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HUMAN:MSH2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | MSH2 | |
Protein Name(s) | DNA mismatch repair protein Msh2
hMSH2 MutS protein homolog 2 | |
External Links | ||
UniProt | P43246 | |
EMBL | U03911 U04045 U41221 U41206 U41207 U41208 U41210 U41211 U41212 U41213 U41214 U41215 U41216 U41217 U41218 U41219 U41220 L47583 L47582 L47581 AY601851 AK304496 BX649122 AC079775 AC138655 BC021566 AF066081 | |
CCDS | CCDS1834.1 CCDS58709.1 | |
PIR | I64819 | |
RefSeq | NP_000242.1 NP_001245210.1 | |
UniGene | Hs.597656 | |
PDB | 2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ | |
PDBsum | 2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ | |
ProteinModelPortal | P43246 | |
SMR | P43246 | |
BioGrid | 110573 | |
DIP | DIP-35054N | |
IntAct | P43246 | |
MINT | MINT-84789 | |
STRING | 9606.ENSP00000233146 | |
PhosphoSite | P43246 | |
BioMuta | MSH2 | |
DMDM | 1171032 | |
MaxQB | P43246 | |
PaxDb | P43246 | |
PeptideAtlas | P43246 | |
PRIDE | P43246 | |
DNASU | 4436 | |
Ensembl | ENST00000233146 ENST00000543555 | |
GeneID | 4436 | |
KEGG | hsa:4436 | |
UCSC | uc002rvy.2 | |
CTD | 4436 | |
GeneCards | GC02P047630 | |
GeneReviews | MSH2 | |
HGNC | HGNC:7325 | |
HPA | CAB009572 | |
MIM | 120435 158320 608089 609309 | |
neXtProt | NX_P43246 | |
Orphanet | 252202 144 587 99817 | |
PharmGKB | PA31133 | |
eggNOG | COG0249 | |
GeneTree | ENSGT00550000074867 | |
HOGENOM | HOG000196498 | |
HOVERGEN | HBG006399 | |
InParanoid | P43246 | |
KO | K08735 | |
OMA | NDWYLAY | |
OrthoDB | EOG76DTRW | |
PhylomeDB | P43246 | |
TreeFam | TF351780 | |
Reactome | REACT_264347 REACT_264501 | |
ChiTaRS | MSH2 | |
EvolutionaryTrace | P43246 | |
GeneWiki | MSH2 | |
GenomeRNAi | 4436 | |
NextBio | 17289 | |
PRO | PR:P43246 | |
Proteomes | UP000005640 | |
Bgee | P43246 | |
CleanEx | HS_MSH2 | |
ExpressionAtlas | P43246 | |
Genevisible | P43246 | |
GO | GO:0016020 GO:0032301 GO:0032302 GO:0000228 GO:0005654 GO:0005524 GO:0019237 GO:0003684 GO:0003677 GO:0008094 GO:0000406 GO:0019899 GO:0032137 GO:0000404 GO:0008022 GO:0042803 GO:0019901 GO:0000403 GO:0030183 GO:0019724 GO:0007050 GO:0008340 GO:0006281 GO:0006302 GO:0007281 GO:0001701 GO:0031573 GO:0042771 GO:0045190 GO:0043570 GO:0008584 GO:0006311 GO:0000710 GO:0006298 GO:0045910 GO:0043524 GO:0045128 GO:0006119 GO:0051096 GO:0006301 GO:0007131 GO:0010224 GO:0010165 GO:0016446 GO:0016447 | |
Gene3D | 3.40.50.300 | |
InterPro | IPR011184 IPR007695 IPR000432 IPR007861 IPR007696 IPR007860 IPR027417 | |
Pfam | PF01624 PF05188 PF05192 PF05190 PF00488 | |
PIRSF | PIRSF005813 | |
SMART | SM00534 SM00533 | |
SUPFAM | SSF48334 SSF52540 | |
PROSITE | PS00486 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071168 |
protein localization to chromatin |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q9NXL9) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051096 |
positive regulation of helicase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045910 |
negative regulation of DNA recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045910 |
negative regulation of DNA recombination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045190 |
isotype switching |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030183 |
B cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019724 |
B cell mediated immunity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016447 |
somatic recombination of immunoglobulin gene segments |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010224 |
response to UV-B |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010165 |
response to X-ray |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008584 |
male gonad development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043570 |
maintenance of DNA repeat elements |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0043531 |
ADP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032405 |
MutLalpha complex binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032357 |
oxidized purine DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032357 |
oxidized purine DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032302 |
MutSbeta complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032301 |
MutSalpha complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032181 |
dinucleotide repeat insertion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032143 |
single thymine insertion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032142 |
single guanine insertion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032139 |
dinucleotide insertion or deletion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032137 |
guanine/thymine mispair binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0032137 |
guanine/thymine mispair binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0030983 |
