GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12796784
Citation |
Xu, B, Goulding, EH, Zang, K, Cepoi, D, Cone, RD, Jones, KR, Tecott, LH and Reichardt, LF (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6:736-42 |
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Abstract |
The melanocortin-4 receptor (MC4R) is critically involved in regulating energy balance, and obesity has been observed in mice with mutations in the gene for brain-derived neurotrophic factor (BDNF). Here we report that BDNF is expressed at high levels in the ventromedial hypothalamus (VMH) where its expression is regulated by nutritional state and by MC4R signaling. In addition, similar to MC4R mutants, mouse mutants that expresses the BDNF receptor TrkB at a quarter of the normal amount showed hyperphagia and excessive weight gain on higher-fat diets. Furthermore, BDNF infusion into the brain suppressed the hyperphagia and excessive weight gain observed on higher-fat diets in mice with deficient MC4R signaling. These results show that MC4R signaling controls BDNF expression in the VMH and support the hypothesis that BDNF is an important effector through which MC4R signaling controls energy balance. |
Links |
PubMed PMC2710100 Online version:10.1038/nn1073 |
Keywords |
Aging; Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor/genetics; Brain-Derived Neurotrophic Factor/physiology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Circadian Rhythm/physiology; Diet, Fat-Restricted/methods; Drinking; Eating; Energy Intake/drug effects; Energy Intake/genetics; Energy Metabolism/physiology; Feeding Behavior; Female; Food Deprivation; Gene Expression Regulation; Humans; Hypothalamic Area, Lateral/cytology; Hypothalamic Area, Lateral/metabolism; Hypothalamic Hormones/genetics; Hypothalamic Hormones/metabolism; Hypothalamus, Middle/metabolism; Immunohistochemistry; In Situ Hybridization; Injections, Intraventricular/methods; Intracellular Signaling Peptides and Proteins; Male; Melanins/genetics; Melanins/metabolism; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Neuropeptide Y/genetics; Neuropeptide Y/metabolism; Neuropeptides/genetics; Neuropeptides/metabolism; Obesity/genetics; Obesity/metabolism; Phenylalanine/analogs & derivatives; Phenylalanine/pharmacology; Pituitary Hormones/genetics; Pituitary Hormones/metabolism; Polyenes/pharmacology; RNA, Messenger/drug effects; Receptor, Melanocortin, Type 4; Receptor, trkB/genetics; Receptor, trkB/metabolism; Receptors, Corticotropin/genetics; Receptors, Corticotropin/physiology; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Recombinant Proteins; Sex Characteristics; alpha-MSH/administration & dosage; alpha-MSH/analogs & derivatives; beta-Galactosidase/metabolism |
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Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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