HUMAN:PDGFA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PDGFA (synonyms: PDGF1)
Protein Name(s)	Platelet-derived growth factor subunit A PDGF subunit A PDGF-1 Platelet-derived growth factor A chain Platelet-derived growth factor alpha polypeptide
External Links
UniProt	P04085
EMBL	X03795 X06374 M20494 M20488 M20489 M20490 M20491 M20492 M20493 M19988 M21571 M19984 M19985 M19986 M19987 M19989 M21571 M19984 M19985 M19986 M19987 AB451309 AB451439 AC147651 S62078
CCDS	CCDS34578.1 CCDS47524.1
PIR	A28964 B28964
RefSeq	NP_002598.4 NP_148983.1 XP_006715796.1
UniGene	Hs.535898
PDB	3MJK
PDBsum	3MJK
ProteinModelPortal	P04085
SMR	P04085
BioGrid	111180
DIP	DIP-5735N
IntAct	P04085
STRING	9606.ENSP00000346508
BindingDB	P04085
ChEMBL	CHEMBL3137294
PhosphoSite	P04085
PaxDb	P04085
PRIDE	P04085
DNASU	5154
Ensembl	ENST00000354513 ENST00000402802
GeneID	5154
KEGG	hsa:5154
UCSC	uc003sir.3 uc003sis.3
CTD	5154
GeneCards	GC07M000536
H-InvDB	HIX0167622
HGNC	HGNC:8799
HPA	CAB005579
MIM	173430
neXtProt	NX_P04085
PharmGKB	PA33144
eggNOG	NOG75094
GeneTree	ENSGT00510000046755
HOGENOM	HOG000286027
HOVERGEN	HBG053546
InParanoid	P04085
KO	K04359
OMA	HASKHAP
OrthoDB	EOG78H3VV
PhylomeDB	P04085
TreeFam	TF319554
Reactome	REACT_147727 REACT_163874 REACT_16888 REACT_17025 REACT_75829
SignaLink	P04085
EvolutionaryTrace	P04085
GeneWiki	PDGFA
GenomeRNAi	5154
NextBio	19930
PRO	PR:P04085
Proteomes	UP000005640
Bgee	P04085
CleanEx	HS_PDGFA
ExpressionAtlas	P04085
Genevestigator	P04085
GO	GO:0009986 GO:0005788 GO:0005576 GO:0005615 GO:0000139 GO:0005902 GO:0031093 GO:0005518 GO:0008083 GO:0048407 GO:0005161 GO:0046982 GO:0042803 GO:0030036 GO:0001525 GO:0007596 GO:0001775 GO:0030031 GO:0007267 GO:1990401 GO:0007173 GO:0030198 GO:0038095 GO:0008543 GO:0001942 GO:0045087 GO:0048839 GO:0048286 GO:0050919 GO:0010512 GO:0010544 GO:0048011 GO:0009887 GO:0048015 GO:0030168 GO:0002576 GO:0048008 GO:0051781 GO:0030335 GO:0008284 GO:0045740 GO:0070374 GO:0048146 GO:0043406 GO:0043410 GO:0002053 GO:0035793 GO:0014068 GO:0031954 GO:0051897 GO:0032956 GO:0060683 GO:0050730 GO:0014910 GO:0042493 GO:0032355 GO:0001666 GO:0010035 GO:0032526 GO:0009611 GO:0043588 GO:0007179 GO:0042060
Gene3D	2.10.90.10
InterPro	IPR029034 IPR023581 IPR000072 IPR006782
Pfam	PF00341 PF04692
SMART	SM00141
SUPFAM	SSF57501
PROSITE	PS00249 PS50278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1990401	embryonic lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:9409235^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	PMID:7073684^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01127	F	Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:2439522^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:10806482^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:2836953^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:2439522^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:2536956^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7073684^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01127	F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:2439522^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10806482^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:2836953^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:3754619^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17470632^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014910	regulation of smooth muscle cell migration	PMID:9409235^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010544	negative regulation of platelet activation	PMID:2538439^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	PMID:2538439^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:2538439^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:2836953^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:291037^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:2538439^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:2836953^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17470632^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7073684^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:3754619^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:2536956^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16234	F	Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:2836953^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:2439522^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|involved_in	GO:2000278	regulation of DNA biosynthetic process	PMID:11788434^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:2000278	regulation of DNA biosynthetic process	PMID:19019919^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0072124	regulation of glomerular mesangial cell proliferation	PMID:11788434^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:11788434^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060683	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:19019919^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:11788434^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:11788434^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	PMID:19019919^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:12070119^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:11788434^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:11788434^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:12070119^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	C	Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20033	