HUMAN:MSH3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MSH3 (synonyms: DUC1, DUG)
Protein Name(s)	DNA mismatch repair protein Msh3 hMSH3 Divergent upstream protein DUP Mismatch repair protein 1 MRP1
External Links
UniProt	P20585
EMBL	J04810 U61981 D61419 AY275681 AC008434 AC010270 AC022493 BC011817 BC130434 BC130436
CCDS	CCDS34195.1
PIR	A33507
RefSeq	NP_002430.3
UniGene	Hs.280987 Hs.648635
PDB	3THW 3THX 3THY 3THZ
PDBsum	3THW 3THX 3THY 3THZ
ProteinModelPortal	P20585
SMR	P20585
BioGrid	110574
DIP	DIP-35127N
IntAct	P20585
MINT	MINT-192778
STRING	9606.ENSP00000265081
PhosphoSite	P20585
DMDM	317373576
MaxQB	P20585
PaxDb	P20585
PRIDE	P20585
Ensembl	ENST00000265081
GeneID	4437
KEGG	hsa:4437
UCSC	uc003kgz.4
CTD	4437
GeneCards	GC05P079986
H-InvDB	HIX0032037
HGNC	HGNC:7326
HPA	HPA036080 HPA036081
MIM	600887 608089
neXtProt	NX_P20585
PharmGKB	PA31134
eggNOG	COG0249
GeneTree	ENSGT00550000074949
HOGENOM	HOG000029776
HOVERGEN	HBG006400
InParanoid	P20585
KO	K08736
OMA	GYLLCIT
OrthoDB	EOG7X6KZF
PhylomeDB	P20585
TreeFam	TF300525
Reactome	REACT_228019
ChiTaRS	MSH3
GeneWiki	MSH3
GenomeRNAi	4437
NextBio	17293
PRO	PR:P20585
Proteomes	UP000005640
Bgee	P20585
CleanEx	HS_MSH3
Genevestigator	P20585
GO	GO:0016020 GO:0032302 GO:0000228 GO:0005634 GO:0005524 GO:0019237 GO:0003684 GO:0008094 GO:0000406 GO:0019899 GO:0000404 GO:0000403 GO:0006200 GO:0006281 GO:0043570 GO:0000710 GO:0006298 GO:0045910 GO:0051096 GO:0007131 GO:0016447
Gene3D	3.30.420.110 3.40.1170.10 3.40.50.300
InterPro	IPR007695 IPR000432 IPR007861 IPR007696 IPR016151 IPR007860 IPR027417
Pfam	PF01624 PF05188 PF05192 PF05190 PF00488
SMART	SM00534 SM00533
SUPFAM	SSF48334 SSF52540 SSF53150 SSF55271
PROSITE	PS00486

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005634	nucleus	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26300262^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NXL9	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:17715146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:17715146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:16388310^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|enables	GO:0042803	protein homodimerization activity	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|contributes_to	GO:0032357	oxidized purine DNA binding	PMID:11756455^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
contributes_to	GO:0032181	dinucleotide repeat insertion binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032142	single guanine insertion binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0032139	dinucleotide insertion or deletion binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
NOT\|enables	GO:0032137	guanine/thymine mispair binding	PMID:11809883^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:8942985^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:8782829^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	PMID:11809883^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11427529^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F	Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 UniProtKB:P20585	P	Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 PomBase:SPAC8F11.03 UniProtKB:P20585	P	Seeded From UniProt	complete
involved_in	GO:0043111	replication fork arrest	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
enables	GO:0032357	oxidized purine DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145772 UniProtKB:P20585	F	Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688 UniProtKB:P20585	C	Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779	C	Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:1343961 PANTHER:PTN002260779 SGD:S000001162 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 SGD:S000001162	F	Seeded From UniProt	complete
involved_in	GO:0007131	reciprocal meiotic recombination	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 PomBase:SPAC8F11.03	P	Seeded From UniProt	complete
involved_in	GO:0006312	mitotic recombination	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 FB:FBgn0015546 MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN000145505 PomBase:SPBC19G7.01c PomBase:SPCC285.16c SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 TAIR:locus:2095097 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 WB:WBGene00003418 WB:WBGene00003422	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450	F	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN002260779 TAIR:locus:2095097 TAIR:locus:2131829 UniProtKB:O04716	F	Seeded From UniProt	complete
involved_in	GO:0000735	removal of nonhomologous ends	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
involved_in	GO:0000710	meiotic mismatch repair	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145759 SGD:S000000688	P	Seeded From UniProt	complete
enables	GO:0000406	double-strand/single-strand DNA junction binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145772 SGD:S000000688	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR016151 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR016151 InterPro:IPR017261 InterPro:IPR036678	P	Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR016151 InterPro:IPR017261 InterPro:IPR036678	F	Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	Reactome:R-HSA-5358606	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5578663 Reactome:R-HSA-5577259 Reactome:R-HSA-5444511 Reactome:R-HSA-5358513	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^3.0 ^3.1 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page
↑ Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page
↑ Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page
↑ Risinger, JI et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet. 14 102-5 PubMed GONUTS page
↑ Schmutte, C et al. (2001) The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem. 276 33011-8 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26300262-1] 1.0 ^1.1 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:17715146-3] 3.0 ^3.1 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page

[PMID:8942985-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page

[PMID:16388310-5] Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page

[PMID:11756455-6] Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page

[PMID:11809883-7] 7.0 ^7.1 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page

[PMID:8782829-8] Risinger, JI et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat. Genet. 14 102-5 PubMed GONUTS page

[PMID:11427529-9] Schmutte, C et al. (2001) The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem. 276 33011-8 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:MSH3

Contents

Annotations

Notes

References

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