HUMAN:POTE1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	POT1
Protein Name(s)	Protection of telomeres protein 1 hPot1 POT1-like telomere end-binding protein
External Links
UniProt	Q9NUX5
EMBL	AY823520 AK001230 AK001935 AK022580 AK026234 AC004925 AC096665 AC110791 CH471070 BC002923 AL050120
CCDS	CCDS5793.1
PIR	T08766
RefSeq	NP_001036059.1 NP_056265.2 XP_006715980.1
UniGene	Hs.31968
PDB	1XJV 3KJO 3KJP 5H65 5UN7
PDBsum	1XJV 3KJO 3KJP 5H65 5UN7
ProteinModelPortal	Q9NUX5
SMR	Q9NUX5
BioGrid	117417
CORUM	Q9NUX5
DIP	DIP-29610N
IntAct	Q9NUX5
STRING	9606.ENSP00000350249
BindingDB	Q9NUX5
ChEMBL	CHEMBL5908
iPTMnet	Q9NUX5
PhosphoSitePlus	Q9NUX5
BioMuta	POT1
DMDM	50401179
EPD	Q9NUX5
MaxQB	Q9NUX5
PaxDb	Q9NUX5
PeptideAtlas	Q9NUX5
PRIDE	Q9NUX5
DNASU	25913
Ensembl	ENST00000357628
GeneID	25913
KEGG	hsa:25913
UCSC	uc003vlm.4
CTD	25913
DisGeNET	25913
EuPathDB	HostDB:ENSG00000128513.14
GeneCards	POT1
HGNC	HGNC:17284
HPA	HPA068538
MalaCards	POT1
MIM	606478 615848 616568
neXtProt	NX_Q9NUX5
OpenTargets	ENSG00000128513
Orphanet	67038 618
PharmGKB	PA134934904
eggNOG	KOG4757 ENOG410Z1J0
GeneTree	ENSGT00390000018285
HOGENOM	HOG000015271
HOVERGEN	HBG053641
InParanoid	Q9NUX5
KO	K11109
OMA	DKTSWIP
OrthoDB	EOG091G01T8
PhylomeDB	Q9NUX5
TreeFam	TF328398
Reactome	R-HSA-1221632 R-HSA-171306 R-HSA-2559586
SIGNOR	Q9NUX5
ChiTaRS	POT1
EvolutionaryTrace	Q9NUX5
GeneWiki	POT1
GenomeRNAi	25913
PRO	PR:Q9NUX5
Proteomes	UP000005640
Bgee	ENSG00000128513
CleanEx	HS_POT1
ExpressionAtlas	Q9NUX5
Genevisible	Q9NUX5
GO	GO:0000781 GO:0000784 GO:0000783 GO:0005654 GO:0005634 GO:0070187 GO:1905773 GO:0017151 GO:1990955 GO:0098505 GO:0043047 GO:0010521 GO:0061821 GO:0042162 GO:0032508 GO:0070200 GO:0051974 GO:0032211 GO:1905776 GO:0060383 GO:0051096 GO:0051973 GO:0032212 GO:1905774 GO:0032210 GO:0032202 GO:0016233 GO:0007004 GO:0061820
InterPro	IPR012340 IPR028389 IPR032042 IPR011564
PANTHER	PTHR14513
Pfam	PF02765 PF16686
SMART	SM00976
SUPFAM	SSF50249

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2001032	regulation of double-strand break repair via nonhomologous end joining	PMID:29227966^[1]	ECO:0000314			P		Figure 2 POT1 promotes NHEJ fidelity but inhibits NHEJ efficiency	complete CACAO 13287
enables	GO:0061821	telomeric D-loop binding	PMID:19734539^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0002171)	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:17237768^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0098505	G-rich strand telomeric DNA binding	PMID:17237768^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1905774	regulation of DNA helicase activity	PMID:19734539^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_activity_of:(UniProtKB:P54132)	Seeded From UniProt	complete
involved_in	GO:1905776	positive regulation of DNA helicase activity	PMID:19734539^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_activity_of:(UniProtKB:Q14191)	Seeded From UniProt	complete
enables	GO:1905773	8-hydroxy-2'-deoxyguanosine DNA binding	PMID:19734539^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(GO:0000781) has_input:(CHEBI:40304) occurs_at:(SO:0002171)	Seeded From UniProt	complete
enables	GO:1990955	G-rich single-stranded DNA binding	PMID:19734539^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(GO:0000781) has_input:(CHEBI:40304)	Seeded From UniProt	complete
enables	GO:0098505	G-rich strand telomeric DNA binding	PMID:22763445^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070200	establishment of protein localization to telomere	PMID:25589350^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:Q9BQ15)\|transports_or_maintains_localization_of:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0032210	regulation of telomere maintenance via telomerase	PMID:26586433^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q13315	P		Seeded From UniProt	complete
NOT\|enables	GO:0061849	telomeric G-quadruplex DNA binding	PMID:19734539^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:15181449^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
part_of	GO:0070187	shelterin complex	PMID:15383534^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061820	telomeric D-loop disassembly	PMID:22039056^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O94761	P	occurs_at:(GO:0000781)	Seeded From UniProt	complete
part_of	GO:0070187	shelterin complex	PMID:23685356^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:23685356^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	PMID:23685356^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070187	shelterin complex	PMID:21852327^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:24270157^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0098505	G-rich strand telomeric DNA binding	PMID:21852327^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060383	positive regulation of DNA strand elongation	PMID:16043710^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	PMID:15632080^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:17237768^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:16043710^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:16030011^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043047	single-stranded telomeric DNA binding	PMID:15632080^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043047	single-stranded telomeric DNA binding	PMID:17237767^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:16030011^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:12768206^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:12781132^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032211	negative regulation of telomere maintenance via telomerase	PMID:15181449^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q96AP0	P		Seeded From UniProt	complete
involved_in	GO:0032202	telomere assembly	PMID:16043710^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	PMID:16030011^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14191	F		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	PMID:16030011^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54132	F		Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:17632522^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q96AP0	P		Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:15657433^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0010521	telomerase inhibitor activity	PMID:15632080^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000783	nuclear telomere cap complex	PMID:16880378^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043047	single-stranded telomeric DNA binding	PMID:12768206^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007004	telomere maintenance via telomerase	PMID:12768206^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:12768206^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0098505	G-rich strand telomeric DNA binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000376531 PomBase:SPAC26H5.06 UniProtKB:Q9NUX5	F		Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000376531 SGD:S000002379 UniProtKB:Q9NUX5	P		Seeded From UniProt	complete
involved_in	GO:0032210	regulation of telomere maintenance via telomerase	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000376531 SGD:S000002379 UniProtKB:Q9NUX5	P		Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920086 PANTHER:PTN000376531 PomBase:SPAC26H5.06 SGD:S000002379 TAIR:locus:2164295 UniProtKB:Q9NUX5	P		Seeded From UniProt	complete
enables	GO:0010521	telomerase inhibitor activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000376531 SGD:S000002379 UniProtKB:Q9NUX5	F		Seeded From UniProt	complete
part_of	GO:0000783	nuclear telomere cap complex	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920086 MGI:MGI:2141503 PANTHER:PTN000376531 UniProtKB:Q9NUX5	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011564 InterPro:IPR028389	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011564	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011564	F		Seeded From UniProt	complete
enables	GO:0043047	single-stranded telomeric DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028389 InterPro:IPR032042	F		Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:17237768^[3] Reactome:R-HSA-181450 Reactome:R-HSA-176700	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032211	negative regulation of telomere maintenance via telomerase	PMID:17237768^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070187	shelterin complex	PMID:17237768^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3785711 Reactome:R-HSA-181450 Reactome:R-HSA-176700	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yu, Y et al. (2017) POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY) 9 2529-2543 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Ghosh, A et al. (2009) Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1. J. Biol. Chem. 284 31074-84 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wang, F et al. (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445 506-10 PubMed GONUTS page
↑ Chen, LY et al. (2012) The human CST complex is a terminator of telomerase activity. Nature 488 540-4 PubMed GONUTS page
↑ Pandita, RK et al. (2015) Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res. 75 858-69 PubMed GONUTS page
↑ Tong, AS et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13 1633-46 PubMed GONUTS page
↑ ^7.0 ^7.1 Liu, D et al. (2004) PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. 6 673-80 PubMed GONUTS page
↑ Liu, D et al. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279 51338-42 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ Ghosh, AK et al. (2012) RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance. J. Biol. Chem. 287 196-209 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kappei, D et al. (2013) HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J. 32 1681-701 PubMed GONUTS page
↑ ^12.0 ^12.1 Choi, KH et al. (2011) Characterization of the DNA binding specificity of Shelterin complexes. Nucleic Acids Res. 39 9206-23 PubMed GONUTS page
↑ Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Zaug, AJ et al. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. U.S.A. 102 10864-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Kelleher, C et al. (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. 25 808-18 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Opresko, PL et al. (2005) POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J. Biol. Chem. 280 32069-80 PubMed GONUTS page
↑ Xin, H et al. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445 559-62 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Loayza, D & De Lange, T (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423 1013-8 PubMed GONUTS page
↑ Colgin, LM et al. (2003) Human POT1 facilitates telomere elongation by telomerase. Curr. Biol. 13 942-6 PubMed GONUTS page
↑ Hockemeyer, D et al. (2007) Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nat. Struct. Mol. Biol. 14 754-61 PubMed GONUTS page
↑ Yang, Q et al. (2005) POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol. 25 1070-80 PubMed GONUTS page
↑ O'Connor, MS et al. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl. Acad. Sci. U.S.A. 103 11874-9 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29227966-1] Yu, Y et al. (2017) POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY) 9 2529-2543 PubMed GONUTS page

[PMID:19734539-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Ghosh, A et al. (2009) Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1. J. Biol. Chem. 284 31074-84 PubMed GONUTS page

[PMID:17237768-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wang, F et al. (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445 506-10 PubMed GONUTS page

[PMID:22763445-4] Chen, LY et al. (2012) The human CST complex is a terminator of telomerase activity. Nature 488 540-4 PubMed GONUTS page

[PMID:25589350-5] Pandita, RK et al. (2015) Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Res. 75 858-69 PubMed GONUTS page

[PMID:26586433-6] Tong, AS et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13 1633-46 PubMed GONUTS page

[PMID:15181449-7] 7.0 ^7.1 Liu, D et al. (2004) PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. 6 673-80 PubMed GONUTS page

[PMID:15383534-8] Liu, D et al. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J. Biol. Chem. 279 51338-42 PubMed GONUTS page

[PMID:19135898-9] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:22039056-10] Ghosh, AK et al. (2012) RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance. J. Biol. Chem. 287 196-209 PubMed GONUTS page

[PMID:23685356-11] 11.0 ^11.1 ^11.2 Kappei, D et al. (2013) HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. EMBO J. 32 1681-701 PubMed GONUTS page

[PMID:21852327-12] 12.0 ^12.1 Choi, KH et al. (2011) Characterization of the DNA binding specificity of Shelterin complexes. Nucleic Acids Res. 39 9206-23 PubMed GONUTS page

[PMID:24270157-13] Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page

[PMID:16043710-14] 14.0 ^14.1 ^14.2 Zaug, AJ et al. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. U.S.A. 102 10864-9 PubMed GONUTS page

[PMID:15632080-15] 15.0 ^15.1 ^15.2 Kelleher, C et al. (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol. Cell. Biol. 25 808-18 PubMed GONUTS page

[PMID:16030011-16] 16.0 ^16.1 ^16.2 ^16.3 Opresko, PL et al. (2005) POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J. Biol. Chem. 280 32069-80 PubMed GONUTS page

[PMID:17237767-17] Xin, H et al. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445 559-62 PubMed GONUTS page

[PMID:12768206-18] 18.0 ^18.1 ^18.2 ^18.3 Loayza, D & De Lange, T (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423 1013-8 PubMed GONUTS page

[PMID:12781132-19] Colgin, LM et al. (2003) Human POT1 facilitates telomere elongation by telomerase. Curr. Biol. 13 942-6 PubMed GONUTS page

[PMID:17632522-20] Hockemeyer, D et al. (2007) Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nat. Struct. Mol. Biol. 14 754-61 PubMed GONUTS page

[PMID:15657433-21] Yang, Q et al. (2005) POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol. 25 1070-80 PubMed GONUTS page

[PMID:16880378-22] O'Connor, MS et al. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc. Natl. Acad. Sci. U.S.A. 103 11874-9 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:POTE1

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