HUMAN:PAK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PAK1
Protein Name(s)	Serine/threonine-protein kinase PAK 1 Alpha-PAK p21-activated kinase 1 PAK-1 p65-PAK
External Links
UniProt	Q13153
EMBL	U51120 U24152 AF071884 AP000486 AP003680 BC109299
CCDS	CCDS44687.1 CCDS8250.1
PIR	G01773
RefSeq	NP_001122092.1 NP_002567.3 XP_005274082.1 XP_006718636.1 XP_006718637.1 XP_006718638.1 XP_006718639.1
UniGene	Hs.435714
PDB	1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90
PDBsum	1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90
ProteinModelPortal	Q13153
SMR	Q13153
BioGrid	111095
DIP	DIP-31016N
IntAct	Q13153
MINT	MINT-92897
STRING	9606.ENSP00000278568
BindingDB	Q13153
ChEMBL	CHEMBL4600
GuidetoPHARMACOLOGY	2133
PhosphoSite	Q13153
DMDM	90111767
MaxQB	Q13153
PaxDb	Q13153
PRIDE	Q13153
DNASU	5058
Ensembl	ENST00000278568 ENST00000356341
GeneID	5058
KEGG	hsa:5058
UCSC	uc001oyg.4 uc001oyh.4
CTD	5058
GeneCards	GC11M077033
HGNC	HGNC:8590
HPA	CAB005312 HPA003565
MIM	602590
neXtProt	NX_Q13153
PharmGKB	PA32917
eggNOG	COG0515
GeneTree	ENSGT00760000119176
HOGENOM	HOG000234202
HOVERGEN	HBG108518
InParanoid	Q13153
KO	K04409
OMA	MIVASIP
OrthoDB	EOG7CK36J
PhylomeDB	Q13153
TreeFam	TF105351
BRENDA	2.7.11.1
Reactome	REACT_12623 REACT_160086 REACT_163701 REACT_19226 REACT_19236 REACT_19238 REACT_22272 REACT_228016 REACT_228085 REACT_228226 REACT_25299
SignaLink	Q13153
ChiTaRS	PAK1
EvolutionaryTrace	Q13153
GeneWiki	PAK1
GenomeRNAi	5058
NextBio	19488
PRO	PR:Q13153
Proteomes	UP000005640
Bgee	Q13153
CleanEx	HS_PAK1
ExpressionAtlas	Q13153
Genevestigator	Q13153
GO	GO:0030424 GO:0005911 GO:0005737 GO:0005829 GO:0030425 GO:0005925 GO:0030426 GO:0014704 GO:0031965 GO:0005886 GO:0043234 GO:0001726 GO:0032587 GO:0030018 GO:0005524 GO:0005518 GO:0004672 GO:0004674 GO:0031532 GO:0006915 GO:0007411 GO:0048754 GO:0032869 GO:0016358 GO:0006887 GO:0038095 GO:0038096 GO:0045087 GO:0060244 GO:0007528 GO:0048812 GO:0033148 GO:0043507 GO:0033138 GO:0001934 GO:0051496 GO:0046777 GO:0006468 GO:0043113 GO:0001666 GO:0031295 GO:0050852 GO:0042060
Gene3D	3.90.810.10
InterPro	IPR000095 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00786 PF00069
SMART	SM00285 SM00220
SUPFAM	SSF56112
PROSITE	PS50108 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:23260667^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:23260667^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:23260667^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0048365	Rac GTPase binding	PMID:11950598^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O55043,UniProtKB:Q9DE64	F	has_input:(UniProtKB:O93466)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11950598^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:23260667^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23260667^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23260667^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:23333386^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0002619)	Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	PMID:25198505^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
involved_in	GO:0031116	positive regulation of microtubule polymerization	PMID:25198505^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25766321^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071437	invadopodium	PMID:25766321^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:25766321^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16278681^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16278681^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060244	negative regulation of cell proliferation involved in contact inhibition	PMID:12912914^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	PMID:11864573^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35465	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:20457839^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:8805275^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	PMID:8805275^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11864573^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:12912914^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	PMID:16278681^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19667065^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35465	C		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:9395435^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:16278681^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:9395435^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35465	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35465	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35465	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35465	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9852149^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:12912914^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	PMID:12189148^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18669	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16278681^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19667065^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:8805275^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9852149^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:23633677^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	PMID:12912914^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|involved_in	GO:0000165	MAPK cascade	PMID:8805275^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050770	regulation of axonogenesis	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267698 PANTHER:PTN000685295	P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0267698 PANTHER:PTN002390586 UniProtKB:A0A0B4KGS4 UniProtKB:Q13153 UniProtKB:Q13177 WB:WBGene00003144	F		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339975 PANTHER:PTN002390586	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002390586 WB:WBGene00003144 WB:WBGene00003911	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11278486^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10559936^[18]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
