HUMAN:SNAI2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SNAI2 (synonyms: SLUG, SLUGH)
Protein Name(s)	Zinc finger protein SNAI2 Neural crest transcription factor Slug Protein snail homolog 2
External Links
UniProt	O43623
EMBL	AF042001 AF084243 AK312661 AK223368 CH471068 BC014890 BC015895
CCDS	CCDS6146.1
RefSeq	NP_003059.1
UniGene	Hs.360174
ProteinModelPortal	O43623
SMR	O43623
BioGrid	112476
STRING	9606.ENSP00000020945
PhosphoSite	O43623
PaxDb	O43623
PRIDE	O43623
DNASU	6591
Ensembl	ENST00000020945 ENST00000396822
GeneID	6591
KEGG	hsa:6591
UCSC	uc003xqp.3
CTD	6591
GeneCards	GC08M049830
HGNC	HGNC:11094
HPA	CAB011671
MIM	172800 602150 608890
neXtProt	NX_O43623
Orphanet	2884 895
PharmGKB	PA35945
eggNOG	COG5048
GeneTree	ENSGT00390000011027
HOGENOM	HOG000261665
HOVERGEN	HBG007477
InParanoid	O43623
KO	K05706
OMA	HINSAKK
OrthoDB	EOG7P2XSG
PhylomeDB	O43623
TreeFam	TF315515
GeneWiki	SNAI2
GenomeRNAi	6591
NextBio	25641
PRO	PR:O43623
Proteomes	UP000005640
Bgee	O43623
CleanEx	HS_SNAI2
Genevestigator	O43623
GO	GO:0005737 GO:0000790 GO:0005634 GO:0003682 GO:0046872 GO:0001078 GO:0003705 GO:0043565 GO:0060070 GO:0060536 GO:0003273 GO:0071364 GO:0044344 GO:0071479 GO:0035921 GO:0001837 GO:0003198 GO:0060429 GO:2000811 GO:0090090 GO:0035414 GO:0006933 GO:0033629 GO:1900387 GO:0032331 GO:0043518 GO:2001240 GO:1902230 GO:0010839 GO:2000647 GO:0000122 GO:0010957 GO:0070563 GO:0014032 GO:0007219 GO:0001649 GO:0060021 GO:0043473 GO:0030335 GO:0045600 GO:0035066 GO:0060693 GO:0032642 GO:0045667 GO:2000810 GO:0007605 GO:0050872
Gene3D	3.30.160.60
InterPro	IPR029795 IPR007087 IPR015880 IPR013087
PANTHER	PTHR11389:SF400
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:E9Q3T6 UniProtKB:O14978 UniProtKB:O95125 UniProtKB:O95863 UniProtKB:P10071 UniProtKB:P10754 UniProtKB:P17028 UniProtKB:P28698 UniProtKB:P36508 UniProtKB:P41183 UniProtKB:P47806 UniProtKB:P52738 UniProtKB:Q02085 UniProtKB:Q05516 UniProtKB:Q08376 UniProtKB:Q0VDQ9 UniProtKB:Q16600 UniProtKB:Q61967 UniProtKB:Q6DJT9 UniProtKB:Q6NUN9 UniProtKB:Q86UQ0 UniProtKB:Q8CIV7 UniProtKB:Q8K0L9 UniProtKB:Q8K3J5 UniProtKB:Q8NI51 UniProtKB:Q91ZD1 UniProtKB:Q96RE9 UniProtKB:Q99684 UniProtKB:Q9BU19 UniProtKB:Q9ESP5 UniProtKB:Q9GZX5 UniProtKB:Q9H116 UniProtKB:Q9NQX1 UniProtKB:Q9NZL3 UniProtKB:Q9QY31 UniProtKB:Q9UM63 UniProtKB:Q9UPG8 UniProtKB:Q9UQR1 UniProtKB:Q9WTJ2 UniProtKB:Q9Y2X9 UniProtKB:Q9Y473 UniProtKB:Q9Y5A6	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:11912130^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(ENSEMBL:ENSG00000039068) occurs_at:(SO:0001158)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:11912130^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0001227) part_of:(GO:0000122) has_input:(ENSEMBL:ENSG00000039068)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25893292^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:10518215^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97469	P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:17984306^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000810	regulation of bicellular tight junction assembly	PMID:15314165^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	PMID:15314165^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900387	negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter	PMID:17984306^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900387	negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter	PMID:16707493^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900387	negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter	PMID:15737616^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19756381^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19502595^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:18716062^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070563	negative regulation of vitamin D receptor signaling pathway	PMID:19502595^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060429	epithelium development	PMID:18716062^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97469	P		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:19756381^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:21182836^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10518215^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10866665^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	PMID:15314165^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	PMID:12444107^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035921	desmosome disassembly	PMID:9182671^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033629	negative regulation of cell adhesion mediated by integrin	PMID:16707493^[7]	ECO:0000305	curator inference used in manual assertion	GO:0001227	P		Seeded From UniProt	complete
