MOUSE:AQP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Aqp1
Protein Name(s)	Aquaporin-1 AQP-1 Aquaporin-CHIP Delayed early response protein 2 DER2 Water channel protein for red blood cells and kidney proximal tubule
External Links
UniProt	Q02013
EMBL	L02914 AK081886 AK086688 AK157333 AK158226 AK158389 AK171627 AK172361 BC007125
CCDS	CCDS20164.1
PIR	B44499
RefSeq	NP_031498.1
UniGene	Mm.18625
ProteinModelPortal	Q02013
SMR	Q02013
BioGrid	198170
IntAct	Q02013
MINT	MINT-4088080
PhosphoSite	Q02013
MaxQB	Q02013
PaxDb	Q02013
PRIDE	Q02013
Ensembl	ENSMUST00000004774
GeneID	11826
KEGG	mmu:11826
UCSC	uc009caq.1
CTD	358
MGI	MGI:103201
eggNOG	COG0580
GeneTree	ENSGT00760000119223
HOGENOM	HOG000288286
HOVERGEN	HBG000312
InParanoid	Q02013
KO	K09864
OMA	FNNHWIF
OrthoDB	EOG7N8ZWD
PhylomeDB	Q02013
TreeFam	TF312940
Reactome	REACT_199094 REACT_199098 REACT_213947 REACT_259079
NextBio	279727
PRO	PR:Q02013
Proteomes	UP000000589
Bgee	Q02013
CleanEx	MM_AQP1
Genevestigator	Q02013
GO	GO:0016324 GO:0030424 GO:0043679 GO:0009925 GO:0016323 GO:0005903 GO:0031526 GO:0005737 GO:0070062 GO:0016021 GO:0005887 GO:0016020 GO:0032809 GO:0031965 GO:0005634 GO:0005886 GO:0042383 GO:0020003 GO:0020005 GO:0008519 GO:0035379 GO:0046875 GO:0015168 GO:0005223 GO:0030184 GO:0005267 GO:0015079 GO:0015250 GO:0005372 GO:0015696 GO:0048593 GO:0035378 GO:0015670 GO:0006884 GO:0019725 GO:0071474 GO:0071320 GO:0071280 GO:0071549 GO:0070301 GO:0071456 GO:0071241 GO:0071260 GO:0071288 GO:0071732 GO:0071300 GO:0071472 GO:0033554 GO:0034644 GO:0033326 GO:0006182 GO:0051458 GO:0030950 GO:0003094 GO:0015793 GO:0042538 GO:0021670 GO:0044241 GO:0085018 GO:0072220 GO:0072239 GO:0072232 GO:0072230 GO:0043066 GO:0043154 GO:0030185 GO:0042476 GO:0030157 GO:0045766 GO:0030335 GO:0010634 GO:0048146 GO:0010592 GO:0046878 GO:0071805 GO:0006813 GO:0070295 GO:0042493 GO:0043627 GO:0032940 GO:0033363 GO:0019233 GO:0035377 GO:0030104 GO:0006833 GO:0042060
Gene3D	1.20.1080.10
InterPro	IPR023271 IPR023274 IPR000425 IPR022357
PANTHER	PTHR19139
Pfam	PF00230
PRINTS	PR02013 PR00783
SUPFAM	SSF81338
TIGRFAMs	TIGR00861
PROSITE	PS00221

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005901	caveola	PMID:23238222^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0010006) part_of:(UBERON:0006966)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:23238222^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0010006) part_of:(UBERON:0006966)	Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	PMID:23238222^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0010006) part_of:(UBERON:0006966)	Seeded From UniProt	complete
involved_in	GO:0085018	maintenance of symbiont-containing vacuole by host	PMID:18665841^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072239	metanephric glomerulus vasculature development	PMID:18618131^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072232	metanephric proximal convoluted tubule segment 2 development	PMID:18618131^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072230	metanephric proximal straight tubule development	PMID:18618131^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072220	metanephric descending thin limb development	PMID:18618131^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071474	cellular hyperosmotic response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071472	cellular response to salt stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071288	cellular response to mercury ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0071241	cellular response to inorganic substance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0046878	positive regulation of saliva secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:10839360^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54763	F		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
enables	GO:0035379	carbon dioxide transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
involved_in	GO:0035378	carbon dioxide transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0035377	transepithelial water transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
involved_in	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0030185	nitric oxide transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
enables	GO:0030184	nitric oxide transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
involved_in	GO:0021670	lateral ventricle development	PMID:16133142^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0020003	symbiont-containing vacuole	PMID:18665841^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019725	cellular homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:16133142^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:16133142^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015793	glycerol transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0015696	ammonium transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0015670	carbon dioxide transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
enables	GO:0015250	water channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0015168	glycerol transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0015079	potassium ion transmembrane transporter activity	PMID:18665841^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
enables	GO:0008519	ammonium transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
involved_in	GO:0006884	cell volume homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	PMID:18665841^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0005903	brush border	PMID:16133142^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0005223	intracellular cGMP-activated cation channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0035379	carbon dioxide transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002709505 UniProtKB:P29972 ZFIN:ZDB-GENE-030131-7764	F		Seeded From UniProt	complete
involved_in	GO:0035378	carbon dioxide transmembrane transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000440666 UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13270 FB:FBgn0000180 FB:FBgn0015872 MGI:MGI:103201 PANTHER:PTN000440616 RGD:2143 UniProtKB:P06624	C		Seeded From UniProt	complete
enables	GO:0015250	water channel activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13270 FB:FBgn0015872 MGI:MGI:107387 MGI:MGI:1096865 MGI:MGI:96990 PANTHER:PTN000440616 RGD:2141 RGD:2143 RGD:3090 UniProtKB:P06624 UniProtKB:P29972 UniProtKB:P30301 UniProtKB:P41181 UniProtKB:P55064 UniProtKB:P55087 UniProtKB:Q5A1Z4 ZFIN:ZDB-GENE-030131-7764 ZFIN:ZDB-GENE-040801-41	F		Seeded From UniProt	complete
enables	GO:0015168	glycerol transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002709505 RGD:2141 UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0008519	ammonium transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002709505 UniProtKB:P29972 ZFIN:ZDB-GENE-030131-7764	F		Seeded From UniProt	complete
involved_in	GO:0006972	hyperosmotic response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002709505 RGD:2141 UniProtKB:P29972	P		Seeded From UniProt	complete
involved_in	GO:0003097	renal water transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103201 PANTHER:PTN002709506 UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0085018	maintenance of symbiont-containing vacuole by host	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071732	cellular response to nitric oxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071474	cellular hyperosmotic response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071472	cellular response to salt stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071320	cellular response to cAMP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071300	cellular response to retinoic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071288	cellular response to mercury ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071280	cellular response to copper ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071241	cellular response to inorganic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:15998844^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:11035042^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1333777	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:10662735^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107387	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:9468475^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:28281)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:16525162^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:12133842^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:11035042^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:10795927^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:29659)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:10724035^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:10662735^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070295	renal water absorption	PMID:10021457^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:29681)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19724054^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000558)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051458	corticotropin secretion	PMID:18511498^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:17515)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:11891232^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:17161)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046878	positive regulation of saliva secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044241	lipid digestion	PMID:11121384^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:32834)	Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	PMID:19298815^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P		Seeded From UniProt	complete
