HUMAN:MEN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MEN1 (synonyms: SCG2)
Protein Name(s)	Menin
External Links
UniProt	O00255
EMBL	U93236 U93237 U93237 AP001462 EF443091 EF443092 EF443093 EF443094 EF443095 EF443096 EF443097 BC002544 BC002664
CCDS	CCDS31600.1 CCDS8083.1
RefSeq	NP_000235.2 NP_570711.1 NP_570712.1 NP_570713.1 NP_570714.1 NP_570715.1 NP_570716.1 XP_005274058.1 XP_005274059.1 XP_005274060.1 XP_006718620.1
UniGene	Hs.423348
PDB	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8
PDBsum	3U84 3U85 3U86 3U88 4GPQ 4GQ3 4GQ4 4GQ6 4I80 4OG3 4OG4 4OG5 4OG6 4OG7 4OG8
ProteinModelPortal	O00255
SMR	O00255
BioGrid	110384
DIP	DIP-24236N
IntAct	O00255
MINT	MINT-1543749
STRING	9606.ENSP00000337088
ChEMBL	CHEMBL1615381
PhosphoSite	O00255
MaxQB	O00255
PaxDb	O00255
PRIDE	O00255
DNASU	4221
Ensembl	ENST00000312049 ENST00000315422 ENST00000337652 ENST00000377313 ENST00000377321 ENST00000377326 ENST00000394374 ENST00000394376
GeneID	4221
KEGG	hsa:4221
UCSC	uc001obj.3 uc001obl.3 uc001obm.3
CTD	4221
GeneCards	GC11M064570
GeneReviews	MEN1
HGNC	HGNC:7010
HPA	HPA030342
MIM	131100 145000 613733
neXtProt	NX_O00255
Orphanet	99879 99877 652 913
PharmGKB	PA30746
eggNOG	NOG67412
GeneTree	ENSGT00390000014237
HOVERGEN	HBG000208
InParanoid	O00255
KO	K14970
OMA	LTAACSE
OrthoDB	EOG7QC7WH
PhylomeDB	O00255
TreeFam	TF323888
Reactome	REACT_120734 REACT_200731 REACT_200753
ChiTaRS	MEN1
GeneWiki	MEN1
GenomeRNAi	4221
NextBio	16643
PRO	PR:O00255
Proteomes	UP000005640
Bgee	O00255
CleanEx	HS_MEN1 HS_SCG2
ExpressionAtlas	O00255
Genevestigator	O00255
GO	GO:0000785 GO:0032154 GO:0005737 GO:0005829 GO:0035097 GO:0016363 GO:0005654 GO:0005634 GO:0043234 GO:0003682 GO:0003690 GO:0000400 GO:0030674 GO:0047485 GO:0070412 GO:0043565 GO:0044212 GO:0000403 GO:0007420 GO:0007050 GO:0006974 GO:0006338 GO:0006281 GO:0048704 GO:0010467 GO:0030097 GO:0034968 GO:0001776 GO:0000165 GO:0060135 GO:0045786 GO:0008285 GO:0045736 GO:0046329 GO:0046621 GO:0045668 GO:0001933 GO:0043433 GO:0051974 GO:0000122 GO:0045892 GO:0002076 GO:0002051 GO:0060021 GO:0051781 GO:0043280 GO:0031062 GO:0045669 GO:0032092 GO:0045944 GO:0030511 GO:0032925 GO:0010332 GO:0009411 GO:0006367 GO:0006351 GO:0007179
InterPro	IPR007747
PANTHER	PTHR12693
Pfam	PF05053

