HUMAN:MYC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MYC (synonyms: BHLHE39)
Protein Name(s)	Myc proto-oncogene protein Class E basic helix-loop-helix protein 39 bHLHe39 Proto-oncogene c-Myc Transcription factor p64
External Links
UniProt	P01106
EMBL	L00058 L00057 K00535 K00534 K00535 K00534 X00196 X00198 X00364 V00568 K01906 K01905 K02276 X00676 D10493 D10493 BT019768 AY214166 AK312883 AC103819 CH471060 BC000141 BC000917 BC058901 M13929
CCDS	CCDS6359.2
PIR	A01349 A01350
RefSeq	NP_002458.2
UniGene	Hs.202453
PDB	1A93 1EE4 1MV0 1NKP 2A93 2OR9
PDBsum	1A93 1EE4 1MV0 1NKP 2A93 2OR9
DisProt	DP00260
ProteinModelPortal	P01106
SMR	P01106
BioGrid	110694
DIP	DIP-28143N
IntAct	P01106
MINT	MINT-257327
STRING	9606.ENSP00000367207
BindingDB	P01106
ChEMBL	CHEMBL1250348
DrugBank	DB08813
PhosphoSite	P01106
UniCarbKB	P01106
DMDM	127619
SWISS-2DPAGE	P01106
MaxQB	P01106
PaxDb	P01106
PRIDE	P01106
DNASU	4609
Ensembl	ENST00000377970
GeneID	4609
KEGG	hsa:4609
UCSC	uc003ysi.3 uc022bbe.1
CTD	4609
GeneCards	GC08P128748
H-InvDB	HIX0007784
HGNC	HGNC:7553
HPA	CAB000084 CAB010307
MIM	113970 190080
neXtProt	NX_P01106
Orphanet	543 99861
PharmGKB	PA31353
eggNOG	NOG42590
GeneTree	ENSGT00510000046414
HOGENOM	HOG000043075
HOVERGEN	HBG000472
InParanoid	P01106
KO	K04377
OrthoDB	EOG7GJ6CX
PhylomeDB	P01106
TreeFam	TF106001
BioCyc	MetaCyc:ENSG00000136997-MONOMER
Reactome	REACT_118780 REACT_120734 REACT_160243 REACT_160254 REACT_200799 REACT_9029
SignaLink	P01106
ChiTaRS	MYC
EvolutionaryTrace	P01106
GeneWiki	Myc
GenomeRNAi	4609
NextBio	17740
PRO	PR:P01106
Proteomes	UP000005640
Bgee	P01106
CleanEx	HS_MYC
ExpressionAtlas	P01106
Genevestigator	P01106
GO	GO:0005730 GO:0005654 GO:0005634 GO:0043234 GO:0003677 GO:0070888 GO:0032403 GO:0070491 GO:0000978 GO:0001077 GO:0003700 GO:0008134 GO:0001658 GO:0060070 GO:0007050 GO:0006879 GO:0006974 GO:0035690 GO:0034644 GO:0006338 GO:0051276 GO:0006112 GO:0044346 GO:0010467 GO:0000165 GO:0043066 GO:0051782 GO:0048147 GO:0045656 GO:0032873 GO:0000122 GO:0007219 GO:0015671 GO:0008284 GO:0043280 GO:2000573 GO:0050679 GO:0048146 GO:0002053 GO:0090096 GO:2001022 GO:0045944 GO:0045893 GO:0010468 GO:0032204 GO:0042493 GO:0010332 GO:0070848 GO:0006367 GO:0006351 GO:0007179
Gene3D	4.10.280.10
InterPro	IPR011598 IPR003327 IPR002418 IPR012682
Pfam	PF00010 PF02344 PF01056
PIRSF	PIRSF001705
PRINTS	PR00044
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19786833^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000110092)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:19786833^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:P24385)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:19786833^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:P24385) occurs_at:(SO:0005836)	Seeded From UniProt	complete
involved_in	GO:1905643	positive regulation of DNA methylation	PMID:19786833^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0000122) has_direct_input:(UniProtKB:P24385) occurs_at:(SO:0005836)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR002418 InterPro:IPR011598	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:25775507^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q08874	F		Seeded From UniProt	complete
enables	GO:0001047	core promoter binding	PMID:30873824^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:25956029^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15459207^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0010021) has_regulation_target:(UniProtKB:P04764) happens_during:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:15459207^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0010021)	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:15459207^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0010021) happens_during:(GO:0070371)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15459207^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q01986	P	occurs_in:(CL:0010021) has_regulation_target:(UniProtKB:P04764) happens_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:12837246^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01108	P	regulates_expression_of:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01108	P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0032986	protein-DNA complex disassembly	PMID:19160485^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19160485^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:19160485^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13105	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19160485^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:19160485^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10723141^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:7015)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:10723141^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:10723141^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032204	regulation of telomere maintenance	PMID:17765874^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15358760^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:19179467^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:9924025^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01108	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:18818310^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:15674325^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25490	F		Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	PMID:10962037^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002620)	Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	PMID:10962037^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:18987311^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	PMID:10962037^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:15674325^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:9924025^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:18987311^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9924025^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P48200)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10962037^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P04637)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18818310^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17558397^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045656	negative regulation of monocyte differentiation	PMID:9924025^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19179467^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17873522^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28350	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18291362^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:17873522^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:28748)	Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:19179467^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:50131)	Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:17873522^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032873	negative regulation of stress-activated MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28350	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:18987311^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0015671	oxygen transport	PMID:9924025^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	PMID:19179467^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15674325^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61244	F		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:10962037^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002620) happens_during:(GO:0000085)	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17873522^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	PMID:9924025^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21533051^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	PMID:9924025^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:17558397^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:17558397^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11793365^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9924025^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q28350	F		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01108	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01108	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:17873522^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9924025^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P02794)	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21447833^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15994933^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15994933^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002418 InterPro:IPR003327 InterPro:IPR012682	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002418 InterPro:IPR003327	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002418 InterPro:IPR003327 InterPro:IPR012682	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9187264^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	PMID:18987311^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044346	fibroblast apoptotic process	PMID:10962037^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10597290^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904837	beta-catenin-TCF complex assembly	Reactome:R-HSA-201722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173796	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	Reactome:R-HSA-1980143	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	Reactome:R-HSA-8866911	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9011985 Reactome:R-HSA-9011984 Reactome:R-HSA-9011983 Reactome:R-HSA-9011981 Reactome:R-HSA-9011975 Reactome:R-HSA-8932400 Reactome:R-HSA-8865280 Reactome:R-HSA-8865265 Reactome:R-HSA-6790036 Reactome:R-HSA-5696914 Reactome:R-HSA-5687113 Reactome:R-HSA-5687083 Reactome:R-HSA-4411357 Reactome:R-HSA-2220985 Reactome:R-HSA-1980067 Reactome:R-HSA-1484099	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	Reactome:R-HSA-69206	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hervouet, E et al. (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4 487-99 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Sun, XX et al. (2015) The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc. Natl. Acad. Sci. U.S.A. 112 3734-9 PubMed GONUTS page
↑ Wang, J et al. (2019) Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells. J. Cell. Biochem. 120 1807-1818 PubMed GONUTS page
↑ Kim, JY et al. (2015) The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis. Am. J. Pathol. 185 2061-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Mizukami, Y et al. (2004) ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J. Biol. Chem. 279 50120-31 PubMed GONUTS page
↑ Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wanzel, M et al. (2008) A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat. Cell Biol. 10 1051-61 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Oh, S et al. (2000) Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene 19 1485-90 PubMed GONUTS page
↑ Kim, H & Chen, J (2007) c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem. Biophys. Res. Commun. 362 842-7 PubMed GONUTS page
↑ Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Höglund, A et al. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113 4281-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Wu, KJ et al. (1999) Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 283 676-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Jung, P et al. (2008) AP4 encodes a c-MYC-inducible repressor of p21. Proc. Natl. Acad. Sci. U.S.A. 105 15046-51 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Yu, M et al. (2005) PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Oncogene 24 1982-93 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Felsher, DW et al. (2000) Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 97 10544-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Lin, L et al. (2008) The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Proc. Natl. Acad. Sci. U.S.A. 105 17420-5 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Popov, N et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat. Cell Biol. 9 765-74 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Popov, N et al. (2007) Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. Cell Cycle 6 2327-31 PubMed GONUTS page
↑ Han, A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur. J. Pharmacol. 583 26-31 PubMed GONUTS page
↑ Yochum, GS (2011) Multiple Wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PLoS ONE 6 e18966 PubMed GONUTS page
↑ Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page
↑ Liu, Y et al. (2011) TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Blood 117 5643-51 PubMed GONUTS page
↑ ^24.0 ^24.1 Huang, A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 65 5607-19 PubMed GONUTS page
↑ Shayo, C et al. (1997) Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937. Mol. Pharmacol. 51 983-90 PubMed GONUTS page
↑ Bannasch, D et al. (1999) Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene 18 6810-7 PubMed GONUTS page

[PMID:19786833-1] 1.0 ^1.1 ^1.2 ^1.3 Hervouet, E et al. (2009) Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics 4 487-99 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25775507-3] Sun, XX et al. (2015) The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc. Natl. Acad. Sci. U.S.A. 112 3734-9 PubMed GONUTS page

[PMID:30873824-4] Wang, J et al. (2019) Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells. J. Cell. Biochem. 120 1807-1818 PubMed GONUTS page

[PMID:25956029-5] Kim, JY et al. (2015) The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis. Am. J. Pathol. 185 2061-8 PubMed GONUTS page

[PMID:15459207-6] 6.0 ^6.1 ^6.2 ^6.3 Mizukami, Y et al. (2004) ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J. Biol. Chem. 279 50120-31 PubMed GONUTS page

[PMID:12837246-7] Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page

[PMID:19160485-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wanzel, M et al. (2008) A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat. Cell Biol. 10 1051-61 PubMed GONUTS page

[PMID:10723141-9] 9.0 ^9.1 ^9.2 Oh, S et al. (2000) Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene 19 1485-90 PubMed GONUTS page

[PMID:17765874-10] Kim, H & Chen, J (2007) c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem. Biophys. Res. Commun. 362 842-7 PubMed GONUTS page

[PMID:15358760-11] Zeng, L et al. (2004) Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. J. Biol. Chem. 279 48801-7 PubMed GONUTS page

[PMID:19179467-12] 12.0 ^12.1 ^12.2 ^12.3 Höglund, A et al. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113 4281-8 PubMed GONUTS page

[PMID:9924025-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Wu, KJ et al. (1999) Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science 283 676-9 PubMed GONUTS page

[PMID:18818310-14] 14.0 ^14.1 Jung, P et al. (2008) AP4 encodes a c-MYC-inducible repressor of p21. Proc. Natl. Acad. Sci. U.S.A. 105 15046-51 PubMed GONUTS page

[PMID:15674325-15] 15.0 ^15.1 ^15.2 Yu, M et al. (2005) PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation. Oncogene 24 1982-93 PubMed GONUTS page

[PMID:10962037-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Felsher, DW et al. (2000) Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 97 10544-8 PubMed GONUTS page

[PMID:18987311-17] 17.0 ^17.1 ^17.2 ^17.3 Lin, L et al. (2008) The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Proc. Natl. Acad. Sci. U.S.A. 105 17420-5 PubMed GONUTS page

[PMID:17558397-18] 18.0 ^18.1 ^18.2 Popov, N et al. (2007) The ubiquitin-specific protease USP28 is required for MYC stability. Nat. Cell Biol. 9 765-74 PubMed GONUTS page

[PMID:17873522-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Popov, N et al. (2007) Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. Cell Cycle 6 2327-31 PubMed GONUTS page

[PMID:18291362-20] Han, A et al. (2008) Sulindac suppresses beta-catenin expression in human cancer cells. Eur. J. Pharmacol. 583 26-31 PubMed GONUTS page

[PMID:21533051-21] Yochum, GS (2011) Multiple Wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PLoS ONE 6 e18966 PubMed GONUTS page

[PMID:11793365-22] Wong, SC et al. (2002) Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol. 196 145-53 PubMed GONUTS page

[PMID:21447833-23] Liu, Y et al. (2011) TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Blood 117 5643-51 PubMed GONUTS page

[PMID:15994933-24] 24.0 ^24.1 Huang, A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 65 5607-19 PubMed GONUTS page

[PMID:9187264-25] Shayo, C et al. (1997) Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937. Mol. Pharmacol. 51 983-90 PubMed GONUTS page

[PMID:10597290-26] Bannasch, D et al. (1999) Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene 18 6810-7 PubMed GONUTS page

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HUMAN:MYC

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