HUMAN:SOX2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SOX2
Protein Name(s)	Transcription factor SOX-2
External Links
UniProt	P48431
EMBL	Z31560 L07335 BC013923
CCDS	CCDS3239.1
RefSeq	NP_003097.1
UniGene	Hs.518438 Hs.732963
PDB	1O4X 2LE4
PDBsum	1O4X 2LE4
ProteinModelPortal	P48431
SMR	P48431
BioGrid	112540
DIP	DIP-59913N
IntAct	P48431
STRING	9606.ENSP00000323588
PhosphoSite	P48431
DMDM	1351091
MaxQB	P48431
PaxDb	P48431
PRIDE	P48431
DNASU	6657
Ensembl	ENST00000325404
GeneID	6657
KEGG	hsa:6657
UCSC	uc003fkx.3
CTD	6657
GeneCards	GC03P181429
GeneReviews	SOX2
HGNC	HGNC:11195
HPA	CAB010648 HPA045725
MIM	184429 206900
neXtProt	NX_P48431
Orphanet	77298 98938 2542 3157
PharmGKB	PA36032
eggNOG	NOG321816
GeneTree	ENSGT00760000118988
HOGENOM	HOG000231647
HOVERGEN	HBG105663
InParanoid	P48431
KO	K16796
OMA	MSALQYN
OrthoDB	EOG7TMZVP
PhylomeDB	P48431
TreeFam	TF351735
Reactome	REACT_200670 REACT_200759 REACT_200812
SignaLink	P48431
EvolutionaryTrace	P48431
GeneWiki	SOX2
GenomeRNAi	6657
NextBio	25951
PRO	PR:P48431
Proteomes	UP000005640
Bgee	P48431
CleanEx	HS_SOX2
Genevestigator	P48431
GO	GO:0005737 GO:0005829 GO:0044798 GO:0005634 GO:0005667 GO:0003682 GO:0003677 GO:0035198 GO:0001077 GO:0043565 GO:0003700 GO:0044212 GO:0000976 GO:0021984 GO:0007050 GO:0021987 GO:0006325 GO:0050973 GO:0050910 GO:0048852 GO:0001714 GO:0060441 GO:0001654 GO:0030900 GO:0021879 GO:0021781 GO:0048839 GO:0042472 GO:0060235 GO:0048286 GO:0030539 GO:0090090 GO:0050680 GO:0045665 GO:0045668 GO:0000122 GO:0048663 GO:0097150 GO:0030910 GO:0001649 GO:0046148 GO:0021983 GO:0022409 GO:0030858 GO:0043410 GO:0002052 GO:0045666 GO:0045747 GO:0045944 GO:0045893 GO:0043281 GO:0010468 GO:0006355 GO:0070848 GO:0032526 GO:0009611 GO:0060042 GO:0035019 GO:0042246 GO:0043586
Gene3D	1.10.30.10
InterPro	IPR009071 IPR022097
Pfam	PF00505 PF12336
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR009071	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:29253717^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000137845) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q04890	F		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	PMID:19736317^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:16153702^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16153702^[4]	ECO:0000305	curator inference used in manual assertion	GO:0003677	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16153702^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16153702^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48432	P		Seeded From UniProt	complete
	GO:0043066	negative regulation of apoptosis	PMID:21415100^[5]	ECO:0000315			P		Fig 5. More apoptotic cells could be observed in the tumor tissues of DU145-shRNA1-SOX2 xenograft mice that were treated with Dox and CDDP than those of control mice that were treated under the same condition.	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18285410^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	PMID:18187129^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:18268498^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:18407919^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18027866^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18407919^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48430	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:18407919^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:18187129^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18268498^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	PMID:18710938^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	PMID:18388306^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	PMID:19409607^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	PMID:18285410^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021983	pituitary gland development	PMID:18285410^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021781	glial cell fate commitment	PMID:17291498^[14]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:18388306^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:17982423^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:18268498^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:7849401^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:7849401^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18000303^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18027866^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18027866^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18285410^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17291498^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000125)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7849401^[16]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18027866^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:7849401^[16]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:19427902^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18285410^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18407919^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:7849401^[16]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001654	eye development	PMID:18285410^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:18187129^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48432	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030807 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807 RGD:1565646 UniProtKB:P48430 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384	C		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030807 UniProtKB:P48431	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98363 