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HUMAN:NF2L2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | NFE2L2 (synonyms: NRF2) | |
Protein Name(s) | Nuclear factor erythroid 2-related factor 2
NF-E2-related factor 2 NFE2-related factor 2 HEBP1 Nuclear factor, erythroid derived 2, like 2 | |
External Links | ||
UniProt | Q16236 | |
EMBL | AK304555 AK314816 AB208786 AC019080 AC079305 CH471058 BC011558 AL135266 S74017 | |
CCDS | CCDS42782.1 CCDS46457.1 CCDS46458.1 | |
RefSeq | NP_001138884.1 NP_001138885.1 NP_006155.2 | |
UniGene | Hs.744006 | |
PDB | 2FLU 2LZ1 3ZGC 4IFL | |
PDBsum | 2FLU 2LZ1 3ZGC 4IFL | |
ProteinModelPortal | Q16236 | |
SMR | Q16236 | |
BioGrid | 110852 | |
DIP | DIP-29971N | |
IntAct | Q16236 | |
MINT | MINT-2844437 | |
STRING | 9606.ENSP00000380252 | |
ChEMBL | CHEMBL3038498 | |
PhosphoSite | Q16236 | |
DMDM | 25453452 | |
MaxQB | Q16236 | |
PaxDb | Q16236 | |
PRIDE | Q16236 | |
DNASU | 4780 | |
Ensembl | ENST00000397062 ENST00000397063 ENST00000446151 ENST00000464747 | |
GeneID | 4780 | |
KEGG | hsa:4780 | |
UCSC | uc002ulg.5 | |
CTD | 4780 | |
GeneCards | GC02M178092 | |
HGNC | HGNC:7782 | |
HPA | CAB020317 HPA002990 HPA043438 | |
MIM | 600492 | |
neXtProt | NX_Q16236 | |
PharmGKB | PA31588 | |
eggNOG | NOG309753 | |
GeneTree | ENSGT00550000074399 | |
HOGENOM | HOG000234410 | |
HOVERGEN | HBG052609 | |
InParanoid | Q16236 | |
KO | K05638 | |
OMA | TKDKHSS | |
OrthoDB | EOG715Q3N | |
PhylomeDB | Q16236 | |
TreeFam | TF326681 | |
SignaLink | Q16236 | |
ChiTaRS | NFE2L2 | |
EvolutionaryTrace | Q16236 | |
GeneWiki | NFE2L2 | |
GenomeRNAi | 4780 | |
NextBio | 18432 | |
PMAP-CutDB | Q16236 | |
PRO | PR:Q16236 | |
Proteomes | UP000005640 | |
Bgee | Q16236 | |
CleanEx | HS_NFE2L2 | |
ExpressionAtlas | Q16236 | |
Genevestigator | Q16236 | |
GO | GO:0005813 GO:0000785 GO:0005737 GO:0005829 GO:0005634 GO:0005886 GO:0003677 GO:0019904 GO:0001102 GO:0000980 GO:0001205 GO:0003700 GO:0044212 GO:0000976 GO:0070301 GO:0071499 GO:0071356 GO:0030968 GO:2000352 GO:1903206 GO:1902176 GO:0030194 GO:0010628 GO:2000379 GO:0045944 GO:0036091 GO:0036003 GO:0010499 GO:0043161 GO:0016567 GO:0045995 GO:2000121 GO:0006366 | |
Gene3D | 1.10.880.10 | |
InterPro | IPR004827 IPR004826 IPR029845 IPR008917 | |
PANTHER | PTHR24411:SF3 | |
Pfam | PF03131 | |
SMART | SM00338 | |
SUPFAM | SSF47454 | |
PROSITE | PS50217 PS00036 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
P |
Figure 3b: knockdown of Nrf2 prevents tBHQ-induced expression of the IR (insulin receptor) gene |
complete | |||||
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061419 |
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_transcription_of:(ENSEMBL:ENSG00000100292) |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0036499 |
PERK-mediated unfolded protein response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
exists_during:(GO:0034976) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071498 |
cellular response to fluid shear stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P15559) |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(UniProtKB:P15559) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000305 |
curator inference used in manual assertion |
GO:0003700 GO:0010628 |
P |
has_regulation_target:(UniProtKB:P10599) |
Seeded From UniProt |
complete | |
involved_in |
GO:1903206 |
negative regulation of hydrogen peroxide-induced cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P10599) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000352 |
negative regulation of endothelial cell apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002618) |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902176 |
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0002618) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071499 |
cellular response to laminar fluid shear stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0036003 |
positive regulation of transcription from RNA polymerase II promoter in response to stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0001102 |
RNA polymerase II activating transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010499 |
proteasomal ubiquitin-independent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000540) |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_in:(CL:0000540) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108420 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108420 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108420 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108420 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108420 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000696622 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1904753 |
negative regulation of vascular associated smooth muscle cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904385 |
cellular response to angiotensin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060548 |
negative regulation of cell death |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046223 |
aflatoxin catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036091 |
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010976 |
positive regulation of neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007568 |
aging |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0001221 |
transcription cofactor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O54968 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000121 |
regulation of removal of superoxide radicals |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1903788 |
positive regulation of glutathione biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902037 |
negative regulation of hematopoietic stem cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0061396 |
regulation of transcription from RNA polymerase II promoter in response to copper ion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046326 |
positive regulation of glucose import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045995 |
