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HUMAN:RL7A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RPL7A (synonyms: SURF-3, SURF3)
Protein Name(s) 60S ribosomal protein L7a

PLA-X polypeptide Surfeit locus protein 3

External Links
UniProt P62424
EMBL X06705
X52138
X61923
M36072
AK291123
AK311743
AL158826
CH471090
BC005128
BC021979
BC023594
BC023624
BC071900
BC071901
BC073802
BC105290
CCDS CCDS6965.1
PIR S19717
RefSeq NP_000963.1
UniGene Hs.499839
PDB 4UG0
4V6X
5AJ0
PDBsum 4UG0
4V6X
5AJ0
ProteinModelPortal P62424
SMR P62424
BioGrid 112050
DIP DIP-31502N
IntAct P62424
MINT MINT-1149515
STRING 9606.ENSP00000361076
iPTMnet P62424
PhosphoSite P62424
SwissPalm P62424
BioMuta RPL7A
DMDM 54039239
SWISS-2DPAGE P62424
EPD P62424
PaxDb P62424
PRIDE P62424
TopDownProteomics P62424
DNASU 6130
Ensembl ENST00000323345
GeneID 6130
KEGG hsa:6130
UCSC uc004cde.2
CTD 6130
GeneCards RPL7A
HGNC HGNC:10364
HPA HPA046794
MIM 185640
neXtProt NX_P62424
PharmGKB PA34760
eggNOG KOG3166
COG1358
GeneTree ENSGT00390000004753
HOGENOM HOG000216644
HOVERGEN HBG002936
InParanoid P62424
KO K02936
OMA TCTCVAF
PhylomeDB P62424
TreeFam TF300788
Reactome R-HSA-156827
R-HSA-156902
R-HSA-1799339
R-HSA-192823
R-HSA-2408557
R-HSA-72689
R-HSA-72706
R-HSA-72764
R-HSA-975956
R-HSA-975957
ChiTaRS RPL7A
GeneWiki RPL7A
GenomeRNAi 6130
NextBio 23809
PRO PR:P62424
Proteomes UP000005640
Bgee P62424
CleanEx HS_RPL7A
ExpressionAtlas P62424
Genevisible P62424
GO GO:0005737
GO:0005829
GO:0022625
GO:0070062
GO:0005925
GO:0016020
GO:0005730
GO:0005634
GO:0042788
GO:0044822
GO:0003723
GO:0003735
GO:0034641
GO:0044267
GO:0010467
GO:0000184
GO:0042254
GO:0001887
GO:0016259
GO:0044281
GO:0006614
GO:0006412
GO:0006414
GO:0006413
GO:0006415
GO:0019058
GO:0016032
GO:0019083
Gene3D 3.30.1330.30
InterPro IPR029064
IPR001921
IPR004038
IPR018492
IPR004037
Pfam PF01248
PRINTS PR00881
PR00882
SUPFAM SSF55315
PROSITE PS01082

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0045296

cadherin binding

PMID:25468996[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16791210[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:16791210[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:10848616[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0042788

polysomal ribosome

PMID:10848616[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0022625

cytosolic large ribosomal subunit

PMID:12962325[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006412

translation

PMID:12962325[8]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003735

structural constituent of ribosome

PMID:12962325[8]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0022625

cytosolic large ribosomal subunit

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10864
PANTHER:PTN000559990
RGD:1307586
RGD:620497
SGD:S000001025
SGD:S000003103
SGD:S000003968
SGD:S000006141
TAIR:locus:2042087
TAIR:locus:2062057
TAIR:locus:2081715
TAIR:locus:2176337
TAIR:locus:2201811
UniProtKB:P62906

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000559990
SGD:S000000752
UniProtKB:Q9NX24

F

Seeded From UniProt

complete

involved_in

GO:0000470

maturation of LSU-rRNA

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000559990
SGD:S000001025
SGD:S000003968

P

Seeded From UniProt

complete

involved_in

GO:0042254

ribosome biogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004037

P

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004037

C

Seeded From UniProt

complete

part_of

GO:0022625

cytosolic large ribosomal subunit

PMID:8360149[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006412

translation

PMID:8360149[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003735

structural constituent of ribosome

PMID:8360149[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:8360149[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019083

viral transcription

Reactome:R-HSA-168273

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

Reactome:R-HSA-1799339

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

GO:0005730

nucleolus

PMID:25294810[11]

ECO:0000314

C

Figure 4(C1) shows accumulation of GFP-RPL7a in nucleolus of control cells.

complete
CACAO 11506

involved_in

GO:0006413

translational initiation

Reactome:R-HSA-72613

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-927889
Reactome:R-HSA-927836
Reactome:R-HSA-927832
Reactome:R-HSA-927813
Reactome:R-HSA-927789
Reactome:R-HSA-72673
Reactome:R-HSA-72672
Reactome:R-HSA-72671
Reactome:R-HSA-6791218
Reactome:R-HSA-192841
Reactome:R-HSA-192704
Reactome:R-HSA-1799335
Reactome:R-HSA-1799332
Reactome:R-HSA-156826

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

involved_in

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Reactome:R-HSA-927802

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005840

ribosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0689

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
  2. ↑ 2.0 2.1 Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
  3. ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  4. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  5. ↑ 5.0 5.1 Lalli, E et al. (2000) Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA. Mol. Cell. Biol. 20 4910-21 PubMed GONUTS page
  6. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  7. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Odintsova, TI et al. (2003) Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. J. Protein Chem. 22 249-58 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 Seshadri, T et al. (1993) Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. J. Biol. Chem. 268 18474-80 PubMed GONUTS page
  11. ↑ Kazyken, D et al. (2014) The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget 5 9577-93 PubMed GONUTS page
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