HUMAN:MSH2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MSH2
Protein Name(s)	DNA mismatch repair protein Msh2 hMSH2 MutS protein homolog 2
External Links
UniProt	P43246
EMBL	U03911 U04045 U41221 U41206 U41207 U41208 U41210 U41211 U41212 U41213 U41214 U41215 U41216 U41217 U41218 U41219 U41220 L47583 L47582 L47581 AY601851 AK304496 BX649122 AC079775 AC138655 BC021566 AF066081
CCDS	CCDS1834.1 CCDS58709.1
PIR	I64819
RefSeq	NP_000242.1 NP_001245210.1
UniGene	Hs.597656
PDB	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
PDBsum	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
ProteinModelPortal	P43246
SMR	P43246
BioGrid	110573
DIP	DIP-35054N
IntAct	P43246
MINT	MINT-84789
STRING	9606.ENSP00000233146
PhosphoSite	P43246
BioMuta	MSH2
DMDM	1171032
MaxQB	P43246
PaxDb	P43246
PeptideAtlas	P43246
PRIDE	P43246
DNASU	4436
Ensembl	ENST00000233146 ENST00000543555
GeneID	4436
KEGG	hsa:4436
UCSC	uc002rvy.2
CTD	4436
GeneCards	GC02P047630
GeneReviews	MSH2
HGNC	HGNC:7325
HPA	CAB009572
MIM	120435 158320 608089 609309
neXtProt	NX_P43246
Orphanet	252202 144 587 99817
PharmGKB	PA31133
eggNOG	COG0249
GeneTree	ENSGT00550000074867
HOGENOM	HOG000196498
HOVERGEN	HBG006399
InParanoid	P43246
KO	K08735
OMA	NDWYLAY
OrthoDB	EOG76DTRW
PhylomeDB	P43246
TreeFam	TF351780
Reactome	REACT_264347 REACT_264501
ChiTaRS	MSH2
EvolutionaryTrace	P43246
GeneWiki	MSH2
GenomeRNAi	4436
NextBio	17289
PRO	PR:P43246
Proteomes	UP000005640
Bgee	P43246
CleanEx	HS_MSH2
ExpressionAtlas	P43246
Genevisible	P43246
GO	GO:0016020 GO:0032301 GO:0032302 GO:0000228 GO:0005654 GO:0005524 GO:0019237 GO:0003684 GO:0003677 GO:0008094 GO:0000406 GO:0019899 GO:0032137 GO:0000404 GO:0008022 GO:0042803 GO:0019901 GO:0000403 GO:0030183 GO:0019724 GO:0007050 GO:0008340 GO:0006281 GO:0006302 GO:0007281 GO:0001701 GO:0031573 GO:0042771 GO:0045190 GO:0043570 GO:0008584 GO:0006311 GO:0000710 GO:0006298 GO:0045910 GO:0043524 GO:0045128 GO:0006119 GO:0051096 GO:0006301 GO:0007131 GO:0010224 GO:0010165 GO:0016446 GO:0016447
Gene3D	3.40.50.300
InterPro	IPR011184 IPR007695 IPR000432 IPR007861 IPR007696 IPR007860 IPR027417
Pfam	PF01624 PF05188 PF05192 PF05190 PF00488
PIRSF	PIRSF005813
SMART	SM00534 SM00533
SUPFAM	SSF48334 SSF52540
PROSITE	PS00486

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0003682	chromatin binding	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	PMID:26300262^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9NXL9)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26300262^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26300262^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NXL9	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:26300262^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJA3	F		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	PMID:17715146^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:17715146^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0019724	B cell mediated immunity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0016447	somatic recombination of immunoglobulin gene segments	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43247	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:16388310^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0043531	ADP binding	PMID:15105434^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032405	MutLalpha complex binding	PMID:16403449^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032357	oxidized purine DNA binding	PMID:11801590^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032357	oxidized purine DNA binding	PMID:11756455^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0032181	dinucleotide repeat insertion binding	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032142	single guanine insertion binding	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032139	dinucleotide insertion or deletion binding	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:11809883^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:11801590^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:11756455^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	PMID:8942985^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0016887	ATPase activity	PMID:16403449^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0005524	ATP binding	PMID:15105434^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	PMID:11809883^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0003690	double-stranded DNA binding	PMID:11809883^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0000400	four-way junction DNA binding	PMID:12034830^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0000287	magnesium ion binding	PMID:16403449^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:23622243^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:14657349^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13535	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17715146^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14191	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:14676842^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:12414623^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11429708^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11427529^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:10856833^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:9788596^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQ84	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:14706347^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07992	F		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:7923193^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:7923193^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:7923193^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 TAIR:locus:2095097 UniProtKB:P43246	P		Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015546 PANTHER:PTN000145640 PomBase:SPBC19G7.01c UniProtKB:P43246 WB:WBGene00003418 ZFIN:ZDB-GENE-040426-2932	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643 WB:WBGene00003418	P		Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246	C		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246	C		Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779	C		Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 UniProtKB:P43246 UniProtKB:P52701	F		Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:1343961 PANTHER:PTN002260779 SGD:S000001162 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 SGD:S000001162	F		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 UniProtKB:P43246	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 FB:FBgn0015546 MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN000145505 PomBase:SPBC19G7.01c PomBase:SPCC285.16c SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 TAIR:locus:2095097 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 WB:WBGene00003418 WB:WBGene00003422	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 RGD:620786 SGD:S000005450 UniProtKB:P43246	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN002260779 TAIR:locus:2095097 TAIR:locus:2131829 UniProtKB:O04716	F		Seeded From UniProt	complete
contributes_to	GO:0000400	four-way junction DNA binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F		Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	PMID:16713580^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:23603115^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P52701	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:23603115^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P40692	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:11555625^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048304	positive regulation of isotype switching to IgG isotypes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0048298	positive regulation of isotype switching to IgA isotypes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0045190	isotype switching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	C		Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	F		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	F		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0019724	B cell mediated immunity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
enables	GO:0019237	centromeric DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	F		Seeded From UniProt	complete
involved_in	GO:0016447	somatic recombination of immunoglobulin gene segments	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0016446	somatic hypermutation of immunoglobulin genes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0006119	oxidative phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	C		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	F		Seeded From UniProt	complete
involved_in	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43247 ensembl:ENSMUSP00000024967	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032642	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR032642 InterPro:IPR036678	F		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR032642 InterPro:IPR036678	P		Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR036678	F		Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032642	C		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	Reactome:R-HSA-5358606 Reactome:R-HSA-5358565	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-6806394 Reactome:R-HSA-5632970 Reactome:R-HSA-5578663 Reactome:R-HSA-5577259 Reactome:R-HSA-5577244 Reactome:R-HSA-5444516 Reactome:R-HSA-5444511 Reactome:R-HSA-5358912 Reactome:R-HSA-5358599 Reactome:R-HSA-5358597 Reactome:R-HSA-5358525 Reactome:R-HSA-5358518 Reactome:R-HSA-5358513 Reactome:R-HSA-5358510	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page
↑ Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page
↑ ^7.0 ^7.1 Martik, D et al. (2004) Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. J. Biol. Chem. 279 28402-10 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Plotz, G et al. (2006) Analysis of the human MutLalpha.MutSalpha complex. Biochem. Biophys. Res. Commun. 340 852-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Gu, Y et al. (2002) Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J. Biol. Chem. 277 11135-42 PubMed GONUTS page
↑ ^10.0 ^10.1 Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page
↑ Subramanian, D & Griffith, JD (2002) Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases. Nucleic Acids Res. 30 2427-34 PubMed GONUTS page
↑ Li, F et al. (2013) The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153 590-600 PubMed GONUTS page
↑ Wang, Y & Qin, J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100 15387-92 PubMed GONUTS page
↑ Nielsen, FC et al. (2004) Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA. Oncogene 23 1457-68 PubMed GONUTS page
↑ Sun, X et al. (2002) Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Res. 62 6026-30 PubMed GONUTS page
↑ Jäger, AC et al. (2001) HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes. Oncogene 20 3590-5 PubMed GONUTS page
↑ Schmutte, C et al. (2001) The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem. 276 33011-8 PubMed GONUTS page
↑ Rasmussen, LJ et al. (2000) Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. Mutat. Res. 460 41-52 PubMed GONUTS page
↑ Schmutte, C et al. (1998) Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 58 4537-42 PubMed GONUTS page
↑ Lan, L et al. (2004) Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells. DNA Repair (Amst.) 3 135-43 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Fishel, R et al. (1994) Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res. 54 5539-42 PubMed GONUTS page
↑ ^23.00 ^23.01 ^23.02 ^23.03 ^23.04 ^23.05 ^23.06 ^23.07 ^23.08 ^23.09 ^23.10 ^23.11 ^23.12 ^23.13 ^23.14 ^23.15 ^23.16 ^23.17 ^23.18 ^23.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page
↑ ^25.0 ^25.1 Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page
↑ Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page