involved_in	GO:0010763	positive regulation of fibroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	F		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35465 ensembl:ENSRNOP00000073036	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033923	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22153498^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13153-1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17389360^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13153-1	F		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-389356	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3928640 Reactome:R-HSA-3928625 Reactome:R-HSA-3928620 Reactome:R-HSA-3928619	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8964634 Reactome:R-HSA-8964619 Reactome:R-HSA-8964614 Reactome:R-HSA-8964605 Reactome:R-HSA-8964604 Reactome:R-HSA-8964599 Reactome:R-HSA-5687086 Reactome:R-HSA-5669250 Reactome:R-HSA-5669240 Reactome:R-HSA-5669158 Reactome:R-HSA-5668947 Reactome:R-HSA-5627775 Reactome:R-HSA-5624492 Reactome:R-HSA-5357483 Reactome:R-HSA-5357477 Reactome:R-HSA-5357472 Reactome:R-HSA-5357445 Reactome:R-HSA-451366 Reactome:R-HSA-451347 Reactome:R-HSA-445072 Reactome:R-HSA-430183 Reactome:R-HSA-399952 Reactome:R-HSA-399939 Reactome:R-HSA-399930 Reactome:R-HSA-3928641 Reactome:R-HSA-3928625 Reactome:R-HSA-3928619 Reactome:R-HSA-389788 Reactome:R-HSA-376123 Reactome:R-HSA-2730889 Reactome:R-HSA-2730856 Reactome:R-HSA-2029460 Reactome:R-HSA-2029456 Reactome:R-HSA-2029454	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-5669250 Reactome:R-HSA-399952 Reactome:R-HSA-399939 Reactome:R-HSA-3928640 Reactome:R-HSA-3928625 Reactome:R-HSA-3928620	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0268	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
part_of	GO:0071437	invadopodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0148	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Li, DQ et al. (2012) MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep 2 1657-69 PubMed GONUTS page
↑ ^2.0 ^2.1 Paris, S et al. (2002) Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker. Int. J. Biochem. Cell Biol. 34 826-37 PubMed GONUTS page
↑ Zhang, X et al. (2013) Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway. Biochem. Biophys. Res. Commun. 431 404-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Tian, X et al. (2014) Microtubule dynamics control HGF-induced lung endothelial barrier enhancement. PLoS ONE 9 e105912 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wang, G et al. (2015) PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion. Cell Death Dis 6 e1682 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Talukder, AH et al. (2006) CRIPak, a novel endogenous Pak1 inhibitor. Oncogene 25 1311-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Zegers, MM et al. (2003) Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J. 22 4155-65 PubMed GONUTS page
↑ ^8.0 ^8.1 Koh, CG et al. (2002) The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr. Biol. 12 317-21 PubMed GONUTS page
↑ Hunter, MP & Zegers, MM (2010) Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism. Am. J. Physiol., Cell Physiol. 299 C21-32 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Brown, JL et al. (1996) Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6 598-605 PubMed GONUTS page
↑ ^11.0 ^11.1 Polzien, L et al. (2009) Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J. Biol. Chem. 284 28004-20 PubMed GONUTS page
↑ ^12.0 ^12.1 Sells, MA et al. (1997) Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7 202-10 PubMed GONUTS page
↑ ^13.0 ^13.1 Buss, F et al. (1998) The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. J. Cell Biol. 143 1535-45 PubMed GONUTS page
↑ Shalom-Barak, T & Knaus, UG (2002) A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. J. Biol. Chem. 277 40659-65 PubMed GONUTS page
↑ Borroni, EM et al. (2013) β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Sci Signal 6 ra30.1-11, S1-3 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chong, C et al. (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276 17347-53 PubMed GONUTS page
↑ Edwards, DC et al. (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1 253-9 PubMed GONUTS page
↑ Wang, J et al. (2011) Structural insights into the autoactivation mechanism of p21-activated protein kinase. Structure 19 1752-61 PubMed GONUTS page
↑ Meng, Q et al. (2007) Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc. Natl. Acad. Sci. U.S.A. 104 5866-71 PubMed GONUTS page