involved_in	GO:0032642	regulation of chemokine production	PMID:21182836^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	PMID:19756381^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15314165^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	PMID:12444107^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010957	negative regulation of vitamin D biosynthetic process	PMID:19502595^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010957	negative regulation of vitamin D biosynthetic process	PMID:18485278^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010839	negative regulation of keratinocyte proliferation	PMID:16707493^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	PMID:12444107^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:18663143^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10866665^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003273	cell migration involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97469	P	occurs_in:(UBERON:0002087)	Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97469	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:17984306^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:9182671^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:18663143^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:11912130^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSG00000039068) occurs_at:(SO:0001158)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:16707493^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:10866665^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:19756381^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18663143^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11912130^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000039068)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10866665^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:20128911^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037618 MGI:MGI:1353563 PANTHER:PTN001227002 ZFIN:ZDB-GENE-100318-5	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000286 FB:FBgn0000289 FB:FBgn0003448 MGI:MGI:1096393 MGI:MGI:1353563 MGI:MGI:2139287 MGI:MGI:2176606 MGI:MGI:98330 PANTHER:PTN001227002 RGD:1310136 SGD:S000004972 UniProtKB:O43623 UniProtKB:Q2M1K9 UniProtKB:Q4WJ81 UniProtKB:Q8NAP3 UniProtKB:Q9P1Z0 UniProtKB:Q9Y2X9 WB:WBGene00001324	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037618 MGI:MGI:1353563 PANTHER:PTN001227002 RGD:1310136 UniProtKB:Q9Y2X9	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003448 FB:FBgn0037617 FB:FBgn0039860 PANTHER:PTN001227002	F		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:2000647	negative regulation of stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0060693	regulation of branching involved in salivary gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0060536	cartilage morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0060429	epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0050872	white fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0035921	desmosome disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	F		Seeded From UniProt	complete
involved_in	GO:0003273	cell migration involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97469 ensembl:ENSMUSP00000023356	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:20951801^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	PMID:20951801^[20] PMID:20951801^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:0061314	Notch signaling involved in heart development	PMID:20951801^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0003198) occurs_in:(CL:2000008) part_of:(GO:0003180)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8944026	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hajra, KM et al. (2002) The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 1613-8 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page
↑ ^4.0 ^4.1 Inukai, T et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell 4 343-52 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Leong, KG et al. (2007) Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med. 204 2935-48 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Kajita, M et al. (2004) Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol. Cell. Biol. 24 7559-66 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Turner, FE et al. (2006) Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J. Biol. Chem. 281 21321-31 PubMed GONUTS page
↑ Tripathi, MK et al. (2005) Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells. Biochem. Biophys. Res. Commun. 329 508-15 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Lambertini, E et al. (2009) Slug gene expression supports human osteoblast maturation. Cell. Mol. Life Sci. 66 3641-53 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Larriba, MJ et al. (2009) Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis 30 1459-68 PubMed GONUTS page
↑ ^11.0 ^11.1 Arnoux, V et al. (2008) Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol. Biol. Cell 19 4738-49 PubMed GONUTS page
↑ ^12.0 ^12.1 Piva, R et al. (2011) Slug contributes to the regulation of CXCL12 expression in human osteoblasts. Exp. Cell Res. 317 1159-68 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Hemavathy, K et al. (2000) Human Slug is a repressor that localizes to sites of active transcription. Mol. Cell. Biol. 20 5087-95 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Sánchez-Martín, M et al. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum. Mol. Genet. 11 3231-6 PubMed GONUTS page
↑ ^15.0 ^15.1 Savagner, P et al. (1997) The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol. 137 1403-19 PubMed GONUTS page
↑ Mittal, MK et al. (2008) In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells. Biochem. Biophys. Res. Commun. 372 30-4 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Niessen, K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 182 315-25 PubMed GONUTS page
↑ Lambertini, E et al. (2010) SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. BMC Mol. Biol. 11 13 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Riley, MF et al. (2011) NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Biochim. Biophys. Acta 1812 121-9 PubMed GONUTS page

