HUMAN:KPCD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKD1 (synonyms: PKD, PKD1, PRKCM)
Protein Name(s)	Serine/threonine-protein kinase D1 Protein kinase C mu type Protein kinase D nPKC-D1 nPKC-mu
External Links
UniProt	Q15139
EMBL	X75756 AK314170 AL135858 CH471078
CCDS	CCDS9637.1
PIR	A53215
RefSeq	NP_002733.2
UniGene	Hs.508999
ProteinModelPortal	Q15139
SMR	Q15139
BioGrid	111573
DIP	DIP-38481N
IntAct	Q15139
MINT	MINT-88491
STRING	9606.ENSP00000333568
BindingDB	Q15139
ChEMBL	CHEMBL2093867
GuidetoPHARMACOLOGY	1489
PhosphoSite	Q15139
DMDM	209572639
MaxQB	Q15139
PaxDb	Q15139
PRIDE	Q15139
DNASU	5587
Ensembl	ENST00000331968 ENST00000616995
GeneID	5587
KEGG	hsa:5587
UCSC	uc001wqh.3
CTD	5587
GeneCards	GC14M030045
H-InvDB	HIX0037727
HGNC	HGNC:9407
HPA	CAB018367 HPA029834
MIM	605435
neXtProt	NX_Q15139
PharmGKB	PA33771
eggNOG	COG0515
GeneTree	ENSGT00770000120480
HOVERGEN	HBG003564
InParanoid	Q15139
KO	K06070
OrthoDB	EOG75B84N
PhylomeDB	Q15139
TreeFam	TF314320
BRENDA	2.7.11.13
Reactome	REACT_115810
SignaLink	Q15139
ChiTaRS	PRKD1
GeneWiki	Protein_kinase_D1
GenomeRNAi	5587
NextBio	21670
PRO	PR:Q15139
Proteomes	UP000005640
Bgee	Q15139
CleanEx	HS_PKD1 HS_PRKD1
ExpressionAtlas	Q15139
Genevestigator	Q15139
GO	GO:0005938 GO:0005911 GO:0005737 GO:0005829 GO:0005887 GO:0005634 GO:0005886 GO:0005802 GO:0005524 GO:0042802 GO:0046872 GO:0004697 GO:0004674 GO:0001525 GO:0006915 GO:0008283 GO:0034599 GO:0035924 GO:0007030 GO:0048193 GO:0006954 GO:0045087 GO:0007229 GO:0035556 GO:0060548 GO:0045806 GO:0018105 GO:0045766 GO:0043536 GO:0032793 GO:2001028 GO:0038033 GO:0010595 GO:0001938 GO:1901727 GO:0043123 GO:0010976 GO:0051092 GO:0045669 GO:0033138 GO:0045944 GO:0046777 GO:0089700 GO:2001044 GO:0010837 GO:0007165 GO:0044281 GO:0030148 GO:0006665 GO:0048010
Gene3D	2.30.29.30
InterPro	IPR020454 IPR011009 IPR002219 IPR001849 IPR011993 IPR000719 IPR017441 IPR015727 IPR002290 IPR008271
PANTHER	PTHR22968
Pfam	PF00130 PF00169 PF00069
PIRSF	PIRSF000552
PRINTS	PR00008
SMART	SM00109 SM00233 SM00220
SUPFAM	SSF56112
PROSITE	PS50003 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004697	protein kinase C activity	PMID:12637538^[1]	ECO:0000314			F		Figure 1	complete CACAO 3491
	GO:0005794	Golgi apparatus	PMID:11239398^[2]	ECO:0000314			C		Figure 1, D	complete CACAO 3700
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28428613^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000421	autophagosome membrane	PMID:22095288^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:22095288^[4]	ECO:0000305	curator inference used in manual assertion	GO:0004674	P	regulates_activity_of:(UniProtKB:Q8NEB9)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:22095288^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q8NEB9)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:22095288^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q8NEB9)	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:22095288^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071447	cellular response to hydroperoxide	PMID:22095288^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:22095288^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071447)\|part_of:(GO:0034198)	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:24623306^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:24623306^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:24623306^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:24623306^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	PMID:24623306^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11239398^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:12637538^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001028	positive regulation of endothelial cell chemotaxis	PMID:18440775^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1901727	positive regulation of histone deacetylase activity	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	has_input:(UniProtKB:Q9UQL6) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:18059339^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18059339^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18440775^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18440775^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18059339^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0089700	protein kinase D signaling	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:18440775^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:18059339^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618) has_input:(UniProtKB:P04792)\|occurs_in(CL:0002618) has_input:(UniProtKB:Q9UQL6)	Seeded From UniProt	complete
involved_in	GO:0032793	positive regulation of CREB transcription factor activity	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:18440775^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18440775^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P04792)	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:20497126^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9BZL6	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:12505989^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12505989^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048193	Golgi vesicle transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62101	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18332134^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62101	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12505989^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18332134^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:12505989^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:19211839^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010837	regulation of keratinocyte proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62101	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:18332134^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007030	Golgi organization	PMID:19211839^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62101	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:19211839^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0089700	protein kinase D signaling	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000540182 UniProtKB:Q15139 UniProtKB:Q9BZL6	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10831594^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15139	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015727	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR015727 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR015727	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8119958^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10856238^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10856238^[15] Reactome:R-HSA-429698	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001044	regulation of integrin-mediated signaling pathway	PMID:21488147^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:21488147^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045806	negative regulation of endocytosis	PMID:21488147^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:21488147^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8119958^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030148	sphingolipid biosynthetic process	Reactome:R-HSA-1660661	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Storz, P et al. (2003) Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J. Biol. Chem. 278 17969-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Liljedahl, M et al. (2001) Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell 104 409-20 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Eisenberg-Lerner, A & Kimchi, A (2012) PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ. 19 788-97 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Evans, IM et al. (2010) Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem. J. 429 565-72 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Liu, D et al. (2008) The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene 27 2989-98 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Storz, P & Toker, A (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J. 22 109-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Ha, CH et al. (2008) Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. J. Biol. Chem. 283 14590-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Czöndör, K et al. (2009) Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol. Biol. Cell 20 2108-20 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Storz, P et al. (2000) Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32. J. Biol. Chem. 275 24601-7 PubMed GONUTS page
↑ ^14.0 ^14.1 Johannes, FJ et al. (1994) PKCu is a novel, atypical member of the protein kinase C family. J. Biol. Chem. 269 6140-8 PubMed GONUTS page
↑ ^15.0 ^15.1 Matthews, SA et al. (2000) Spatial and temporal regulation of protein kinase D (PKD). EMBO J. 19 2935-45 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Evans, IM & Zachary, IC (2011) Protein kinase D in vascular biology and angiogenesis. IUBMB Life 63 258-63 PubMed GONUTS page

