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PMID:15283758

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Citation

Hashimoto, S, Huang, Y, Mizel, D, Briggs, J and Schnermann, J (2004) Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR. Acta Physiol. Scand. 181:455-62

Abstract

By crossing aquaporin 1 (AQP1)-/- and adenosine 1 receptor (A1AR)-/- mice, we generated an animal model that combines a proximal tubular absorption defect with absence of tubuloglomerular feedback (TGF) regulation of glomerular filtration rate (GFR). The aim of studies in these animals was to determine whether a TGF-induced reduction of GFR is a prerequisite for preventing potentially fatal fluid losses.

Links

PubMed Online version:10.1111/j.1365-201X.2004.01318.x

Keywords

Absorption; Animals; Aquaporin 1; Aquaporins/deficiency; Aquaporins/physiology; Disease Models, Animal; Feedback; Female; Glomerular Filtration Rate/drug effects; Glomerular Filtration Rate/physiology; Kidney Diseases/metabolism; Kidney Tubules, Proximal/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A1/deficiency; Receptor, Adenosine A1/physiology; Renin/blood; Sodium/metabolism; Transforming Growth Factors/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:AQP1

acts_upstream_of_or_within

GO:0003094: glomerular filtration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857807

P

Seeded From UniProt

complete

MOUSE:AA1R

acts_upstream_of_or_within

GO:0003093: regulation of glomerular filtration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2388340

P

Seeded From UniProt

complete

MOUSE:AQP1

acts_upstream_of_or_within

GO:0003094: glomerular filtration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857807

P

has_participant:(EMAPA:28239)

Seeded From UniProt

complete


See also

References

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