HUMAN:PTPRO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTPRO (synonyms: GLEPP1, PTPU2)
Protein Name(s)	Receptor-type tyrosine-protein phosphatase O R-PTP-O Glomerular epithelial protein 1 Protein tyrosine phosphatase U2 PTP-U2 PTPase U2
External Links
UniProt	Q16827
EMBL	Z48541 U20489 AF187043 AF187044 AK290982 AC007542 AC022334 AC092183 CH471094 CH471094 CH471094 BC035960 BC126201 BC126203
CCDS	CCDS44837.1 CCDS53754.1 CCDS8674.1 CCDS8675.1
PIR	A57064 S60613
RefSeq	NP_002839.1 NP_109592.1 NP_109593.1 NP_109594.1 NP_109595.1 NP_109596.1
UniGene	Hs.160871
PDB	2G59 2GJT
PDBsum	2G59 2GJT
ProteinModelPortal	Q16827
SMR	Q16827
BioGrid	111764
IntAct	Q16827
MINT	MINT-1415956
STRING	9606.ENSP00000281171
DEPOD	Q16827
iPTMnet	Q16827
PhosphoSitePlus	Q16827
BioMuta	PTPRO
DMDM	209572663
MaxQB	Q16827
PaxDb	Q16827
PeptideAtlas	Q16827
PRIDE	Q16827
DNASU	5800
Ensembl	ENST00000281171 ENST00000348962 ENST00000442921 ENST00000445537 ENST00000542557 ENST00000543886 ENST00000544244
GeneID	5800
KEGG	hsa:5800
UCSC	uc001rcu.3
CTD	5800
DisGeNET	5800
GeneCards	PTPRO
HGNC	HGNC:9678
HPA	HPA034525
MalaCards	PTPRO
MIM	600579 614196
neXtProt	NX_Q16827
OpenTargets	ENSG00000151490
Orphanet	93214 93217 93213 93216
PharmGKB	PA34023
eggNOG	KOG0791 COG5599
GeneTree	ENSGT00770000120452
HOGENOM	HOG000115792
HOVERGEN	HBG053763
InParanoid	Q16827
KO	K18035
OMA	ISSGWPD
OrthoDB	EOG091G00JF
PhylomeDB	Q16827
TreeFam	TF351926
BioCyc	ZFISH:HS07740-MONOMER
BRENDA	3.1.3.48
ChiTaRS	PTPRO
EvolutionaryTrace	Q16827
GeneWiki	PTPRO
GenomeRNAi	5800
PRO	PR:Q16827
Proteomes	UP000005640
Bgee	ENSG00000151490
CleanEx	HS_PTPRO
ExpressionAtlas	Q16827
Genevisible	Q16827
GO	GO:0016324 GO:0030424 GO:0043197 GO:0070062 GO:0030426 GO:0016021 GO:0005887 GO:0030027 GO:0016328 GO:0043005 GO:0005886 GO:0016791 GO:0042803 GO:0004725 GO:0005001 GO:0017147 GO:0007411 GO:0000902 GO:0072112 GO:0032835 GO:0030032 GO:0002548 GO:0090090 GO:0010812 GO:0003105 GO:0010977 GO:0090260 GO:0035335 GO:0006470 GO:0003093 GO:0036060
CDD	cd00063
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR013783 IPR029021 IPR000242 IPR016130 IPR003595 IPR000387
Pfam	PF00041 PF00102
PRINTS	PR00700
SMART	SM00060 SM00194 SM00404
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	PMID:26063811^[1]	ECO:0000314			P		Figure 2B and 2C: Ptpro dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells	complete CACAO 12265
part_of	GO:0070062	extracellular exosome	PMID:19056867^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0090260	negative regulation of retinal ganglion cell axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	F		Seeded From UniProt	complete
involved_in	GO:0036060	slit diaphragm assembly	PMID:20633639^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036060	slit diaphragm assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:19233845^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032835	glomerulus development	PMID:21722858^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	C		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	F		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28613	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98945	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28613	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7665166^[6]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	C		Seeded From UniProt	complete
enables	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	PMID:7665166^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:19233845^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:19167335^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62797	P		Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28613	P		Seeded From UniProt	complete
involved_in	GO:0003093	regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	PMID:19233845^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:E9Q612	P		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	F		Seeded From UniProt	complete
involved_in	GO:0036060	slit diaphragm assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	F		Seeded From UniProt	complete
involved_in	GO:0003093	regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9Q612 ensembl:ENSMUSP00000076364	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62797 ensembl:ENSRNOP00000044055	F		Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62797 ensembl:ENSRNOP00000044055	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10498613^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:10498613^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:10498613^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Matozaki, T et al. (2010) Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. Cell. Signal. 22 1811-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gobert, RP et al. (2009) GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis. J. Biol. Chem. 284 11385-95 PubMed GONUTS page
↑ Ozaltin, F et al. (2011) Disruption of PTPRO causes childhood-onset nephrotic syndrome. Am. J. Hum. Genet. 89 139-47 PubMed GONUTS page
↑ ^6.0 ^6.1 Wiggins, RC et al. (1995) Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. Genomics 27 174-81 PubMed GONUTS page
↑ Barr, AJ et al. (2009) Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 136 352-63 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Aguiar, RC et al. (1999) PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest. Blood 94 2403-13 PubMed GONUTS page

[PMID:26063811-1] Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page

[PMID:19056867-2] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20633639-3] Matozaki, T et al. (2010) Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. Cell. Signal. 22 1811-7 PubMed GONUTS page

[PMID:19233845-4] 4.0 ^4.1 ^4.2 Gobert, RP et al. (2009) GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis. J. Biol. Chem. 284 11385-95 PubMed GONUTS page

[PMID:21722858-5] Ozaltin, F et al. (2011) Disruption of PTPRO causes childhood-onset nephrotic syndrome. Am. J. Hum. Genet. 89 139-47 PubMed GONUTS page

[PMID:7665166-6] 6.0 ^6.1 Wiggins, RC et al. (1995) Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. Genomics 27 174-81 PubMed GONUTS page

[PMID:19167335-7] Barr, AJ et al. (2009) Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 136 352-63 PubMed GONUTS page

[PMID:10498613-8] 8.0 ^8.1 ^8.2 Aguiar, RC et al. (1999) PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest. Blood 94 2403-13 PubMed GONUTS page

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HUMAN:PTPRO

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