[PMID:12637538-1] 1.0 ^1.1 Storz, P et al. (2003) Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J. Biol. Chem. 278 17969-76 PubMed GONUTS page

[PMID:11239398-2] 2.0 ^2.1 Liljedahl, M et al. (2001) Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell 104 409-20 PubMed GONUTS page

[PMID:28428613-3] 3.0 ^3.1 ^3.2 Cobbaut, M et al. (2017) Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. Sci Rep 7 887 PubMed GONUTS page

[PMID:22095288-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Eisenberg-Lerner, A & Kimchi, A (2012) PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ. 19 788-97 PubMed GONUTS page

[PMID:24623306-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page

[PMID:18440775-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page

[PMID:20497126-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Evans, IM et al. (2010) Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem. J. 429 565-72 PubMed GONUTS page

[PMID:18059339-8] 8.0 ^8.1 ^8.2 ^8.3 Liu, D et al. (2008) The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene 27 2989-98 PubMed GONUTS page

[PMID:12505989-9] 9.0 ^9.1 ^9.2 ^9.3 Storz, P & Toker, A (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J. 22 109-20 PubMed GONUTS page

[PMID:18332134-10] 10.0 ^10.1 ^10.2 Ha, CH et al. (2008) Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. J. Biol. Chem. 283 14590-9 PubMed GONUTS page

[PMID:19211839-11] 11.0 ^11.1 ^11.2 Czöndör, K et al. (2009) Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons. Mol. Biol. Cell 20 2108-20 PubMed GONUTS page

[PMID:21873635-12] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10831594-13] Storz, P et al. (2000) Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32. J. Biol. Chem. 275 24601-7 PubMed GONUTS page

[PMID:8119958-14] 14.0 ^14.1 Johannes, FJ et al. (1994) PKCu is a novel, atypical member of the protein kinase C family. J. Biol. Chem. 269 6140-8 PubMed GONUTS page

[PMID:10856238-15] 15.0 ^15.1 Matthews, SA et al. (2000) Spatial and temporal regulation of protein kinase D (PKD). EMBO J. 19 2935-45 PubMed GONUTS page

[PMID:21488147-16] 16.0 ^16.1 ^16.2 ^16.3 Evans, IM & Zachary, IC (2011) Protein kinase D in vascular biology and angiogenesis. IUBMB Life 63 258-63 PubMed GONUTS page

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HUMAN:KPCD1

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