 R-MMU-187577 R-MMU-198323 R-MMU-2559582 R-MMU-2559586 R-MMU-68949 R-MMU-69202 R-MMU-69231 R-MMU-69563 R-MMU-69656
ChiTaRS	Cdkn1b
NextBio	281690
PRO	PR:P46414
Proteomes	UP000000589
CleanEx	MM_CDKN1B
Genevisible	P46414
GO	GO:0031464 GO:0005737 GO:0005829 GO:0005768 GO:0005634 GO:0004861 GO:0008656 GO:0019903 GO:0006919 GO:0048102 GO:0007050 GO:0071236 GO:0071285 GO:0071407 GO:0000082 GO:0048839 GO:0071850 GO:0043066 GO:0030308 GO:0008285 GO:0051271 GO:0045736 GO:0050680 GO:0060770 GO:0033673 GO:0045930 GO:0042326 GO:0045892 GO:0007219 GO:0010942 GO:0008284 GO:0031116 GO:0045732 GO:0006813 GO:0043200 GO:0046686 GO:0042493 GO:0032355 GO:0009749 GO:0001666 GO:0043434 GO:0007605
InterPro	IPR003175 IPR029843
PANTHER	PTHR10265 PTHR10265:SF9
Pfam	PF02234

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007507	heart development	PMID:24380855^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905179	negative regulation of cardiac muscle tissue regeneration	PMID:24380855^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	PMID:24380855^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:1905179) occurs_in:(UBERON:0002082)	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:24380855^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0002082)	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:8534916^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002567658 RGD:69062	F		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000814137 UniProtKB:P46527 ZFIN:ZDB-GENE-040123-1	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN000814137 RGD:69062 UniProtKB:P46527	P		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000814137 UniProtKB:P46527	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 RGD:69062 UniProtKB:P46527	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 UniProtKB:P46527	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 RGD:69062 UniProtKB:P46527	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 RGD:69062 UniProtKB:P46527	C		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 UniProtKB:P46527	F		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007096	regulation of exit from mitosis	PMID:9784491^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104564	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	PMID:8033213^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006813	potassium ion transport	PMID:16393152^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929183	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15964824^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21300049^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15652749^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25535395^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20016102^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19056892^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16195383^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32927) part_of:(CL:0000169)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15652749^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10827137^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43806	C		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:8033213^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:12130539^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	F		Seeded From UniProt	complete
enables	GO:0004860	protein kinase inhibitor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001890	placenta development	PMID:9784491^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104564	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904030	negative regulation of cyclin-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902746	regulation of lens fiber cell differentiation	PMID:9784491^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104564	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071850	mitotic cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19056892^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071285	cellular response to lithium ion	PMID:19056892^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071236	cellular response to antibiotic	PMID:19056892^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	PMID:16014817^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888808	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051271	negative regulation of cellular component movement	PMID:15652749^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:10079221^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:10079221^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048102	autophagic cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045786	negative regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:12130539^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:16014817^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888808	P	regulates_o_occurs_in:(EMAPA:29836) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:35710) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042326	negative regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033673	negative regulation of kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031116	positive regulation of microtubule polymerization	PMID:15652749^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96739	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	F		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:11751454^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P46527	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:12759355^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888808	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008219	cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69062	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:10079221^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:25535395^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08769 ensembl:ENSRNOP00000050173	P		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:1904030	negative regulation of cyclin-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0048102	autophagic cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C		Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C		Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F		Seeded From UniProt	complete
enables	GO:0004860	protein kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6I9V6 ensembl:ENSP00000228872	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6I9V6 ensembl:ENSP00000228872	C		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	C		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9618292 Reactome:R-MMU-5671980	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004860	protein kinase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0649	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Tane, S et al. (2014) CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem. Biophys. Res. Commun. 443 1105-9 PubMed GONUTS page
↑ Poon, RY et al. (1995) Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell 6 1197-213 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhang, P et al. (1998) Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 12 3162-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Toyoshima, H & Hunter, T (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78 67-74 PubMed GONUTS page
↑ Jansen, LA et al. (2005) Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia 46 1871-80 PubMed GONUTS page
↑ Laub, F et al. (2005) Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol. Cell. Biol. 25 5699-711 PubMed GONUTS page
↑ Tateya, T et al. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev. Biol. 352 329-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Baldassarre, G et al. (2005) p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell 7 51-63 PubMed GONUTS page
↑ ^10.0 ^10.1 Li, W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc. Natl. Acad. Sci. U.S.A. 112 166-71 PubMed GONUTS page
↑ Grimsley-Myers, CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 29 15859-69 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page
↑ Karnik, SK et al. (2005) Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl. Acad. Sci. U.S.A. 102 14659-64 PubMed GONUTS page
↑ Pasumarthi, KB et al. (2000) Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene. Circ. Res. 86 1069-77 PubMed GONUTS page
↑ ^15.0 ^15.1 Lazaro, JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 16 1792-805 PubMed GONUTS page
↑ ^16.0 ^16.1 Mukai, M et al. (2005) Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors. Biol. Reprod. 73 951-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Chen, P & Segil, N (1999) p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development 126 1581-90 PubMed GONUTS page
↑ Legrier, ME et al. (2001) Cell cycle regulation during mouse olfactory neurogenesis. Cell Growth Differ. 12 591-601 PubMed GONUTS page
↑ Kwon, YH et al. (2003) The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury. J. Biol. Chem. 278 30348-55 PubMed GONUTS page

[PMID:24380855-1] 1.0 ^1.1 ^1.2 ^1.3 Tane, S et al. (2014) CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem. Biophys. Res. Commun. 443 1105-9 PubMed GONUTS page

[PMID:8534916-2] Poon, RY et al. (1995) Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell 6 1197-213 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9784491-4] 4.0 ^4.1 ^4.2 Zhang, P et al. (1998) Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 12 3162-7 PubMed GONUTS page

[PMID:8033213-5] 5.0 ^5.1 Toyoshima, H & Hunter, T (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78 67-74 PubMed GONUTS page

[PMID:16393152-6] Jansen, LA et al. (2005) Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia 46 1871-80 PubMed GONUTS page

[PMID:15964824-7] Laub, F et al. (2005) Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol. Cell. Biol. 25 5699-711 PubMed GONUTS page

[PMID:21300049-8] Tateya, T et al. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev. Biol. 352 329-40 PubMed GONUTS page

[PMID:15652749-9] 9.0 ^9.1 ^9.2 ^9.3 Baldassarre, G et al. (2005) p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell 7 51-63 PubMed GONUTS page

[PMID:25535395-10] 10.0 ^10.1 Li, W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc. Natl. Acad. Sci. U.S.A. 112 166-71 PubMed GONUTS page

[PMID:20016102-11] Grimsley-Myers, CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 29 15859-69 PubMed GONUTS page

[PMID:19056892-12] 12.0 ^12.1 ^12.2 ^12.3 Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page

[PMID:16195383-13] Karnik, SK et al. (2005) Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc. Natl. Acad. Sci. U.S.A. 102 14659-64 PubMed GONUTS page

[PMID:10827137-14] Pasumarthi, KB et al. (2000) Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene. Circ. Res. 86 1069-77 PubMed GONUTS page

[PMID:12130539-15] 15.0 ^15.1 Lazaro, JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 16 1792-805 PubMed GONUTS page

[PMID:16014817-16] 16.0 ^16.1 Mukai, M et al. (2005) Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors. Biol. Reprod. 73 951-8 PubMed GONUTS page

[PMID:10079221-17] 17.0 ^17.1 ^17.2 Chen, P & Segil, N (1999) p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development 126 1581-90 PubMed GONUTS page

[PMID:11751454-18] Legrier, ME et al. (2001) Cell cycle regulation during mouse olfactory neurogenesis. Cell Growth Differ. 12 591-601 PubMed GONUTS page

[PMID:12759355-19] Kwon, YH et al. (2003) The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury. J. Biol. Chem. 278 30348-55 PubMed GONUTS page

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