HUMAN:SIX1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SIX1
Protein Name(s)	Homeobox protein SIX1 Sine oculis homeobox homolog 1
External Links
UniProt	Q15475
EMBL	X91868 AF323497 BT007083 BC008874
CCDS	CCDS9748.1
RefSeq	NP_005973.1
UniGene	Hs.633506
PDB	4EGC
PDBsum	4EGC
ProteinModelPortal	Q15475
SMR	Q15475
BioGrid	112386
DIP	DIP-34448N
IntAct	Q15475
MINT	MINT-140054
STRING	9606.ENSP00000247182
PhosphoSite	Q15475
DMDM	2495290
MaxQB	Q15475
PaxDb	Q15475
PRIDE	Q15475
DNASU	6495
Ensembl	ENST00000247182
GeneID	6495
KEGG	hsa:6495
UCSC	uc001xfb.4
CTD	6495
GeneCards	GC14M061113
GeneReviews	SIX1
HGNC	HGNC:10887
HPA	CAB058690 HPA001893
MIM	601205 605192 608389
neXtProt	NX_Q15475
Orphanet	90635 107 52429
PharmGKB	PA35787
eggNOG	NOG289502
GeneTree	ENSGT00540000070251
HOGENOM	HOG000261680
HOVERGEN	HBG003609
InParanoid	Q15475
KO	K15614
OMA	FAQPREG
OrthoDB	EOG7C5M8Z
PhylomeDB	Q15475
TreeFam	TF315545
SignaLink	Q15475
ChiTaRS	SIX1
GeneWiki	SIX1
GenomeRNAi	6495
NextBio	25247
PRO	PR:Q15475
Proteomes	UP000005640
Bgee	Q15475
CleanEx	HS_SIX1
ExpressionAtlas	Q15475
Genevestigator	Q15475
GO	GO:0005737 GO:0005730 GO:0005634 GO:0005667 GO:0003682 GO:0003677 GO:0043565 GO:0003700 GO:0044212 GO:0035909 GO:0006915 GO:0001658 GO:0090103 GO:0048701 GO:0048704 GO:0030855 GO:0021610 GO:0048699 GO:0048839 GO:0042472 GO:0001822 GO:0072172 GO:0072075 GO:0042474 GO:0051451 GO:0090191 GO:0043524 GO:0000122 GO:0048665 GO:0001759 GO:0071599 GO:0003151 GO:0007389 GO:0060037 GO:0090190 GO:2000729 GO:0072513 GO:0045944 GO:0045893 GO:0072107 GO:0034504 GO:0072095 GO:0045664 GO:0032880 GO:0008582 GO:0006355 GO:0007605 GO:0007519 GO:0048538 GO:0030878 GO:0006351 GO:0072193 GO:0001657
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000047 InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q62232	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15141091^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15141091^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15141091^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15141091^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15141091^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0072172	mesonephric tubule formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0072095	regulation of branch elongation involved in ureteric bud branching	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0072075	metanephric mesenchyme development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0051451	myoblast migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15141091^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16670092^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15141091^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	PMID:19497856^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16670092^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19497856^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:19497856^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:19497856^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62231	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:106034 PANTHER:PTN000044272	P		Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002571893 ZFIN:ZDB-GENE-040426-2308	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 MGI:MGI:106034 MGI:MGI:106220 PANTHER:PTN000044272 RGD:620909 UniProtKB:O95343	P		Seeded From UniProt	complete
involved_in	GO:0014857	regulation of skeletal muscle cell proliferation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002571893 ZFIN:ZDB-GENE-040426-2308 ZFIN:ZDB-GENE-040718-155	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 PANTHER:PTN002571893	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 PANTHER:PTN000044272	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003460 MGI:MGI:102764 MGI:MGI:102778 MGI:MGI:102780 MGI:MGI:106034 MGI:MGI:106220 MGI:MGI:1341840 PANTHER:PTN000044272 RGD:620906 UniProtKB:Q15475 WB:WBGene00000453 WB:WBGene00000455 WB:WBGene00006775	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 ZFIN:ZDB-GENE-040718-155	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 dictyBase:DDB_G0272967	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1905243	cellular response to 3,3',5-triiodo-L-thyronine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V970 ensembl:ENSRNOP00000037345	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V970 ensembl:ENSRNOP00000037345	C		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V970 ensembl:ENSRNOP00000037345	F		Seeded From UniProt	complete
involved_in	GO:2001014	regulation of skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0072193	ureter smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0072172	mesonephric tubule formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0072095	regulation of branch elongation involved in ureteric bud branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0072075	metanephric mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0071599	otic vesicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0061551	trigeminal ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0061197	fungiform papilla morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0061055	myotome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0051451	myoblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0050678	regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0043586	tongue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0042474	middle ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0030910	olfactory placode formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0021610	facial nerve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0014842	regulation of skeletal muscle satellite cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0008582	regulation of synaptic growth at neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	F		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
involved_in	GO:0048513	animal organ development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Ruf, RG et al. (2004) SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc. Natl. Acad. Sci. U.S.A. 101 8090-5 PubMed GONUTS page
↑ ^3.0 ^3.1 Chai, L et al. (2006) Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J. Biol. Chem. 281 18918-26 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Patrick, AN et al. (2009) Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J. Biol. Chem. 284 20781-90 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:15141091-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Ruf, RG et al. (2004) SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc. Natl. Acad. Sci. U.S.A. 101 8090-5 PubMed GONUTS page

[PMID:16670092-3] 3.0 ^3.1 Chai, L et al. (2006) Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J. Biol. Chem. 281 18918-26 PubMed GONUTS page

[PMID:19497856-4] 4.0 ^4.1 ^4.2 ^4.3 Patrick, AN et al. (2009) Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J. Biol. Chem. 284 20781-90 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

HUMAN:SIX1

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

m

n

o

p

r

s

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools