HUMAN:IQGA1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IQGAP1 (synonyms: KIAA0051)
Protein Name(s)	Ras GTPase-activating-like protein IQGAP1 p195
External Links
UniProt	P46940
EMBL	L33075 D29640 CH471101 BC151834
CCDS	CCDS10362.1
PIR	A54854
RefSeq	NP_003861.1
UniGene	Hs.430551
PDB	1X0H 2RR8 3FAY 3I6X
PDBsum	1X0H 2RR8 3FAY 3I6X
ProteinModelPortal	P46940
SMR	P46940
BioGrid	114353
DIP	DIP-32597N
IntAct	P46940
MINT	MINT-4999354
STRING	9606.ENSP00000268182
PhosphoSite	P46940
DMDM	1170586
MaxQB	P46940
PaxDb	P46940
PeptideAtlas	P46940
PRIDE	P46940
DNASU	8826
Ensembl	ENST00000268182
GeneID	8826
KEGG	hsa:8826
UCSC	uc002bpl.1
CTD	8826
GeneCards	GC15P090931
H-InvDB	HIX0172824
HGNC	HGNC:6110
HPA	CAB013302 HPA014055
MIM	603379
neXtProt	NX_P46940
PharmGKB	PA29910
eggNOG	COG5261
GeneTree	ENSGT00600000084379
HOGENOM	HOG000004842
HOVERGEN	HBG052143
InParanoid	P46940
KO	K16848
OMA	QDILYQA
OrthoDB	EOG7FNC6M
PhylomeDB	P46940
TreeFam	TF313078
Reactome	REACT_18274 REACT_23832
ChiTaRS	IQGAP1
EvolutionaryTrace	P46940
GeneWiki	IQGAP1
GenomeRNAi	8826
NextBio	33114
PMAP-CutDB	P46940
PRO	PR:P46940
Proteomes	UP000005640
Bgee	P46940
CleanEx	HS_IQGAP1
ExpressionAtlas	P46940
Genevestigator	P46940
GO	GO:0005884 GO:0030424 GO:0030054 GO:0031252 GO:0005737 GO:0036464 GO:0070062 GO:0031234 GO:0005925 GO:0030426 GO:0016328 GO:0005874 GO:0030496 GO:0043005 GO:0005634 GO:0005886 GO:0036057 GO:0005509 GO:0005516 GO:0005096 GO:0005095 GO:0005547 GO:0019901 GO:0019903 GO:0043539 GO:0005099 GO:0071277 GO:0071364 GO:0006112 GO:0007173 GO:0072015 GO:0043086 GO:0035305 GO:1990138 GO:0043547 GO:0045860 GO:0071902 GO:0001817 GO:0050796 GO:0007165 GO:0007264 GO:0044281
Gene3D	1.10.418.10 1.10.506.10 4.10.270.10
InterPro	IPR001715 IPR000048 IPR027401 IPR027417 IPR000593 IPR023152 IPR001936 IPR008936 IPR001202
Pfam	PF00307 PF00612 PF00616 PF03836
SMART	SM00033 SM00015 SM00323 SM00456
SUPFAM	SSF47576 SSF48350 SSF52540
PROSITE	PS50021 PS50096 PS00509 PS50018 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005886	plasma membrane	PMID:29033352^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:29033352^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29033352^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:20883816^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20883816^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	PMID:26242911^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:26242911^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:26242911^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:26242911^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071364)	Seeded From UniProt	complete
enables	GO:0031267	small GTPase binding	PMID:26242911^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P60953	F		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:25554515^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15311	F		Seeded From UniProt	complete
enables	GO:0044548	S100 protein binding	PMID:25554515^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25815	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25554515^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	PMID:25554515^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7Q7	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7Q7	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7Q7	C		Seeded From UniProt	complete
colocalizes_with	GO:0015630	microtubule cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7Q7	C	part_of:(CL:0000540)	Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7Q7	C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1990138	neuron projection extension	PMID:15695813^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	PMID:17563371^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P15056) part_of:(GO:0071364)\|has_direct_input(UniProtKB:P15056) part_of:(GO:0007173)	Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:17563371^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:17563371^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	PMID:15121898^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:18567582^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:17563371^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P15056) part_of:(GO:0007173)\|has_regulation_target(UniProtKB:P15056) part_of:(GO:0071364)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17563371^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15056	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:18567582^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	activated_by:(CHEBI:29108)	Seeded From UniProt	complete
involved_in	GO:0072015	glomerular visceral epithelial cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B5DFH1	P		Seeded From UniProt	complete
part_of	GO:0036057	slit diaphragm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:B5DFH1	C		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:22493426^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:15166316^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:16380380^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28827	F		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:21525035^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	PMID:22493426^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005095	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:1990776	response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
involved_in	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
involved_in	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
involved_in	GO:1900006	positive regulation of dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	F		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7Q7 ensembl:ENSRNOP00000018021	C		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
enables	GO:0048365	Rac GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	F		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
involved_in	GO:0035305	negative regulation of dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
enables	GO:0017048	Rho GTPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	C		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JKF1 ensembl:ENSMUSP00000128278	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008936	P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001936 InterPro:IPR023152	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8051149^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005884	actin filament	PMID:8670801^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:8670801^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:8051149^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005095	GTPase inhibitor activity	PMID:8670801^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:18567582^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6798743 Reactome:R-HSA-451377	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5672329 Reactome:R-HSA-5672304 Reactome:R-HSA-5626549 Reactome:R-HSA-5626507 Reactome:R-HSA-5626469	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Liu, J et al. (2017) The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell 21 635-649.e8 PubMed GONUTS page
↑ ^2.0 ^2.1 Johnson, M et al. (2011) IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int. J. Biochem. Cell Biol. 43 65-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Cao, D et al. (2015) Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. J. Biol. Chem. 290 23766-80 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Nammalwar, RC et al. (2015) Ezrin interacts with the scaffold protein IQGAP1 and affects its cortical localization. Biochim. Biophys. Acta 1853 2086-94 PubMed GONUTS page
↑ Li, Z et al. (2005) IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J. Biol. Chem. 280 13871-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ren, JG et al. (2007) IQGAP1 modulates activation of B-Raf. Proc. Natl. Acad. Sci. U.S.A. 104 10465-9 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Villacé, P et al. (2004) The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 32 2411-20 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^13.0 ^13.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Ren, JG et al. (2008) IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J. Biol. Chem. 283 22972-82 PubMed GONUTS page
↑ ^15.0 ^15.1 Dixon, MJ et al. (2012) IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J. Biol. Chem. 287 22483-96 PubMed GONUTS page
↑ Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page
↑ Phillips-Mason, PJ et al. (2006) The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. J. Biol. Chem. 281 4903-10 PubMed GONUTS page
↑ Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page
↑ ^19.0 ^19.1 Weissbach, L et al. (1994) Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J. Biol. Chem. 269 20517-21 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Hart, MJ et al. (1996) IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 15 2997-3005 PubMed GONUTS page

