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Jansen, LA, Uhlmann, EJ, Crino, PB, Gutmann, DH and Wong, M (2005) Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia 46:1871-80
Individuals with tuberous sclerosis complex (TSC) frequently have intractable epilepsy. To gain insights into mechanisms of epileptogenesis in TSC, we previously developed a mouse model of TSC with conditional inactivation of the Tsc1 gene in glia (Tsc1(GFAP)CKO mice). These mice develop progressive seizures, suggesting that glial dysfunction may be involved in epileptogenesis in TSC. Here, we investigated the hypothesis that impairment of potassium uptake through astrocyte inward rectifier potassium (Kir) channels may contribute to epileptogenesis in Tsc1(GFAP)CKO mice.
Animals; Astrocytes/metabolism; Cells, Cultured; Cyclin-Dependent Kinase 2/metabolism; Cyclin-Dependent Kinase 2/physiology; Epilepsy/genetics; Epilepsy/metabolism; Epilepsy/physiopathology; Extracellular Space/metabolism; Genes, Tumor Suppressor/physiology; Glutamic Acid/metabolism; Glutamic Acid/physiology; Hippocampus/cytology; Hippocampus/metabolism; Mice; Mice, Knockout; Potassium/metabolism; Potassium/physiology; Potassium Channels, Inwardly Rectifying/genetics; Potassium Channels, Inwardly Rectifying/metabolism; Potassium Channels, Inwardly Rectifying/physiology; Tuberous Sclerosis/genetics; Tuberous Sclerosis/metabolism; Tuberous Sclerosis/physiopathology; Tumor Suppressor Proteins/metabolism; Tumor Suppressor Proteins/physiology
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