[PMID:11912130-1] 1.0 ^1.1 ^1.2 ^1.3 Hajra, KM et al. (2002) The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62 1613-8 PubMed GONUTS page

[PMID:19274049-2] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25893292-3] Hwangbo, C et al. (2016) Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene 35 389-401 PubMed GONUTS page

[PMID:10518215-4] 4.0 ^4.1 Inukai, T et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell 4 343-52 PubMed GONUTS page

[PMID:17984306-5] 5.0 ^5.1 ^5.2 Leong, KG et al. (2007) Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med. 204 2935-48 PubMed GONUTS page

[PMID:15314165-6] 6.0 ^6.1 ^6.2 ^6.3 Kajita, M et al. (2004) Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol. Cell. Biol. 24 7559-66 PubMed GONUTS page

[PMID:16707493-7] 7.0 ^7.1 ^7.2 ^7.3 Turner, FE et al. (2006) Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J. Biol. Chem. 281 21321-31 PubMed GONUTS page

[PMID:15737616-8] Tripathi, MK et al. (2005) Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells. Biochem. Biophys. Res. Commun. 329 508-15 PubMed GONUTS page

[PMID:19756381-9] 9.0 ^9.1 ^9.2 ^9.3 Lambertini, E et al. (2009) Slug gene expression supports human osteoblast maturation. Cell. Mol. Life Sci. 66 3641-53 PubMed GONUTS page

[PMID:19502595-10] 10.0 ^10.1 ^10.2 Larriba, MJ et al. (2009) Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis 30 1459-68 PubMed GONUTS page

[PMID:18716062-11] 11.0 ^11.1 Arnoux, V et al. (2008) Erk5 controls Slug expression and keratinocyte activation during wound healing. Mol. Biol. Cell 19 4738-49 PubMed GONUTS page

[PMID:21182836-12] 12.0 ^12.1 Piva, R et al. (2011) Slug contributes to the regulation of CXCL12 expression in human osteoblasts. Exp. Cell Res. 317 1159-68 PubMed GONUTS page

[PMID:10866665-13] 13.0 ^13.1 ^13.2 ^13.3 Hemavathy, K et al. (2000) Human Slug is a repressor that localizes to sites of active transcription. Mol. Cell. Biol. 20 5087-95 PubMed GONUTS page

[PMID:12444107-14] 14.0 ^14.1 ^14.2 Sánchez-Martín, M et al. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum. Mol. Genet. 11 3231-6 PubMed GONUTS page

[PMID:9182671-15] 15.0 ^15.1 Savagner, P et al. (1997) The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol. 137 1403-19 PubMed GONUTS page

[PMID:18485278-16] Mittal, MK et al. (2008) In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells. Biochem. Biophys. Res. Commun. 372 30-4 PubMed GONUTS page

[PMID:18663143-17] 17.0 ^17.1 ^17.2 Niessen, K et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol. 182 315-25 PubMed GONUTS page

[PMID:20128911-18] Lambertini, E et al. (2010) SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. BMC Mol. Biol. 11 13 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20951801-20] 20.0 ^20.1 ^20.2 ^20.3 Riley, MF et al. (2011) NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT. Biochim. Biophys. Acta 1812 121-9 PubMed GONUTS page

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