GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:AKTS1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Akt1s1 (ECO:0000312 with MGI:MGI:1914855) (synonyms: Pras (ECO:0000303 with PMID:14973226[1])) | |
| Protein Name(s) | Proline-rich AKT1 substrate 1
Proline-rich AKT substrate | |
| External Links | ||
| UniProt | Q9D1F4 | |
| EMBL | AK003638 AK141771 AK154110 BC132372 BC132374 | |
| CCDS | CCDS21218.1 | |
| RefSeq | NP_001240849.1 NP_001277623.1 NP_001277624.1 NP_080546.1 XP_006541182.1 XP_006541183.1 XP_006541184.1 XP_006541185.1 | |
| UniGene | Mm.148007 Mm.491121 | |
| ProteinModelPortal | Q9D1F4 | |
| IntAct | Q9D1F4 | |
| PhosphoSite | Q9D1F4 | |
| MaxQB | Q9D1F4 | |
| PaxDb | Q9D1F4 | |
| PRIDE | Q9D1F4 | |
| Ensembl | ENSMUST00000054343 ENSMUST00000107880 | |
| GeneID | 67605 | |
| KEGG | mmu:67605 | |
| UCSC | uc009grd.2 | |
| CTD | 84335 | |
| MGI | MGI:1914855 | |
| eggNOG | NOG40718 | |
| GeneTree | ENSGT00390000017397 | |
| HOGENOM | HOG000236322 | |
| HOVERGEN | HBG059465 | |
| InParanoid | Q9D1F4 | |
| KO | K16184 | |
| PhylomeDB | Q9D1F4 | |
| Reactome | REACT_196588 REACT_213550 REACT_220918 | |
| ChiTaRS | Akt1s1 | |
| NextBio | 325025 | |
| PRO | PR:Q9D1F4 | |
| Proteomes | UP000000589 | |
| Bgee | Q9D1F4 | |
| CleanEx | MM_AKT1S1 | |
| ExpressionAtlas | Q9D1F4 | |
| Genevestigator | Q9D1F4 | |
| GO | GO:0005829 GO:0005634 GO:0031931 GO:0045792 GO:0006469 GO:0032007 GO:0048011 GO:0007219 GO:0043523 | |
| InterPro | IPR026682 | |
| PANTHER | PTHR21844 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016310 |
phosphorylation |
ECO:0000314 |
P |
Figure 6. Analysis of the levels of total and phosphorylated Akt protein. |
complete | |||||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0267824 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031931 |
TORC1 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001094901 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001094901 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001094901 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045792 |
negative regulation of cell size |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1312049 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0031931 |
TORC1 complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007219 |
Notch signaling pathway |
ECO:0000247 |
sequence alignment evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006469 |
negative regulation of protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1312049 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1312049 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032007 |
negative regulation of TOR signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048011 |
neurotrophin TRK receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Saito, A et al. (2004) Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. J. Neurosci. 24 1584-93 PubMed GONUTS page
- ↑ Ohta, T et al. (2006) Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models. Endocrinology 147 1761-9 PubMed GONUTS page
- ↑ Saito, A et al. (2006) Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Stroke 37 513-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Chern, JJ & Choi, KW (2002) Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129 4005-13 PubMed GONUTS page
g
n
r
