HUMAN:PGH2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTGS2 (synonyms: COX2)
Protein Name(s)	Prostaglandin G/H synthase 2 Cyclooxygenase-2 COX-2 PHS II Prostaglandin H2 synthase 2 PGH synthase 2 PGHS-2 Prostaglandin-endoperoxide synthase 2
External Links
UniProt	P35354
EMBL	L15326 M90100 D28235 U04636 AY462100 AY229989 AY382629 AK292167 AL033533 CH471067 BC013734
CCDS	CCDS1371.1
PIR	A46150
RefSeq	NP_000954.1
UniGene	Hs.196384
PDB	1V0X
PDBsum	1V0X
ProteinModelPortal	P35354
SMR	P35354
BioGrid	111715
DIP	DIP-28131N
IntAct	P35354
MINT	MINT-203337
STRING	9606.ENSP00000356438
BindingDB	P35354
ChEMBL	CHEMBL2094253
DrugBank	DB00316 DB00945 DB00041 DB00233 DB01435 DB01419 DB01014 DB00963 DB00887 DB00821 DB00482 DB00856 DB00515 DB00720 DB00250 DB00035 DB00586 DB00861 DB00154 DB01395 DB00005 DB00749 DB00773 DB01628 DB00573 DB00712 DB01404 DB01050 DB00159 DB00328 DB01009 DB00465 DB00480 DB06725 DB01283 DB01397 DB00939 DB00784 DB00814 DB00244 DB00461 DB00788 DB06802 DB04552 DB06804 DB00991 DB00812 DB00554 DB08910 DB00884 DB01398 DB00936 DB01399 DB00795 DB00605 DB00870 DB08819 DB00469 DB00360 DB01041 DB01600 DB00500 DB00620 DB01401
GuidetoPHARMACOLOGY	1376
PeroxiBase	3321
PhosphoSite	P35354
DMDM	3915797
MaxQB	P35354
PaxDb	P35354
PRIDE	P35354
DNASU	5743
Ensembl	ENST00000367468
GeneID	5743
KEGG	hsa:5743
UCSC	uc001gsb.3
CTD	5743
GeneCards	GC01M186640
HGNC	HGNC:9605
HPA	CAB000113 HPA001335
MIM	600262
neXtProt	NX_P35354
PharmGKB	PA293
eggNOG	NOG39991
GeneTree	ENSGT00390000010743
HOGENOM	HOG000013149
HOVERGEN	HBG000366
InParanoid	P35354
KO	K11987
OMA	ICNNVKG
OrthoDB	EOG7RFTHC
PhylomeDB	P35354
TreeFam	TF329675
BioCyc	MetaCyc:HS01115-MONOMER
BRENDA	1.14.99.1
Reactome	REACT_11213 REACT_150149 REACT_150422
SABIO-RK	P35354
UniPathway	UPA00662
GeneWiki	Prostaglandin-endoperoxide_synthase_2 PTGS2
GenomeRNAi	5743
NextBio	22358
PRO	PR:P35354
Proteomes	UP000005640
Bgee	P35354
CleanEx	HS_PTGS2
ExpressionAtlas	P35354
Genevestigator	P35354
GO	GO:0005901 GO:0005737 GO:0005789 GO:0043005 GO:0005634 GO:0043234 GO:0050473 GO:0019899 GO:0020037 GO:0008289 GO:0046872 GO:0004601 GO:0004666 GO:0001525 GO:0019369 GO:0030282 GO:0050873 GO:0006928 GO:0071318 GO:0071456 GO:0071260 GO:0034644 GO:0019371 GO:0046697 GO:0007566 GO:0042633 GO:0006954 GO:0007612 GO:0019372 GO:0035633 GO:0007613 GO:0051926 GO:0045786 GO:0008285 GO:0045986 GO:0032227 GO:0030728 GO:0043065 GO:0090336 GO:0090050 GO:0031622 GO:0090271 GO:0042346 GO:0045429 GO:0090362 GO:0031394 GO:0048661 GO:0045987 GO:0031915 GO:0051968 GO:0071636 GO:0045907 GO:0010575 GO:0001516 GO:0006693 GO:0008217 GO:0050727 GO:0042493 GO:0032355 GO:0070542 GO:0009750 GO:0051384 GO:0032496 GO:0010226 GO:0010042 GO:0006979 GO:0034612 GO:0033280 GO:0019233 GO:0044281
Gene3D	1.10.640.10
InterPro	IPR029576 IPR000742 IPR010255 IPR019791
PANTHER	PTHR11903:SF8
Pfam	PF03098
PRINTS	PR00457
SMART	SM00181
SUPFAM	SSF48113
PROSITE	PS50026 PS50292

