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HUMAN:ZN281

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ZNF281 (synonyms: GZP1, ZBP99)
Protein Name(s) Zinc finger protein 281

GC-box-binding zinc finger protein 1 Transcription factor ZBP-99 Zinc finger DNA-binding protein 99

External Links
UniProt Q9Y2X9
EMBL AF125158
AJ132591
AJ132592
AK022916
AC104461
BC051905
BC060820
CCDS CCDS1402.1
CCDS60384.1
PIR JC7089
RefSeq NP_001268222.1
NP_001268223.1
NP_036614.1
XP_016856376.1
XP_016856377.1
UniGene Hs.59757
Hs.703449
Hs.735801
ProteinModelPortal Q9Y2X9
SMR Q9Y2X9
BioGrid 117074
IntAct Q9Y2X9
STRING 9606.ENSP00000294740
iPTMnet Q9Y2X9
PhosphoSitePlus Q9Y2X9
BioMuta ZNF281
DMDM 13124664
EPD Q9Y2X9
PaxDb Q9Y2X9
PeptideAtlas Q9Y2X9
PRIDE Q9Y2X9
Ensembl ENST00000294740
ENST00000367352
ENST00000367353
GeneID 23528
KEGG hsa:23528
UCSC uc001gve.5
CTD 23528
DisGeNET 23528
GeneCards ZNF281
HGNC HGNC:13075
HPA HPA051228
neXtProt NX_Q9Y2X9
OpenTargets ENSG00000162702
PharmGKB PA37651
eggNOG KOG1721
COG5048
GeneTree ENSGT00530000063238
HOGENOM HOG000293204
HOVERGEN HBG055321
InParanoid Q9Y2X9
OMA QKDIEPR
OrthoDB EOG091G06OI
PhylomeDB Q9Y2X9
TreeFam TF331779
ChiTaRS ZNF281
GeneWiki ZNF281
GenomeRNAi 23528
PRO PR:Q9Y2X9
Proteomes UP000005640
Bgee ENSG00000162702
CleanEx HS_ZNF281
Genevisible Q9Y2X9
GO GO:0005654
GO:0005634
GO:0001047
GO:0046872
GO:0000978
GO:0043565
GO:0003714
GO:0003700
GO:0044212
GO:0001078
GO:0010172
GO:0010629
GO:0000122
GO:0045892
GO:0045893
GO:0048863
GO:0006351
Gene3D 2.20.28.10
3.30.160.60
3.30.40.10
InterPro IPR004039
IPR013087
IPR013083
SMART SM00355
SUPFAM SSF57667
PROSITE PS00028
PS50157

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006974

cellular response to DNA damage stimulus

PMID:28394347[1]

ECO:0000314

P

ZNF281 is thought to play a role in DNA repair. When cells were subjected to stress through DNA damage, the levels of ZNF281 were increased. Figure 4 shows that ZNF281 is a substrate of the ATM/ATR complex which is involved in NHEJ.

complete
CACAO 12779

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:E9Q3T6
UniProtKB:O14978
UniProtKB:O95125
UniProtKB:O95863
UniProtKB:P10071
UniProtKB:P10754
UniProtKB:P17028
UniProtKB:P28698
UniProtKB:P36508
UniProtKB:P41183
UniProtKB:P47806
UniProtKB:P52738
UniProtKB:Q02085
UniProtKB:Q05516
UniProtKB:Q08376
UniProtKB:Q0VDQ9
UniProtKB:Q16600
UniProtKB:Q61967
UniProtKB:Q6DJT9
UniProtKB:Q6NUN9
UniProtKB:Q86UQ0
UniProtKB:Q8CIV7
UniProtKB:Q8K0L9
UniProtKB:Q8K3J5
UniProtKB:Q8NI51
UniProtKB:Q91ZD1
UniProtKB:Q96RE9
UniProtKB:Q99684
UniProtKB:Q9BU19
UniProtKB:Q9ESP5
UniProtKB:Q9GZX5
UniProtKB:Q9H116
UniProtKB:Q9NQX1
UniProtKB:Q9NZL3
UniProtKB:Q9QY31
UniProtKB:Q9UM63
UniProtKB:Q9UPG8
UniProtKB:Q9UQR1
UniProtKB:Q9WTJ2
UniProtKB:Q9Y2X9
UniProtKB:Q9Y473
UniProtKB:Q9Y5A6

F

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

PMID:10448078[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:10448078[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:10448078[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048863

stem cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99LI5

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10405178[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:10448078[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:12771217[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:10448078[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:12771217[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:10405178[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:10448078[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:12771217[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010172

embryonic body morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99LI5

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10448078[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99LI5

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:10448078[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q99LI5

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037618
MGI:MGI:1353563
PANTHER:PTN001227002
ZFIN:ZDB-GENE-100318-5

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000286
FB:FBgn0000289
FB:FBgn0003448
MGI:MGI:1096393
MGI:MGI:1353563
MGI:MGI:2139287
MGI:MGI:2176606
MGI:MGI:98330
PANTHER:PTN001227002
RGD:1310136
SGD:S000004972
UniProtKB:O43623
UniProtKB:Q2M1K9
UniProtKB:Q4WJ81
UniProtKB:Q8NAP3
UniProtKB:Q9P1Z0
UniProtKB:Q9Y2X9
WB:WBGene00001324

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037618
MGI:MGI:1353563
PANTHER:PTN001227002
RGD:1310136
UniProtKB:Q9Y2X9

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003448
FB:FBgn0037617
FB:FBgn0039860
PANTHER:PTN001227002

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048863

stem cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99LI5
ensembl:ENSMUSP00000107677

P

Seeded From UniProt

complete

involved_in

GO:0010172

embryonic body morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99LI5
ensembl:ENSMUSP00000107677

P

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99LI5
ensembl:ENSMUSP00000107677

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99LI5
ensembl:ENSMUSP00000107677

F

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99LI5
ensembl:ENSMUSP00000107677

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013087

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Raschellà, G et al. (2017) New factors in mammalian DNA repair-the chromatin connection. Oncogene PubMed GONUTS page
  2. ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Law, DJ et al. (1999) ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. Biochem. Biophys. Res. Commun. 262 113-20 PubMed GONUTS page
  4. ↑ 4.0 4.1 Lisowsky, T et al. (1999) Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. FEBS Lett. 453 369-74 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Zhang, X et al. (2003) ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. Nucleic Acids Res. 31 2900-14 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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