HUMAN:SP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SP2 (synonyms: KIAA0048)
Protein Name(s)	Transcription factor Sp2
External Links
UniProt	Q02086
EMBL	D28588 AC018521 CH471109 BC016680 BC033814 M97190
CCDS	CCDS11521.2
PIR	A44489
RefSeq	NP_003101.3
UniGene	Hs.514276
ProteinModelPortal	Q02086
SMR	Q02086
BioGrid	112551
IntAct	Q02086
STRING	9606.ENSP00000365931
PhosphoSite	Q02086
DMDM	119370531
MaxQB	Q02086
PaxDb	Q02086
PRIDE	Q02086
DNASU	6668
Ensembl	ENST00000376741
GeneID	6668
KEGG	hsa:6668
UCSC	uc002imk.3
CTD	6668
GeneCards	GC17P045973
HGNC	HGNC:11207
HPA	CAB010245 HPA003357
MIM	601801
neXtProt	NX_Q02086
PharmGKB	PA36044
eggNOG	COG5048
GeneTree	ENSGT00760000118984
HOGENOM	HOG000234295
HOVERGEN	HBG008933
InParanoid	Q02086
KO	K09192
OMA	DKRSGEQ
OrthoDB	EOG7JQBMX
PhylomeDB	Q02086
TreeFam	TF350150
SignaLink	Q02086
ChiTaRS	SP2
GeneWiki	Sp2_transcription_factor
GenomeRNAi	6668
NextBio	25999
PRO	PR:Q02086
Proteomes	UP000005640
Bgee	Q02086
CleanEx	HS_SP2
ExpressionAtlas	Q02086
Genevestigator	Q02086
GO	GO:0005634 GO:0003677 GO:0042826 GO:0046872 GO:0072358 GO:0048568 GO:0048144 GO:0006955 GO:0001701 GO:0035264 GO:0006357 GO:0006351
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016363	nuclear matrix	PMID:16467376^[1]	ECO:0000314			C		Figure 5B shows that sp2 is associated with the nuclear matrix	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:10744779^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(NCBI_Gene:13026) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10744779^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:13026)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:10744779^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(NCBI_Gene:13026)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q9JHX2	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:17827154^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030451	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:1341900^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:1341900^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Moorefield, KS et al. (2006) Sp2 localizes to subnuclear foci associated with the nuclear matrix. Mol. Biol. Cell 17 1711-22 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bakovic, M et al. (2000) Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter. J. Lipid Res. 41 583-94 PubMed GONUTS page
↑ Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Kingsley, C & Winoto, A (1992) Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12 4251-61 PubMed GONUTS page

[PMID:16467376-1] Moorefield, KS et al. (2006) Sp2 localizes to subnuclear foci associated with the nuclear matrix. Mol. Biol. Cell 17 1711-22 PubMed GONUTS page

[PMID:19274049-2] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:10744779-3] 3.0 ^3.1 ^3.2 Bakovic, M et al. (2000) Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter. J. Lipid Res. 41 583-94 PubMed GONUTS page

[PMID:17827154-4] Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1341900-6] 6.0 ^6.1 Kingsley, C & Winoto, A (1992) Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12 4251-61 PubMed GONUTS page

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HUMAN:SP2

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