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0150077	regulation of neuroinflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:24089527^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090362	positive regulation of platelet-derived growth factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35355	P	Seeded From UniProt	complete
involved_in	GO:0090336	positive regulation of brown fat cell differentiation	PMID:20448152^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	P	Seeded From UniProt	complete
involved_in	GO:0090271	positive regulation of fibroblast growth factor production	PMID:9630216^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35355	P	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:9630216^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35355	P	Seeded From UniProt	complete
involved_in	GO:0071636	positive regulation of transforming growth factor beta production	PMID:9630216^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35355	P	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:9630216^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35355	P	Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	P	Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	PMID:20448152^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	PMID:1380156^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:9630216^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35355	P	Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	PMID:1380156^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	PMID:20448152^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:21296955^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:14511332^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16373578^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29477	F	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14511332^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	C	Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	PMID:16373578^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:14511332^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05769	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:12355421^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	C	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:1990776	response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0097756	negative regulation of blood vessel diameter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0090362	positive regulation of platelet-derived growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0090271	positive regulation of fibroblast growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0071636	positive regulation of transforming growth factor beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0071284	cellular response to lead ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0051926	negative regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0045986	negative regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0042633	hair cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0035633	maintenance of permeability of blood-brain barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	C	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0032227	negative regulation of synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0031915	positive regulation of synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0030728	ovulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0030282	bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
enables	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	F	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0010042	response to manganese ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0009750	response to fructose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35355 ensembl:ENSRNOP00000003567	P	Seeded From UniProt	complete
involved_in	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0150077	regulation of neuroinflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0090336	positive regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0071471	cellular response to non-ionic osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0050873	brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	F	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0031622	positive regulation of fever generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0031394	positive regulation of prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	F	Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	C	Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	F	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05769 ensembl:ENSMUSP00000035065	P	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	F	Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	F	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P	Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029576	P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255 InterPro:IPR029576	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010255	P	Seeded From UniProt	complete
enables	GO:0004666	prostaglandin-endoperoxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.99.1	F	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	PMID:24089527^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042759	long-chain fatty acid biosynthetic process	Reactome:R-HSA-9027604 Reactome:R-HSA-9018679 Reactome:R-HSA-9018677	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	Reactome:R-HSA-197264	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019372	lipoxygenase pathway	Reactome:R-HSA-9025094 Reactome:R-HSA-2142770	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019371	cyclooxygenase pathway	Reactome:R-HSA-2162123	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-6783783	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-9028255 Reactome:R-HSA-9027627 Reactome:R-HSA-9027607 Reactome:R-HSA-9027532 Reactome:R-HSA-9026408 Reactome:R-HSA-9020261 Reactome:R-HSA-9018880 Reactome:R-HSA-6790029 Reactome:R-HSA-2314686 Reactome:R-HSA-2309787 Reactome:R-HSA-2309779 Reactome:R-HSA-2309773 Reactome:R-HSA-2161951	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F	Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492	C	Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0643 UniPathway:UPA00662	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
involved_in	GO:0006693	prostaglandin metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0644	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0031090	organelle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0165	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chen, SF et al. (2013) Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J. Biol. Chem. 288 33462-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Vegiopoulos, A et al. (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328 1158-61 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tsujii, M et al. (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93 705-16 PubMed GONUTS page
↑ ^4.0 ^4.1 Hla, T & Neilson, K (1992) Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. U.S.A. 89 7384-8 PubMed GONUTS page
↑ Camacho, M et al. (2011) Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli. J. Lipid Res. 52 720-31 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Maihöfner, C et al. (2003) Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. Eur. J. Neurosci. 18 1527-34 PubMed GONUTS page
↑ ^7.0 ^7.1 Kim, SF et al. (2005) Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310 1966-70 PubMed GONUTS page
↑ Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page

[PMID:24089527-1] 1.0 ^1.1 Chen, SF et al. (2013) Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex. J. Biol. Chem. 288 33462-9 PubMed GONUTS page

[PMID:20448152-2] 2.0 ^2.1 ^2.2 Vegiopoulos, A et al. (2010) Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328 1158-61 PubMed GONUTS page

[PMID:9630216-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tsujii, M et al. (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93 705-16 PubMed GONUTS page

[PMID:1380156-4] 4.0 ^4.1 Hla, T & Neilson, K (1992) Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. U.S.A. 89 7384-8 PubMed GONUTS page

[PMID:21296955-5] Camacho, M et al. (2011) Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli. J. Lipid Res. 52 720-31 PubMed GONUTS page

[PMID:14511332-6] 6.0 ^6.1 ^6.2 Maihöfner, C et al. (2003) Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. Eur. J. Neurosci. 18 1527-34 PubMed GONUTS page

[PMID:16373578-7] 7.0 ^7.1 Kim, SF et al. (2005) Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310 1966-70 PubMed GONUTS page

[PMID:12355421-8] Ju, WK & Neufeld, AH (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J. Comp. Neurol. 452 392-9 PubMed GONUTS page

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HUMAN:PGH2

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