HUMAN:VGFR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KDR (synonyms: FLK1, VEGFR2)
Protein Name(s)	Vascular endothelial growth factor receptor 2 VEGFR-2 Fetal liver kinase 1 FLK-1 Kinase insert domain receptor KDR Protein-tyrosine kinase receptor flk-1
External Links
UniProt	P35968
EMBL	EU826563 FJ899739 AF035121 AF063658 AC021220 AC111194 BC131822 L04947 X61656 X89776
CCDS	CCDS3497.1
PIR	JC1402
RefSeq	NP_002244.1
UniGene	Hs.479756
PDB	1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE
PDBsum	1VR2 1Y6A 1Y6B 1YWN 2M59 2MET 2MEU 2OH4 2P2H 2P2I 2QU5 2QU6 2RL5 2X1W 2X1X 2XIR 3B8Q 3B8R 3BE2 3C7Q 3CJF 3CJG 3CP9 3CPB 3CPC 3DTW 3EFL 3EWH 3KVQ 3S35 3S36 3S37 3U6J 3V2A 3V6B 3VHE 3VHK 3VID 3VNT 3VO3 4AG8 4AGC 4AGD 4ASD 4ASE
ProteinModelPortal	P35968
SMR	P35968
BioGrid	109992
DIP	DIP-486N
IntAct	P35968
MINT	MINT-127732
STRING	9606.ENSP00000263923
BindingDB	P35968
ChEMBL	CHEMBL2111336
DrugBank	DB06626 DB08875 DB06589 DB08901 DB08896 DB00398 DB01268
GuidetoPHARMACOLOGY	1813
PhosphoSite	P35968
DMDM	9087218
PaxDb	P35968
PRIDE	P35968
DNASU	3791
Ensembl	ENST00000263923
GeneID	3791
KEGG	hsa:3791
UCSC	uc003has.3 uc011bzx.2
CTD	3791
GeneCards	GC04M055944
HGNC	HGNC:6307
HPA	CAB004028
MIM	191306 602089
neXtProt	NX_P35968
Orphanet	91415
PharmGKB	PA30086
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOVERGEN	HBG053432
InParanoid	P35968
KO	K05098
OMA	ISYAGMV
OrthoDB	EOG75F4CC
PhylomeDB	P35968
TreeFam	TF325768
BRENDA	2.7.10.1
Reactome	REACT_12473 REACT_12583 REACT_13552 REACT_228024 REACT_228063 REACT_228166
SignaLink	P35968
EvolutionaryTrace	P35968
GeneWiki	Kinase_insert_domain_receptor
GenomeRNAi	3791
NextBio	14887
PRO	PR:P35968
Proteomes	UP000005640
Bgee	P35968
CleanEx	HS_KDR
ExpressionAtlas	P35968
Genevestigator	P35968
GO	GO:0030054 GO:0016023 GO:0005769 GO:0005768 GO:0009897 GO:0005576 GO:0005794 GO:0005887 GO:0045121 GO:0005634 GO:0005886 GO:0097443 GO:0005524 GO:0019838 GO:0051879 GO:0005178 GO:0004713 GO:0004716 GO:0004714 GO:0038085 GO:0005021 GO:0001525 GO:0048754 GO:0055074 GO:0035584 GO:0045165 GO:0048469 GO:0002042 GO:0035924 GO:0035162 GO:0045446 GO:0003158 GO:0030198 GO:0048286 GO:0001945 GO:0043066 GO:2000352 GO:0001541 GO:0038083 GO:0018108 GO:0045766 GO:0030335 GO:0008284 GO:0010595 GO:0001938 GO:0070374 GO:0051894 GO:0043410 GO:0002053 GO:0051770 GO:0014068 GO:0050927 GO:0001934 GO:2001214 GO:0046777 GO:0008360 GO:0023014 GO:0043129 GO:0007169 GO:0048010 GO:0038084 GO:0001570 GO:0016032
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR013106 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR001824 IPR009136
PANTHER	PTHR24416:SF45
Pfam	PF07679 PF07714 PF07686
PRINTS	PR01834
SMART	SM00409 SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109 PS00240

