HUMAN:EPS15

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	EPS15 (synonyms: AF1P)
Protein Name(s)	Epidermal growth factor receptor substrate 15 Protein Eps15 Protein AF-1p
External Links
UniProt	P42566
EMBL	U07707 Z29064 AK313396 DQ367924 BX647676 AL671986 AC104170 CH471059
CCDS	CCDS557.1
PIR	S43074
RefSeq	NP_001153441.1 NP_001972.1
UniGene	Hs.83722
PDB	1C07 1EH2 1F8H 1FF1 2IV9 2JXC
PDBsum	1C07 1EH2 1F8H 1FF1 2IV9 2JXC
ProteinModelPortal	P42566
SMR	P42566
BioGrid	108374
DIP	DIP-33064N
IntAct	P42566
MINT	MINT-107223
STRING	9606.ENSP00000360798
PhosphoSite	P42566
DMDM	67476728
OGP	P42566
MaxQB	P42566
PaxDb	P42566
PeptideAtlas	P42566
PRIDE	P42566
Ensembl	ENST00000371733
GeneID	2060
KEGG	hsa:2060
UCSC	uc001csp.3 uc001csq.1
CTD	2060
GeneCards	GC01M051819
HGNC	HGNC:3419
HPA	CAB010164 HPA008451
MIM	600051
neXtProt	NX_P42566
PharmGKB	PA27838
eggNOG	NOG301764
GeneTree	ENSGT00760000118985
HOGENOM	HOG000004804
HOVERGEN	HBG005591
InParanoid	P42566
KO	K12472
OMA	HAEGQGN
PhylomeDB	P42566
TreeFam	TF324293
Reactome	REACT_12484
SignaLink	P42566
ChiTaRS	EPS15
EvolutionaryTrace	P42566
GeneWiki	EPS15
GenomeRNAi	2060
NextBio	8377
PRO	PR:P42566
Proteomes	UP000005640
Bgee	P42566
CleanEx	HS_EPS15
ExpressionAtlas	P42566
Genevestigator	P42566
GO	GO:0030122 GO:0060170 GO:0005905 GO:0005737 GO:0005829 GO:0031901 GO:0043231 GO:0016020 GO:0005886 GO:0005509 GO:0031593 GO:0008283 GO:0048268 GO:0032456 GO:0006897 GO:0007173 GO:0006895 GO:0042059 GO:0015031 GO:0016050
Gene3D	1.10.238.10
InterPro	IPR011992 IPR018247 IPR002048 IPR000261 IPR003903
SMART	SM00054 SM00027 SM00726
PROSITE	PS00018 PS50222 PS50031 PS50330

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0046718	entry of virus into host cell	PMID:20202662^[1]	ECO:0000315			P	Fig. 4B and Fig. 4C	complete CACAO 2407
	GO:0019065	receptor-mediated endocytosis of virus by host	PMID:21047970^[2]	ECO:0000315			P	Fig. 2B Part of the clathrin-mediated endocytosis entry pathway.	complete CACAO 2434
enables	GO:0045296	cadherin binding	PMID:25468996^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:16159959^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019065	receptor-mediated endocytosis of virus by host cell	PMID:21047970^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	PMID:20202662^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006895	Golgi to endosome transport	PMID:24768539^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	PMID:24768539^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0048268	clathrin coat assembly	PMID:12807910^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032456	endocytic recycling	PMID:12807910^[7]	ECO:0000305	curator inference used in manual assertion	GO:0048268	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15465819^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0098884	C	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	C	Seeded From UniProt	complete
involved_in	GO:0098884	postsynaptic neurotransmitter receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	C	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	P	Seeded From UniProt	complete
enables	GO:0038024	cargo receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	F	Seeded From UniProt	complete
involved_in	GO:0032456	endocytic recycling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	C	Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	C	Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PSY8 ensembl:ENSRNOP00000059209	P	Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	F	Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	C	Seeded From UniProt	complete
part_of	GO:0030132	clathrin coat of coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	C	Seeded From UniProt	complete
part_of	GO:0030122	AP-2 adaptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	C	Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P42567 ensembl:ENSMUSP00000099790	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F	Seeded From UniProt	complete
involved_in	GO:0016050	vesicle organization	PMID:9762922^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	PMID:9762922^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Reactome:R-HSA-182971	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8875490 Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8867047 Reactome:R-HSA-8867044 Reactome:R-HSA-8867041 Reactome:R-HSA-8866283 Reactome:R-HSA-8866279 Reactome:R-HSA-8866275 Reactome:R-HSA-8862280 Reactome:R-HSA-8856813 Reactome:R-HSA-8856808 Reactome:R-HSA-183072 Reactome:R-HSA-182990 Reactome:R-HSA-182986	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005905	clathrin-coated pit	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0168 UniProtKB-SubCell:SL-0069	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0729	F	Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bhattacharyya, S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401 18-28 PubMed GONUTS page
↑ ^2.0 ^2.1 Hunt, CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J. Virol. 85 334-47 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Regan-Klapisz, E et al. (2005) Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. J. Cell. Sci. 118 4437-50 PubMed GONUTS page
↑ ^5.0 ^5.1 Yuan, WC et al. (2014) K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol. Cell 54 586-600 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^7.0 ^7.1 Morgan, JR et al. (2003) Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling. J. Biol. Chem. 278 33583-92 PubMed GONUTS page
↑ de Melker, AA et al. (2004) Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment. J. Biol. Chem. 279 55465-73 PubMed GONUTS page
↑ ^9.0 ^9.1 Lewin, DA et al. (1998) Cloning, expression, and localization of a novel gamma-adaptin-like molecule. FEBS Lett. 435 263-8 PubMed GONUTS page

[PMID:20202662-1] 1.0 ^1.1 Bhattacharyya, S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401 18-28 PubMed GONUTS page

[PMID:21047970-2] 2.0 ^2.1 Hunt, CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J. Virol. 85 334-47 PubMed GONUTS page

[PMID:25468996-3] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:16159959-4] Regan-Klapisz, E et al. (2005) Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. J. Cell. Sci. 118 4437-50 PubMed GONUTS page

[PMID:24768539-5] 5.0 ^5.1 Yuan, WC et al. (2014) K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol. Cell 54 586-600 PubMed GONUTS page

[PMID:19946888-6] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:12807910-7] 7.0 ^7.1 Morgan, JR et al. (2003) Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling. J. Biol. Chem. 278 33583-92 PubMed GONUTS page

[PMID:15465819-8] Melker, AA et al. (2004) Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment. J. Biol. Chem. 279 55465-73 PubMed GONUTS page

[PMID:9762922-9] 9.0 ^9.1 Lewin, DA et al. (1998) Cloning, expression, and localization of a novel gamma-adaptin-like molecule. FEBS Lett. 435 263-8 PubMed GONUTS page

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HUMAN:EPS15

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