HUMAN:UFO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AXL (synonyms: UFO)
Protein Name(s)	Tyrosine-protein kinase receptor UFO AXL oncogene
External Links
UniProt	P30530
EMBL	M76125 S65125 X57019 AC011510 BC032229
CCDS	CCDS12574.1 CCDS12575.1
PIR	A41527
RefSeq	NP_001690.2 NP_068713.2
UniGene	Hs.590970
PDB	2C5D 4RA0
PDBsum	2C5D 4RA0
ProteinModelPortal	P30530
SMR	P30530
BioGrid	107036
IntAct	P30530
MINT	MINT-2735752
STRING	9606.ENSP00000301178
BindingDB	P30530
ChEMBL	CHEMBL4895
GuidetoPHARMACOLOGY	1835
MEROPS	I43.001
PhosphoSite	P30530
DMDM	239938818
MaxQB	P30530
PaxDb	P30530
PRIDE	P30530
DNASU	558
Ensembl	ENST00000301178 ENST00000359092
GeneID	558
KEGG	hsa:558
UCSC	uc010ehi.1 uc010ehk.3
CTD	558
GeneCards	GC19P041725
HGNC	HGNC:905
HPA	HPA037422 HPA037423
MIM	109135
neXtProt	NX_P30530
PharmGKB	PA25197
eggNOG	COG0515
HOGENOM	HOG000231685
HOVERGEN	HBG006346
InParanoid	P30530
KO	K05115
OMA	QVQGEPP
OrthoDB	EOG77DJ5C
PhylomeDB	P30530
TreeFam	TF317402
BRENDA	2.7.10.1
Reactome	REACT_228166
SignaLink	P30530
ChiTaRS	AXL
EvolutionaryTrace	P30530
GeneWiki	AXL_receptor_tyrosine_kinase
GenomeRNAi	558
NextBio	2293
PRO	PR:P30530
Proteomes	UP000005640
Bgee	P30530
CleanEx	HS_AXL
ExpressionAtlas	P30530
Genevestigator	P30530
GO	GO:0009986 GO:0005615 GO:0070062 GO:0005887 GO:0005524 GO:0001786 GO:0004714 GO:0043277 GO:0001974 GO:0048469 GO:0031668 GO:0070301 GO:0035457 GO:0071222 GO:0097028 GO:0007167 GO:0034101 GO:0021885 GO:0006954 GO:0045087 GO:0001779 GO:2000669 GO:0032689 GO:0051250 GO:0043524 GO:0032720 GO:0001764 GO:0031100 GO:0042698 GO:0018108 GO:0006909 GO:0030168 GO:0001961 GO:0032825 GO:0051897 GO:0043491 GO:0032940 GO:0007165 GO:0007283 GO:0034446 GO:0060068
Gene3D	2.60.40.10
InterPro	IPR003961 IPR007110 IPR013783 IPR003599 IPR013106 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635
Pfam	PF00041 PF07714 PF07686
PRINTS	PR00109
SMART	SM00060 SM00409 SM00219
SUPFAM	SSF49265 SSF56112
PROSITE	PS50853 PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044228	host cell surface	PMID:21529875^[1]	ECO:0000314			C		Fig. 7 and Fig. 8	complete CACAO 2202
	GO:0046718	entry of virus into host cell	PMID:21047970^[2]	ECO:0000315			P		Fig. 1	complete CACAO 2431
	GO:0048549	positive regulation of pinocytosis	PMID:21047970^[2]	ECO:0000315			P		Fig. 7A	complete CACAO 2433
part_of	GO:0044228	host cell surface	PMID:21529875^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048549	positive regulation of pinocytosis	PMID:21047970^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	PMID:21047970^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19581412^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000669	negative regulation of dendritic cell apoptotic process	PMID:19657094^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097028	dendritic cell differentiation	PMID:19657094^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	happens_during:(GO:0035457)	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:19657094^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	PMID:19657094^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000451) happens_during:(GO:0035457)	Seeded From UniProt	complete
involved_in	GO:0035457	cellular response to interferon-alpha	PMID:19657094^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000451)	Seeded From UniProt	complete
involved_in	GO:0032825	positive regulation of natural killer cell differentiation	PMID:18840707^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000837)	Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	PMID:18840707^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000837)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19657094^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21501828^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20088931^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001961	positive regulation of cytokine-mediated signaling pathway	PMID:18840707^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000837)	Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:21501828^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN002814496	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN002814496 RGD:620028 UniProtKB:P30530	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN002814496	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0033791 MGI:MGI:101766 PANTHER:PTN002521290	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 MGI:MGI:96969 PANTHER:PTN002814495 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101766 PANTHER:PTN002521290	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 MGI:MGI:96969 PANTHER:PTN002814495 RGD:3082 WB:WBGene00020504 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN001231011 RGD:69283 UniProtKB:P30530 UniProtKB:Q12866	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0001779	natural killer cell differentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN002814496	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:22327215^[10]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY0 ensembl:ENSRNOP00000028131	P		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY0 ensembl:ENSRNOP00000028131	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY0 ensembl:ENSRNOP00000028131	P		Seeded From UniProt	complete
