HUMAN:SRC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SRC (synonyms: SRC1)
Protein Name(s)	Proto-oncogene tyrosine-protein kinase Src Proto-oncogene c-Src pp60c-src p60-Src
External Links
UniProt	P12931
EMBL	AL133293 AL133293 CH471077 CH471077 CH471077 CH471077 BC011566 BC051270 K03218 M16237 M16243 M16244 M16245 K03212 K03213 K03214 K03215 K03216 K03217 X02647 X03995 X03996 X03997 X03998 X03999 X04000
CCDS	CCDS13294.1
PIR	A26891
RefSeq	NP_005408.1 NP_938033.1
UniGene	Hs.195659
PDB	1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 3ZMP 3ZMQ 4F59 4F5A 4F5B 4HXJ 4K11 4MXO 4MXX 4MXY 4MXZ
PDBsum	1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 3ZMP 3ZMQ 4F59 4F5A 4F5B 4HXJ 4K11 4MXO 4MXX 4MXY 4MXZ
ProteinModelPortal	P12931
SMR	P12931
BioGrid	112592
DIP	DIP-1059N
IntAct	P12931
MINT	MINT-93621
STRING	9606.ENSP00000350941
BindingDB	P12931
ChEMBL	CHEMBL2363074
DrugBank	DB06616 DB01254 DB08901
GuidetoPHARMACOLOGY	2206
PhosphoSite	P12931
DMDM	125711
OGP	P12931
MaxQB	P12931
PaxDb	P12931
PRIDE	P12931
DNASU	6714
Ensembl	ENST00000358208 ENST00000373558 ENST00000373567 ENST00000373578
GeneID	6714
KEGG	hsa:6714
UCSC	uc002xgx.3
CTD	6714
GeneCards	GC20P035973
HGNC	HGNC:11283
HPA	CAB004023 HPA030875
MIM	190090
neXtProt	NX_P12931
PharmGKB	PA36111
eggNOG	COG0515
GeneTree	ENSGT00760000118938
HOGENOM	HOG000233858
HOVERGEN	HBG008761
InParanoid	P12931
KO	K05704
OMA	CHRLTNV
OrthoDB	EOG7GTT2V
PhylomeDB	P12931
TreeFam	TF351634
BioCyc	MetaCyc:HS02256-MONOMER
BRENDA	2.7.10.2
Reactome	REACT_11043 REACT_111040 REACT_111080 REACT_111225 REACT_115755 REACT_12065 REACT_12519 REACT_12578 REACT_15381 REACT_15523 REACT_160274 REACT_17025 REACT_18334 REACT_19140 REACT_19183 REACT_19405 REACT_21384 REACT_22351 REACT_22365 REACT_22384 REACT_228024 REACT_228063 REACT_228085 REACT_228166 REACT_228170 REACT_228189 REACT_228226 REACT_23847 REACT_23916 REACT_9417
SignaLink	P12931
ChiTaRS	SRC
EvolutionaryTrace	P12931
GeneWiki	Src_(gene)
GenomeRNAi	6714
NextBio	26186
PMAP-CutDB	P12931
PRO	PR:P12931
Proteomes	UP000005640
Bgee	P12931
CleanEx	HS_SRC
ExpressionAtlas	P12931
Genevestigator	P12931
GO	GO:0005901 GO:0005737 GO:0005829 GO:0070062 GO:0005770 GO:0005764 GO:0005743 GO:0005739 GO:0043005 GO:0005634 GO:0005886 GO:0014069 GO:0005524 GO:0019899 GO:0046875 GO:0070851 GO:0020037 GO:0005178 GO:0044325 GO:0016301 GO:0004715 GO:0051219 GO:0004672 GO:0004713 GO:0005102 GO:0042169 GO:0005070 GO:0032148 GO:0034332 GO:0007411 GO:0007596 GO:0045453 GO:0060444 GO:0007049 GO:0008283 GO:0071398 GO:0071456 GO:0032869 GO:0071222 GO:0071393 GO:0007173 GO:0038096 GO:0008543 GO:0030900 GO:0045087 GO:0007229 GO:0035556 GO:0050900 GO:0061024 GO:2000811 GO:0043066 GO:0043154 GO:2001237 GO:0051895 GO:2001243 GO:0051902 GO:0032463 GO:0045892 GO:0048011 GO:0048477 GO:0018105 GO:0018108 GO:0030168 GO:0043065 GO:0090263 GO:0045785 GO:0045737 GO:0050715 GO:2000573 GO:0070374 GO:0010907 GO:0046628 GO:0033625 GO:0043406 GO:0043552 GO:0010641 GO:0071803 GO:0031954 GO:0051897 GO:0014911 GO:0045893 GO:0050847 GO:0046777 GO:0007265 GO:0045124 GO:2001286 GO:0022407 GO:2000641 GO:0010632 GO:0033146 GO:0043393 GO:0043114 GO:0010447 GO:0042493 GO:0051602 GO:0042542 GO:0070555 GO:0009612 GO:0051385 GO:0031667 GO:0009615 GO:0007172 GO:0007165 GO:0016337 GO:0043149 GO:0031295 GO:0045056 GO:0007179 GO:0060065 GO:0016032
Gene3D	3.30.505.10
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:12051764^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q96P31)	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:1903997	positive regulation of non-membrane spanning protein tyrosine kinase activity	PMID:20018849^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_direct_input:(UniProtKB:Q05397)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:20018849^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	has_direct_input:(UniProtKB:Q05397)	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:20018849^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_direct_input:(UniProtKB:Q05397)	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:19141530^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05106	F		Seeded From UniProt	complete
involved_in	GO:0051057	positive regulation of small GTPase mediated signal transduction	PMID:18541665^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:25425738^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35612	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:25425738^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:25425738^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:22303479^[8]	ECO:0000314			F		c-Src involved in STAT3 phosphorylation induced by Piwil2: Figure 4.	complete CACAO 3679
involved_in	GO:0032211	negative regulation of telomere maintenance via telomerase	PMID:21531765^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	PMID:21531765^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:19059439^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q05655)	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:19059439^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q05655	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:19059439^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q05655)	Seeded From UniProt	complete
involved_in	GO:0086098	angiotensin-activated signaling pathway involved in heart process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05480	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05480	P	occurs_in:(UBERON:0002084) occurs_in:(CL:0000746)	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:25006397^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q03135	F		Seeded From UniProt	complete
involved_in	GO:0010632	regulation of epithelial cell migration	PMID:21724833^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022407	regulation of cell-cell adhesion	PMID:21724833^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	PMID:21724833^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001286	regulation of caveolin-mediated endocytosis	PMID:21724833^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:21724833^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3S7	F		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	PMID:24036928^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002327)	Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:24036928^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002327)	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:24036928^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002327)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:18054784^[16]	ECO:0000305	curator inference used in manual assertion	GO:0010634 GO:2000394	P	has_input:(UniProtKB:P09327)	Seeded From UniProt	complete
involved_in	GO:2000394	positive regulation of lamellipodium morphogenesis	PMID:18054784^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P09327)	Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:18054784^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P09327)	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:20624904^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:20624904^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071393	cellular response to progesterone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WUD9	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:19281832^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WUD9	P		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WUD9	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:8953041^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22460	F	occurs_in:(UBERON:0001083)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:12538589^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HBA0	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:15248232^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:17848177^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:22402981^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	PMID:16479011^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09619	F		Seeded From UniProt	complete
involved_in	GO:0051902	negative regulation of mitochondrial depolarization	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P31749)\|has_regulation_target:(UniProtKB:O43524)	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:16441665^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14764	F	happens_during:(GO:0070849)	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	PMID:12925710^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54762	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:16441665^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05480	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P55211)\|has_regulation_target:(UniProtKB:P55212)\|has_regulation_target:(UniProtKB:P42574)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:8070403^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P56945	F		Seeded From UniProt	complete
involved_in	GO:0032463	negative regulation of protein homooligomerization	PMID:19767770^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q07812)	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21036157^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20605918^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19767770^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:20605918^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:20605918^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:12615910^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19767770^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16441665^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:19332538^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:16441665^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q14764)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:18616680^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	P		Seeded From UniProt	complete
enables	GO:0070851	growth factor receptor binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 UniProtKB:P12931	F		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 RGD:620795	P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98397 PANTHER:PTN000701142	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:Q9H3Y6 WB:WBGene00005077	P		Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98397 PANTHER:PTN000701142	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P08631	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 RGD:621423	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701142 RGD:620795	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P07948	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262733 PANTHER:PTN002521528 RGD:2641 RGD:620795 RGD:621017 UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[34]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95527 PANTHER:PTN002521528 UniProtKB:P09769 UniProtKB:P51451 UniProtKB:Q13882 WB:WBGene00005077	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9799234^[35]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:20100835^[36]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:18697750^[37]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:15735019^[38]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1381360^[39]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12923167^[40]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11448999^[41]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:22732588^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000588	positive regulation of platelet-derived growth factor receptor-beta signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0086098	angiotensin-activated signaling pathway involved in heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0071803	positive regulation of podosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