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23784080^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88559	C	exists_during:(GO:0007128) part_of:(CL:0000017)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:12837246^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12837246^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000164362)	Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:11274402^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	PMID:12837246^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11526476^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11526476^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00653	F		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11526476^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	PMID:12226747^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12226747^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:15331604^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:15640349^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:20484083^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:12226747^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:11526476^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15199122^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	PMID:14508515^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:20484083^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:20484083^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	PMID:11274402^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0018024	histone-lysine N-methyltransferase activity	PMID:14992727^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:12874027^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	PMID:12874027^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:16690369^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:15331604^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:16690369^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:12874027^[12]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:14508515^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11500056^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9465067^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15199122^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14508515^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:15331604^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:12226747^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:12874027^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000403	Y-form DNA binding	PMID:15331604^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	PMID:15331604^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:12226747^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9989505^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	F		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	C		Seeded From UniProt	complete
contributes_to	GO:0018024	histone-lysine N-methyltransferase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1316736 PANTHER:PTN000976222 UniProtKB:O00255	P		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1316736 PANTHER:PTN000976222 RGD:3078	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	C		Seeded From UniProt	complete
enables	GO:0000403	Y-form DNA binding	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000976222 UniProtKB:O00255	F		Seeded From UniProt	complete
involved_in	GO:0045668	negative regulation of osteoblast differentiation	PMID:15563473^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:14992727^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UBL3	C		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:14992727^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15291	C		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:14992727^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14686	C		Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:17500065^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17500065^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15640349^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	PMID:15563473^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1316736	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034968	histone lysine methylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0018024	P		Seeded From UniProt	complete
involved_in	GO:0034968	histone lysine methylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0018024	P		Seeded From UniProt	complete
involved_in	GO:1902807	negative regulation of cell cycle G1/S phase transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0071559	response to transforming growth factor beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0071375	cellular response to peptide hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0061469	regulation of type B pancreatic cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0032925	regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	F		Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVR8 ensembl:ENSRNOP00000028592	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007747	C		Seeded From UniProt	complete
involved_in	GO:1904837	beta-catenin-TCF complex assembly	Reactome:R-HSA-201722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173796	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5672304	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3364042 Reactome:R-HSA-3364026 Reactome:R-HSA-3364014 Reactome:R-HSA-2186643	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Borowiak, M et al. (2013) HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. Carcinogenesis 34 2664-72 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Kaji, H et al. (2001) Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc. Natl. Acad. Sci. U.S.A. 98 3837-42 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Heppner, C et al. (2001) The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 20 4917-25 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gallo, A et al. (2002) Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation. Oncogene 21 6434-45 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 La, P et al. (2004) Direct binding of DNA by tumor suppressor menin. J. Biol. Chem. 279 49045-54 PubMed GONUTS page
↑ ^7.0 ^7.1 Milne, TA et al. (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 102 749-54 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Nakata, Y et al. (2010) c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116 1280-90 PubMed GONUTS page
↑ ^9.0 ^9.1 Yokoyama, A et al. (2004) Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol. 24 5639-49 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Obungu, VH et al. (2003) Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain. Oncogene 22 6347-58 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Hughes, CM et al. (2004) Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol. Cell 13 587-97 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Jin, S et al. (2003) Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res. 63 4204-10 PubMed GONUTS page
↑ ^13.0 ^13.1 Farley, SM et al. (2006) Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage. J. Surg. Res. 133 29-37 PubMed GONUTS page
↑ Lemmens, IH et al. (2001) Menin interacts directly with the homeobox-containing protein Pem. Biochem. Biophys. Res. Commun. 286 426-31 PubMed GONUTS page
↑ Guru, SC et al. (1998) Menin, the product of the MEN1 gene, is a nuclear protein. Proc. Natl. Acad. Sci. U.S.A. 95 1630-4 PubMed GONUTS page
↑ Agarwal, SK et al. (1999) Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96 143-52 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^18.0 ^18.1 Naito, J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J. Biol. Chem. 280 4785-91 PubMed GONUTS page
↑ ^19.0 ^19.1 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

[PMID:23784080-1] Borowiak, M et al. (2013) HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene. Carcinogenesis 34 2664-72 PubMed GONUTS page

[PMID:12837246-2] 2.0 ^2.1 ^2.2 Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page

[PMID:11274402-3] 3.0 ^3.1 Kaji, H et al. (2001) Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling. Proc. Natl. Acad. Sci. U.S.A. 98 3837-42 PubMed GONUTS page

[PMID:11526476-4] 4.0 ^4.1 ^4.2 ^4.3 Heppner, C et al. (2001) The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. Oncogene 20 4917-25 PubMed GONUTS page

[PMID:12226747-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gallo, A et al. (2002) Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation. Oncogene 21 6434-45 PubMed GONUTS page

[PMID:15331604-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 La, P et al. (2004) Direct binding of DNA by tumor suppressor menin. J. Biol. Chem. 279 49045-54 PubMed GONUTS page

[PMID:15640349-7] 7.0 ^7.1 Milne, TA et al. (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 102 749-54 PubMed GONUTS page

[PMID:20484083-8] 8.0 ^8.1 ^8.2 Nakata, Y et al. (2010) c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood 116 1280-90 PubMed GONUTS page

[PMID:15199122-9] 9.0 ^9.1 Yokoyama, A et al. (2004) Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol. Cell. Biol. 24 5639-49 PubMed GONUTS page

[PMID:14508515-10] 10.0 ^10.1 ^10.2 Obungu, VH et al. (2003) Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain. Oncogene 22 6347-58 PubMed GONUTS page

[PMID:14992727-11] 11.0 ^11.1 ^11.2 ^11.3 Hughes, CM et al. (2004) Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol. Cell 13 587-97 PubMed GONUTS page

[PMID:12874027-12] 12.0 ^12.1 ^12.2 ^12.3 Jin, S et al. (2003) Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res. 63 4204-10 PubMed GONUTS page

[PMID:16690369-13] 13.0 ^13.1 Farley, SM et al. (2006) Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage. J. Surg. Res. 133 29-37 PubMed GONUTS page

[PMID:11500056-14] Lemmens, IH et al. (2001) Menin interacts directly with the homeobox-containing protein Pem. Biochem. Biophys. Res. Commun. 286 426-31 PubMed GONUTS page

[PMID:9465067-15] Guru, SC et al. (1998) Menin, the product of the MEN1 gene, is a nuclear protein. Proc. Natl. Acad. Sci. U.S.A. 95 1630-4 PubMed GONUTS page

[PMID:9989505-16] Agarwal, SK et al. (1999) Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96 143-52 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15563473-18] 18.0 ^18.1 Naito, J et al. (2005) Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunD. J. Biol. Chem. 280 4785-91 PubMed GONUTS page

[PMID:17500065-19] 19.0 ^19.1 Cho, YW et al. (2007) PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J. Biol. Chem. 282 20395-406 PubMed GONUTS page

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