MOUSE:BDNF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bdnf
Protein Name(s)	Brain-derived neurotrophic factor BDNF
External Links
UniProt	P21237
EMBL	X55573 BC034862
CCDS	CCDS38194.1
PIR	S12555
RefSeq	NP_001041604.1 NP_001041606.1 NP_001041607.1 NP_001272345.1 NP_001272346.1 NP_001272347.1 NP_001272348.1 NP_001272349.1 NP_001272350.1 NP_001272351.1
UniGene	Mm.1442
ProteinModelPortal	P21237
SMR	P21237
DIP	DIP-5724N
IntAct	P21237
PhosphoSite	P21237
MaxQB	P21237
PRIDE	P21237
Ensembl	ENSMUST00000111043 ENSMUST00000111044 ENSMUST00000111045 ENSMUST00000111046 ENSMUST00000111047 ENSMUST00000111049 ENSMUST00000111050 ENSMUST00000111051 ENSMUST00000176893
GeneID	12064
KEGG	mmu:12064
UCSC	uc008lme.1
CTD	627
MGI	MGI:88145
eggNOG	NOG45248
HOGENOM	HOG000231516
HOVERGEN	HBG006494
InParanoid	P21237
KO	K04355
Reactome	REACT_206713 REACT_209641
NextBio	280377
PRO	PR:P21237
Proteomes	UP000000589
Bgee	P21237
CleanEx	MM_BDNF
ExpressionAtlas	P21237
Genevestigator	P21237
GO	GO:0005737 GO:0016023 GO:0005788 GO:0005576 GO:0048471 GO:0048675 GO:0007411 GO:0007412 GO:0001662 GO:0007623 GO:0016358 GO:0097484 GO:0042596 GO:0007631 GO:0007214 GO:0014047 GO:0048839 GO:0007611 GO:0042490 GO:0043066 GO:0060548 GO:0007406 GO:0043524 GO:0032229 GO:0021675 GO:0008038 GO:0045666 GO:0033138 GO:0019222 GO:0043523 GO:0046668 GO:0048167 GO:0042493 GO:0061193 GO:0001657
Gene3D	2.10.90.10
InterPro	IPR020430 IPR029034 IPR020408 IPR002072 IPR019846
PANTHER	PTHR11589
Pfam	PF00243
PIRSF	PIRSF001789
PRINTS	PR01912 PR00268
ProDom	PD002052
SMART	SM00140
SUPFAM	SSF57501
PROSITE	PS00248 PS50270