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004716	receptor signaling protein tyrosine kinase activity	PMID:23139789^[1]	ECO:0000314			F		Figure one shows that 'HUVECs were subjected to geldanamycin (17-DMAG) treatment for indicated times, lysed and processed for immunoblotting (IB) to analyze indicated protein levels. Arrowhead indicates mature VEGFR2; TfR, transferrin receptor. (B) Quantification of mature VEGFR2 levels in control and geldanamycin-treated endothelial cells'	complete CACAO 5697
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:28637396^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:18977327^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000044)	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25893857^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P33151	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:30873824^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20702	F		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:26879375^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:26879375^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000207821) part_of:(GO:1904881)	Seeded From UniProt	complete
involved_in	GO:1904881	cellular response to hydrogen sulfide	PMID:26879375^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:26879375^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000071)	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:24863063^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0038190)	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:24863063^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0038190)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:21885851^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_movement_of:(CL:0002543)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:23529610^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:23529610^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:23529610^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097443	sorting endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	C		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:12820653^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	PMID:7929439^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:7929439^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:10022831^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:1417831^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:10022831^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:7929439^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7929439^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:10022831^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05106	F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:10022831^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:1417831^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:10022831^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001214	positive regulation of vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	P		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	PMID:9804796^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	PMID:9837777^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	PMID:10600473^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:15215251^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:11387210^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:10102632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:10102632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:10037737^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:19033661^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:23262137^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:11387210^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:11387210^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:10102632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:19033661^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10102632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10037737^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:9804796^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15215251^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10102632^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23262137^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:23262137^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:23262137^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:15215251^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:11387210^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:10102632^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10037737^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003158	endothelium development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:11387210^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19033661^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35918	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:97531 PANTHER:PTN001230896 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:96683 PANTHER:PTN002814439 RGD:2965 RGD:621737 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968 ZFIN:ZDB-GENE-980526-326	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96683 PANTHER:PTN002814441 RGD:2965 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0045446	endothelial cell differentiation	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96683 PANTHER:PTN002814441	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 MGI:MGI:1339758 MGI:MGI:96677 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001974926 UniProtKB:P35968	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96683 PANTHER:PTN002814441	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814439 RGD:2965 UniProtKB:P17948 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 RGD:2965 RGD:3284 RGD:3285 RGD:620568 UniProtKB:P07333 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96683 PANTHER:PTN001974926 RGD:2621 RGD:2965 RGD:621737 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96683 PANTHER:PTN001562281 ZFIN:ZDB-GENE-000705-1 ZFIN:ZDB-GENE-050407-1 ZFIN:ZDB-GENE-980526-326	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9398617^[24]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7999104^[25]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:15962004^[26]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10037737^[20]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	PMID:23798385^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P07585	P		Seeded From UniProt	complete