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000180420 UniProtKB:P01127 UniProtKB:P04085	P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859631 PANTHER:PTN000180420 RGD:3283 UniProtKB:P01127 UniProtKB:P04085 UniProtKB:Q9NRA1	P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000180420 RGD:3283 UniProtKB:P01127 UniProtKB:P04085	P	Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000908679 UniProtKB:P01127 UniProtKB:P04085	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97528 PANTHER:PTN000180420 UniProtKB:B1H0W5 UniProtKB:P01127 UniProtKB:P04085	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97528 PANTHER:PTN000180420 UniProtKB:P01127 UniProtKB:P04085	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859631 MGI:MGI:97527 PANTHER:PTN000908679 RGD:3282 UniProtKB:P01127 UniProtKB:P04085 UniProtKB:Q9NRA1	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97527 PANTHER:PTN000908679 RGD:3283 RGD:621880 UniProtKB:P04085 UniProtKB:Q9NRA1	C	Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1859631 PANTHER:PTN000180420 UniProtKB:P01127 UniProtKB:P04085 UniProtKB:Q9NRA1	F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:16462734^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005518	collagen binding	PMID:8900172^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072 InterPro:IPR006782	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072 InterPro:IPR006782	C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20534510^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04085-1	F	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:2842868^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:10508235^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:10508235^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001775	cell activation	PMID:10508235^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	Reactome:R-HSA-186785 Reactome:R-HSA-8865276 Reactome:R-HSA-382053	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	Reactome:R-HSA-1474244	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005796	Golgi lumen	Reactome:R-HSA-8865276 Reactome:R-HSA-186785	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-382053	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8865276 Reactome:R-HSA-8864036 Reactome:R-HSA-5672965 Reactome:R-HSA-481007 Reactome:R-HSA-389086 Reactome:R-HSA-389083 Reactome:R-HSA-382058 Reactome:R-HSA-382056 Reactome:R-HSA-382055 Reactome:R-HSA-382054 Reactome:R-HSA-382052 Reactome:R-HSA-380782 Reactome:R-HSA-380780 Reactome:R-HSA-2400009 Reactome:R-HSA-2396337 Reactome:R-HSA-2316434 Reactome:R-HSA-186834 Reactome:R-HSA-186826 Reactome:R-HSA-186819 Reactome:R-HSA-186800 Reactome:R-HSA-186785 Reactome:R-HSA-186780 Reactome:R-HSA-186778 Reactome:R-HSA-186773 Reactome:R-HSA-186765 Reactome:R-HSA-1524186 Reactome:R-HSA-1524182	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Clunn, GF et al. (1997) Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 17 2622-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Johnsson, A et al. (1982) Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem. Biophys. Res. Commun. 104 66-74 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Womer, RB et al. (1987) PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication. J. Cell. Physiol. 132 65-72 PubMed GONUTS page
↑ ^4.0 ^4.1 Li, X et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2 302-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Escobedo, JA et al. (1988) A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science 240 1532-4 PubMed GONUTS page
↑ ^6.0 ^6.1 Matsui, T et al. (1989) Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243 800-4 PubMed GONUTS page
↑ ^7.0 ^7.1 Betsholtz, C et al. () cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320 695-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Ball, SG et al. (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol. 177 489-500 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Bryckaert, MC et al. (1989) Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation. J. Biol. Chem. 264 4336-41 PubMed GONUTS page
↑ Heldin, CH et al. (1979) Platelet-derived growth factor: purification and partial characterization. Proc. Natl. Acad. Sci. U.S.A. 76 3722-6 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Ricono, JM et al. (2002) Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells. Am. J. Physiol. Renal Physiol. 282 F211-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Ricono, JM et al. (2009) PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am. J. Physiol. Renal Physiol. 296 F406-17 PubMed GONUTS page
↑ ^13.0 ^13.1 Arita, Y et al. (2002) Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105 2893-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Le Bras, B et al. (2006) VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat. Neurosci. 9 340-8 PubMed GONUTS page
↑ Somasundaram, R & Schuppan, D (1996) Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB). J. Biol. Chem. 271 26884-91 PubMed GONUTS page
↑ Shim, AH et al. (2010) Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc. Natl. Acad. Sci. U.S.A. 107 11307-12 PubMed GONUTS page
↑ Beckmann, MP et al. (1988) Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 241 1346-9 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Heldin, CH & Westermark, B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79 1283-316 PubMed GONUTS page