enables	GO:0035379	carbon dioxide transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035378	carbon dioxide transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035377	transepithelial water transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034644	cellular response to UV	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033363	secretory granule organization	PMID:18511498^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032940	secretion by cell	PMID:18511498^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032809	neuronal cell body membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
part_of	GO:0032127	dense core granule membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P47865	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:17257750^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35790) part_of:(CL:0000379)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	PMID:19298815^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	regulates_o_occurs_in:(EMAPA:17602) regulates_o_results_in_movement_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030185	nitric oxide transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
enables	GO:0030184	nitric oxide transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030104	water homeostasis	PMID:12034763^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:18231)	Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
colocalizes_with	GO:0020005	symbiont-containing vacuole membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019934	cGMP-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019725	cellular homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:16476579^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21705333^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:19179619^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35370) part_of:(CL:0000075)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:12181190^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18511498^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17515)\|part_of:(EMAPA:18426)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15952169^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168)\|part_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015793	glycerol transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015793	glycerol transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015696	ammonium transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015670	carbon dioxide transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
enables	GO:0015250	water channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0015250	water channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	F		Seeded From UniProt	complete
enables	GO:0015168	glycerol transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0015168	glycerol transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	P		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
enables	GO:0008519	ammonium transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006884	cell volume homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:12133842^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1351654	P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:9886922^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16139)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:16936111^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:16508653^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:16138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:15647389^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:14637313^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:12676067^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:11078688^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:11035042^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:10836992^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:28281)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:10642600^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:36560)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:10613915^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	occurs_in:(EMAPA:32867) occurs_in:(CL:0000071)\|occurs_in:(EMAPA:36292) occurs_in:(CL:0000071)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:10021464^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:32867)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	PMID:10644730^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006833	water transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	P		Seeded From UniProt	complete
part_of	GO:0005903	brush border	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0005903	brush border	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17377981^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32871) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17257750^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35790) part_of:(CL:0000379)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16508653^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16139) part_of:(CL:0000071)\|part_of:(EMAPA:36292) part_of:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12133842^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000232)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11891232^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35935) part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11078688^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32867) part_of:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2141	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	C		Seeded From UniProt	complete
enables	GO:0005372	water transmembrane transporter activity	PMID:10644730^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005372	water transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
enables	GO:0005223	intracellular cGMP-activated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003097	renal water transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29972	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003094	glomerular filtration	PMID:15283758^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857807	P	has_participant:(EMAPA:28239)	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005223	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005223	P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005267	P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005267	P		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015079	P		Seeded From UniProt	complete
involved_in	GO:0072488	ammonium transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008519	P		Seeded From UniProt	complete
involved_in	GO:0072488	ammonium transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008519	P		Seeded From UniProt	complete