involved_in	GO:0051901	positive regulation of mitochondrial depolarization	PMID:23798385^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P07585	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:23798385^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P07585	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20660291^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20080685^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17293873^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009136	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001824 InterPro:IPR009136 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR001824 InterPro:IPR008266 InterPro:IPR009136 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009136	C		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009136	F		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009136	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	PMID:20660291^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:1417831^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:1656371^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:19267251^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:1417831^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:10022831^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194313 Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5357479 Reactome:R-HSA-5357432 Reactome:R-HSA-5357429 Reactome:R-HSA-5218854 Reactome:R-HSA-5218851 Reactome:R-HSA-5218847 Reactome:R-HSA-5218839 Reactome:R-HSA-5218838 Reactome:R-HSA-5218836 Reactome:R-HSA-5218832 Reactome:R-HSA-5218830 Reactome:R-HSA-5218826 Reactome:R-HSA-5218824 Reactome:R-HSA-5218822 Reactome:R-HSA-5218820 Reactome:R-HSA-5218819 Reactome:R-HSA-5218818 Reactome:R-HSA-5218815 Reactome:R-HSA-5218814 Reactome:R-HSA-5218812 Reactome:R-HSA-5218811 Reactome:R-HSA-5218809 Reactome:R-HSA-5218806 Reactome:R-HSA-5218804 Reactome:R-HSA-5218645 Reactome:R-HSA-5218643 Reactome:R-HSA-5218642 Reactome:R-HSA-5218640 Reactome:R-HSA-4420206 Reactome:R-HSA-4420202 Reactome:R-HSA-4420153 Reactome:R-HSA-4420143 Reactome:R-HSA-4420140 Reactome:R-HSA-4420128 Reactome:R-HSA-4420121 Reactome:R-HSA-4420117 Reactome:R-HSA-4420107 Reactome:R-HSA-4420099 Reactome:R-HSA-4420083 Reactome:R-HSA-4088281 Reactome:R-HSA-195408 Reactome:R-HSA-194310	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bruns, AF et al. (2012) A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS ONE 7 e48539 PubMed GONUTS page
↑ Chen, L et al. (2017) Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia. Exp. Biol. Med. (Maywood) 242 1432-1443 PubMed GONUTS page
↑ Würdinger, T et al. (2008) miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 14 382-93 PubMed GONUTS page
↑ Yamana, S et al. (2015) The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE 10 e0124259 PubMed GONUTS page
↑ Wang, J et al. (2019) Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells. J. Cell. Biochem. 120 1807-1818 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Zhou, Y et al. (2016) Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. Am. J. Physiol., Cell Physiol. 310 C305-17 PubMed GONUTS page
↑ ^7.0 ^7.1 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page
↑ Chamorro-Jorganes, A et al. (2011) MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler. Thromb. Vasc. Biol. 31 2595-606 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Zeng, L et al. (2013) Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation 127 1712-22 PubMed GONUTS page
↑ Masson-Gadais, B et al. (2003) Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 8 37-52 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Waltenberger, J et al. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269 26988-95 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Soldi, R et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18 882-92 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Terman, BI et al. (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187 1579-86 PubMed GONUTS page
↑ ^14.0 ^14.1 Gerber, HP et al. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273 30336-43 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Jia, H et al. (2004) Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. J. Biol. Chem. 279 36148-57 PubMed GONUTS page
↑ Kroll, J & Waltenberger, J (1998) VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem. Biophys. Res. Commun. 252 743-6 PubMed GONUTS page
↑ Kroll, J & Waltenberger, J (1999) A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. Biochem. Biophys. Res. Commun. 265 636-9 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Takahashi, T et al. (2001) A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20 2768-78 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Dougher, M & Terman, BI (1999) Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 18 1619-27 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Kendall, RL et al. (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J. Biol. Chem. 274 6453-60 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Zhang, H et al. (2008) AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J. Clin. Invest. 118 3904-16 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Tiwari, A et al. (2013) The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am. J. Physiol. Heart Circ. Physiol. 304 H687-96 PubMed GONUTS page
↑ ^23.00 ^23.01 ^23.02 ^23.03 ^23.04 ^23.05 ^23.06 ^23.07 ^23.08 ^23.09 ^23.10 ^23.11 ^23.12 ^23.13 ^23.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cunningham, SA et al. (1997) Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites. Biochem. Biophys. Res. Commun. 240 635-9 PubMed GONUTS page
↑ Dougher-Vermazen, M et al. (1994) Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor. Biochem. Biophys. Res. Commun. 205 728-38 PubMed GONUTS page
↑ Matsumoto, T et al. (2005) VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J. 24 2342-53 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Buraschi, S et al. (2013) Decorin causes autophagy in endothelial cells via Peg3. Proc. Natl. Acad. Sci. U.S.A. 110 E2582-91 PubMed GONUTS page
↑ ^28.0 ^28.1 Mitola, S et al. (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116 3677-80 PubMed GONUTS page
↑ Yang, Y et al. (2010) Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling. Proc. Natl. Acad. Sci. U.S.A. 107 1906-11 PubMed GONUTS page
↑ Ruch, C et al. (2007) Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat. Struct. Mol. Biol. 14 249-50 PubMed GONUTS page
↑ Terman, BI et al. (1991) Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6 1677-83 PubMed GONUTS page
↑ Somanath, PR et al. (2009) Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis 12 177-85 PubMed GONUTS page

