GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:23043106

From GONUTS
Jump to: navigation, search
Citation

Kim, M, Kim, S, Lim, JH, Lee, C, Choi, HC and Woo, CH (2012) Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J. Biol. Chem. 287:40722-31

Abstract

Laminar flow protects from atherosclerosis in endothelium.

Links

PubMed PMC3504785 Online version:10.1074/jbc.M112.381509

Keywords

Animals; Atherosclerosis/enzymology; Atherosclerosis/genetics; Atherosclerosis/physiopathology; Atherosclerosis/prevention & control; Endothelium, Vascular/cytology; Endothelium, Vascular/enzymology; Endothelium, Vascular/metabolism; Human Umbilical Vein Endothelial Cells/enzymology; Human Umbilical Vein Endothelial Cells/metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 7/genetics; Mitogen-Activated Protein Kinase 7/metabolism; NF-E2-Related Factor 2/genetics; NF-E2-Related Factor 2/metabolism; Regional Blood Flow; Transcriptional Activation; Up-Regulation

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:MK07

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:MK07

located_in

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:MK07

involved_in

GO:2000352: negative regulation of endothelial cell apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

HUMAN:MK07

enables

GO:0051019: mitogen-activated protein kinase binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q16236

F

Seeded From UniProt

complete

HUMAN:MK07

involved_in

GO:0071499: cellular response to laminar fluid shear stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MK07

involved_in

GO:0070301: cellular response to hydrogen peroxide

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MK07

involved_in

GO:1902176: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

HUMAN:MK07

involved_in

GO:0036003: positive regulation of transcription from RNA polymerase II promoter in response to stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NF2L2

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:NF2L2

located_in

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:2000352: negative regulation of endothelial cell apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

HUMAN:NF2L2

enables

GO:0061629: RNA polymerase II-specific DNA-binding transcription factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13164

F

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:1902176: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0002618)

Seeded From UniProt

complete

MOUSE:NF2L2

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:NF2L2

located_in

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:NF2L2

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:NF2L2

part_of

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:2000352: negative regulation of endothelial cell apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:1902176: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:0036003: positive regulation of transcription from RNA polymerase II promoter in response to stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NF2L2

enables

GO:0001102: RNA polymerase II activating transcription factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q13164

F

Seeded From UniProt

complete

HUMAN:NF2L2

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:NF2L2

part_of

GO:0005829: cytosol

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:0071499: cellular response to laminar fluid shear stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NF2L2

involved_in

GO:0070301: cellular response to hydrogen peroxide

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KLF2

involved_in

GO:0036003: positive regulation of transcription from RNA polymerase II promoter in response to stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KLF2

involved_in

GO:0071499: cellular response to laminar fluid shear stress

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

See Help:References for how to manage references in GONUTS.