involved_in	GO:0072488	ammonium transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008519	P		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005223	P		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005223	P		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
involved_in	GO:0042538	hyperosmotic salinity response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
part_of	GO:0032809	neuronal cell body membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
involved_in	GO:0021670	lateral ventricle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
involved_in	GO:0015793	glycerol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
enables	GO:0015250	water channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	F		Seeded From UniProt	complete
enables	GO:0015168	glycerol transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	F		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
involved_in	GO:0006972	hyperosmotic response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
involved_in	GO:0006833	water transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	P		Seeded From UniProt	complete
part_of	GO:0005903	brush border	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29975 ensembl:ENSRNOP00000015692	C		Seeded From UniProt	complete
enables	GO:0015267	channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000425	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000425	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000425	P		Seeded From UniProt	complete
enables	GO:0015250	water channel activity	PMID:11066060^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:11066060^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Rutkovskiy, A et al. (2013) Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia. J. Mol. Cell. Cardiol. 56 22-33 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Radtke, AL & O'Riordan, MX (2008) Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell. Microbiol. 10 2197-207 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Georgas, K et al. (2008) Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem. Cell Biol. 130 927-42 PubMed GONUTS page
↑ Cowan, CA et al. (2000) EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 26 417-30 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Johansson, PA et al. (2005) Aquaporin-1 in the choroid plexuses of developing mammalian brain. Cell Tissue Res. 322 353-64 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sohara, E et al. (2005) Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am. J. Physiol. Renal Physiol. 289 F1195-200 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yang, B et al. (2001) Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J. Biol. Chem. 276 624-8 PubMed GONUTS page
↑ ^9.0 ^9.1 van Hoek, AN et al. (2000) Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am. J. Physiol. Renal Physiol. 278 F310-6 PubMed GONUTS page
↑ Ma, T et al. (1998) Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J. Biol. Chem. 273 4296-9 PubMed GONUTS page
↑ Zhao, D et al. (2006) Urea and urine concentrating ability in mice lacking AQP1 and AQP3. Am. J. Physiol. Renal Physiol. 291 F429-38 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Yang, B & Verkman, AS (2002) Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J. Biol. Chem. 277 36782-6 PubMed GONUTS page
↑ Verkman, AS et al. (2000) Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp. Physiol. 85 Spec No 233S-241S PubMed GONUTS page
↑ Yang, B et al. (2000) Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum. Gene Ther. 11 567-75 PubMed GONUTS page
↑ Chou, CL et al. (1999) Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J. Clin. Invest. 103 491-6 PubMed GONUTS page
↑ Blanc, L et al. (2009) The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood 114 3928-34 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Arnaoutova, I et al. (2008) Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells. Mol. Endocrinol. 22 1924-34 PubMed GONUTS page
↑ ^18.0 ^18.1 Thiagarajah, JR & Verkman, AS (2002) Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J. Biol. Chem. 277 19139-44 PubMed GONUTS page
↑ Ma, T et al. (2001) Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am. J. Physiol., Cell Physiol. 280 C126-34 PubMed GONUTS page
↑ ^20.0 ^20.1 Ruiz-Ederra, J & Verkman, AS (2009) Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Exp. Eye Res. 89 159-65 PubMed GONUTS page
↑ ^21.0 ^21.1 Shields, SD et al. (2007) Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain 131 8-20 PubMed GONUTS page
↑ Zhang, D et al. (2002) Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production. J. Gen. Physiol. 119 561-9 PubMed GONUTS page
↑ Oshio, K et al. (2006) Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem. Biophys. Res. Commun. 341 1022-8 PubMed GONUTS page
↑ Kao, L et al. (2011) Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J. Biol. Chem. 286 32563-74 PubMed GONUTS page
↑ Li, L et al. (2009) Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am. J. Physiol. Gastrointest. Liver Physiol. 296 G816-22 PubMed GONUTS page
↑ Mennone, A et al. (2002) Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am. J. Physiol. Gastrointest. Liver Physiol. 283 G739-46 PubMed GONUTS page
↑ Kang, TH et al. (2005) Identification and characterization of an aquaporin 1 immunoreactive amacrine-type cell of the mouse retina. J. Comp. Neurol. 488 352-67 PubMed GONUTS page
↑ Yang, B et al. (1999) Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am. J. Physiol. 276 C76-81 PubMed GONUTS page
↑ Ruiz-Ederra, J & Verkman, AS (2006) Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Invest. Ophthalmol. Vis. Sci. 47 3960-7 PubMed GONUTS page
↑ ^30.0 ^30.1 Ni, J et al. (2006) Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int. 69 1518-25 PubMed GONUTS page
↑ Yang, B et al. (2005) Phenotype analysis of aquaporin-8 null mice. Am. J. Physiol., Cell Physiol. 288 C1161-70 PubMed GONUTS page
↑ Jiang, J et al. (2003) Role of aquaporin and sodium channel in pleural water movement. Respir Physiol Neurobiol 139 83-8 PubMed GONUTS page
↑ Jiang, JJ et al. (2003) Effect of aquaporin-1 deletion on pleural fluid transport. Acta Pharmacol. Sin. 24 301-5 PubMed GONUTS page
↑ ^34.0 ^34.1 Song, Y et al. (2000) Role of aquaporin water channels in pleural fluid dynamics. Am. J. Physiol., Cell Physiol. 279 C1744-50 PubMed GONUTS page
↑ Vallon, V et al. (2000) Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. Am. J. Physiol. Renal Physiol. 278 F1030-3 PubMed GONUTS page
↑ Pallone, TL et al. (2000) Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J. Clin. Invest. 105 215-22 PubMed GONUTS page
↑ Song, Y et al. (2000) Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J. Gen. Physiol. 115 17-27 PubMed GONUTS page
↑ Bai, C et al. (1999) Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J. Clin. Invest. 103 555-61 PubMed GONUTS page
↑ ^39.0 ^39.1 Yang, B et al. (2000) Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J. Biol. Chem. 275 2686-92 PubMed GONUTS page
↑ Varadaraj, K et al. (2007) Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Dev. Dyn. 236 1319-28 PubMed GONUTS page
↑ Hashimoto, S et al. (2004) Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR. Acta Physiol. Scand. 181 455-62 PubMed GONUTS page
↑ ^42.0 ^42.1 Offenberg, H et al. (2000) mRNAs encoding aquaporins are present during murine preimplantation development. Mol. Reprod. Dev. 57 323-30 PubMed GONUTS page