[PMID:29033352-1] 1.0 ^1.1 ^1.2 Liu, J et al. (2017) The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell 21 635-649.e8 PubMed GONUTS page

[PMID:20883816-2] 2.0 ^2.1 Johnson, M et al. (2011) IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int. J. Biochem. Cell Biol. 43 65-73 PubMed GONUTS page

[PMID:26242911-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Cao, D et al. (2015) Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. J. Biol. Chem. 290 23766-80 PubMed GONUTS page

[PMID:25468996-4] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:25554515-5] 5.0 ^5.1 ^5.2 ^5.3 Nammalwar, RC et al. (2015) Ezrin interacts with the scaffold protein IQGAP1 and affects its cortical localization. Biochim. Biophys. Acta 1853 2086-94 PubMed GONUTS page

[PMID:15695813-6] Li, Z et al. (2005) IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J. Biol. Chem. 280 13871-8 PubMed GONUTS page

[PMID:17563371-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ren, JG et al. (2007) IQGAP1 modulates activation of B-Raf. Proc. Natl. Acad. Sci. U.S.A. 104 10465-9 PubMed GONUTS page

[PMID:21423176-8] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:23533145-9] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:15121898-10] Villacé, P et al. (2004) The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res. 32 2411-20 PubMed GONUTS page

[PMID:19199708-11] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-12] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-13] 13.0 ^13.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:18567582-14] 14.0 ^14.1 ^14.2 Ren, JG et al. (2008) IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J. Biol. Chem. 283 22972-82 PubMed GONUTS page

[PMID:22493426-15] 15.0 ^15.1 Dixon, MJ et al. (2012) IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold. J. Biol. Chem. 287 22483-96 PubMed GONUTS page

[PMID:15166316-16] Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page

[PMID:16380380-17] Phillips-Mason, PJ et al. (2006) The receptor protein-tyrosine phosphatase PTPmu interacts with IQGAP1. J. Biol. Chem. 281 4903-10 PubMed GONUTS page

[PMID:21525035-18] Bharti, P et al. (2011) PEX14 is required for microtubule-based peroxisome motility in human cells. J. Cell. Sci. 124 1759-68 PubMed GONUTS page

[PMID:8051149-19] 19.0 ^19.1 Weissbach, L et al. (1994) Identification of a human rasGAP-related protein containing calmodulin-binding motifs. J. Biol. Chem. 269 20517-21 PubMed GONUTS page

[PMID:8670801-20] 20.0 ^20.1 ^20.2 Hart, MJ et al. (1996) IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 15 2997-3005 PubMed GONUTS page

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