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Category:GO:0030122 ! AP-2 adaptor complex
name: AP-2 adaptor complex
namespace: cellular_component
def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426]
synonym: "HA2" EXACT []
synonym: "HA2 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0098797 ! plasma membrane protein complex
relationship: part_of: GO:0030128 ! clathrin coat of endocytic vesicle
relationship: part_of: GO:0030132 ! clathrin coat of coated pit
AmiGO
<GOterm>GO:0030122</GOterm>
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