regulation of embryonic development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042149 |
cellular response to glucose starvation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0036499 |
PERK-mediated unfolded protein response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030194 |
positive regulation of blood coagulation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008134 |
transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000785 |
chromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60795 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903071 |
positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0036499 |
PERK-mediated unfolded protein response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
has_input:(UniProtKB:P15559) |
Seeded From UniProt |
complete | ||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
has_input:(UniProtKB:P10599) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006366 |
transcription by RNA polymerase II |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Barthel, SR et al. (2016) Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor. Cell. Mol. Life Sci. 73 4121-40 PubMed GONUTS page
- ↑ Huppke, P et al. (2017) Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. Nat Commun 8 818 PubMed GONUTS page
- ↑ 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page
- ↑ Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page
- ↑ 6.0 6.1 Martin, D et al. (2014) Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J. Biol. Chem. 289 30625-34 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Im, JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum. Mol. Genet. 21 3013-24 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Kim, M et al. (2012) Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J. Biol. Chem. 287 40722-31 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Rushworth, SA & MacEwan, DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111 3793-801 PubMed GONUTS page
- ↑ 11.0 11.1 Zhang, DD et al. (2005) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 280 30091-9 PubMed GONUTS page
- ↑ Wang, Y et al. (2001) Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. Biochem. J. 355 45-9 PubMed GONUTS page
- ↑ Wang, XJ & Zhang, DD (2009) Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS ONE 4 e5492 PubMed GONUTS page
- ↑ 14.0 14.1 Hwang, YP et al. (2008) Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner. Toxicol. Appl. Pharmacol. 231 318-27 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 15.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Digaleh, H et al. (2013) Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy. Cell. Mol. Life Sci. 70 4681-94 PubMed GONUTS page
- ↑ 17.0 17.1 Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
- ↑ Dias, V et al. (2013) The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3 461-91 PubMed GONUTS page
- ↑ 19.0 19.1 Moi, P et al. (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 91 9926-30 PubMed GONUTS page
c
- Catarrhini
- GO:0070301 ! cellular response to hydrogen peroxide
- GO:0071356 ! cellular response to tumor necrosis factor
- GO:0071499 ! cellular response to laminar fluid shear stress
- GO:1904385 ! cellular response to angiotensin
- GO:0071456 ! cellular response to hypoxia
- GO:0042149 ! cellular response to glucose starvation
- GO:0035690 ! cellular response to drug
- GO:0071498 ! cellular response to fluid shear stress
- GO:0034599 ! cellular response to oxidative stress
- GO:0045454 ! cell redox homeostasis
- GO:0005813 ! centrosome
- Chordata
- GO:0000785 ! chromatin
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
d
e
n
- GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
- GO:1902037 ! negative regulation of hematopoietic stem cell differentiation
- GO:0010667 ! negative regulation of cardiac muscle cell apoptotic process
- GO:2000352 ! negative regulation of endothelial cell apoptotic process
- GO:1904753 ! negative regulation of vascular associated smooth muscle cell migration
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
- GO:0007568 ! obsolete aging
- GO:0060548 ! obsolete negative regulation of cell death
- GO:1903206 ! obsolete negative regulation of hydrogen peroxide-induced cell death
- GO:0036091 ! obsolete positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
- GO:0061419 ! obsolete positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
- GO:0036003 ! obsolete positive regulation of transcription from RNA polymerase II promoter in response to stress
- GO:1903071 ! obsolete positive regulation of ER-associated ubiquitin-dependent protein catabolic process
- GO:0061396 ! obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion
p
- GO:0036499 ! PERK-mediated unfolded protein response
- GO:0005886 ! plasma membrane
- GO:0030194 ! positive regulation of blood coagulation
- GO:0010628 ! positive regulation of gene expression
- GO:0043536 ! positive regulation of blood vessel endothelial cell migration
- GO:0010976 ! positive regulation of neuron projection development
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0046326 ! positive regulation of D-glucose import
- GO:0045766 ! positive regulation of angiogenesis
- GO:2000379 ! positive regulation of reactive oxygen species metabolic process
- GO:1903788 ! positive regulation of glutathione biosynthetic process
- Primates
- GO:0010499 ! proteasomal ubiquitin-independent protein catabolic process
- GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process
- GO:0032993 ! protein-DNA complex
- GO:0019904 ! protein domain specific binding
- GO:0016567 ! protein ubiquitination
r
- GO:0045995 ! regulation of embryonic development
- GO:2000121 ! regulation of removal of superoxide radicals
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0034976 ! response to endoplasmic reticulum stress
- GO:0000980 ! RNA polymerase II distal enhancer sequence-specific DNA binding
- GO:0001102 ! RNA polymerase II activating transcription factor binding
t