HUMAN:TRFL

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LTF (synonyms: GIG12, LF)
Protein Name(s)	Lactotransferrin Lactoferrin Growth-inhibiting protein 12 Talalactoferrin Lactoferricin-H Lfcin-H Kaliocin-1 Lactoferroxin-A Lactoferroxin-B Lactoferroxin-C
External Links
UniProt	P02788
EMBL	X53961 U07643 AF332168 AY178998 AY137470 M73700 M93150 AY165046 AY493417 EU622050 AK292813 AK298035 AC098613 BC015822 BC015823 BC022347 S52659 X52941 M83202 M83205 U95626 M18642
CCDS	CCDS33747.1 CCDS56251.1
PIR	G01394
RefSeq	NP_001186078.1 NP_002334.2
UniGene	Hs.529517
PDB	1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS
PDBsum	1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS
DisProt	DP00616
ProteinModelPortal	P02788
SMR	P02788
BioGrid	110235
DIP	DIP-41354N
IntAct	P02788
MINT	MINT-1511753
Allergome	1384
MEROPS	S60.001
PhosphoSite	P02788
UniCarbKB	P02788
DMDM	85700158
MaxQB	P02788
PaxDb	P02788
PRIDE	P02788
DNASU	4057
Ensembl	ENST00000231751 ENST00000426532
GeneID	4057
KEGG	hsa:4057
UCSC	uc003cpq.3
CTD	4057
GeneCards	GC03M046477
HGNC	HGNC:6720
HPA	CAB008645
MIM	150210 245480
neXtProt	NX_P02788
PharmGKB	PA30482
eggNOG	NOG87503
GeneTree	ENSGT00390000001619
HOVERGEN	HBG000055
InParanoid	P02788
KO	K17283
OMA	NKCACSS
OrthoDB	EOG7D59N7
PhylomeDB	P02788
TreeFam	TF324013
Reactome	REACT_121118 REACT_121256 REACT_75925
ChiTaRS	LTF
EvolutionaryTrace	P02788
GeneWiki	Lactoferrin
GenomeRNAi	4057
NextBio	15896
PRO	PR:P02788
Proteomes	UP000005640
Bgee	P02788
ExpressionAtlas	P02788
Genevestigator	P02788
GO	GO:0005576 GO:0005615 GO:0070062 GO:0005634 GO:0097013 GO:0030141 GO:0042581 GO:0003677 GO:0008199 GO:0008201 GO:0005506 GO:0043539 GO:0004252 GO:0019731 GO:0019732 GO:0060349 GO:0006959 GO:0002227 GO:0051701 GO:0033214 GO:0006826 GO:0043066 GO:0031665 GO:2001205 GO:1900229 GO:2000308 GO:0001503 GO:0090382 GO:1900159 GO:1902732 GO:0043123 GO:0051092 GO:0045669 GO:0033690 GO:0071902 GO:0034145 GO:0001817 GO:0032680 GO:0052572 GO:0001895 GO:0006351
InterPro	IPR016357 IPR001156 IPR018195
Pfam	PF00405
PIRSF	PIRSF002549
PRINTS	PR00422
SMART	SM00094
PROSITE	PS00205 PS00206 PS00207 PS51408

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044218	other organism cell membrane	PMID:15155221^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:15155221^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:15155221^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:15155221^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:15155221^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:15155221^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17567961^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17567961^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)\|part_of:(GO:0009986) part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:18714013^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18714013^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17567961^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0044793	negative regulation by host of viral process	PMID:12522210^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032780	negative regulation of ATPase activity	PMID:25193851^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P27958:PRO_0000037573)	Seeded From UniProt	complete
involved_in	GO:0048525	negative regulation of viral process	PMID:25193851^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P27958:PRO_0000037573)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25193851^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:25193851^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P27958)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	PMID:23580065^[11]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12788072^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004869	cysteine-type endopeptidase inhibitor activity	PMID:12788072^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000117	negative regulation of cysteine-type endopeptidase activity	PMID:12788072^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001205	negative regulation of osteoclast development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24627	P		Seeded From UniProt	complete
involved_in	GO:2000308	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24627	P		Seeded From UniProt	complete
involved_in	GO:1902732	positive regulation of chondrocyte proliferation	PMID:15166119^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	PMID:12037568^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900159	positive regulation of bone mineralization involved in bone maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24627	P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	PMID:15166119^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:15166119^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24627	P	occurs_in:(CL:0000062)	Seeded From UniProt	complete
part_of	GO:0042581	specific granule	PMID:2981589^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000775)	Seeded From UniProt	complete
involved_in	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	PMID:20345905^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0033690	positive regulation of osteoblast proliferation	PMID:15166119^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032680	regulation of tumor necrosis factor production	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	PMID:11083624^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:1599934^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	PMID:12037568^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002227	innate immune response in mucosa	PMID:12037568^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	PMID:20345905^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:11907569^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:11907569^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08071 ensembl:ENSMUSP00000035077	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08071 ensembl:ENSMUSP00000035077	C		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	F		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018195 InterPro:IPR030684	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016357	C		Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	P		Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030684	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:9596699^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:9596699^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045837	negative regulation of membrane potential	PMID:9596699^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051673	membrane disruption in other organism	PMID:9596699^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:9596699^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:9596699^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:9596699^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:9770539^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	PMID:9770539^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1904724	tertiary granule lumen	Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097013	phagocytic vesicle lumen	Reactome:R-HSA-8951552 Reactome:R-HSA-8951549 Reactome:R-HSA-1222641 Reactome:R-HSA-1222491	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033214	siderophore-dependent iron import into cell	Reactome:R-HSA-1222449	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-977136 Reactome:R-HSA-976734 Reactome:R-HSA-6810643 Reactome:R-HSA-6798749 Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0410	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Bals, R et al. (1998) Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102 874-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Chapple, DS et al. (2004) Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide. Antimicrob. Agents Chemother. 48 2190-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wang, Z et al. (2007) Characterization of an eppin protein complex from human semen and spermatozoa. Biol. Reprod. 77 476-84 PubMed GONUTS page
↑ ^4.0 ^4.1 Edström, AM et al. (2008) The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J. Immunol. 181 3413-21 PubMed GONUTS page
↑ Nozaki, A et al. (2003) Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein. J. Biol. Chem. 278 10162-73 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Picard-Jean, F et al. (2014) The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein. Antiviral Res. 111 13-22 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^11.0 ^11.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Ohashi, A et al. (2003) New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Biochem. Biophys. Res. Commun. 306 98-103 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Cornish, J et al. (2004) Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145 4366-74 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Singh, PK et al. (2002) A component of innate immunity prevents bacterial biofilm development. Nature 417 552-5 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Ando, K et al. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277 2051-66 PubMed GONUTS page
↑ Cramer, E et al. (1985) Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold. Blood 65 423-32 PubMed GONUTS page
↑ Lupetti, A et al. (2000) Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob. Agents Chemother. 44 3257-63 PubMed GONUTS page
↑ Bellamy, W et al. (1992) Identification of the bactericidal domain of lactoferrin. Biochim. Biophys. Acta 1121 130-6 PubMed GONUTS page
↑ ^20.0 ^20.1 Reeves, EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416 291-7 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 Chapple, DS et al. (1998) Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111. Infect. Immun. 66 2434-40 PubMed GONUTS page
↑ ^22.0 ^22.1 Qiu, J et al. (1998) Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae. Proc. Natl. Acad. Sci. U.S.A. 95 12641-6 PubMed GONUTS page

[PMID:9727055-1] 1.0 ^1.1 ^1.2 ^1.3 Bals, R et al. (1998) Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102 874-80 PubMed GONUTS page

[PMID:15155221-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Chapple, DS et al. (2004) Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide. Antimicrob. Agents Chemother. 48 2190-8 PubMed GONUTS page

[PMID:17567961-3] 3.0 ^3.1 ^3.2 Wang, Z et al. (2007) Characterization of an eppin protein complex from human semen and spermatozoa. Biol. Reprod. 77 476-84 PubMed GONUTS page

[PMID:18714013-4] 4.0 ^4.1 Edström, AM et al. (2008) The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J. Immunol. 181 3413-21 PubMed GONUTS page

[PMID:12522210-5] Nozaki, A et al. (2003) Identification of a lactoferrin-derived peptide possessing binding activity to hepatitis C virus E2 envelope protein. J. Biol. Chem. 278 10162-73 PubMed GONUTS page

[PMID:25193851-6] 6.0 ^6.1 ^6.2 ^6.3 Picard-Jean, F et al. (2014) The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein. Antiviral Res. 111 13-22 PubMed GONUTS page

[PMID:23533145-7] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19199708-8] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:21630459-9] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:16502470-10] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:23580065-11] 11.0 ^11.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:22664934-12] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:12788072-13] 13.0 ^13.1 ^13.2 Ohashi, A et al. (2003) New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Biochem. Biophys. Res. Commun. 306 98-103 PubMed GONUTS page

[PMID:15166119-14] 14.0 ^14.1 ^14.2 ^14.3 Cornish, J et al. (2004) Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology 145 4366-74 PubMed GONUTS page

[PMID:12037568-15] 15.0 ^15.1 ^15.2 Singh, PK et al. (2002) A component of innate immunity prevents bacterial biofilm development. Nature 417 552-5 PubMed GONUTS page

[PMID:20345905-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Ando, K et al. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277 2051-66 PubMed GONUTS page

[PMID:2981589-17] Cramer, E et al. (1985) Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold. Blood 65 423-32 PubMed GONUTS page

[PMID:11083624-18] Lupetti, A et al. (2000) Candidacidal activities of human lactoferrin peptides derived from the N terminus. Antimicrob. Agents Chemother. 44 3257-63 PubMed GONUTS page

[PMID:1599934-19] Bellamy, W et al. (1992) Identification of the bactericidal domain of lactoferrin. Biochim. Biophys. Acta 1121 130-6 PubMed GONUTS page

[PMID:11907569-20] 20.0 ^20.1 Reeves, EP et al. (2002) Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416 291-7 PubMed GONUTS page

[PMID:9596699-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 Chapple, DS et al. (1998) Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111. Infect. Immun. 66 2434-40 PubMed GONUTS page

[PMID:9770539-22] 22.0 ^22.1 Qiu, J et al. (1998) Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae. Proc. Natl. Acad. Sci. U.S.A. 95 12641-6 PubMed GONUTS page

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