[PMID:23139789-1] Bruns, AF et al. (2012) A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS ONE 7 e48539 PubMed GONUTS page

[PMID:28637396-2] Chen, L et al. (2017) Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia. Exp. Biol. Med. (Maywood) 242 1432-1443 PubMed GONUTS page

[PMID:18977327-3] Würdinger, T et al. (2008) miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 14 382-93 PubMed GONUTS page

[PMID:25893857-4] Yamana, S et al. (2015) The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. PLoS ONE 10 e0124259 PubMed GONUTS page

[PMID:30873824-5] Wang, J et al. (2019) Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells. J. Cell. Biochem. 120 1807-1818 PubMed GONUTS page

[PMID:26879375-6] 6.0 ^6.1 ^6.2 ^6.3 Zhou, Y et al. (2016) Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. Am. J. Physiol., Cell Physiol. 310 C305-17 PubMed GONUTS page

[PMID:24863063-7] 7.0 ^7.1 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page

[PMID:21885851-8] Chamorro-Jorganes, A et al. (2011) MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler. Thromb. Vasc. Biol. 31 2595-606 PubMed GONUTS page

[PMID:23529610-9] 9.0 ^9.1 ^9.2 Zeng, L et al. (2013) Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation 127 1712-22 PubMed GONUTS page

[PMID:12820653-10] Masson-Gadais, B et al. (2003) Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. Cell Stress Chaperones 8 37-52 PubMed GONUTS page

[PMID:7929439-11] 11.0 ^11.1 ^11.2 ^11.3 Waltenberger, J et al. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269 26988-95 PubMed GONUTS page

[PMID:10022831-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Soldi, R et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18 882-92 PubMed GONUTS page

[PMID:1417831-13] 13.0 ^13.1 ^13.2 ^13.3 Terman, BI et al. (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187 1579-86 PubMed GONUTS page

[PMID:9804796-14] 14.0 ^14.1 Gerber, HP et al. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273 30336-43 PubMed GONUTS page

[PMID:15215251-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Jia, H et al. (2004) Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. J. Biol. Chem. 279 36148-57 PubMed GONUTS page

[PMID:9837777-16] Kroll, J & Waltenberger, J (1998) VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem. Biophys. Res. Commun. 252 743-6 PubMed GONUTS page

[PMID:10600473-17] Kroll, J & Waltenberger, J (1999) A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. Biochem. Biophys. Res. Commun. 265 636-9 PubMed GONUTS page

[PMID:11387210-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Takahashi, T et al. (2001) A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20 2768-78 PubMed GONUTS page

[PMID:10102632-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Dougher, M & Terman, BI (1999) Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene 18 1619-27 PubMed GONUTS page

[PMID:10037737-20] 20.0 ^20.1 ^20.2 ^20.3 Kendall, RL et al. (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J. Biol. Chem. 274 6453-60 PubMed GONUTS page

[PMID:19033661-21] 21.0 ^21.1 ^21.2 Zhang, H et al. (2008) AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J. Clin. Invest. 118 3904-16 PubMed GONUTS page

[PMID:23262137-22] 22.0 ^22.1 ^22.2 ^22.3 Tiwari, A et al. (2013) The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am. J. Physiol. Heart Circ. Physiol. 304 H687-96 PubMed GONUTS page

[PMID:21873635-23] 23.00 ^23.01 ^23.02 ^23.03 ^23.04 ^23.05 ^23.06 ^23.07 ^23.08 ^23.09 ^23.10 ^23.11 ^23.12 ^23.13 ^23.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9398617-24] Cunningham, SA et al. (1997) Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites. Biochem. Biophys. Res. Commun. 240 635-9 PubMed GONUTS page

[PMID:7999104-25] Dougher-Vermazen, M et al. (1994) Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor. Biochem. Biophys. Res. Commun. 205 728-38 PubMed GONUTS page

[PMID:15962004-26] Matsumoto, T et al. (2005) VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J. 24 2342-53 PubMed GONUTS page

[PMID:23798385-27] 27.0 ^27.1 ^27.2 Buraschi, S et al. (2013) Decorin causes autophagy in endothelial cells via Peg3. Proc. Natl. Acad. Sci. U.S.A. 110 E2582-91 PubMed GONUTS page

[PMID:20660291-28] 28.0 ^28.1 Mitola, S et al. (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116 3677-80 PubMed GONUTS page

[PMID:20080685-29] Yang, Y et al. (2010) Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling. Proc. Natl. Acad. Sci. U.S.A. 107 1906-11 PubMed GONUTS page

[PMID:17293873-30] Ruch, C et al. (2007) Structure of a VEGF-VEGF receptor complex determined by electron microscopy. Nat. Struct. Mol. Biol. 14 249-50 PubMed GONUTS page

[PMID:1656371-31] Terman, BI et al. (1991) Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 6 1677-83 PubMed GONUTS page

[PMID:19267251-32] Somanath, PR et al. (2009) Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis 12 177-85 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

HUMAN:VGFR2

Contents

Annotations

Notes

References

a

c

e

g

h

i

k

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools