HUMAN:PICAL

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PICALM (synonyms: CALM)
Protein Name(s)	Phosphatidylinositol-binding clathrin assembly protein Clathrin assembly lymphoid myeloid leukemia protein
External Links
UniProt	Q13492
EMBL	U45976 AK300275 AB210017 AP000767 CH471076 BC048259 BC064357 BC073961 AF060939 AF060940
CCDS	CCDS31653.1 CCDS55783.1 CCDS55784.1 CCDS8272.1
RefSeq	NP_001008660.1 NP_001193875.1 NP_001193876.1 NP_009097.2 XP_005274388.1
UniGene	Hs.163893
ProteinModelPortal	Q13492
SMR	Q13492
BioGrid	113902
IntAct	Q13492
MINT	MINT-1636298
STRING	9606.ENSP00000342095
PhosphoSite	Q13492
DMDM	116242714
MaxQB	Q13492
PaxDb	Q13492
PRIDE	Q13492
Ensembl	ENST00000356360 ENST00000393346 ENST00000526033 ENST00000528398 ENST00000532317
GeneID	8301
KEGG	hsa:8301
UCSC	uc001pbl.3 uc001pbm.3
CTD	8301
GeneCards	GC11M085668
HGNC	HGNC:15514
HPA	HPA019053 HPA019061
MIM	603025
neXtProt	NX_Q13492
Orphanet	99861
PharmGKB	PA33287
eggNOG	NOG267212
GeneTree	ENSGT00390000008805
HOVERGEN	HBG049391
InParanoid	Q13492
OMA	WNAATMA
OrthoDB	EOG76QFM8
PhylomeDB	Q13492
TreeFam	TF314861
Reactome	REACT_19400
ChiTaRS	PICALM
GeneWiki	PICALM
GenomeRNAi	8301
NextBio	31101
PMAP-CutDB	Q13492
PRO	PR:Q13492
Proteomes	UP000005640
Bgee	Q13492
CleanEx	HS_PICALM
ExpressionAtlas	Q13492
Genevestigator	Q13492
GO	GO:0030118 GO:0030136 GO:0005905 GO:0005794 GO:0043231 GO:0016020 GO:0097418 GO:0043025 GO:0005634 GO:0048471 GO:0045211 GO:0042734 GO:0031982 GO:0005545 GO:0035615 GO:0030276 GO:0032050 GO:0007409 GO:0035459 GO:0008283 GO:0048268 GO:0072583 GO:0048813 GO:0016197 GO:0030097 GO:0055072 GO:0097459 GO:0010629 GO:1902963 GO:0048261 GO:1902961 GO:1902004 GO:1901216 GO:0045893 GO:0006461 GO:0031623 GO:0006898 GO:1902959 GO:0030100 GO:0032880 GO:0016188 GO:0016192
Gene3D	1.20.58.150 1.25.40.90
InterPro	IPR011417 IPR014712 IPR013809 IPR008942 IPR030412
PANTHER	PTHR22951:SF16
Pfam	PF07651
SMART	SM00273
SUPFAM	SSF48464
PROSITE	PS50942

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0051701	interaction with host	PMID:20445327^[1]	ECO:0000314			P		in figure 2 and figure 3	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000111	ECO:0000305	curator inference used in manual assertion	GO:0150093	F		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:22118466^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:22118466^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072583	clathrin-dependent endocytosis	PMID:26005850^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q07954) occurs_in:(UBERON:0013694)\|has_input(UniProtKB:P05067:PRO_0000000093) occurs_in:(UBERON:0013694) occurs_in:(GO:0016323) part_of:(GO:0150093)	Seeded From UniProt	complete
enables	GO:0050750	low-density lipoprotein particle receptor binding	PMID:26005850^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07954	F	activated_by:(CHEBI:64646) part_of:(GO:1904646) occurs_in:(UBERON:0013694)	Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:25898166^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q06AH7)\|has_input:(UniProtKB:P01133)	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:26005850^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002144) part_of:(UBERON:0000451)\|part_of:(CL:0002144) part_of:(UBERON:0003881)	Seeded From UniProt	complete
part_of	GO:0031224	intrinsic component of membrane	PMID:25898166^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55012	C		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:25898166^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55012	F		Seeded From UniProt	complete
involved_in	GO:0006900	vesicle budding from membrane	PMID:25898166^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0045334)	Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	PMID:25898166^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	PMID:25898166^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097753	membrane bending	PMID:25898166^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0005905) part_of:(GO:0097494)	Seeded From UniProt	complete
part_of	GO:0045334	clathrin-coated endocytic vesicle	PMID:25898166^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097494	regulation of vesicle size	PMID:25898166^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(GO:0045334)	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:26005850^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P20339 UniProtKB:P62491	P	occurs_in:(CL:1001602) has_regulation_target:(UniProtKB:P20339)\|occurs_in(CL:1001602) has_regulation_target:(UniProtKB:Q15907)	Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	PMID:26005850^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P20339 UniProtKB:Q15907	F	activated_by:(CHEBI:64646) part_of:(GO:1904646) occurs_in:(CL:1001602)	Seeded From UniProt	complete
involved_in	GO:2000009	negative regulation of protein localization to cell surface	PMID:21221849^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P42262)	Seeded From UniProt	complete
involved_in	GO:1903077	negative regulation of protein localization to plasma membrane	PMID:21221849^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P42262) part_of:(GO:2000009)	Seeded From UniProt	complete
NOT\|involved_in	GO:1902003	regulation of amyloid-beta formation	PMID:26005850^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:26005850^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:0150093	amyloid-beta clearance by transcytosis	PMID:26005850^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P	occurs_in:(UBERON:0002421) part_of:(GO:0090647) occurs_in:(UBERON:0013694) occurs_in:(UBERON:0000201)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:26005850^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:0150093	amyloid-beta clearance by transcytosis	PMID:26005850^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P	occurs_in:(UBERON:0000201) occurs_in:(UBERON:0001915) has_regulation_target:(UniProtKB:P05067:PRO_0000000092)\|occurs_in(UBERON:0000201) occurs_in:(UBERON:0001915) has_regulation_target:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
part_of	GO:0070381	endosome to plasma membrane transport vesicle	PMID:26005850^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:26005850^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001602)	Seeded From UniProt	complete
involved_in	GO:0150093	amyloid-beta clearance by transcytosis	PMID:26005850^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q07954	P	has_input:(UniProtKB:P05067:PRO_0000000093) occurs_in:(CL:1001602) has_target_start_location:(GO:0016323) has_target_end_location:(GO:0016324)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	PMID:24577224^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:24577224^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:23589030^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097418	neurofibrillary tangle	PMID:23589030^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072583	clathrin-dependent endocytosis	PMID:22952941^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072583	clathrin-dependent endocytosis	PMID:24577224^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	PMID:22952941^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:23589030^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035459	vesicle cargo loading	PMID:24577224^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:23589030^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10636	F		Seeded From UniProt	complete
involved_in	GO:0016188	synaptic vesicle maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22952941^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905224	clathrin-coated pit assembly	PMID:16262731^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16262731^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M6Y3	C		Seeded From UniProt	complete
involved_in	GO:0048268	clathrin coat assembly	PMID:16262731^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048261	negative regulation of receptor-mediated endocytosis	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11425879^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55012	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55012	C		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032050	clathrin heavy chain binding	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	PMID:14985334^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	PMID:16262731^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0030132	clathrin coat of coated pit	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030132	clathrin coat of coated pit	PMID:16262731^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030122	AP-2 adaptor complex	PMID:16262731^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	PMID:18182011^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016197	endosomal transport	PMID:16262731^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16491119^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	PMID:10436022^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005545	1-phosphatidylinositol binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O55012	F		Seeded From UniProt	complete
part_of	GO:0098894	extrinsic component of presynaptic endocytic zone membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN001119474 RGD:621054 RGD:69276	C		Seeded From UniProt	complete
involved_in	GO:0098711	iron ion import across plasma membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002742299 UniProtKB:Q13492	P		Seeded From UniProt	complete
involved_in	GO:0072583	clathrin-dependent endocytosis	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0086372 MGI:MGI:2385902 PANTHER:PTN000536700 TAIR:locus:505006543 UniProtKB:Q13492	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0086372 MGI:MGI:109132 PANTHER:PTN001119474 RGD:621054 RGD:69276 WB:WBGene00006751	P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN001119474 RGD:621054 RGD:69276 WB:WBGene00006751	C		Seeded From UniProt	complete
enables	GO:0032050	clathrin heavy chain binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN000536700 RGD:69276 UniProtKB:Q13492	F		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000536700 RGD:621054 RGD:69276 UniProtKB:Q13492 dictyBase:DDB_G0278685	C		Seeded From UniProt	complete
involved_in	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN001119474	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001119474 RGD:621054 RGD:69276	C		Seeded From UniProt	complete
involved_in	GO:0006900	vesicle budding from membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN000536700 UniProtKB:Q13492	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0086372 MGI:MGI:109132 MGI:MGI:2385902 PANTHER:PTN000536700 RGD:621054 RGD:69276 TAIR:locus:505006543 UniProtKB:Q13492 WB:WBGene00006751	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0086372 MGI:MGI:2385902 PANTHER:PTN000536700 UniProtKB:Q13492 WB:WBGene00006751	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN000536700 RGD:621054 RGD:69276 TAIR:locus:2040115 TAIR:locus:2049587 TAIR:locus:2182432 TAIR:locus:505006543 WB:WBGene00006751 dictyBase:DDB_G0278685	C		Seeded From UniProt	complete
enables	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000536700 RGD:621054 RGD:69276	F		Seeded From UniProt	complete
enables	GO:0005545	1-phosphatidylinositol binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109132 PANTHER:PTN000536700 RGD:621054	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000536700 RGD:621054 RGD:69276 dictyBase:DDB_G0278685	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902963	negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0150093	amyloid-beta clearance by transcytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0072583	clathrin-dependent endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	C		Seeded From UniProt	complete
involved_in	GO:0035459	vesicle cargo loading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	C		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0016188	synaptic vesicle maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	P		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M6Y3 ensembl:ENSMUSP00000146501	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011417	F		Seeded From UniProt	complete
enables	GO:0005545	1-phosphatidylinositol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014712 InterPro:IPR030412	F		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030412	P		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014712 InterPro:IPR030412	C		Seeded From UniProt	complete
enables	GO:0030276	clathrin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014712	F		Seeded From UniProt	complete
involved_in	GO:0048268	clathrin coat assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014712 InterPro:IPR030412	P		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:8643484^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:8643484^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8867613	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0070	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Huh, JY et al. (2010) Clathrin assembly lymphoid myeloid leukemia-AF10-positive acute leukemias: a report of 2 cases with a review of the literature. Korean J Lab Med 30 117-21 PubMed GONUTS page
↑ ^2.0 ^2.1 Miller, SE et al. (2011) The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell 147 1118-31 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Zhao, Z et al. (2015) Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat. Neurosci. 18 978-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Miller, SE et al. (2015) CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. Dev. Cell 33 163-75 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^6.0 ^6.1 Harel, A et al. (2011) CALM, a clathrin assembly protein, influences cell surface GluR2 abundance. Neuromolecular Med. 13 88-90 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Kanatsu, K et al. (2014) Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nat Commun 5 3386 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Ando, K et al. (2013) Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 125 861-78 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Scotland, PB et al. (2012) The PICALM protein plays a key role in iron homeostasis and cell proliferation. PLoS ONE 7 e44252 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Meyerholz, A et al. (2005) Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. Traffic 6 1225-34 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Tebar, F et al. (1999) Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol. Biol. Cell 10 2687-702 PubMed GONUTS page
↑ Vecchi, M et al. (2001) Nucleocytoplasmic shuttling of endocytic proteins. J. Cell Biol. 153 1511-7 PubMed GONUTS page
↑ Huang, F et al. (2004) Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J. Biol. Chem. 279 16657-61 PubMed GONUTS page
↑ Harel, A et al. (2008) Evidence for CALM in directing VAMP2 trafficking. Traffic 9 417-29 PubMed GONUTS page
↑ Archangelo, LF et al. (2006) The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. Oncogene 25 4099-109 PubMed GONUTS page
↑ ^17.00 ^17.01 ^17.02 ^17.03 ^17.04 ^17.05 ^17.06 ^17.07 ^17.08 ^17.09 ^17.10 ^17.11 ^17.12 ^17.13 ^17.14 ^17.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^18.0 ^18.1 Dreyling, MH et al. (1996) The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc. Natl. Acad. Sci. U.S.A. 93 4804-9 PubMed GONUTS page