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043523	regulation of neuron apoptosis	PMID:20067784^[1]	ECO:0000315			P		Table.1,2	complete
	GO:0051930	regulation of sensory perception of pain	PMID:20067784^[1]	ECO:0000315			P		Fig.1E,F	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:26708520^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000055128B_10090	P	occurs_in:(CL:1001451) regulates_o_occurs_in:(CL:1001451)	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:26708520^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000055128B_10090	P	occurs_in:(CL:1001451) regulates_o_occurs_in:(CL:1001451)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:19448629^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:19448629^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0099083	retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission	PMID:19448629^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060076) occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:22209827^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:23785138^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22209827^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 RGD:619728	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 UniProtKB:P01138	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 PANTHER:PTN000904283	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 MGI:MGI:97321 MGI:MGI:97380 PANTHER:PTN000904283 RGD:1598328	P		Seeded From UniProt	complete
involved_in	GO:0038180	nerve growth factor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 PANTHER:PTN000904283	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 MGI:MGI:97380 PANTHER:PTN000904283	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 PANTHER:PTN000904283 RGD:2202	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 PANTHER:PTN000904283 RGD:2202	C		Seeded From UniProt	complete
involved_in	GO:0021675	nerve development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88145 MGI:MGI:97380 PANTHER:PTN000904283	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 UniProtKB:P20783	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 RGD:2202	C		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000173497 RGD:1598328	P		Seeded From UniProt	complete
involved_in	GO:0007422	peripheral nervous system development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97321 MGI:MGI:97380 PANTHER:PTN000904283	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 UniProtKB:P20783	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000904283 RGD:1598328 RGD:2202	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23363	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990138	neuron projection extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900122	positive regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900122	positive regulation of receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097484	dendrite extension	PMID:24035762^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061193	taste bud development	PMID:24378336^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857136	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	PMID:24378336^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857136	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060080	inhibitory postsynaptic potential	PMID:24201284^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176750	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23363	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:7605630^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857136	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048675	axon extension	PMID:24035762^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048672	positive regulation of collateral sprouting	PMID:24573299^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048672	positive regulation of collateral sprouting	PMID:24573299^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048672	positive regulation of collateral sprouting	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048670	regulation of collateral sprouting	PMID:24573299^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2443199	P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048668	collateral sprouting	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048172	regulation of short-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:17442827^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:16819522^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046668	regulation of retinal cell programmed cell death	PMID:11747369^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045843	negative regulation of striated muscle tissue development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:12798291^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:8861722^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17571) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:15869495^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930038	P	occurs_in:(EMAPA:17563) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:16516892^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:12904469^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042596	fear response	PMID:15249684^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176750	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:15249684^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176750	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042490	mechanoreceptor differentiation	PMID:15376326^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1857232 MGI:MGI:1857233	P	occurs_in:(EMAPA:19141) results_in_acquisition_of_features_of:(CL:0000199)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:23878391^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_has_input:(MGI:MGI:95824) regulates_o_occurs_in:(EMAPA:35665) occurs_in:(EMAPA:35665)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:16754670^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23363	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032229	negative regulation of synaptic transmission, GABAergic	PMID:16754670^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15242649^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:14715936^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031099	regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030516	regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:24573299^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030061	mitochondrial crista	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021675	nerve development	PMID:7605630^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857136	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019222	regulation of metabolic process	PMID:12796784^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663046	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:12890780^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:25765) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014047	glutamate secretion	PMID:16819522^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010832	negative regulation of myotube differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008038	neuron recognition	PMID:15844198^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007631	feeding behavior	PMID:12796784^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663046	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:15249684^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176750	P	has_participant:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007412	axon target recognition	PMID:15464571^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930038	P	occurs_in:(EMAPA:17573) occurs_in:(CL:0000101)\|occurs_in:(EMAPA:16798) occurs_in:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15014133^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1929986	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007406	negative regulation of neuroblast proliferation	PMID:12798291^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007214	gamma-aminobutyric acid signaling pathway	PMID:16754670^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P23560	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	C		Seeded From UniProt	complete
enables	GO:0005169	neurotrophin TRKB receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2202	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	PMID:15249684^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176750	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001657	ureteric bud development	PMID:16018995^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060080	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002072	F		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-MMU-181822 Reactome:R-MMU-181788	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-MMU-9032771 Reactome:R-MMU-9006144 Reactome:R-MMU-205099 Reactome:R-MMU-204967	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Valdés-Sánchez, T et al. (2010) BDNF is essentially required for the early postnatal survival of nociceptors. Dev. Biol. 339 465-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Wang, Y et al. (2016) Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion. Exp Brain Res 234 1057-65 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Dean, C et al. (2009) Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nat. Neurosci. 12 767-76 PubMed GONUTS page
↑ ^5.0 ^5.1 Ng, T et al. (2012) Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regul. Pept. 174 79-89 PubMed GONUTS page
↑ Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Ouyang, Q et al. (2013) Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80 97-112 PubMed GONUTS page
↑ ^9.0 ^9.1 Huang, T & Krimm, RF (2014) BDNF and NT4 play interchangeable roles in gustatory development. Dev. Biol. 386 308-20 PubMed GONUTS page
↑ Bloodgood, BL et al. (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121-5 PubMed GONUTS page
↑ ^11.0 ^11.1 Ernfors, P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14 1153-64 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Suzuki, R et al. (2014) SPIG1 negatively regulates BDNF maturation. J. Neurosci. 34 3429-42 PubMed GONUTS page
↑ Lynch, G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J. Neurosci. 27 4424-34 PubMed GONUTS page
↑ ^14.0 ^14.1 Yano, H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat. Neurosci. 9 1009-18 PubMed GONUTS page
↑ Wahlin, KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp. Eye Res. 73 693-701 PubMed GONUTS page
↑ ^16.0 ^16.1 Cheng, A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev. Biol. 258 319-33 PubMed GONUTS page
↑ Staecker, H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res. Dev. Brain Res. 92 49-60 PubMed GONUTS page
↑ Guo, H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur. J. Neurosci. 21 2019-23 PubMed GONUTS page
↑ Li, HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett. 580 1723-8 PubMed GONUTS page
↑ Schubert, M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J. Neurosci. 23 7084-92 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Monteggia, LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc. Natl. Acad. Sci. U.S.A. 101 10827-32 PubMed GONUTS page
↑ Sedý, J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev. Dyn. 231 551-63 PubMed GONUTS page
↑ Lambert, WM et al. (2013) Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol. Cell. Biol. 33 3700-14 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Kanematsu, T et al. (2006) Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J. Biol. Chem. 281 22180-9 PubMed GONUTS page
↑ Gauthier, LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118 127-38 PubMed GONUTS page
↑ Sadakata, T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J. Neurosci. 24 43-52 PubMed GONUTS page
↑ ^27.0 ^27.1 Xu, B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6 736-42 PubMed GONUTS page
↑ Gorski, JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J. Neurosci. 23 6856-65 PubMed GONUTS page
↑ Fritzsch, B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev. Dyn. 233 570-83 PubMed GONUTS page
↑ Hellard, D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev. Biol. 275 34-43 PubMed GONUTS page
↑ Tessarollo, L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J. Neurosci. 24 2575-84 PubMed GONUTS page
↑ Sajithlal, G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev. Biol. 284 323-36 PubMed GONUTS page

[PMID:20067784-1] 1.0 ^1.1 Valdés-Sánchez, T et al. (2010) BDNF is essentially required for the early postnatal survival of nociceptors. Dev. Biol. 339 465-76 PubMed GONUTS page

[PMID:26708520-2] 2.0 ^2.1 Wang, Y et al. (2016) Downregulation of miR-210 protected bupivacaine-induced neurotoxicity in dorsal root ganglion. Exp Brain Res 234 1057-65 PubMed GONUTS page

[PMID:24006456-3] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:19448629-4] 4.0 ^4.1 ^4.2 Dean, C et al. (2009) Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nat. Neurosci. 12 767-76 PubMed GONUTS page

[PMID:22209827-5] 5.0 ^5.1 Ng, T et al. (2012) Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regul. Pept. 174 79-89 PubMed GONUTS page

[PMID:23785138-6] Baeza-Raja, B et al. (2013) p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 33 10221-34 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24035762-8] 8.0 ^8.1 Ouyang, Q et al. (2013) Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80 97-112 PubMed GONUTS page

[PMID:24378336-9] 9.0 ^9.1 Huang, T & Krimm, RF (2014) BDNF and NT4 play interchangeable roles in gustatory development. Dev. Biol. 386 308-20 PubMed GONUTS page

[PMID:24201284-10] Bloodgood, BL et al. (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503 121-5 PubMed GONUTS page

[PMID:7605630-11] 11.0 ^11.1 Ernfors, P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14 1153-64 PubMed GONUTS page

[PMID:24573299-12] 12.0 ^12.1 ^12.2 ^12.3 Suzuki, R et al. (2014) SPIG1 negatively regulates BDNF maturation. J. Neurosci. 34 3429-42 PubMed GONUTS page

[PMID:17442827-13] Lynch, G et al. (2007) Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. J. Neurosci. 27 4424-34 PubMed GONUTS page

[PMID:16819522-14] 14.0 ^14.1 Yano, H et al. (2006) BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat. Neurosci. 9 1009-18 PubMed GONUTS page

[PMID:11747369-15] Wahlin, KJ et al. (2001) Neurotrophic signaling in normal and degenerating rodent retinas. Exp. Eye Res. 73 693-701 PubMed GONUTS page

[PMID:12798291-16] 16.0 ^16.1 Cheng, A et al. (2003) Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev. Biol. 258 319-33 PubMed GONUTS page

[PMID:8861722-17] Staecker, H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res. Dev. Brain Res. 92 49-60 PubMed GONUTS page

[PMID:15869495-18] Guo, H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur. J. Neurosci. 21 2019-23 PubMed GONUTS page

[PMID:16516892-19] Li, HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett. 580 1723-8 PubMed GONUTS page

[PMID:12904469-20] Schubert, M et al. (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J. Neurosci. 23 7084-92 PubMed GONUTS page

[PMID:15249684-21] 21.0 ^21.1 ^21.2 ^21.3 Monteggia, LM et al. (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc. Natl. Acad. Sci. U.S.A. 101 10827-32 PubMed GONUTS page

[PMID:15376326-22] Sedý, J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev. Dyn. 231 551-63 PubMed GONUTS page

[PMID:23878391-23] Lambert, WM et al. (2013) Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Mol. Cell. Biol. 33 3700-14 PubMed GONUTS page

[PMID:16754670-24] 24.0 ^24.1 ^24.2 Kanematsu, T et al. (2006) Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J. Biol. Chem. 281 22180-9 PubMed GONUTS page

[PMID:15242649-25] Gauthier, LR et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118 127-38 PubMed GONUTS page

[PMID:14715936-26] Sadakata, T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J. Neurosci. 24 43-52 PubMed GONUTS page

[PMID:12796784-27] 27.0 ^27.1 Xu, B et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6 736-42 PubMed GONUTS page

[PMID:12890780-28] Gorski, JA et al. (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J. Neurosci. 23 6856-65 PubMed GONUTS page

[PMID:15844198-29] Fritzsch, B et al. (2005) Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev. Dyn. 233 570-83 PubMed GONUTS page

[PMID:15464571-30] Hellard, D et al. (2004) Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice. Dev. Biol. 275 34-43 PubMed GONUTS page

[PMID:15014133-31] Tessarollo, L et al. (2004) NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea. J. Neurosci. 24 2575-84 PubMed GONUTS page

[PMID:16018995-32] Sajithlal, G et al. (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev. Biol. 284 323-36 PubMed GONUTS page

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MOUSE:BDNF

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