GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16397181
| Citation |
Saito, A, Hayashi, T, Okuno, S, Nishi, T and Chan, PH (2006) Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia. Stroke 37:513-7 |
|---|---|
| Abstract |
A proline-rich Akt substrate (PRAS) contributes to the regulation of apoptosis after a variety of cell death stimuli, as well as in an in vivo transient focal cerebral ischemia (tFCI) model. We reported previously that overexpression of copper/zinc-superoxide dismutase (SOD1) reduces apoptotic cell death after tFCI. Our present study was designed to clarify the relationship between the PRAS signaling pathway and oxidative stress in the regulation of apoptosis after tFCI. |
| Links |
PubMed Online version:10.1161/01.STR.0000198826.56611.a2 |
| Keywords |
14-3-3 Proteins/metabolism; Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Blotting, Western; Brain/pathology; Brain Ischemia/pathology; Heterozygote; Hydrazones/chemistry; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; Ischemic Attack, Transient/pathology; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Oxidative Stress; Oxygen/metabolism; Phosphoproteins/chemistry; Phosphoproteins/physiology; Phosphorylation; Proline/chemistry; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction; Superoxide Dismutase/metabolism; Time Factors |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
