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PMID:16462734
| Citation |
Le Bras, B, Barallobre, MJ, Homman-Ludiye, J, Ny, A, Wyns, S, Tammela, T, Haiko, P, Karkkainen, MJ, Yuan, L, Muriel, MP, Chatzopoulou, E, Bréant, C, Zalc, B, Carmeliet, P, Alitalo, K, Eichmann, A and Thomas, JL (2006) VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat. Neurosci. 9:340-8 |
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| Abstract |
Vascular endothelial growth factor C (VEGF-C) was first identified as a regulator of the vascular system, where it is required for the development of lymphatic vessels. Here we report actions of VEGF-C in the central nervous system. We detected the expression of the VEGF-C receptor VEGFR-3 in neural progenitor cells in Xenopus laevis and mouse embryos. In Xenopus tadpole VEGF-C knockdowns and in mice lacking Vegfc, the proliferation of neural progenitors expressing VEGFR-3 was severely reduced, in the absence of intracerebral blood vessel defects. In addition, Vegfc-deficient mouse embryos showed a selective loss of oligodendrocyte precursor cells (OPCs) in the embryonic optic nerve. In vitro, VEGF-C stimulated the proliferation of OPCs expressing VEGFR-3 and nestin-positive ventricular neural cells. VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3. |
| Links |
PubMed Online version:10.1038/nn1646 |
| Keywords |
Animals; Brain/cytology; Brain/embryology; Brain/metabolism; Cell Differentiation/physiology; Cells, Cultured; Evolution, Molecular; Intermediate Filament Proteins/metabolism; Larva; Lateral Ventricles/cytology; Lateral Ventricles/embryology; Lateral Ventricles/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Nerve Growth Factors/metabolism; Nerve Tissue Proteins/metabolism; Neurons/cytology; Neurons/metabolism; Oligodendroglia/cytology; Oligodendroglia/metabolism; Optic Nerve/cytology; Optic Nerve/embryology; Optic Nerve/metabolism; Rats; Rats, Wistar; Stem Cells/cytology; Stem Cells/metabolism; Vascular Endothelial Growth Factor C/genetics; Vascular Endothelial Growth Factor C/metabolism; Vascular Endothelial Growth Factor Receptor-3/metabolism; Xenopus laevis |
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Significance
Annotations
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