enables	GO:0032036	myosin heavy chain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY0 ensembl:ENSRNOP00000028131	F		Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY0 ensembl:ENSRNOP00000028131	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY0 ensembl:ENSRNOP00000028131	P		Seeded From UniProt	complete
involved_in	GO:0097350	neutrophil clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0060068	vagina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0051250	negative regulation of lymphocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0043277	apoptotic cell clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0042698	ovulation cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0034101	erythrocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0032940	secretion by cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0021885	forebrain cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0007167	enzyme linked receptor protein signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0001818	negative regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0001779	natural killer cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00993 ensembl:ENSMUSP00000002677	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:1656220^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:1656220^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:1656220^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5357479 Reactome:R-HSA-5357432 Reactome:R-HSA-5357429 Reactome:R-HSA-5218819	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0001618	virus receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1183	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Brindley, MA et al. (2011) Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology 415 83-94 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hunt, CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J. Virol. 85 334-47 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Scutera, S et al. (2009) Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J. Immunol. 183 3004-13 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Park, IK et al. (2009) The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development. Blood 113 2470-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Morizono, K et al. (2011) The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe 9 286-98 PubMed GONUTS page
↑ Ekman, C et al. (2010) Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. J. Thromb. Haemost. 8 838-44 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ruan, GX & Kazlauskas, A (2012) Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J. 31 1692-703 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 O'Bryan, JP et al. (1991) axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell. Biol. 11 5016-31 PubMed GONUTS page

[PMID:21529875-1] 1.0 ^1.1 Brindley, MA et al. (2011) Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology 415 83-94 PubMed GONUTS page

[PMID:21047970-2] 2.0 ^2.1 ^2.2 ^2.3 Hunt, CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J. Virol. 85 334-47 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19581412-4] Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page

[PMID:19657094-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Scutera, S et al. (2009) Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J. Immunol. 183 3004-13 PubMed GONUTS page

[PMID:18840707-6] 6.0 ^6.1 ^6.2 Park, IK et al. (2009) The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development. Blood 113 2470-7 PubMed GONUTS page

[PMID:21501828-7] 7.0 ^7.1 Morizono, K et al. (2011) The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell Host Microbe 9 286-98 PubMed GONUTS page

[PMID:20088931-8] Ekman, C et al. (2010) Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. J. Thromb. Haemost. 8 838-44 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22327215-10] Ruan, GX & Kazlauskas, A (2012) Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J. 31 1692-703 PubMed GONUTS page

[PMID:1656220-11] 11.0 ^11.1 ^11.2 O'Bryan, JP et al. (1991) axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell. Biol. 11 5016-31 PubMed GONUTS page

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