[PMID:23260667-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Li, DQ et al. (2012) MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response. Cell Rep 2 1657-69 PubMed GONUTS page

[PMID:11950598-2] 2.0 ^2.1 Paris, S et al. (2002) Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker. Int. J. Biochem. Cell Biol. 34 826-37 PubMed GONUTS page

[PMID:23333386-3] Zhang, X et al. (2013) Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway. Biochem. Biophys. Res. Commun. 431 404-8 PubMed GONUTS page

[PMID:25198505-4] 4.0 ^4.1 Tian, X et al. (2014) Microtubule dynamics control HGF-induced lung endothelial barrier enhancement. PLoS ONE 9 e105912 PubMed GONUTS page

[PMID:25766321-5] 5.0 ^5.1 ^5.2 Wang, G et al. (2015) PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion. Cell Death Dis 6 e1682 PubMed GONUTS page

[PMID:16278681-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Talukder, AH et al. (2006) CRIPak, a novel endogenous Pak1 inhibitor. Oncogene 25 1311-9 PubMed GONUTS page

[PMID:12912914-7] 7.0 ^7.1 ^7.2 ^7.3 Zegers, MM et al. (2003) Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J. 22 4155-65 PubMed GONUTS page

[PMID:11864573-8] 8.0 ^8.1 Koh, CG et al. (2002) The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr. Biol. 12 317-21 PubMed GONUTS page

[PMID:20457839-9] Hunter, MP & Zegers, MM (2010) Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism. Am. J. Physiol., Cell Physiol. 299 C21-32 PubMed GONUTS page

[PMID:8805275-10] 10.0 ^10.1 ^10.2 ^10.3 Brown, JL et al. (1996) Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6 598-605 PubMed GONUTS page

[PMID:19667065-11] 11.0 ^11.1 Polzien, L et al. (2009) Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J. Biol. Chem. 284 28004-20 PubMed GONUTS page

[PMID:9395435-12] 12.0 ^12.1 Sells, MA et al. (1997) Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr. Biol. 7 202-10 PubMed GONUTS page

[PMID:9852149-13] 13.0 ^13.1 Buss, F et al. (1998) The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. J. Cell Biol. 143 1535-45 PubMed GONUTS page

[PMID:12189148-14] Shalom-Barak, T & Knaus, UG (2002) A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase. J. Biol. Chem. 277 40659-65 PubMed GONUTS page

[PMID:23633677-15] Borroni, EM et al. (2013) β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Sci Signal 6 ra30.1-11, S1-3 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11278486-17] Chong, C et al. (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 276 17347-53 PubMed GONUTS page

[PMID:10559936-18] Edwards, DC et al. (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat. Cell Biol. 1 253-9 PubMed GONUTS page

[PMID:22153498-19] Wang, J et al. (2011) Structural insights into the autoactivation mechanism of p21-activated protein kinase. Structure 19 1752-61 PubMed GONUTS page

[PMID:17389360-20] Meng, Q et al. (2007) Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1. Proc. Natl. Acad. Sci. U.S.A. 104 5866-71 PubMed GONUTS page

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HUMAN:PAK1

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