[PMID:20445327-1] Huh, JY et al. (2010) Clathrin assembly lymphoid myeloid leukemia-AF10-positive acute leukemias: a report of 2 cases with a review of the literature. Korean J Lab Med 30 117-21 PubMed GONUTS page

[PMID:22118466-2] 2.0 ^2.1 Miller, SE et al. (2011) The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM. Cell 147 1118-31 PubMed GONUTS page

[PMID:26005850-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Zhao, Z et al. (2015) Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat. Neurosci. 18 978-87 PubMed GONUTS page

[PMID:25898166-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Miller, SE et al. (2015) CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. Dev. Cell 33 163-75 PubMed GONUTS page

[PMID:25468996-5] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:21221849-6] 6.0 ^6.1 Harel, A et al. (2011) CALM, a clathrin assembly protein, influences cell surface GluR2 abundance. Neuromolecular Med. 13 88-90 PubMed GONUTS page

[PMID:19946888-7] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:24577224-8] 8.0 ^8.1 ^8.2 ^8.3 Kanatsu, K et al. (2014) Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase. Nat Commun 5 3386 PubMed GONUTS page

[PMID:23589030-9] 9.0 ^9.1 ^9.2 ^9.3 Ando, K et al. (2013) Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains. Acta Neuropathol. 125 861-78 PubMed GONUTS page

[PMID:22952941-10] 10.0 ^10.1 ^10.2 Scotland, PB et al. (2012) The PICALM protein plays a key role in iron homeostasis and cell proliferation. PLoS ONE 7 e44252 PubMed GONUTS page

[PMID:16262731-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Meyerholz, A et al. (2005) Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation. Traffic 6 1225-34 PubMed GONUTS page

[PMID:10436022-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Tebar, F et al. (1999) Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol. Biol. Cell 10 2687-702 PubMed GONUTS page

[PMID:11425879-13] Vecchi, M et al. (2001) Nucleocytoplasmic shuttling of endocytic proteins. J. Cell Biol. 153 1511-7 PubMed GONUTS page

[PMID:14985334-14] Huang, F et al. (2004) Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference. J. Biol. Chem. 279 16657-61 PubMed GONUTS page

[PMID:18182011-15] Harel, A et al. (2008) Evidence for CALM in directing VAMP2 trafficking. Traffic 9 417-29 PubMed GONUTS page

[PMID:16491119-16] Archangelo, LF et al. (2006) The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10. Oncogene 25 4099-109 PubMed GONUTS page

[PMID:21873635-17] 17.00 ^17.01 ^17.02 ^17.03 ^17.04 ^17.05 ^17.06 ^17.07 ^17.08 ^17.09 ^17.10 ^17.11 ^17.12 ^17.13 ^17.14 ^17.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8643484-18] 18.0 ^18.1 Dreyling, MH et al. (1996) The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc. Natl. Acad. Sci. U.S.A. 93 4804-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

HUMAN:PICAL

Contents

Annotations

Notes

References

1

a

b

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools