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HUMAN:NF2L2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NFE2L2 (synonyms: NRF2)
Protein Name(s) Nuclear factor erythroid 2-related factor 2

NF-E2-related factor 2 NFE2-related factor 2 HEBP1 Nuclear factor, erythroid derived 2, like 2

External Links
UniProt Q16236
EMBL AK304555
AK314816
AB208786
AC019080
AC079305
CH471058
BC011558
AL135266
S74017
CCDS CCDS42782.1
CCDS46457.1
CCDS46458.1
RefSeq NP_001138884.1
NP_001138885.1
NP_006155.2
UniGene Hs.744006
PDB 2FLU
2LZ1
3ZGC
4IFL
PDBsum 2FLU
2LZ1
3ZGC
4IFL
ProteinModelPortal Q16236
SMR Q16236
BioGrid 110852
DIP DIP-29971N
IntAct Q16236
MINT MINT-2844437
STRING 9606.ENSP00000380252
ChEMBL CHEMBL3038498
PhosphoSite Q16236
DMDM 25453452
MaxQB Q16236
PaxDb Q16236
PRIDE Q16236
DNASU 4780
Ensembl ENST00000397062
ENST00000397063
ENST00000446151
ENST00000464747
GeneID 4780
KEGG hsa:4780
UCSC uc002ulg.5
CTD 4780
GeneCards GC02M178092
HGNC HGNC:7782
HPA CAB020317
HPA002990
HPA043438
MIM 600492
neXtProt NX_Q16236
PharmGKB PA31588
eggNOG NOG309753
GeneTree ENSGT00550000074399
HOGENOM HOG000234410
HOVERGEN HBG052609
InParanoid Q16236
KO K05638
OMA TKDKHSS
OrthoDB EOG715Q3N
PhylomeDB Q16236
TreeFam TF326681
SignaLink Q16236
ChiTaRS NFE2L2
EvolutionaryTrace Q16236
GeneWiki NFE2L2
GenomeRNAi 4780
NextBio 18432
PMAP-CutDB Q16236
PRO PR:Q16236
Proteomes UP000005640
Bgee Q16236
CleanEx HS_NFE2L2
ExpressionAtlas Q16236
Genevestigator Q16236
GO GO:0005813
GO:0000785
GO:0005737
GO:0005829
GO:0005634
GO:0005886
GO:0003677
GO:0019904
GO:0001102
GO:0000980
GO:0001205
GO:0003700
GO:0044212
GO:0000976
GO:0070301
GO:0071499
GO:0071356
GO:0030968
GO:2000352
GO:1903206
GO:1902176
GO:0030194
GO:0010628
GO:2000379
GO:0045944
GO:0036091
GO:0036003
GO:0010499
GO:0043161
GO:0016567
GO:0045995
GO:2000121
GO:0006366
Gene3D 1.10.880.10
InterPro IPR004827
IPR004826
IPR029845
IPR008917
PANTHER PTHR24411:SF3
Pfam PF03131
SMART SM00338
SUPFAM SSF47454
PROSITE PS50217
PS00036

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010628

positive regulation of gene expression

PMID:27155659[1]

ECO:0000315

P

Figure 3b: knockdown of Nrf2 prevents tBHQ-induced expression of the IR (insulin receptor) gene

complete
CACAO 12127

involved_in

GO:0045454

cell redox homeostasis

PMID:29018201[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[3]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR004827
InterPro:IPR008917

F

Seeded From UniProt

complete

involved_in

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

PMID:24844779[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSG00000100292)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P09450

F

Seeded From UniProt

complete

involved_in

GO:0036499

PERK-mediated unfolded protein response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60795

P

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60795

C

exists_during:(GO:0034976)

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60795

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:22013210[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071498

cellular response to fluid shear stress

PMID:25190803[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:25190803[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17015834[7]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P15559)

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:17015834[7]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(UniProtKB:P15559)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22492997[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22492997[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22492997[8]

ECO:0000305

curator inference used in manual assertion

GO:0003700
GO:0010628

P

has_regulation_target:(UniProtKB:P10599)

Seeded From UniProt

complete

involved_in

GO:1903206

negative regulation of hydrogen peroxide-induced cell death

PMID:22492997[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q99497

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22492997[8]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q99497

P

has_regulation_target:(UniProtKB:P10599)

Seeded From UniProt

complete

involved_in

GO:2000352

negative regulation of endothelial cell apoptotic process

PMID:23043106[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

involved_in

GO:1902176

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

PMID:23043106[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

involved_in

GO:0071499

cellular response to laminar fluid shear stress

PMID:23043106[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

PMID:18202225[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

PMID:23043106[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18202225[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036003

positive regulation of transcription from RNA polymerase II promoter in response to stress

PMID:23043106[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:23043106[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18202225[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23043106[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001102

RNA polymerase II activating transcription factor binding

PMID:23043106[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13164

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:15983046[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:11256947[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q6P1K2

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:15983046[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010499

proteasomal ubiquitin-independent protein catabolic process

PMID:19424503[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18554677[14]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000540)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:18554677[14]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(CL:0000540)

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108420
PANTHER:PTN000696622

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108420
PANTHER:PTN000696686

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108420
PANTHER:PTN000696622
RGD:620360
UniProtKB:Q16236

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108420
MGI:MGI:97308
MGI:MGI:99421
PANTHER:PTN000696622
RGD:620360
UniProtKB:Q14494
UniProtKB:Q16236
ZFIN:ZDB-GENE-030723-2

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108420
PANTHER:PTN000696622
UniProtKB:Q16236
ZFIN:ZDB-GENE-030723-2

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000696622
RGD:620360
ZFIN:ZDB-GENE-030723-2

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1904753

negative regulation of vascular associated smooth muscle cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:1904385

cellular response to angiotensin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0071456

cellular response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0046223

aflatoxin catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

F

Seeded From UniProt

complete

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0036091

positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0010976

positive regulation of neuron projection development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

C

Seeded From UniProt

complete

enables

GO:0001221

transcription cofactor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54968
ensembl:ENSRNOP00000002114

F

Seeded From UniProt

complete

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:2000121

regulation of removal of superoxide radicals

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:1903788

positive regulation of glutathione biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:1902037

negative regulation of hematopoietic stem cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0061396

regulation of transcription from RNA polymerase II promoter in response to copper ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0046326

positive regulation of glucose import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0045995

regulation of embryonic development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0036499

PERK-mediated unfolded protein response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

C

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0030194

positive regulation of blood coagulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

F

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

F

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

F

Seeded From UniProt

complete

part_of

GO:0000785

chromatin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60795
ensembl:ENSMUSP00000099733

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004826
InterPro:IPR008917
InterPro:IPR029845

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004827
InterPro:IPR029845

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004826
InterPro:IPR029845

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029845

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004826
InterPro:IPR004827
InterPro:IPR008917

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029845

P

Seeded From UniProt

complete

involved_in

GO:1903071

positive regulation of ER-associated ubiquitin-dependent protein catabolic process

PMID:23800989[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

PMID:22934019[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036499

PERK-mediated unfolded protein response

PMID:22934019[17]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:17015834[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

has_input:(UniProtKB:P15559)

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:24252804[18]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

has_input:(UniProtKB:P10599)

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:7937919[19]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:7937919[19]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Barthel, SR et al. (2016) Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor. Cell. Mol. Life Sci. 73 4121-40 PubMed GONUTS page
  2. Huppke, P et al. (2017) Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. Nat Commun 8 818 PubMed GONUTS page
  3. 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  4. Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page
  5. Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page
  6. 6.0 6.1 Martin, D et al. (2014) Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J. Biol. Chem. 289 30625-34 PubMed GONUTS page
  7. 7.0 7.1 7.2 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Im, JY et al. (2012) DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway. Hum. Mol. Genet. 21 3013-24 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Kim, M et al. (2012) Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J. Biol. Chem. 287 40722-31 PubMed GONUTS page
  10. 10.0 10.1 10.2 Rushworth, SA & MacEwan, DJ (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 111 3793-801 PubMed GONUTS page
  11. 11.0 11.1 Zhang, DD et al. (2005) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 280 30091-9 PubMed GONUTS page
  12. Wang, Y et al. (2001) Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. Biochem. J. 355 45-9 PubMed GONUTS page
  13. Wang, XJ & Zhang, DD (2009) Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS ONE 4 e5492 PubMed GONUTS page
  14. 14.0 14.1 Hwang, YP et al. (2008) Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner. Toxicol. Appl. Pharmacol. 231 318-27 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 15.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  16. Digaleh, H et al. (2013) Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy. Cell. Mol. Life Sci. 70 4681-94 PubMed GONUTS page
  17. 17.0 17.1 Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
  18. Dias, V et al. (2013) The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3 461-91 PubMed GONUTS page
  19. 19.0 19.1 Moi, P et al. (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 91 9926-30 PubMed GONUTS page