HUMAN:PDX1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PDX1 (synonyms: IPF1, STF1)
Protein Name(s)	Pancreas/duodenum homeobox protein 1 PDX-1 Glucose-sensitive factor GSF Insulin promoter factor 1 IPF-1 Insulin upstream factor 1 IUF-1 Islet/duodenum homeobox-1 IDX-1 Somatostatin-transactivating factor 1 STF-1
External Links
UniProt	P52945
EMBL	U35632 S82178 S82168 U30329 X99894 AF035260 AF035259 AF049893 AL353195 CH471075
CCDS	CCDS9327.1
PIR	G01926
RefSeq	NP_000200.1
UniGene	Hs.32938
ProteinModelPortal	P52945
SMR	P52945
BioGrid	109860
IntAct	P52945
MINT	MINT-1894661
STRING	9606.ENSP00000370421
PhosphoSite	P52945
DMDM	1708540
PaxDb	P52945
PRIDE	P52945
DNASU	3651
Ensembl	ENST00000381033
GeneID	3651
KEGG	hsa:3651
UCSC	uc001urt.2
CTD	3651
GeneCards	GC13P028494
GeneReviews	PDX1
HGNC	HGNC:6107
HPA	CAB025873
MIM	125853 260370 600733 606392
neXtProt	NX_P52945
Orphanet	552 2805 99885
PharmGKB	PA162399173
eggNOG	NOG271681
GeneTree	ENSGT00760000118940
HOGENOM	HOG000115484
HOVERGEN	HBG004525
InParanoid	P52945
KO	K07594
OMA	PPPCLYM
OrthoDB	EOG744TB4
PhylomeDB	P52945
TreeFam	TF326223
Reactome	REACT_13778 REACT_13819
SignaLink	P52945
GeneWiki	PDX1
GenomeRNAi	3651
NextBio	14279
PRO	PR:P52945
Proteomes	UP000005640
Bgee	P52945
CleanEx	HS_PDX1
Genevestigator	P52945
GO	GO:0005829 GO:0005634 GO:0003682 GO:0001046 GO:0000978 GO:0003705 GO:0003700 GO:0007417 GO:0051594 GO:0048565 GO:0031018 GO:0031017 GO:0006091 GO:0042593 GO:0006006 GO:0030073 GO:0001889 GO:0016331 GO:0008285 GO:1902236 GO:0000122 GO:2000675 GO:0007263 GO:0009887 GO:0031100 GO:0010260 GO:0010942 GO:0008284 GO:0043388 GO:0032024 GO:0045944 GO:0010157 GO:0034097 GO:0042493 GO:0070542 GO:0051384 GO:0010040 GO:0043201 GO:0035094 GO:0033273 GO:0009611 GO:0007224 GO:0048863 GO:0006366 GO:0060290 GO:0003309
Gene3D	1.10.10.60
InterPro	IPR017995 IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00025 PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[1]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000047 InterPro:IPR001356 InterPro:IPR001827 InterPro:IPR009057	F	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P20263	F	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:24567802^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051594	detection of glucose	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52947	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52947	P	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	PMID:17941991^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:17941991^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:12124776^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52947	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 FB:FBgn0004053 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:P14651 UniProtKB:P14652 UniProtKB:P31249	P	Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102851 PANTHER:PTN002903050 ZFIN:ZDB-GENE-990415-122	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0051481 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:O43364 UniProtKB:P14652	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 MGI:MGI:102851 MGI:MGI:96175 PANTHER:PTN002518688 RGD:62387	F	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002903050 RGD:62387 UniProtKB:P52945	P	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102851 MGI:MGI:96174 MGI:MGI:96184 PANTHER:PTN002518688 UniProtKB:P14651	F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0060290	transdifferentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0051594	detection of glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0043279	response to alkaloid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0043201	response to leucine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0033273	response to vitamin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
	GO:0003309	type B pancreatic cell differentiation	PMID:24567802^[2]	ECO:0000315			P	Figure 2c shows gene expression of PDX1 and insulin in islet cells	complete CACAO 9903
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
	GO:0003309	type B pancreatic cell differentiation	PMID:24567802^[2]	ECO:0000314			P	Figure 3 shows the differentiated and undifferentiated cells from the islet pancreatic tissues that were infected with PDX1. Very few PDX1+ cells were seen in the differentiated condition. PDX1+ were found in the monolayer in the undifferentiated cell conditions.	complete CACAO 9904
involved_in	GO:0031100	animal organ regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0010260	animal organ senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0010157	response to chlorate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52947 ensembl:ENSRNOP00000066935	F	Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0031017	exocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	C	Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR017995 InterPro:IPR020479	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017995	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017995	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970 InterPro:IPR017995	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	PMID:8988180^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:8954967^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006091	generation of precursor metabolites and energy	PMID:8954967^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17941991^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

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↑ ^1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Seeberger, KL et al. (2014) Identification and differentiation of PDX1 β-cell progenitors within the human pancreatic epithelium. World J Diabetes 5 59-68 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Muniappan, L & Ozcan, S (2007) Induction of insulin secretion in engineered liver cells by nitric oxide. BMC Physiol. 7 11 PubMed GONUTS page
↑ Zhou, J et al. (2002) Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. J. Cell. Physiol. 192 304-14 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Stoffers, DA et al. (1997) Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat. Genet. 15 106-10 PubMed GONUTS page
↑ ^7.0 ^7.1 Watada, H et al. (1996) Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem. Biophys. Res. Commun. 229 746-51 PubMed GONUTS page

[PMID:19274049-1] 1.0 ^1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:24567802-2] 2.0 ^2.1 ^2.2 Seeberger, KL et al. (2014) Identification and differentiation of PDX1 β-cell progenitors within the human pancreatic epithelium. World J Diabetes 5 59-68 PubMed GONUTS page

[PMID:17941991-3] 3.0 ^3.1 ^3.2 Muniappan, L & Ozcan, S (2007) Induction of insulin secretion in engineered liver cells by nitric oxide. BMC Physiol. 7 11 PubMed GONUTS page

[PMID:12124776-4] Zhou, J et al. (2002) Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. J. Cell. Physiol. 192 304-14 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8988180-6] Stoffers, DA et al. (1997) Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat. Genet. 15 106-10 PubMed GONUTS page

[PMID:8954967-7] 7.0 ^7.1 Watada, H et al. (1996) Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem. Biophys. Res. Commun. 229 746-51 PubMed GONUTS page

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