mismatched DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0030983 |
mismatched DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0030983 |
mismatched DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0003697 |
single-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0000400 |
four-way junction DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
contributes_to |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032301 |
MutSalpha complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006301 |
postreplication repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045910 |
negative regulation of DNA recombination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043570 |
maintenance of DNA repeat elements |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015546 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032302 |
MutSbeta complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000145640 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032301 |
MutSalpha complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0032300 |
mismatch repair complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
C |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0032143 |
single thymine insertion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260779 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0032137 |
guanine/thymine mispair binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031573 |
intra-S DNA damage checkpoint |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010224 |
response to UV-B |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010165 |
response to X-ray |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260779 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006302 |
double-strand break repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006301 |
postreplication repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10625 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101816 |
F |
Seeded From UniProt |
complete | ||
contributes_to |
GO:0000400 |
four-way junction DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000145640 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0032137 |
guanine/thymine mispair binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048304 |
positive regulation of isotype switching to IgG isotypes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048298 |
positive regulation of isotype switching to IgA isotypes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045910 |
negative regulation of DNA recombination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045190 |
isotype switching |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032301 |
MutSalpha complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0032137 |
guanine/thymine mispair binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031573 |
intra-S DNA damage checkpoint |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030983 |
mismatched DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030183 |
B cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019724 |
B cell mediated immunity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0019237 |
centromeric DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0016887 |
ATPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016447 |
somatic recombination of immunoglobulin gene segments |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0016446 |
somatic hypermutation of immunoglobulin genes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010224 |
response to UV-B |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010165 |
response to X-ray |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008584 |
male gonad development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008340 |
determination of adult lifespan |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007281 |
germ cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007050 |
cell cycle arrest |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006302 |
double-strand break repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006301 |
postreplication repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006119 |
oxidative phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002204 |
somatic recombination of immunoglobulin genes involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001701 |
in utero embryonic development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P43247 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000432 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006298 |
mismatch repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000432 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0030983 |
mismatched DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000432 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0032300 |
mismatch repair complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006298 |
mismatch repair |
Reactome:R-HSA-5358606 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6806394 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Traver, S et al. (2015) MCM9 Is Required for Mammalian DNA Mismatch Repair. Mol. Cell 59 831-9 PubMed GONUTS page
- ↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Saydam, N et al. (2007) Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors. Nucleic Acids Res. 35 5706-16 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Acharya, S et al. (1996) hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc. Natl. Acad. Sci. U.S.A. 93 13629-34 PubMed GONUTS page
- ↑ Lin, Y et al. (2006) Transcription promotes contraction of CAG repeat tracts in human cells. Nat. Struct. Mol. Biol. 13 179-80 PubMed GONUTS page
- ↑ 7.0 7.1 Martik, D et al. (2004) Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. J. Biol. Chem. 279 28402-10 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Plotz, G et al. (2006) Analysis of the human MutLalpha.MutSalpha complex. Biochem. Biophys. Res. Commun. 340 852-9 PubMed GONUTS page
- ↑ 9.0 9.1 Gu, Y et al. (2002) Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J. Biol. Chem. 277 11135-42 PubMed GONUTS page
- ↑ 10.0 10.1 Mazurek, A et al. (2002) Activation of human MutS homologs by 8-oxo-guanine DNA damage. J. Biol. Chem. 277 8260-6 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Plotz, G et al. (2002) hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA. Nucleic Acids Res. 30 711-8 PubMed GONUTS page
- ↑ Subramanian, D & Griffith, JD (2002) Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases. Nucleic Acids Res. 30 2427-34 PubMed GONUTS page
- ↑ Li, F et al. (2013) The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell 153 590-600 PubMed GONUTS page
- ↑ Wang, Y & Qin, J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. U.S.A. 100 15387-92 PubMed GONUTS page
- ↑ Nielsen, FC et al. (2004) Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA. Oncogene 23 1457-68 PubMed GONUTS page
- ↑ Sun, X et al. (2002) Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Res. 62 6026-30 PubMed GONUTS page
- ↑ Jäger, AC et al. (2001) HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes. Oncogene 20 3590-5 PubMed GONUTS page
- ↑ Schmutte, C et al. (2001) The interaction of DNA mismatch repair proteins with human exonuclease I. J. Biol. Chem. 276 33011-8 PubMed GONUTS page
- ↑ Rasmussen, LJ et al. (2000) Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis. Mutat. Res. 460 41-52 PubMed GONUTS page
- ↑ Schmutte, C et al. (1998) Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 58 4537-42 PubMed GONUTS page
- ↑ Lan, L et al. (2004) Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells. DNA Repair (Amst.) 3 135-43 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 Fishel, R et al. (1994) Purified human MSH2 protein binds to DNA containing mismatched nucleotides. Cancer Res. 54 5539-42 PubMed GONUTS page
- ↑ 23.00 23.01 23.02 23.03 23.04 23.05 23.06 23.07 23.08 23.09 23.10 23.11 23.12 23.13 23.14 23.15 23.16 23.17 23.18 23.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page
- ↑ 25.0 25.1 Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page
- ↑ Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page
a
c
d
- GO:0003684 ! damaged DNA binding
- GO:0008340 ! determination of adult lifespan
- GO:0032181 ! dinucleotide repeat insertion binding
- GO:0032139 ! dinucleotide insertion or deletion binding
- GO:0003677 ! DNA binding
- GO:0006974 ! DNA damage response
- GO:0006281 ! DNA repair
- GO:0003690 ! double-stranded DNA binding
- GO:0006302 ! double-strand break repair
i
m
- GO:0000287 ! magnesium ion binding
- GO:0043570 ! maintenance of DNA repeat elements
- GO:0008584 ! male gonad development
- Mammalia
- GO:0016020 ! membrane
- Metazoa
- GO:0030983 ! mismatched DNA binding
- GO:0032300 ! mismatch repair complex
- GO:0006298 ! mismatch repair
- GO:0031573 ! mitotic intra-S DNA damage checkpoint signaling
- GO:0032405 ! MutLalpha complex binding
- GO:0032301 ! MutSalpha complex
- GO:0032302 ! MutSbeta complex
n
o
p
- GO:0048304 ! positive regulation of isotype switching to IgG isotypes
- GO:0051096 ! positive regulation of helicase activity
- GO:0048298 ! positive regulation of isotype switching to IgA isotypes
- GO:0006301 ! postreplication repair
- Primates
- GO:0042803 ! protein homodimerization activity
- GO:0019901 ! protein kinase binding
- GO:0071168 ! protein localization to chromatin
s
- GO:0003697 ! single-stranded DNA binding
- GO:0032142 ! single guanine insertion binding
- GO:0032143 ! single thymine insertion binding
- GO:0016446 ! somatic hypermutation of immunoglobulin genes
- GO:0016447 ! somatic recombination of immunoglobulin gene segments
- GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response