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HUMAN:IRF5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IRF5
Protein Name(s) Interferon regulatory factor 5

IRF-5

External Links
UniProt Q13568
EMBL AY504947
AY504946
AY693665
AY693666
AY693668
DQ277633
DQ277634
U51127
EF064718
AC025594
CH236950
CH236950
CH471070
CH471070
BC004201
BC004139
DQ995495
DQ995496
CCDS CCDS43645.1
CCDS56512.1
CCDS5808.1
PIR G02474
RefSeq NP_001092097.2
NP_001092099.1
NP_001092100.1
NP_001229381.1
NP_116032.1
XP_005250374.1
XP_006716037.1
UniGene Hs.521181
PDB 3DSH
PDBsum 3DSH
ProteinModelPortal Q13568
SMR Q13568
BioGrid 109871
DIP DIP-46348N
IntAct Q13568
STRING 9606.ENSP00000349770
PhosphoSite Q13568
DMDM 20178305
MaxQB Q13568
PaxDb Q13568
PRIDE Q13568
DNASU 3663
Ensembl ENST00000249375
ENST00000357234
ENST00000402030
ENST00000465603
ENST00000473745
ENST00000477535
ENST00000619830
GeneID 3663
KEGG hsa:3663
UCSC uc003vog.3
uc003voh.3
CTD 3663
GeneCards GC07P128577
HGNC HGNC:6120
HPA HPA046700
MIM 180300
607218
612245
612251
neXtProt NX_Q13568
Orphanet 206
220393
220402
186
536
771
PharmGKB PA29919
eggNOG NOG45024
GeneTree ENSGT00760000119093
HOGENOM HOG000037433
HOVERGEN HBG105715
InParanoid Q13568
KO K09446
OMA YDGPRDM
PhylomeDB Q13568
TreeFam TF328512
Reactome REACT_25078
REACT_25162
EvolutionaryTrace Q13568
GeneWiki IRF5
GenomeRNAi 3663
NextBio 14327
PRO PR:Q13568
Proteomes UP000005640
Bgee Q13568
CleanEx HS_IRF5
ExpressionAtlas Q13568
Genevestigator Q13568
GO GO:0005737
GO:0005829
GO:0005634
GO:0000975
GO:0003700
GO:0019221
GO:0051607
GO:0060333
GO:0043065
GO:0032727
GO:0032728
GO:0032735
GO:0045944
GO:0032495
GO:0032494
GO:0006351
GO:0060337
Gene3D 1.10.10.10
2.60.200.10
InterPro IPR019817
IPR001346
IPR019471
IPR029838
IPR017855
IPR008984
IPR011991
PANTHER PTHR11949:SF10
Pfam PF00605
PF10401
PRINTS PR00267
SMART SM00348
SUPFAM SSF49879
PROSITE PS00601
PS51507

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001346

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P15314

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0043565,GO:0045944

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12600985[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:3439)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:23332764[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22412986[4]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P29460)

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:22412986[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032735

positive regulation of interleukin-12 production

PMID:22412986[4]

ECO:0000305

curator inference used in manual assertion

GO:0045944

P

Seeded From UniProt

complete

involved_in

GO:0032728

positive regulation of interferon-beta production

PMID:22412986[4]

ECO:0000305

curator inference used in manual assertion

GO:0045944

P

Seeded From UniProt

complete

involved_in

GO:0032727

positive regulation of interferon-alpha production

PMID:22412986[4]

ECO:0000305

curator inference used in manual assertion

GO:0045944

P

Seeded From UniProt

complete

involved_in

GO:0032495

response to muramyl dipeptide

PMID:22412986[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032494

response to peptidoglycan

PMID:22412986[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22412986[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22412986[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096873
MGI:MGI:1859179
MGI:MGI:96395
MGI:MGI:96590
PANTHER:PTN000942746
RGD:2920
UniProtKB:O14896
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q13568
UniProtKB:Q14653
UniProtKB:Q15306
UniProtKB:Q92985
ZFIN:ZDB-GENE-041114-13
ZFIN:ZDB-GENE-070912-330

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1096873
MGI:MGI:1350924
MGI:MGI:1859179
MGI:MGI:1859212
MGI:MGI:96395
MGI:MGI:96590
PANTHER:PTN000942747
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q92985
ZFIN:ZDB-GENE-040718-367
ZFIN:ZDB-GENE-070912-330

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859212
PANTHER:PTN000942746
UniProtKB:P10914
UniProtKB:P14316
UniProtKB:Q02556
UniProtKB:Q14653
UniProtKB:Q15306
UniProtKB:Q92985
ZFIN:ZDB-GENE-070912-330

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18836453[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q13568

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56477
ensembl:ENSMUSP00000127021

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019471
InterPro:IPR019817

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019471
InterPro:IPR019817

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029838

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029838

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001346

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029838

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

Reactome:R-HSA-877300

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1031716
Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ Barnes, BJ et al. (2003) Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. J. Biol. Chem. 278 16630-41 PubMed GONUTS page
  3. ↑ Jolma, A et al. (2013) DNA-binding specificities of human transcription factors. Cell 152 327-39 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Chang Foreman, HC et al. (2012) Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS ONE 7 e33098 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ Chen, W et al. (2008) Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat. Struct. Mol. Biol. 15 1213-20 PubMed GONUTS page
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