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PMID:7665166

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Citation

Wiggins, RC, Wiggins, JE, Goyal, M, Wharram, BL and Thomas, PE (1995) Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. Genomics 27:174-81

Abstract

Human glomerular epithelial protein 1 (GLEPP1), a receptor-like membrane protein tyrosine phosphatase (PTPase), was cloned and sequenced from a human renal cortical cDNA library. The human nucleotide and derived amino acid sequences were, respectively, 90 and 97% identical to those of rabbit. Human GLEPP1 is predicted to contain 1188 amino acids. The predicted mature protein is 1159 amino acids long and contains a large extracellular domain, a single transmembrane domain, and a single intracellular PTPase domain. Monoclonal and polyclonal antibodies raised against a human GLEPP1 fusion protein recognized a protein with distribution restricted to the glomerulus in human kidney and with an apparent molecular weight of approximately 200 kDa. The GLEPP1 gene was assigned to human chromosome 12p12-p13 by fluorescence in situ hybridization.

Links

PubMed Online version:10.1006/geno.1995.1021

Keywords

Amino Acid Sequence; Animals; Antibodies, Monoclonal/immunology; Base Sequence; Cell Size; Chromosome Mapping; Chromosomes, Human, Pair 12; DNA, Complementary/genetics; Genes; Humans; Kidney Glomerulus/cytology; Kidney Glomerulus/enzymology; Membrane Proteins/analysis; Membrane Proteins/genetics; Membrane Proteins/immunology; Membrane Proteins/physiology; Molecular Sequence Data; Molecular Weight; Protein Tyrosine Phosphatases/analysis; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/immunology; Protein Tyrosine Phosphatases/physiology; Rabbits; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Receptors, Cell Surface/analysis; Receptors, Cell Surface/genetics; Receptors, Cell Surface/immunology; Receptors, Cell Surface/physiology; Recombinant Fusion Proteins/immunology; Sequence Homology, Amino Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PTPRO

located_in

GO:0005887: integral component of plasma membrane

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:PTPRO

part_of

GO:0005887: integral component of plasma membrane

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:PTPRO

enables

GO:0005001: transmembrane receptor protein tyrosine phosphatase activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

Notes

See also

References

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