enables	GO:0071253	connexin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0060491	regulation of cell projection assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0060444	branching involved in mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0060065	uterus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0036035	osteoclast development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
involved_in	GO:0010954	positive regulation of protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	F		Seeded From UniProt	complete
part_of	GO:0002102	podosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05480 ensembl:ENSMUSP00000090237	C		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:2000386	positive regulation of ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0098962	regulation of postsynaptic neurotransmitter receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071393	cellular response to progesterone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051895	negative regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051385	response to mineralocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0051222	positive regulation of protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0045056	transcytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0030331	estrogen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
involved_in	GO:0010907	positive regulation of glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0010447	response to acidic pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	C		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	F		Seeded From UniProt	complete
involved_in	GO:0001545	primary ovarian follicle growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WUD9 ensembl:ENSRNOP00000071837	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:9020193^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007172	signal complex assembly	PMID:9924018^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:9020193^[43] PMID:10734107^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	PMID:9020193^[43]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9020193^[43] Reactome:R-HSA-9603420 Reactome:R-HSA-8876948 Reactome:R-HSA-8874080 Reactome:R-HSA-5607750 Reactome:R-HSA-445084 Reactome:R-HSA-4420128 Reactome:R-HSA-4420121 Reactome:R-HSA-429441 Reactome:R-HSA-380780 Reactome:R-HSA-377640 Reactome:R-HSA-177937 Reactome:R-HSA-1433506 Reactome:R-HSA-1295609 Reactome:R-HSA-112333	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045124	regulation of bone resorption	PMID:19267251^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043114	regulation of vascular permeability	PMID:19267251^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033625	positive regulation of integrin activation	PMID:19267251^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:19267251^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:19267251^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038128	ERBB2 signaling pathway	Reactome:R-HSA-1227986	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035635	entry of bacterium into host cell	Reactome:R-HSA-8876493	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-389356 Reactome:R-HSA-388841	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-8948143 Reactome:R-HSA-191636	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	Reactome:R-HSA-8934903	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-9603381	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	Reactome:R-HSA-177929	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9603420 Reactome:R-HSA-9603419 Reactome:R-HSA-8937807 Reactome:R-HSA-8937792 Reactome:R-HSA-8876948 Reactome:R-HSA-8874083 Reactome:R-HSA-8874082 Reactome:R-HSA-8874080 Reactome:R-HSA-5607750 Reactome:R-HSA-443910 Reactome:R-HSA-443905 Reactome:R-HSA-432096 Reactome:R-HSA-429441 Reactome:R-HSA-429415 Reactome:R-HSA-418874 Reactome:R-HSA-418868 Reactome:R-HSA-418858 Reactome:R-HSA-418856 Reactome:R-HSA-418850 Reactome:R-HSA-380780 Reactome:R-HSA-377644 Reactome:R-HSA-377643 Reactome:R-HSA-377641 Reactome:R-HSA-377640 Reactome:R-HSA-374701 Reactome:R-HSA-373716 Reactome:R-HSA-372705 Reactome:R-HSA-372697 Reactome:R-HSA-372693 Reactome:R-HSA-354165 Reactome:R-HSA-354149 Reactome:R-HSA-354124 Reactome:R-HSA-354087 Reactome:R-HSA-354077 Reactome:R-HSA-354073 Reactome:R-HSA-354066 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-1963586 Reactome:R-HSA-191656 Reactome:R-HSA-191654 Reactome:R-HSA-191636 Reactome:R-HSA-186819 Reactome:R-HSA-177937 Reactome:R-HSA-177923 Reactome:R-HSA-1295609 Reactome:R-HSA-112333	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8964329 Reactome:R-HSA-8964311 Reactome:R-HSA-8964287 Reactome:R-HSA-8964278 Reactome:R-HSA-8964252 Reactome:R-HSA-8964242 Reactome:R-HSA-8948143 Reactome:R-HSA-8855747 Reactome:R-HSA-5666104 Reactome:R-HSA-5357479 Reactome:R-HSA-5357432 Reactome:R-HSA-5357429 Reactome:R-HSA-5218851 Reactome:R-HSA-5218839 Reactome:R-HSA-5218838 Reactome:R-HSA-5218830 Reactome:R-HSA-5218826 Reactome:R-HSA-5218822 Reactome:R-HSA-5218820 Reactome:R-HSA-5218819 Reactome:R-HSA-5218811 Reactome:R-HSA-5218809 Reactome:R-HSA-5218645 Reactome:R-HSA-5218643 Reactome:R-HSA-5218640 Reactome:R-HSA-445084 Reactome:R-HSA-443439 Reactome:R-HSA-443418 Reactome:R-HSA-4420206 Reactome:R-HSA-4420140 Reactome:R-HSA-4420128 Reactome:R-HSA-4420121 Reactome:R-HSA-418662 Reactome:R-HSA-418200 Reactome:R-HSA-418176 Reactome:R-HSA-418170 Reactome:R-HSA-418163 Reactome:R-HSA-418158 Reactome:R-HSA-4093336 Reactome:R-HSA-4093327 Reactome:R-HSA-3928651 Reactome:R-HSA-3928645 Reactome:R-HSA-3928642 Reactome:R-HSA-3928641 Reactome:R-HSA-3928640 Reactome:R-HSA-3928639 Reactome:R-HSA-3928633 Reactome:R-HSA-3928631 Reactome:R-HSA-3928628 Reactome:R-HSA-3928627 Reactome:R-HSA-3928625 Reactome:R-HSA-3928615 Reactome:R-HSA-3928614 Reactome:R-HSA-3928607 Reactome:R-HSA-3928604 Reactome:R-HSA-388833 Reactome:R-HSA-388831 Reactome:R-HSA-388829 Reactome:R-HSA-377640 Reactome:R-HSA-210291 Reactome:R-HSA-205319 Reactome:R-HSA-205244 Reactome:R-HSA-205238 Reactome:R-HSA-205234 Reactome:R-HSA-2029459 Reactome:R-HSA-191654 Reactome:R-HSA-1562641 Reactome:R-HSA-1472121 Reactome:R-HSA-1470012 Reactome:R-HSA-1470010 Reactome:R-HSA-1470009 Reactome:R-HSA-1433542 Reactome:R-HSA-1433514 Reactome:R-HSA-1433506 Reactome:R-HSA-1433488 Reactome:R-HSA-1433456 Reactome:R-HSA-1433454 Reactome:R-HSA-1433451 Reactome:R-HSA-1433428 Reactome:R-HSA-1433418	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	Reactome:R-HSA-418163 Reactome:R-HSA-354124	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Xu, MJ et al. (2002) SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem. Biophys. Res. Commun. 293 1037-46 PubMed GONUTS page
↑ Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Li, JP et al. (2010) JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem. 285 5472-8 PubMed GONUTS page
↑ Mikelis, C et al. (2009) Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta. FASEB J. 23 1459-69 PubMed GONUTS page
↑ Shi, GX et al. (2008) Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation. Mol. Cell. Biol. 28 4940-51 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Xu, T et al. (2015) Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin. J. Leukoc. Biol. 97 297-306 PubMed GONUTS page
↑ Lu, Y et al. (2012) Piwil2 suppresses p53 by inducing phosphorylation of signal transducer and activator of transcription 3 in tumor cells. PLoS ONE 7 e30999 PubMed GONUTS page
↑ ^9.0 ^9.1 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Kim, TS et al. (2009) PKCdelta-dependent functional switch of rpS3 between translation and DNA repair. Biochim. Biophys. Acta 1793 395-405 PubMed GONUTS page
↑ Bakhshi, FR et al. (2013) Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 3 816-30 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Lin, G et al. (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev. 25 1412-25 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Bianchi-Smiraglia, A et al. (2013) Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Cell Cycle 12 3377-89 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Khurana, S et al. (2008) Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp. Cell Res. 314 530-42 PubMed GONUTS page
↑ ^17.0 ^17.1 Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page
↑ Luo, SF et al. (2009) Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicol. Appl. Pharmacol. 237 8-21 PubMed GONUTS page
↑ Holmes, TC et al. (1996) Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science 274 2089-91 PubMed GONUTS page
↑ Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page
↑ Mosheimer, BA et al. (2004) Expression and function of RANK in human monocyte chemotaxis. Arthritis Rheum. 50 2309-16 PubMed GONUTS page
↑ Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 Mamidipudi, V & Cartwright, CA (2009) A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. Oncogene 28 4421-33 PubMed GONUTS page
↑ Beauséjour, M et al. (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17 566-78 PubMed GONUTS page
↑ Franco, M et al. (2006) The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol. Cell. Biol. 26 1932-47 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Kim, E et al. (2006) Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. FEBS J. 273 793-804 PubMed GONUTS page
↑ Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page
↑ Sakai, R et al. (1994) A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13 3748-56 PubMed GONUTS page
↑ Yao, X et al. (2010) Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem. Biophys. Res. Commun. 403 30-5 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Obata, Y et al. (2010) The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. J. Cell. Sci. 123 2649-62 PubMed GONUTS page
↑ Miyazaki, T et al. (2003) Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J. Cell Biol. 160 709-18 PubMed GONUTS page
↑ Sallee, JL & Burridge, K (2009) Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J. Biol. Chem. 284 14997-5006 PubMed GONUTS page
↑ Kurata, A et al. (2008) TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. Cancer Sci. 99 1827-34 PubMed GONUTS page
↑ ^34.00 ^34.01 ^34.02 ^34.03 ^34.04 ^34.05 ^34.06 ^34.07 ^34.08 ^34.09 ^34.10 ^34.11 ^34.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Timokhina, I et al. (1998) Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 17 6250-62 PubMed GONUTS page
↑ Goh, YM et al. (2010) Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. J. Biol. Chem. 285 10122-9 PubMed GONUTS page
↑ Sun, J et al. (2008) Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J. Biol. Chem. 283 27444-51 PubMed GONUTS page
↑ Brunton, VG et al. (2005) Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res. 65 1335-42 PubMed GONUTS page
↑ Alai, M et al. (1992) Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J. Biol. Chem. 267 18021-5 PubMed GONUTS page
↑ Araki, T et al. (2003) Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J. Biol. Chem. 278 41677-84 PubMed GONUTS page
↑ Marignani, PA & Carpenter, CL (2001) Vav2 is required for cell spreading. J. Cell Biol. 154 177-86 PubMed GONUTS page
↑ Lesourne, R et al. (2012) Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J. Immunol. 189 1154-61 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 ^43.3 Luttrell, LM et al. (1997) Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J. Biol. Chem. 272 4637-44 PubMed GONUTS page
↑ Luttrell, LM et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283 655-61 PubMed GONUTS page
↑ Maudsley, S et al. (2000) The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J. Biol. Chem. 275 9572-80 PubMed GONUTS page
↑ ^46.0 ^46.1 ^46.2 ^46.3 ^46.4 Somanath, PR et al. (2009) Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis 12 177-85 PubMed GONUTS page

[PMID:12051764-1] Xu, MJ et al. (2002) SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem. Biophys. Res. Commun. 293 1037-46 PubMed GONUTS page

[PMID:28386764-2] Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:20018849-3] 3.0 ^3.1 ^3.2 Li, JP et al. (2010) JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J. Biol. Chem. 285 5472-8 PubMed GONUTS page

[PMID:19141530-4] Mikelis, C et al. (2009) Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta. FASEB J. 23 1459-69 PubMed GONUTS page

[PMID:18541665-5] Shi, GX et al. (2008) Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation. Mol. Cell. Biol. 28 4940-51 PubMed GONUTS page

[PMID:25468996-6] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:25425738-7] 7.0 ^7.1 ^7.2 Xu, T et al. (2015) Lipid raft-associated β-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin. J. Leukoc. Biol. 97 297-306 PubMed GONUTS page

[PMID:22303479-8] Lu, Y et al. (2012) Piwil2 suppresses p53 by inducing phosphorylation of signal transducer and activator of transcription 3 in tumor cells. PLoS ONE 7 e30999 PubMed GONUTS page

[PMID:21531765-9] 9.0 ^9.1 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:19059439-10] 10.0 ^10.1 ^10.2 Kim, TS et al. (2009) PKCdelta-dependent functional switch of rpS3 between translation and DNA repair. Biochim. Biophys. Acta 1793 395-405 PubMed GONUTS page

[PMID:25006397-11] Bakhshi, FR et al. (2013) Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm Circ 3 816-30 PubMed GONUTS page

[PMID:21724833-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Lin, G et al. (2011) Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev. 25 1412-25 PubMed GONUTS page

[PMID:24036928-13] 13.0 ^13.1 ^13.2 Bianchi-Smiraglia, A et al. (2013) Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Cell Cycle 12 3377-89 PubMed GONUTS page

[PMID:19056867-14] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-15] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:18054784-16] 16.0 ^16.1 ^16.2 Khurana, S et al. (2008) Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp. Cell Res. 314 530-42 PubMed GONUTS page

[PMID:20624904-17] 17.0 ^17.1 Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page

[PMID:19281832-18] Luo, SF et al. (2009) Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells. Toxicol. Appl. Pharmacol. 237 8-21 PubMed GONUTS page

[PMID:8953041-19] Holmes, TC et al. (1996) Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain. Science 274 2089-91 PubMed GONUTS page

[PMID:12538589-20] Xu, H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J. Biol. Chem. 278 11520-7 PubMed GONUTS page

[PMID:15248232-21] Mosheimer, BA et al. (2004) Expression and function of RANK in human monocyte chemotaxis. Arthritis Rheum. 50 2309-16 PubMed GONUTS page

[PMID:17848177-22] Banfi, C et al. (2007) Tissue factor induction by protease-activated receptor 1 requires intact caveolin-enriched membrane microdomains in human endothelial cells. J. Thromb. Haemost. 5 2437-44 PubMed GONUTS page

[PMID:19767770-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 Mamidipudi, V & Cartwright, CA (2009) A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. Oncogene 28 4421-33 PubMed GONUTS page

[PMID:22402981-24] Beauséjour, M et al. (2012) Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes. Apoptosis 17 566-78 PubMed GONUTS page

[PMID:16479011-25] Franco, M et al. (2006) The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors. Mol. Cell. Biol. 26 1932-47 PubMed GONUTS page

[PMID:16441665-26] 26.0 ^26.1 ^26.2 ^26.3 Kim, E et al. (2006) Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. FEBS J. 273 793-804 PubMed GONUTS page

[PMID:12925710-27] Vindis, C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162 661-71 PubMed GONUTS page

[PMID:8070403-28] Sakai, R et al. (1994) A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13 3748-56 PubMed GONUTS page

[PMID:21036157-29] Yao, X et al. (2010) Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem. Biophys. Res. Commun. 403 30-5 PubMed GONUTS page

[PMID:20605918-30] 30.0 ^30.1 ^30.2 Obata, Y et al. (2010) The Lyn kinase C-lobe mediates Golgi export of Lyn through conformation-dependent ACSL3 association. J. Cell. Sci. 123 2649-62 PubMed GONUTS page

[PMID:12615910-31] Miyazaki, T et al. (2003) Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J. Cell Biol. 160 709-18 PubMed GONUTS page

[PMID:19332538-32] Sallee, JL & Burridge, K (2009) Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J. Biol. Chem. 284 14997-5006 PubMed GONUTS page

[PMID:18616680-33] Kurata, A et al. (2008) TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. Cancer Sci. 99 1827-34 PubMed GONUTS page

[PMID:21873635-34] 34.00 ^34.01 ^34.02 ^34.03 ^34.04 ^34.05 ^34.06 ^34.07 ^34.08 ^34.09 ^34.10 ^34.11 ^34.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9799234-35] Timokhina, I et al. (1998) Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J. 17 6250-62 PubMed GONUTS page

[PMID:20100835-36] Goh, YM et al. (2010) Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. J. Biol. Chem. 285 10122-9 PubMed GONUTS page

[PMID:18697750-37] Sun, J et al. (2008) Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J. Biol. Chem. 283 27444-51 PubMed GONUTS page

[PMID:15735019-38] Brunton, VG et al. (2005) Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res. 65 1335-42 PubMed GONUTS page

[PMID:1381360-39] Alai, M et al. (1992) Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. J. Biol. Chem. 267 18021-5 PubMed GONUTS page

[PMID:12923167-40] Araki, T et al. (2003) Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. J. Biol. Chem. 278 41677-84 PubMed GONUTS page

[PMID:11448999-41] Marignani, PA & Carpenter, CL (2001) Vav2 is required for cell spreading. J. Cell Biol. 154 177-86 PubMed GONUTS page

[PMID:22732588-42] Lesourne, R et al. (2012) Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J. Immunol. 189 1154-61 PubMed GONUTS page

[PMID:9020193-43] 43.0 ^43.1 ^43.2 ^43.3 Luttrell, LM et al. (1997) Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J. Biol. Chem. 272 4637-44 PubMed GONUTS page

[PMID:9924018-44] Luttrell, LM et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283 655-61 PubMed GONUTS page

[PMID:10734107-45] Maudsley, S et al. (2000) The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J. Biol. Chem. 275 9572-80 PubMed GONUTS page

[PMID:19267251-46] 46.0 ^46.1 ^46.2 ^46.3 ^46.4 Somanath, PR et al. (2009) Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis 12 177-85 PubMed GONUTS page

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[34]

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[44]

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