PMID:12163404

Citation	Chern, JJ and Choi, KW (2002) Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc. Development 129:4005-13
Abstract	Notch (N) activation at the dorsoventral (DV) boundary of the Drosophila eye is required for early eye primordium growth. Despite the apparent DV mirror symmetry, some mutations cause a preferential loss of the ventral domain, suggesting that the growth of individual domains is asymmetrically regulated. We show that the Lobe (L) gene is required non-autonomously for ventral growth but not dorsal growth, and that it mediates the proliferative effect of midline N signaling in a ventral-specific manner. L encodes a novel protein with a conserved domain. Loss of L suppresses the overproliferation phenotype of constitutive N activation in the ventral, but not in the dorsal eye, and gain of L rescues ventral tissue loss in N mutant background. Furthermore, L is necessary and sufficient for the ventral expression of a N ligand, Serrate (Ser), which affects ventral growth. Our data suggest that the control of ventral Ser expression by L represents a molecular mechanism that governs asymmetrical eye growth.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Calcium-Binding Proteins; Cloning, Molecular; Drosophila/embryology; Drosophila/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Eye/embryology; Eye/metabolism; Eye Proteins/genetics; Eye Proteins/metabolism; Ganglia, Invertebrate/cytology; Ganglia, Invertebrate/embryology; Ganglia, Invertebrate/metabolism; Intercellular Signaling Peptides and Proteins; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Receptors, Notch; Signal Transduction/physiology
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