[PMID:23238222-1] 1.0 ^1.1 ^1.2 Rutkovskiy, A et al. (2013) Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia. J. Mol. Cell. Cardiol. 56 22-33 PubMed GONUTS page

[PMID:18665841-2] 2.0 ^2.1 ^2.2 ^2.3 Radtke, AL & O'Riordan, MX (2008) Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell. Microbiol. 10 2197-207 PubMed GONUTS page

[PMID:18618131-3] 3.0 ^3.1 ^3.2 ^3.3 Georgas, K et al. (2008) Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem. Cell Biol. 130 927-42 PubMed GONUTS page

[PMID:10839360-4] Cowan, CA et al. (2000) EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron 26 417-30 PubMed GONUTS page

[PMID:16133142-5] 5.0 ^5.1 ^5.2 ^5.3 Johansson, PA et al. (2005) Aquaporin-1 in the choroid plexuses of developing mammalian brain. Cell Tissue Res. 322 353-64 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15998844-7] Sohara, E et al. (2005) Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am. J. Physiol. Renal Physiol. 289 F1195-200 PubMed GONUTS page

[PMID:11035042-8] 8.0 ^8.1 ^8.2 Yang, B et al. (2001) Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J. Biol. Chem. 276 624-8 PubMed GONUTS page

[PMID:10662735-9] 9.0 ^9.1 van Hoek, AN et al. (2000) Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am. J. Physiol. Renal Physiol. 278 F310-6 PubMed GONUTS page

[PMID:9468475-10] Ma, T et al. (1998) Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J. Biol. Chem. 273 4296-9 PubMed GONUTS page

[PMID:16525162-11] Zhao, D et al. (2006) Urea and urine concentrating ability in mice lacking AQP1 and AQP3. Am. J. Physiol. Renal Physiol. 291 F429-38 PubMed GONUTS page

[PMID:12133842-12] 12.0 ^12.1 ^12.2 Yang, B & Verkman, AS (2002) Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence for UT-B-facilitated water transport in erythrocytes. J. Biol. Chem. 277 36782-6 PubMed GONUTS page

[PMID:10795927-13] Verkman, AS et al. (2000) Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp. Physiol. 85 Spec No 233S-241S PubMed GONUTS page

[PMID:10724035-14] Yang, B et al. (2000) Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum. Gene Ther. 11 567-75 PubMed GONUTS page

[PMID:10021457-15] Chou, CL et al. (1999) Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J. Clin. Invest. 103 491-6 PubMed GONUTS page

[PMID:19724054-16] Blanc, L et al. (2009) The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood 114 3928-34 PubMed GONUTS page

[PMID:18511498-17] 17.0 ^17.1 ^17.2 ^17.3 Arnaoutova, I et al. (2008) Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells. Mol. Endocrinol. 22 1924-34 PubMed GONUTS page

[PMID:11891232-18] 18.0 ^18.1 Thiagarajah, JR & Verkman, AS (2002) Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J. Biol. Chem. 277 19139-44 PubMed GONUTS page

[PMID:11121384-19] Ma, T et al. (2001) Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am. J. Physiol., Cell Physiol. 280 C126-34 PubMed GONUTS page

[PMID:19298815-20] 20.0 ^20.1 Ruiz-Ederra, J & Verkman, AS (2009) Aquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Exp. Eye Res. 89 159-65 PubMed GONUTS page

[PMID:17257750-21] 21.0 ^21.1 Shields, SD et al. (2007) Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain 131 8-20 PubMed GONUTS page

[PMID:12034763-22] Zhang, D et al. (2002) Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production. J. Gen. Physiol. 119 561-9 PubMed GONUTS page

[PMID:16476579-23] Oshio, K et al. (2006) Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem. Biophys. Res. Commun. 341 1022-8 PubMed GONUTS page

[PMID:21705333-24] Kao, L et al. (2011) Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J. Biol. Chem. 286 32563-74 PubMed GONUTS page

[PMID:19179619-25] Li, L et al. (2009) Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am. J. Physiol. Gastrointest. Liver Physiol. 296 G816-22 PubMed GONUTS page

[PMID:12181190-26] Mennone, A et al. (2002) Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am. J. Physiol. Gastrointest. Liver Physiol. 283 G739-46 PubMed GONUTS page

[PMID:15952169-27] Kang, TH et al. (2005) Identification and characterization of an aquaporin 1 immunoreactive amacrine-type cell of the mouse retina. J. Comp. Neurol. 488 352-67 PubMed GONUTS page

[PMID:9886922-28] Yang, B et al. (1999) Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am. J. Physiol. 276 C76-81 PubMed GONUTS page

[PMID:16936111-29] Ruiz-Ederra, J & Verkman, AS (2006) Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Invest. Ophthalmol. Vis. Sci. 47 3960-7 PubMed GONUTS page

[PMID:16508653-30] 30.0 ^30.1 Ni, J et al. (2006) Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int. 69 1518-25 PubMed GONUTS page

[PMID:15647389-31] Yang, B et al. (2005) Phenotype analysis of aquaporin-8 null mice. Am. J. Physiol., Cell Physiol. 288 C1161-70 PubMed GONUTS page

[PMID:14637313-32] Jiang, J et al. (2003) Role of aquaporin and sodium channel in pleural water movement. Respir Physiol Neurobiol 139 83-8 PubMed GONUTS page

[PMID:12676067-33] Jiang, JJ et al. (2003) Effect of aquaporin-1 deletion on pleural fluid transport. Acta Pharmacol. Sin. 24 301-5 PubMed GONUTS page

[PMID:11078688-34] 34.0 ^34.1 Song, Y et al. (2000) Role of aquaporin water channels in pleural fluid dynamics. Am. J. Physiol., Cell Physiol. 279 C1744-50 PubMed GONUTS page

[PMID:10836992-35] Vallon, V et al. (2000) Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. Am. J. Physiol. Renal Physiol. 278 F1030-3 PubMed GONUTS page

[PMID:10642600-36] Pallone, TL et al. (2000) Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J. Clin. Invest. 105 215-22 PubMed GONUTS page

[PMID:10613915-37] Song, Y et al. (2000) Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J. Gen. Physiol. 115 17-27 PubMed GONUTS page

[PMID:10021464-38] Bai, C et al. (1999) Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J. Clin. Invest. 103 555-61 PubMed GONUTS page

[PMID:10644730-39] 39.0 ^39.1 Yang, B et al. (2000) Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J. Biol. Chem. 275 2686-92 PubMed GONUTS page

[PMID:17377981-40] Varadaraj, K et al. (2007) Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Dev. Dyn. 236 1319-28 PubMed GONUTS page

[PMID:15283758-41] Hashimoto, S et al. (2004) Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR. Acta Physiol. Scand. 181 455-62 PubMed GONUTS page

[PMID:11066060-42] 42.0 ^42.1 Offenberg, H et al. (2000) mRNAs encoding aquaporins are present during murine preimplantation development. Mol. Reprod. Dev. 57 323-30 PubMed GONUTS page

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MOUSE:AQP1

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