PANTHER:PTN000030384	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000030745 ZFIN:ZDB-GENE-980526-333	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:2654070 MGI:MGI:98364 PANTHER:PTN000030384 UniProtKB:P48431 UniProtKB:Q06945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000411 FB:FBgn0005612 FB:FBgn0005613 FB:FBgn0029123 FB:FBgn0036411 MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98357 MGI:MGI:98359 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98369 MGI:MGI:98660 PANTHER:PTN000030384 RGD:1565646 RGD:3759 RGD:69351 UniProtKB:P35713 UniProtKB:P35716 UniProtKB:P48430 UniProtKB:P48431 UniProtKB:Q05066 UniProtKB:Q06945 UniProtKB:Q9BT81 UniProtKB:Q9H6I2 WB:WBGene00004771	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103559 MGI:MGI:107543 MGI:MGI:98362 MGI:MGI:98363 MGI:MGI:98364 MGI:MGI:98366 MGI:MGI:98660 PANTHER:PTN000030384 ZFIN:ZDB-GENE-990715-6	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98364 PANTHER:PTN000030807	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21245162^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:20713518^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001714	endodermal cell fate specification	PMID:21245162^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	P		Seeded From UniProt	complete
involved_in	GO:0042246	tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	P		Seeded From UniProt	complete
involved_in	GO:0022409	positive regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	P		Seeded From UniProt	complete
	GO:0045289	luciferin monooxygenase activity	PMID:22265740^[22]	ECO:0000314			F		In figure 6 B Co-transfection of the SOX2 overexpression vector with the TRKC-LUC Site A + B reporter resulted in a 2.0-fold increase in luciferase activity compared to cells transfected with the empty overexpression vector	complete CACAO 5071
involved_in	GO:0021984	adenohypophysis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A543 ensembl:ENSRNOP00000016236	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032643	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032643	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022097 InterPro:IPR032643	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:19736317^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	Reactome:R-HSA-452723	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6800120 Reactome:R-HSA-6790036 Reactome:R-HSA-5626938 Reactome:R-HSA-480685 Reactome:R-HSA-480204 Reactome:R-HSA-452894 Reactome:R-HSA-2972979 Reactome:R-HSA-2972978 Reactome:R-HSA-2972977 Reactome:R-HSA-2972975 Reactome:R-HSA-2972967 Reactome:R-HSA-2972966 Reactome:R-HSA-2972965 Reactome:R-HSA-2972964 Reactome:R-HSA-2972962 Reactome:R-HSA-2972960 Reactome:R-HSA-2972956 Reactome:R-HSA-2972949 Reactome:R-HSA-2972948 Reactome:R-HSA-1112609	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Akhter, R et al. (2018) Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease. Neurobiol. Aging 63 110-119 PubMed GONUTS page
↑ ^3.0 ^3.1 Stefanovic, S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J. Cell Biol. 186 665-73 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Boyer, LA et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 947-56 PubMed GONUTS page
↑ Jia, X et al. (2011) SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol 3 230-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Kelberman, D et al. (2008) SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development. J. Clin. Endocrinol. Metab. 93 1865-73 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Go, MJ et al. (2008) Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp. Cell Res. 314 1147-54 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Otsubo, T et al. (2008) SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br. J. Cancer 98 824-31 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Rajab, A et al. (2008) Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. Hum. Mol. Genet. 17 2150-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Park, ET et al. (2008) Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int. J. Cancer 122 1253-60 PubMed GONUTS page
↑ Card, DA et al. (2008) Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 28 6426-38 PubMed GONUTS page
↑ ^12.0 ^12.1 Fong, H et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26 1931-8 PubMed GONUTS page
↑ Xu, N et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137 647-58 PubMed GONUTS page
↑ ^14.0 ^14.1 Baer, K et al. (2007) Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone. Exp. Neurol. 204 828-31 PubMed GONUTS page
↑ McGowan, SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 13 1984-2000 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Stevanovic, M et al. (1994) The cDNA sequence and chromosomal location of the human SOX2 gene. Mamm. Genome 5 640-2 PubMed GONUTS page
↑ Zhao, M et al. (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J. Endocrinol. 195 407-14 PubMed GONUTS page
↑ Ha, SC et al. (2009) Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone. Protein Expr. Purif. 67 164-8 PubMed GONUTS page
↑ ^19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 Teo, AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 25 238-50 PubMed GONUTS page
↑ Zhang, Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 24 1746-57 PubMed GONUTS page
↑ Fong, H et al. (2012) Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells. Stem Cell Res 8 206-14 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:29253717-2] Akhter, R et al. (2018) Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease. Neurobiol. Aging 63 110-119 PubMed GONUTS page

