HUMAN:PRKDC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKDC (synonyms: HYRC, HYRC1)
Protein Name(s)	DNA-dependent protein kinase catalytic subunit DNA-PK catalytic subunit DNA-PKcs DNPK1 p460
External Links
UniProt	P78527
EMBL	U47077 U34994 AY316117 U63630 U90415 L27425 AB052953 U35835 AY030284 AB208860
CCDS	CCDS75734.1 CCDS75735.1
PIR	A57099 G02083
RefSeq	NP_001075109.1 NP_008835.5
UniGene	Hs.491682
ProteinModelPortal	P78527
SMR	P78527
BioGrid	111577
DIP	DIP-24186N
IntAct	P78527
MINT	MINT-5006046
BindingDB	P78527
ChEMBL	CHEMBL3142
DrugBank	DB00201
GuidetoPHARMACOLOGY	2800
PhosphoSite	P78527
DMDM	38258929
SWISS-2DPAGE	P78527
MaxQB	P78527
PaxDb	P78527
PRIDE	P78527
Ensembl	ENST00000314191 ENST00000338368
GeneID	5591
KEGG	hsa:5591
UCSC	uc003xqi.3 uc003xqj.3
CTD	5591
GeneCards	GC08M048685
HGNC	HGNC:9413
HPA	CAB005167 HPA035174
MIM	600899
neXtProt	NX_P78527
Orphanet	317425
PharmGKB	PA33776
eggNOG	COG5032
GeneTree	ENSGT00770000120527
HOVERGEN	HBG053681
InParanoid	P78527
KO	K06642
OrthoDB	EOG7DNNT7
PhylomeDB	P78527
TreeFam	TF324494
Reactome	REACT_1022 REACT_1201 REACT_163993
ChiTaRS	PRKDC
GeneWiki	DNA-PKcs
GenomeRNAi	5591
NextBio	21692
PRO	PR:P78527
Proteomes	UP000005640
Bgee	P78527
ExpressionAtlas	P78527
Genevestigator	P78527
GO	GO:0005829 GO:0005958 GO:0016020 GO:0070419 GO:0005730 GO:0005654 GO:0005634 GO:0005667 GO:0005524 GO:0003677 GO:0004677 GO:0044822 GO:0004672 GO:0004674 GO:0008134 GO:0002326 GO:0007420 GO:0006464 GO:0032869 GO:0006281 GO:0006302 GO:0006303 GO:0035234 GO:0007507 GO:0033152 GO:0045087 GO:0008630 GO:0001933 GO:0018105 GO:0043065 GO:0045944 GO:0032481 GO:0002328 GO:0031648 GO:0042752 GO:0010332 GO:0048511 GO:0072431 GO:0001756 GO:0033077 GO:0002360 GO:0033153 GO:0000723
Gene3D	1.10.1070.11 1.25.10.10
InterPro	IPR011989 IPR016024 IPR003152 IPR011009 IPR012582 IPR000403 IPR018936 IPR003151 IPR014009
Pfam	PF02259 PF02260 PF08163 PF00454
SMART	SM00146
SUPFAM	SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS00915 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004672	protein kinase activity	PMID:24485452^[1]	ECO:0000314			F		Figure 6 shows DNA-PK directly phosphorylates T143 of GOLPH3	complete CACAO 9495
	GO:0043066	negative regulation of apoptotic process	PMID:24485452^[1]	ECO:0000315			P		Figure 7: siRNA knockout of DNA-PK results in decreased survival after being subjected to DNA damage, indicating DNA-PK participates in a pathway preventing apoptosis.	complete CACAO 9496
	GO:0004674	protein serine/threonine kinase activity	PMID:24485452^[1]	ECO:0000314			F		Figure 6 shows DNA-PK directly phosphorylates T143 of GOLPH3	complete CACAO 9521
	GO:0004672	protein kinase activity	PMID:7671312^[2]	ECO:0000314			F		Fig. 5B	complete CACAO 10153
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:26237645^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	PMID:26237645^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:26237645^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:26237645^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:27829214^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:28712728^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:22504299^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:22504299^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:22504299^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:22504299^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:22504299^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:22504299^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23381	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22504299^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070419	nonhomologous end joining complex	PMID:25941166^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048660	regulation of smooth muscle cell proliferation	PMID:25852083^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050678	regulation of epithelial cell proliferation	PMID:18710952^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0011108)	Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:18710952^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:18710952^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:7671312^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24485452^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:24485452^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19303849^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:19303849^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:19303849^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19303849^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P22415	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:19303849^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19303849^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	PMID:21731742^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070419	nonhomologous end joining complex	PMID:20383123^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[16]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97313	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97313	P		Seeded From UniProt	complete
involved_in	GO:0033152	immunoglobulin V(D)J recombination	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104779 PANTHER:PTN002596777	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104779 PANTHER:PTN002476708	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001673367 dictyBase:DDB_G0281167	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104779 PANTHER:PTN001673367 UniProtKB:P78527	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0045035 FB:FBgn0053554 MGI:MGI:104779 MGI:MGI:1928394 PANTHER:PTN000124197 RGD:1593265 RGD:68371 SGD:S000000340 SGD:S000001141 SGD:S000003827 UniProtKB:P78527 UniProtKB:Q13315 UniProtKB:Q96Q15 UniProtKB:Q9FR53 UniProtKB:Q9Y4A5 WB:WBGene00000226 WB:WBGene00007028	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001673367 UniProtKB:P78527	F		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104779 PANTHER:PTN001673367	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:15194694^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	PMID:15194694^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004677	DNA-dependent protein kinase activity	PMID:15194694^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001229	negative regulation of response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0048639	positive regulation of developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0048536	spleen development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0002684	positive regulation of immune system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0002638	negative regulation of immunoglobulin production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0002377	immunoglobulin production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZTN0 ensembl:ENSRNOP00000037412	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0035234	ectopic germ cell programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0033153	T cell receptor V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0033152	immunoglobulin V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0030098	lymphocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	F		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	C		Seeded From UniProt	complete
enables	GO:0004677	DNA-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	F		Seeded From UniProt	complete
involved_in	GO:0002360	T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0002328	pro-B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0002326	B cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97313 ensembl:ENSMUSP00000023352	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	F		Seeded From UniProt	complete
enables	GO:0004677	DNA-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582 InterPro:IPR037706	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037706	P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012582	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
involved_in	GO:0097681	double-strand break repair via alternative nonhomologous end joining	PMID:18710952^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:7671312^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:7671312^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-1834949	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	Reactome:R-HSA-8866654	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8938773 Reactome:R-HSA-8938770 Reactome:R-HSA-3134821	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5693615 Reactome:R-HSA-5693604 Reactome:R-HSA-5693578 Reactome:R-HSA-5693575 Reactome:R-HSA-5693574 Reactome:R-HSA-5693533 Reactome:R-HSA-5687360 Reactome:R-HSA-5687183 Reactome:R-HSA-5686924	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-5687183	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Farber-Katz, SE et al. (2014) DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell 156 413-27 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hartley, KO et al. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82 849-56 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Jiang, Y et al. (2015) Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat. Cell Biol. 17 1158-68 PubMed GONUTS page
↑ Chen, H et al. (2016) PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget 7 83241-83257 PubMed GONUTS page
↑ Morchikh, M et al. (2017) HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Mol. Cell 67 387-399.e5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Sajish, M et al. (2012) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nat. Chem. Biol. 8 547-54 PubMed GONUTS page
↑ Craxton, A et al. (2015) XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Cell Death Differ. 22 890-7 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ Medunjanin, S et al. (2015) DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. Cardiovasc. Res. 106 488-97 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Ruis, BL et al. (2008) The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells. Mol. Cell. Biol. 28 6182-95 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Wong, RH et al. (2009) A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 136 1056-72 PubMed GONUTS page
↑ Liaw, H et al. (2011) DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS ONE 6 e21424 PubMed GONUTS page
↑ Roberts, SA et al. (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464 1214-7 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Wang, YG et al. (2004) Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J. Biol. Chem. 279 37282-90 PubMed GONUTS page

[PMID:24485452-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Farber-Katz, SE et al. (2014) DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell 156 413-27 PubMed GONUTS page

[PMID:7671312-2] 2.0 ^2.1 ^2.2 ^2.3 Hartley, KO et al. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82 849-56 PubMed GONUTS page

[PMID:26237645-3] 3.0 ^3.1 ^3.2 ^3.3 Jiang, Y et al. (2015) Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat. Cell Biol. 17 1158-68 PubMed GONUTS page

[PMID:27829214-4] Chen, H et al. (2016) PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget 7 83241-83257 PubMed GONUTS page

[PMID:28712728-5] Morchikh, M et al. (2017) HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Mol. Cell 67 387-399.e5 PubMed GONUTS page

[PMID:22504299-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Sajish, M et al. (2012) Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nat. Chem. Biol. 8 547-54 PubMed GONUTS page

[PMID:25941166-7] Craxton, A et al. (2015) XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Cell Death Differ. 22 890-7 PubMed GONUTS page

[PMID:19135898-8] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:25852083-9] Medunjanin, S et al. (2015) DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. Cardiovasc. Res. 106 488-97 PubMed GONUTS page

[PMID:18710952-10] 10.0 ^10.1 ^10.2 ^10.3 Ruis, BL et al. (2008) The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells. Mol. Cell. Biol. 28 6182-95 PubMed GONUTS page

[PMID:19946888-11] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19303849-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Wong, RH et al. (2009) A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 136 1056-72 PubMed GONUTS page

[PMID:21731742-13] Liaw, H et al. (2011) DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS ONE 6 e21424 PubMed GONUTS page

[PMID:20383123-14] Roberts, SA et al. (2010) Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464 1214-7 PubMed GONUTS page

[PMID:22681889-15] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-16] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15194694-18] 18.0 ^18.1 ^18.2 Wang, YG et al. (2004) Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. J. Biol. Chem. 279 37282-90 PubMed GONUTS page

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