[PMID:9409235-1] 1.0 ^1.1 Clunn, GF et al. (1997) Platelet-derived growth factor beta-receptors can both promote and inhibit chemotaxis in human vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 17 2622-9 PubMed GONUTS page

[PMID:7073684-2] 2.0 ^2.1 ^2.2 Johnsson, A et al. (1982) Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem. Biophys. Res. Commun. 104 66-74 PubMed GONUTS page

[PMID:2439522-3] 3.0 ^3.1 ^3.2 ^3.3 Womer, RB et al. (1987) PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication. J. Cell. Physiol. 132 65-72 PubMed GONUTS page

[PMID:10806482-4] 4.0 ^4.1 Li, X et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2 302-9 PubMed GONUTS page

[PMID:2836953-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Escobedo, JA et al. (1988) A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science 240 1532-4 PubMed GONUTS page

[PMID:2536956-6] 6.0 ^6.1 Matsui, T et al. (1989) Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science 243 800-4 PubMed GONUTS page

[PMID:3754619-7] 7.0 ^7.1 Betsholtz, C et al. () cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature 320 695-9 PubMed GONUTS page

[PMID:17470632-8] 8.0 ^8.1 Ball, SG et al. (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol. 177 489-500 PubMed GONUTS page

[PMID:2538439-9] 9.0 ^9.1 ^9.2 ^9.3 Bryckaert, MC et al. (1989) Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation. J. Biol. Chem. 264 4336-41 PubMed GONUTS page

[PMID:291037-10] Heldin, CH et al. (1979) Platelet-derived growth factor: purification and partial characterization. Proc. Natl. Acad. Sci. U.S.A. 76 3722-6 PubMed GONUTS page

[PMID:11788434-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Ricono, JM et al. (2002) Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells. Am. J. Physiol. Renal Physiol. 282 F211-9 PubMed GONUTS page

[PMID:19019919-12] 12.0 ^12.1 ^12.2 Ricono, JM et al. (2009) PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am. J. Physiol. Renal Physiol. 296 F406-17 PubMed GONUTS page

[PMID:12070119-13] 13.0 ^13.1 Arita, Y et al. (2002) Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105 2893-8 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16462734-15] Le Bras, B et al. (2006) VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat. Neurosci. 9 340-8 PubMed GONUTS page

[PMID:8900172-16] Somasundaram, R & Schuppan, D (1996) Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB). J. Biol. Chem. 271 26884-91 PubMed GONUTS page

[PMID:20534510-17] Shim, AH et al. (2010) Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc. Natl. Acad. Sci. U.S.A. 107 11307-12 PubMed GONUTS page

[PMID:2842868-18] Beckmann, MP et al. (1988) Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science 241 1346-9 PubMed GONUTS page

[PMID:10508235-19] 19.0 ^19.1 ^19.2 Heldin, CH & Westermark, B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79 1283-316 PubMed GONUTS page

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