[PMID:19736317-3] 3.0 ^3.1 Stefanovic, S et al. (2009) Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. J. Cell Biol. 186 665-73 PubMed GONUTS page

[PMID:16153702-4] 4.0 ^4.1 ^4.2 ^4.3 Boyer, LA et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 947-56 PubMed GONUTS page

[PMID:21415100-5] Jia, X et al. (2011) SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol 3 230-8 PubMed GONUTS page

[PMID:18285410-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Kelberman, D et al. (2008) SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development. J. Clin. Endocrinol. Metab. 93 1865-73 PubMed GONUTS page

[PMID:18187129-7] 7.0 ^7.1 ^7.2 Go, MJ et al. (2008) Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp. Cell Res. 314 1147-54 PubMed GONUTS page

[PMID:18268498-8] 8.0 ^8.1 ^8.2 Otsubo, T et al. (2008) SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br. J. Cancer 98 824-31 PubMed GONUTS page

[PMID:18407919-9] 9.0 ^9.1 ^9.2 ^9.3 Rajab, A et al. (2008) Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss. Hum. Mol. Genet. 17 2150-9 PubMed GONUTS page

[PMID:18027866-10] 10.0 ^10.1 ^10.2 ^10.3 Park, ET et al. (2008) Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. Int. J. Cancer 122 1253-60 PubMed GONUTS page

[PMID:18710938-11] Card, DA et al. (2008) Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol. Cell. Biol. 28 6426-38 PubMed GONUTS page

[PMID:18388306-12] 12.0 ^12.1 Fong, H et al. (2008) Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells 26 1931-8 PubMed GONUTS page

[PMID:19409607-13] Xu, N et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 137 647-58 PubMed GONUTS page

[PMID:17291498-14] 14.0 ^14.1 Baer, K et al. (2007) Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone. Exp. Neurol. 204 828-31 PubMed GONUTS page

[PMID:17982423-15] McGowan, SL et al. (2007) Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 13 1984-2000 PubMed GONUTS page

[PMID:7849401-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Stevanovic, M et al. (1994) The cDNA sequence and chromosomal location of the human SOX2 gene. Mamm. Genome 5 640-2 PubMed GONUTS page

[PMID:18000303-17] Zhao, M et al. (2007) Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J. Endocrinol. 195 407-14 PubMed GONUTS page

[PMID:19427902-18] Ha, SC et al. (2009) Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone. Protein Expr. Purif. 67 164-8 PubMed GONUTS page

[PMID:21873635-19] 19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21245162-20] 20.0 ^20.1 Teo, AK et al. (2011) Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 25 238-50 PubMed GONUTS page

[PMID:20713518-21] Zhang, Y et al. (2010) Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 24 1746-57 PubMed GONUTS page

[PMID:22265740-22] Fong, H et al. (2012) Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells. Stem Cell Res 8 206-14 PubMed GONUTS page

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HUMAN:SOX2

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