PMID:20445327

Citation	Huh, JY, Chung, S, Oh, D, Kang, MS, Eom, HS, Cho, EH, Han, MH and Kong, SY (2010) Clathrin assembly lymphoid myeloid leukemia-AF10-positive acute leukemias: a report of 2 cases with a review of the literature. Korean J Lab Med 30:117-21
Abstract	The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with the AF10 gene; these genes are present on chromosomes 11 and 10, respectively. Because the CALM-AF10 rearrangement is a rare chromosomal abnormality, it is not included in routine molecular tests for acute leukemia. Here, we describe the cases of 2 patients with the CALM-AF10 fusion gene. The first patient (case 1) was diagnosed with T-cell ALL, and the second patient (case 2) was diagnosed with AML. Both patient samples showed expression of the homeobox A gene cluster and the histone methyltransferase hDOT1L, which suggests that they mediate leukemic transformation in CALM-AF10-positive and mixed-lineage leukemia-AF10-positive leukemias. Both patients achieved complete remission after induction chemotherapy. The first patient (case 1) relapsed after double-unit cord blood transplantation; there was no evidence of relapse in the second patient (case 2) after allogenic peripheral blood stem cell transplantation. Since CALM-AF10- positive leukemias have been shown to have poor prognosis with conventional therapy, molecular tests for CALM-AF10 rearrangement would be necessary to detect minimal residual disease during follow-up.
Links	PubMed Online version:10.3343/kjlm.2010.30.2.117
Keywords	Adolescent; Adult; Bone Marrow/pathology; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 11; Cord Blood Stem Cell Transplantation; Female; Histone-Lysine N-Methyltransferase/genetics; Histone-Lysine N-Methyltransferase/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Leukemia, Myeloid, Acute/diagnosis; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/therapy; Male; Monomeric Clathrin Assembly Proteins/genetics; Oncogene Proteins, Fusion/genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy; Recurrence; Transcription Factors/genetics; Translocation, Genetic
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:PICAL	Contributes to	GO:0051701: interaction with host	ECO:0000314:		P		in figure 2 and figure 3	complete

References

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