[PMID:26300262-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page

[PMID:19135898-2] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:17715146-4] 4.0 ^4.1 ^4.2 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page

[PMID:8942985-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page

[PMID:16388310-6] Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page

[PMID:15105434-7] 7.0 ^7.1 Martik, D et al. (2004) Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. J. Biol. Chem. 279 28402-10 PubMed GONUTS page

[PMID:16403449-8] 8.0 ^8.1 ^8.2 Plotz, G et al. (2006) Analysis of the human MutLalpha.MutSalpha complex. Biochem. Biophys. Res. Commun. 340 852-9 PubMed GONUTS page

[PMID:11801590-9] 9.0 ^9.1 Gu, Y et al. (2002) Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J. Biol. Chem. 277 11135-42 PubMed GONUTS page

[PMID:11756455-10] 10.0 ^10.1 Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page

[PMID:11809883-11] 11.0 ^11.1 ^11.2 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page

[PMID:12034830-12] Subramanian, D & Griffith, JD (2002) Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases. Nucleic Acids Res. 30 2427-34 PubMed GONUTS page

[PMID:23622243-13] Li, F et al. (2013) The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153 590-600 PubMed GONUTS page

[PMID:14657349-14] Wang, Y & Qin, J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100 15387-92 PubMed GONUTS page

[PMID:14676842-15] Nielsen, FC et al. (2004) Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA. Oncogene 23 1457-68 PubMed GONUTS page

[PMID:12414623-16] Sun, X et al. (2002) Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Res. 62 6026-30 PubMed GONUTS page

[PMID:11429708-17] Jäger, AC et al. (2001) HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes. Oncogene 20 3590-5 PubMed GONUTS page

[PMID:11427529-18] Schmutte, C et al. (2001) The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem. 276 33011-8 PubMed GONUTS page

[PMID:10856833-19] Rasmussen, LJ et al. (2000) Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. Mutat. Res. 460 41-52 PubMed GONUTS page

[PMID:9788596-20] Schmutte, C et al. (1998) Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 58 4537-42 PubMed GONUTS page

[PMID:14706347-21] Lan, L et al. (2004) Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells. DNA Repair (Amst.) 3 135-43 PubMed GONUTS page

[PMID:7923193-22] 22.0 ^22.1 ^22.2 Fishel, R et al. (1994) Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res. 54 5539-42 PubMed GONUTS page

[PMID:21873635-23] 23.00 ^23.01 ^23.02 ^23.03 ^23.04 ^23.05 ^23.06 ^23.07 ^23.08 ^23.09 ^23.10 ^23.11 ^23.12 ^23.13 ^23.14 ^23.15 ^23.16 ^23.17 ^23.18 ^23.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16713580-24] Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page

[PMID:23603115-25] 25.0 ^25.1 Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page

[PMID:11555625-26] Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page

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HUMAN:MSH2

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